TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells

Cell Stem Cell

Volumn 17, Issue 1, 2015, Pages 47-59

  Wu, Zhengming ^a   Wei, Dong ^b   Gao, Wenchao ^c   Xu, Yuting ^a   Hu, Zhiqian ^c   Ma, Zhenyu ^d   Gao, Chunfang ^b   Zhu, Xiaoyan ^e   Li, Qingquan ^a  

^a FUDAN UNIVERSITY   (China)

^b Department of Anus and Intestine Surgery PLA Central Hospital 150   (China)

^c SECOND MILITARY MEDICAL UNIVERSITY   (China)

^d FUDAN UNIVERSITY   (China)

^e FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; GLUTAMIC ACID; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; LYSINE; THROMBOPOIETIN; THROMBOPOIETIN RECEPTOR; TYROSINE; E1A ASSOCIATED P300 PROTEIN; EP300 PROTEIN, HUMAN; FATTY ACID; LRP6 PROTEIN, HUMAN; MPL PROTEIN, HUMAN;

AMINO ACID METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATABOLISM; CELL RENEWAL; COLORECTAL CANCER; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VIVO STUDY; LIVER METASTASIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RANDOMIZATION; REDOX STRESS; TUMOR CELL; TUMOR INITIATING CELL; WNT SIGNALING PATHWAY; ACETYLATION; ANIMAL; BIOSYNTHESIS; CANCER STEM CELL; COLORECTAL TUMOR; DEFICIENCY; GENETICS; KNOCKOUT MOUSE; LIVER TUMOR; METABOLISM; ONCOGENE MYC; OXIDATIVE STRESS; SECONDARY; TUMOR CELL LINE; XENOGRAFT;

ACETYL COENZYME A; ACETYLATION; ANIMALS; CELL LINE, TUMOR; CELLULAR REPROGRAMMING; COLORECTAL NEOPLASMS; E1A-ASSOCIATED P300 PROTEIN; FATTY ACIDS; GENES, MYC; HETEROGRAFTS; HUMANS; LIVER NEOPLASMS; LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN-6; LYSINE; MICE; MICE, KNOCKOUT; NEOPLASTIC STEM CELLS; OXIDATIVE STRESS; RECEPTORS, THROMBOPOIETIN; THROMBOPOIETIN;

EID: 84936991599     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2015.05.016     Document Type: Article

References (38)

1. Barski, A., Cuddapah, S., Cui, K., Roh, T.Y., Schones, D.E., Wang, Z., Wei, G., Chepelev, I., and Zhao, K. (2007). High-resolution profiling of histone methyl-ations in the human genome. Cell 129, 823-837.
2. Bernstein, B.E., Mikkelsen, T.S., Xie, X., Kamal, M., Huebert, D.J., Cuff, J., Fry, B., Meissner, A., Wernig, M., Plath, K., et al. (2006). A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326.
3. Bilic, J., Huang, Y.L., Davidson, G., Zimmermann, T., Cruciat, C.M., Bienz, M., and Niehrs, C. (2007). Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation. Science 316, 1619-1622.
4. Chanprasert, S., Geddis, A.E., Barroga, C., Fox, N.E., and Kaushansky, K. (2006). Thrombopoietin (TPO) induces c-myc expression through a PI3K-and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes. Cell. Signal. 18, 1212-1218.
5. Davidson, G., Wu, W., Shen, J., Bilic, J., Fenger, U., Stannek, P., Glinka, A., and Niehrs, C. (2005). Casein kinase1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature 438, 867-872.
6. Fox, N., Priestley, G., Papayannopoulou, T., and Kaushansky, K. (2002). Thrombopoietin expands hematopoietic stem cells after transplantation. J. Clin. Invest. 110, 389-394.
7. Gao, W., Chen, L., Ma, Z., Du, Z., Zhao, Z., Hu, Z., and Li, Q. (2013). Isolation and phenotypic characterization of colorectal cancer stem cells with organ-specific metastatic potential. Gastroenterology 145, 636-646.e5.
8. Higashino, K., Tsukada, K., and Lieberman, I. (1965). Saccharopine, a product of lysine breakdown by mammalian liver. Biochem. Biophys. Res. Commun. 20, 285-290.
9. Hong, Y., Dumènil, D., van der Loo, B., Goncalves, F., Vainchenker, W., and Erusalimsky, J.D. (1998). Protein kinase C mediates the mitogenic action of thrombopoietin in c-Mpl-expressing UT-7 cells. Blood 91, 813-822.
10. Jessup, J.M., Battle, P., Waller, H., Edmiston, K.H., Stolz, D.B., Watkins, S.C., Locker, J., and Skena, K. (1999). Reactive nitrogen and oxygen radicals formed during hepatic ischemia-reperfusion kill weakly metastatic colorectal cancer cells. Cancer Res. 59, 1825-1829.
11. Kaochar, S., and Tu, B.P. (2012). Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression. Trends Biochem. Sci. 37, 477-483.
12. Kaser, A., Brandacher, G., Steurer, W., Kaser, S., Offner, F.A., Zoller, H., Theurl, I., Widder, W., Molnar, C., Ludwiczek, O., et al. (2001). Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood 98, 2720-2725.
13. Knoepfler, P.S., Zhang, X.Y., Cheng, P.F., Gafken, P.R., McMahon, S.B., and Eisenman, R.N. (2006). Myc influences global chromatin structure. EMBO J. 25, 2723-2734.
14. Knüpfer, H., and Preiss, R. (2010). Serum interleukin-6 levels in colorectal cancer patients-a summary of published results. Int. J. Colorectal Dis. 25, 135-140.
15. Koch, C.M., Andrews, R.M., Flicek, P., Dillon, S.C., Karaöz, U., Clelland, G.K., Wilcox, S., Beare, D.M., Fowler, J.C., Couttet, P., et al. (2007). The landscape of histone modifications across 1% of the human genome in five human cell lines. Genome Res. 17, 691-707.
16. Kueh, A.J., Dixon, M.P., Voss, A.K., and Thomas, T. (2011). HBO1 is required for H3K14 acetylation and normal transcriptional activity during embryonic development. Mol. Cell. Biol. 31, 845-860.
17. Kuzmichev, A., Nishioka, K., Erdjument-Bromage, H., Tempst, P., and Reinberg, D. (2002). Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev. 16, 2893-2905.
18. Lewerenz, J., Hewett, S.J., Huang, Y., Lambros, M., Gout, P.W., Kalivas, P.W., Massie, A., Smolders, I., Methner, A., Pergande, M., et al. (2013). The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities. Antioxid. Redox Signal 18, 522-555.
19. Liu, Y.H., Di, Y.M., Zhou, Z.W., Mo, S.L., and Zhou, S.F. (2010). Multidrug resistance-associated proteins and implications in drug development. Clin. Exp. Pharmacol. Physiol. 37, 115-120.
20. Mao, P., Joshi, K., Li, J., Kim, S.H., Li, P., Santana-Santos, L., Luthra, S., Chandran, U.R., Benos, P.V., Smith, L., et al. (2013). Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3. Proc. Natl. Acad. Sci. USA 110, 8644-8649.
21. Martin, T.G., 3rd, Somberg, K.A., Meng, Y.G., Cohen, R.L., Heid, C.A., de Sauvage, F.J., and Shuman, M.A. (1997). Thrombopoietin levels in patients with cirrhosis before and after orthotopic liver transplantation. Ann. Intern. Med. 127, 285-288.
22. Niehrs, C. (2006). Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene 25, 7469-7481.
23. Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. (1996). The transcriptional coactivators p300 and CBP are histone acetyltrans-ferases. Cell 87, 953-959.
24. Oskarsson, T., Batlle, E., and Massagué, J. (2014). Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell 14, 306-321.
25. Pang, R., Law, W.L., Chu, A.C., Poon, J.T., Lam, C.S., Chow, A.K., Ng, L., Cheung, L.W., Lan, X.R., Lan, H.Y., et al. (2010). A subpopulation of CD26+ cancer stem cells with metastatic capacity in human colorectal cancer. Cell Stem Cell 6, 603-615.
26. Papes, F., Kemper, E.L., Cord-Neto, G., Langone, F., and Arruda, P. (1999). Lysine degradation through the saccharopine pathway in mammals: involvement of both bifunctional and monofunctional lysine-degrading enzymes in mouse. Biochem. J. 344, 555-563.
27. Papes, F., Surpili, M.J., Langone, F., Trigo, J.R., and Arruda, P. (2001). The essential amino acid lysine acts as precursor of glutamate in the mammalian central nervous system. FEBS Lett. 488, 34-38.
28. Richman, P.G., and Meister, A. (1975). Regulation of gamma-glutamyl-cysteine synthetase by nonallosteric feedback inhibition by glutathione. J. Biol. Chem. 250, 1422-1426.
29. Sangeetha, P., Das, U.N., Koratkar, R., and Suryaprabha, P. (1990). Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer. Free Radic. Biol. Med. 8, 15-19.
30. Swigut, T., and Wysocka, J. (2007). H3K27 demethylases, at long last. Cell 131, 29-32.
31. Tang, D.G. (2012). Understanding cancer stem cell heterogeneity and plasticity. Cell Res. 22, 457-472.
32. Tao, G.Z., Lehwald, N., Jang, K.Y., Baek, J., Xu, B., Omary, M.B., and Sylvester, K.G. (2013). Wnt/b-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3. J. Biol. Chem. 288, 17214-17224.
33. Vermeulen, L., De Sousa E Melo, F., van der Heijden, M., Cameron, K., de Jong, J.H., Borovski, T., Tuynman, J.B., Todaro, M., Merz, C., Rodermond, H., et al. (2010). Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat. Cell Biol. 12, 468-476.
34. Vigon, I., Mornon, J.P., Cocault, L., Mitjavila, M.T., Tambourin, P., Gisselbrecht, S., and Souyri, M. (1992). Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification ofamember of the hematopoietic growth factor receptor superfamily. Proc. Natl. Acad. Sci. USA 89, 5640-5644.
35. Visvader, J.E., and Lindeman, G.J. (2008). Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat. Rev. Cancer 8, 755-768.
36. Voutsadakis, I.A. (2014). Thrombocytosis as a prognostic marker in gastrointestinal cancers. World J. Gastrointest. Oncol. 6, 34-40.
37. Wang, F.S., Shao, Z.G., Zhang, J.L., and Liu, Y.F. (2012). Colorectal liver metastases rarely occur in patients with chronic hepatitis virus infection. Hepatogastroenterology 59, 1390-1392.
38. Yuan, L.W., and Gambee, J.E. (2000). Phosphorylation of p300 at serine 89 by protein kinase C. J. Biol. Chem. 275, 40946-40951.