Inhibition of lactate dehydrogenase to treat epilepsy

New England Journal of Medicine

Volumn 373, Issue 2, 2015, Pages 187-189

  Rho, Jong M ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; ISOSAFROLE; KETONE; LACTATE DEHYDROGENASE; LACTIC ACID; OXAMIC ACID; POTASSIUM CHANNEL BLOCKING AGENT; STIRIPENTOL; 1,3 DIOXOLANE DERIVATIVE; ANTICONVULSIVE AGENT; ENZYME INHIBITOR; SAFROLE;

ANTICONVULSANT ACTIVITY; ASTROCYTE; BASAL GANGLION; BRAIN NERVE CELL; ENZYME ACTIVITY; ENZYME INHIBITION; EPILEPSY; GLYCOLYSIS; HIPPOCAMPUS; HUMAN; HYPERPOLARIZATION; INTERNEURON; KETOGENIC DIET; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SEIZURE; SEVERE MYOCLONIC EPILEPSY IN INFANCY; SHORT SURVEY; SUBSTANTIA NIGRA; SUBTHALAMIC NUCLEUS; TEMPORAL LOBE EPILEPSY; ANIMAL; ANTAGONISTS AND INHIBITORS; METABOLISM;

ANIMALS; ANTICONVULSANTS; DIOXOLANES; ENZYME INHIBITORS; EPILEPSY; HUMANS; L-LACTATE DEHYDROGENASE; SAFROLE;

EID: 84936806214     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcibr1503558     Document Type: Article

References (5)

1. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000; 342: 314-9.
2. Neal EG, Chaffe H, Schwartz RH, et al. The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial. Lancet Neurol 2008; 7: 500-6.
3. Juge N, Gray JA, Omote H, et al. Metabolic control of vesicular glutamate transport and release. Neuron 2010; 68: 99-112.
4. Boison D. The adenosine kinase hypothesis of epileptogenesis. Prog Neurobiol 2008; 84: 249-62.
5. Sada N, Lee S, Katsu T, Otsuki T, Inoue T. Epilepsy treatment: targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 2015; 347: 1362-7.