메뉴 건너뛰기




Volumn 13, Issue 10, 2015, Pages 1743-1756

New paradigms in sepsis: From prevention to protection of failing microcirculation

Author keywords

Genome; Infection; Inflammation; Microcirculation; Septic shock

Indexed keywords

CELL PROTEIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; KARYOPHERIN; MENINGOCOCCUS VACCINE; MYELOID DIFFERENTIATION FACTOR 88; STEROL REGULATORY ELEMENT BINDING PROTEIN; STREPTOCOCCUS VACCINE; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; VIRULENCE FACTOR; AUTACOID;

EID: 84942983959     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13061     Document Type: Article
Times cited : (101)

References (100)
  • 2
    • 84942992396 scopus 로고
    • Physiology of hemostasis: cellular aspects
    • In: Nathan DG, Oski FA, eds., 4th edn. Philadelphia, London, Toronto, Montreal, Sidney, Tokyo: W.B. Saunders Company
    • Hawiger J. Physiology of hemostasis: cellular aspects. In: Nathan DG, Oski FA, eds. Hematology of Infancy and Childhood, 4th edn. Philadelphia, London, Toronto, Montreal, Sidney, Tokyo: W.B. Saunders Company, 1992: 1495-512.
    • (1992) Hematology of Infancy and Childhood , pp. 1495-1512
    • Hawiger, J.1
  • 4
    • 45149121950 scopus 로고    scopus 로고
    • Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis
    • Ye X, Ding J, Zhou X, Chen G, Liu SF. Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med 2008; 205: 1303-15.
    • (2008) J Exp Med , vol.205 , pp. 1303-1315
    • Ye, X.1    Ding, J.2    Zhou, X.3    Chen, G.4    Liu, S.F.5
  • 7
    • 84882730275 scopus 로고    scopus 로고
    • Blood Systems Response to Sepsis
    • [Internet]
    • National Heart Lung and Blood Institute Working Group Report. Blood Systems Response to Sepsis [Internet]. 2010. www.nhlbi.nih.gov/meetings/workshops/bsrts.htm.
    • (2010)
  • 8
    • 82555192788 scopus 로고    scopus 로고
    • How to approach genome wars in sepsis?
    • Hawiger J, Musser JM. How to approach genome wars in sepsis? Crit Care 2011; 15: 1007.
    • (2011) Crit Care , vol.15 , pp. 1007
    • Hawiger, J.1    Musser, J.M.2
  • 9
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-55.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6    Schein, R.M.7    Sibbald, W.J.8
  • 10
    • 0031035860 scopus 로고    scopus 로고
    • Dear SIRS, I'm sorry to say that I don't like you
    • Vincent JL. Dear SIRS, I'm sorry to say that I don't like you. Crit Care Med 1997; 25: 372-4.
    • (1997) Crit Care Med , vol.25 , pp. 372-374
    • Vincent, J.L.1
  • 14
    • 0033831191 scopus 로고    scopus 로고
    • Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury
    • Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ. Identification of the Ebola virus glycoprotein as the main viral determinant of vascular cell cytotoxicity and injury. Nat Med 2000; 6: 886-9.
    • (2000) Nat Med , vol.6 , pp. 886-889
    • Yang, Z.Y.1    Duckers, H.J.2    Sullivan, N.J.3    Sanchez, A.4    Nabel, E.G.5    Nabel, G.J.6
  • 16
    • 84930246161 scopus 로고    scopus 로고
    • Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak
    • Wong G, Kobinger GP. Backs against the wall: novel and existing strategies used during the 2014-2015 Ebola virus outbreak. Clin Microbiol Rev 2015; 28: 593-601.
    • (2015) Clin Microbiol Rev , vol.28 , pp. 593-601
    • Wong, G.1    Kobinger, G.P.2
  • 17
    • 4043053773 scopus 로고    scopus 로고
    • Pathogenesis of filoviral haemorrhagic fevers
    • Mahanty S, Bray M. Pathogenesis of filoviral haemorrhagic fevers. Lancet Infect Dis 2004; 4: 487-98.
    • (2004) Lancet Infect Dis , vol.4 , pp. 487-498
    • Mahanty, S.1    Bray, M.2
  • 19
    • 84876492103 scopus 로고    scopus 로고
    • Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia
    • Flick MJ, Du X, Prasad JM, Raghu H, Palumbo JS, Smeds E, Hook M, Degen JL. Genetic elimination of the binding motif on fibrinogen for the S. aureus virulence factor ClfA improves host survival in septicemia. Blood. 2013;121:1783-94.
    • (2013) Blood , vol.121 , pp. 1783-1794
    • Flick, M.J.1    Du, X.2    Prasad, J.M.3    Raghu, H.4    Palumbo, J.S.5    Smeds, E.6    Hook, M.7    Degen, J.L.8
  • 21
    • 84908178935 scopus 로고    scopus 로고
    • The, "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation
    • DiGiandomenico A, Veach RA, Zienkiewicz J, Moore DJ, Wylezinski LS, Hutchens MA, Hawiger J. The, "genomic storm" induced by bacterial endotoxin is calmed by a nuclear transport modifier that attenuates localized and systemic inflammation. PLoS ONE 2014; 9: e110183.
    • (2014) PLoS ONE , vol.9 , pp. e110183
    • DiGiandomenico, A.1    Veach, R.A.2    Zienkiewicz, J.3    Moore, D.J.4    Wylezinski, L.S.5    Hutchens, M.A.6    Hawiger, J.7
  • 23
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • Beutler BA. TLRs and innate immunity. Blood 2009; 113: 1399-407.
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 24
    • 84864800812 scopus 로고    scopus 로고
    • Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome
    • Adamzik M, Hamburger T, Petrat F, Peters J, de Groot H, Hartmann M. Free hemoglobin concentration in severe sepsis: methods of measurement and prediction of outcome. Crit Care 2012; 16: R125.
    • (2012) Crit Care , vol.16 , pp. R125
    • Adamzik, M.1    Hamburger, T.2    Petrat, F.3    Peters, J.4    de Groot, H.5    Hartmann, M.6
  • 25
    • 34247128758 scopus 로고    scopus 로고
    • Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    • Angus DC, Yang L, Kong L, Kellum JA, Delude RL, Tracey KJ, Weissfeld L. Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis. Crit Care Med 2007; 35: 1061-7.
    • (2007) Crit Care Med , vol.35 , pp. 1061-1067
    • Angus, D.C.1    Yang, L.2    Kong, L.3    Kellum, J.A.4    Delude, R.L.5    Tracey, K.J.6    Weissfeld, L.7
  • 27
    • 84866386143 scopus 로고    scopus 로고
    • Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis
    • McDonald B, Urrutia R, Yipp BG, Jenne CN, Kubes P. Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis. Cell Host Microbe 2012; 12: 324-33.
    • (2012) Cell Host Microbe , vol.12 , pp. 324-333
    • McDonald, B.1    Urrutia, R.2    Yipp, B.G.3    Jenne, C.N.4    Kubes, P.5
  • 28
    • 33645961574 scopus 로고    scopus 로고
    • Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol
    • Woywodt A, Blann AD, Kirsch T, Erdbruegger U, Banzet N, Haubitz M, Dignat-George F. Isolation and enumeration of circulating endothelial cells by immunomagnetic isolation: proposal of a definition and a consensus protocol. J Thromb Haemost 2006; 4: 671-7.
    • (2006) J Thromb Haemost , vol.4 , pp. 671-677
    • Woywodt, A.1    Blann, A.D.2    Kirsch, T.3    Erdbruegger, U.4    Banzet, N.5    Haubitz, M.6    Dignat-George, F.7
  • 30
    • 77950218147 scopus 로고    scopus 로고
    • Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department
    • Gaieski DF, Mikkelsen ME, Band RA, Pines JM, Massone R, Furia FF, Shofer FS, Goyal M. Impact of time to antibiotics on survival in patients with severe sepsis or septic shock in whom early goal-directed therapy was initiated in the emergency department. Crit Care Med 2010; 38: 1045-53.
    • (2010) Crit Care Med , vol.38 , pp. 1045-1053
    • Gaieski, D.F.1    Mikkelsen, M.E.2    Band, R.A.3    Pines, J.M.4    Massone, R.5    Furia, F.F.6    Shofer, F.S.7    Goyal, M.8
  • 31
    • 84890200494 scopus 로고    scopus 로고
    • Vasoplegia in septic shock: do we really fight the right enemy?
    • Sharawy N. Vasoplegia in septic shock: do we really fight the right enemy? J Crit Care 2014; 29: 83-7.
    • (2014) J Crit Care , vol.29 , pp. 83-87
    • Sharawy, N.1
  • 32
    • 84897377065 scopus 로고    scopus 로고
    • Why have clinical trials in sepsis failed?
    • Marshall JC. Why have clinical trials in sepsis failed? Trends Mol Med 2014; 20: 195-203.
    • (2014) Trends Mol Med , vol.20 , pp. 195-203
    • Marshall, J.C.1
  • 34
    • 84907958778 scopus 로고    scopus 로고
    • Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection
    • Rauch S, Gough P, Kim HK, Schneewind O, Missiakas D. Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection. Infect Immun 2014; 82: 4889-98.
    • (2014) Infect Immun , vol.82 , pp. 4889-4898
    • Rauch, S.1    Gough, P.2    Kim, H.K.3    Schneewind, O.4    Missiakas, D.5
  • 35
    • 84905842658 scopus 로고    scopus 로고
    • The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli
    • Qiao H, Liu Y, Veach RA, Wylezinski L, Hawiger J. The adaptor CRADD/RAIDD controls activation of endothelial cells by proinflammatory stimuli. J Biol Chem 2014; 289: 21973-83.
    • (2014) J Biol Chem , vol.289 , pp. 21973-21983
    • Qiao, H.1    Liu, Y.2    Veach, R.A.3    Wylezinski, L.4    Hawiger, J.5
  • 36
    • 38449103506 scopus 로고    scopus 로고
    • Sequence-based human leukocyte antigen-B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomes
    • Sanchez A, Wagoner KE, Rollin PE. Sequence-based human leukocyte antigen-B typing of patients infected with Ebola virus in Uganda in 2000: identification of alleles associated with fatal and nonfatal disease outcomes. J Infect Dis 2007; 196(Suppl. 2): S329-36.
    • (2007) J Infect Dis , vol.196 , pp. S329-S336
    • Sanchez, A.1    Wagoner, K.E.2    Rollin, P.E.3
  • 37
    • 79960121968 scopus 로고    scopus 로고
    • Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency
    • Picard C, Casanova JL, Puel A. Infectious diseases in patients with IRAK-4, MyD88, NEMO, or IkappaBalpha deficiency. Clin Microbiol Rev 2011; 24: 490-7.
    • (2011) Clin Microbiol Rev , vol.24 , pp. 490-497
    • Picard, C.1    Casanova, J.L.2    Puel, A.3
  • 38
    • 84901496122 scopus 로고    scopus 로고
    • Discovery of single-gene inborn errors of immunity by next generation sequencing
    • Conley ME, Casanova JL. Discovery of single-gene inborn errors of immunity by next generation sequencing. Curr Opin Immunol 2014; 30: 17-23.
    • (2014) Curr Opin Immunol , vol.30 , pp. 17-23
    • Conley, M.E.1    Casanova, J.L.2
  • 42
    • 84942983747 scopus 로고    scopus 로고
    • National Center for Immunizations and Respiratory Diseases
    • 2014 Accessed 21 April
    • Help Protect Your Preteen and Teen Against Meningococcal Disease. National Center for Immunizations and Respiratory Diseases; 2014. www.cdc.gov/features/meningococcal. Accessed 21 April 2014.
    • (2014)
  • 43
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • O'Neill LA, Bowie AG. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 2007; 7: 353-64.
    • (2007) Nat Rev Immunol , vol.7 , pp. 353-364
    • O'Neill, L.A.1    Bowie, A.G.2
  • 44
    • 0034984262 scopus 로고    scopus 로고
    • Innate immunity and inflammation: a transcriptional paradigm
    • Hawiger J. Innate immunity and inflammation: a transcriptional paradigm. Immunol Res 2001; 23: 99-109.
    • (2001) Immunol Res , vol.23 , pp. 99-109
    • Hawiger, J.1
  • 47
    • 84924265176 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the acetaminophen for the reduction of oxidative injury in severe sepsis trial
    • Janz DR, Bastarache JA, Rice TW, Bernard GR, Warren MA, Wickersham N, Sills G, Oates JA, Roberts LJ 2nd, Ware LB. Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the acetaminophen for the reduction of oxidative injury in severe sepsis trial. Crit Care Med 2015; 43: 534-41.
    • (2015) Crit Care Med , vol.43 , pp. 534-541
    • Janz, D.R.1    Bastarache, J.A.2    Rice, T.W.3    Bernard, G.R.4    Warren, M.A.5    Wickersham, N.6    Sills, G.7    Oates, J.A.8    Roberts 2nd, L.J.9    Ware, L.B.10
  • 48
    • 79951807624 scopus 로고    scopus 로고
    • The link between vascular features and thrombosis
    • Esmon CT, Esmon NL. The link between vascular features and thrombosis. Annu Rev Physiol 2011; 73: 503-14.
    • (2011) Annu Rev Physiol , vol.73 , pp. 503-514
    • Esmon, C.T.1    Esmon, N.L.2
  • 50
    • 84891655634 scopus 로고    scopus 로고
    • The role of mitochondrial dysfunction in sepsis-induced multi-organ failure
    • Singer M. The role of mitochondrial dysfunction in sepsis-induced multi-organ failure. Virulence 2014; 5: 66-72.
    • (2014) Virulence , vol.5 , pp. 66-72
    • Singer, M.1
  • 54
    • 84856259565 scopus 로고    scopus 로고
    • Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy
    • Veach RA, Zienkiewicz J, Collins RD, Hawiger J. Lethality in a murine model of pulmonary anthrax is reduced by combining nuclear transport modifier with antimicrobial therapy. PLoS ONE 2012; 7: e30527.
    • (2012) PLoS ONE , vol.7 , pp. e30527
    • Veach, R.A.1    Zienkiewicz, J.2    Collins, R.D.3    Hawiger, J.4
  • 55
    • 0015254909 scopus 로고
    • Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement
    • Levin J, Poore TE, Young NS, Margolis S, Zauber NP, Townes AS, Bell WR. Gram-negative sepsis: detection of endotoxemia with the limulus test. With studies of associated changes in blood coagulation, serum lipids, and complement. Ann Intern Med 1972; 76: 1-7.
    • (1972) Ann Intern Med , vol.76 , pp. 1-7
    • Levin, J.1    Poore, T.E.2    Young, N.S.3    Margolis, S.4    Zauber, N.P.5    Townes, A.S.6    Bell, W.R.7
  • 58
    • 84891713350 scopus 로고    scopus 로고
    • Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFkappaB1/p50 nuclear localization sequence
    • Zienkiewicz J, Armitage A, Hawiger J. Targeting nuclear import shuttles, importins/karyopherins alpha by a peptide mimicking the NFkappaB1/p50 nuclear localization sequence. J Am Heart Assoc 2013; 2: e000386.
    • (2013) J Am Heart Assoc , vol.2 , pp. e000386
    • Zienkiewicz, J.1    Armitage, A.2    Hawiger, J.3
  • 59
    • 67349218190 scopus 로고    scopus 로고
    • Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor
    • Liu D, Zienkiewicz J, DiGiandomenico A, Hawiger J. Suppression of acute lung inflammation by intracellular peptide delivery of a nuclear import inhibitor. Mol Ther 2009; 17: 796-802.
    • (2009) Mol Ther , vol.17 , pp. 796-802
    • Liu, D.1    Zienkiewicz, J.2    DiGiandomenico, A.3    Hawiger, J.4
  • 60
    • 9144254557 scopus 로고    scopus 로고
    • Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide
    • Liu D, Li C, Chen Y, Burnett C, Liu XY, Downs S, Collins RD, Hawiger J. Nuclear import of proinflammatory transcription factors is required for massive liver apoptosis induced by bacterial lipopolysaccharide. J Biol Chem 2004; 279: 48434-42.
    • (2004) J Biol Chem , vol.279 , pp. 48434-48442
    • Liu, D.1    Li, C.2    Chen, Y.3    Burnett, C.4    Liu, X.Y.5    Downs, S.6    Collins, R.D.7    Hawiger, J.8
  • 64
    • 84906084273 scopus 로고    scopus 로고
    • A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment
    • Tomaiuolo M, Stalker TJ, Welsh JD, Diamond SL, Sinno T, Brass LF. A systems approach to hemostasis: 2. Computational analysis of molecular transport in the thrombus microenvironment. Blood. 2014; 124: 1816-23.
    • (2014) Blood , vol.124 , pp. 1816-1823
    • Tomaiuolo, M.1    Stalker, T.J.2    Welsh, J.D.3    Diamond, S.L.4    Sinno, T.5    Brass, L.F.6
  • 66
    • 84991031123 scopus 로고    scopus 로고
    • Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome
    • Venkata C, Kashyap R, Farmer JC, Afessa B. Thrombocytopenia in adult patients with sepsis: incidence, risk factors, and its association with clinical outcome. Journal of Intensive Care. 2013; 1: 9.
    • (2013) Journal of Intensive Care. , vol.1 , pp. 9
    • Venkata, C.1    Kashyap, R.2    Farmer, J.C.3    Afessa, B.4
  • 67
    • 33747179285 scopus 로고    scopus 로고
    • International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients
    • Voves C, Wuillemin WA, Zeerleder S. International Society on Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis. 2006; 17: 445-51.
    • (2006) Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis. , vol.17 , pp. 445-451
    • Voves, C.1    Wuillemin, W.A.2    Zeerleder, S.3
  • 68
    • 84906085068 scopus 로고    scopus 로고
    • New insights into the spatiotemporal localization of prothrombinase in vivo
    • Ivanciu L, Krishnaswamy S, Camire RM. New insights into the spatiotemporal localization of prothrombinase in vivo. Blood 2014; 124: 1705-14.
    • (2014) Blood , vol.124 , pp. 1705-1714
    • Ivanciu, L.1    Krishnaswamy, S.2    Camire, R.M.3
  • 70
    • 29244446219 scopus 로고    scopus 로고
    • The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia
    • Spiel AO, Firbas C, Mayr FB, Leitner JM, Schmidt B, Knobl P, Varadi K, Jilma B. The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia. Thromb Haemost 2005; 94: 1148-55.
    • (2005) Thromb Haemost , vol.94 , pp. 1148-1155
    • Spiel, A.O.1    Firbas, C.2    Mayr, F.B.3    Leitner, J.M.4    Schmidt, B.5    Knobl, P.6    Varadi, K.7    Jilma, B.8
  • 72
    • 84940173841 scopus 로고    scopus 로고
    • GPCR and RhoA-stimulated transcriptional responses mediating inflammation, differentiation and cell proliferation
    • Yu OM, Heller Brown J. GPCR and RhoA-stimulated transcriptional responses mediating inflammation, differentiation and cell proliferation. Mol Pharmacol 2015; 88: 171-80.
    • (2015) Mol Pharmacol , vol.88 , pp. 171-180
    • Yu, O.M.1    Heller Brown, J.2
  • 76
    • 84874256945 scopus 로고    scopus 로고
    • Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
    • Hotchkiss RS, Monneret G, Payen D. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect Dis 2013; 13: 260-8.
    • (2013) Lancet Infect Dis , vol.13 , pp. 260-268
    • Hotchkiss, R.S.1    Monneret, G.2    Payen, D.3
  • 79
    • 84895551972 scopus 로고    scopus 로고
    • SOCS3, a Major Regulator of Infection and Inflammation
    • Carow B, Rottenberg ME. SOCS3, a Major Regulator of Infection and Inflammation. Front Immunol 2014; 5: 58.
    • (2014) Front Immunol , vol.5 , pp. 58
    • Carow, B.1    Rottenberg, M.E.2
  • 80
    • 23844524089 scopus 로고    scopus 로고
    • Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
    • Jo D, Liu D, Yao S, Collins RD, Hawiger J. Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis. Nat Med 2005; 11: 892-8.
    • (2005) Nat Med , vol.11 , pp. 892-898
    • Jo, D.1    Liu, D.2    Yao, S.3    Collins, R.D.4    Hawiger, J.5
  • 81
    • 77953302258 scopus 로고    scopus 로고
    • Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3
    • Fletcher TC, DiGiandomenico A, Hawiger J. Extended anti-inflammatory action of a degradation-resistant mutant of cell-penetrating suppressor of cytokine signaling 3. The Journal of Biological Chemistry. 2010; 285: 18727-36.
    • (2010) The Journal of Biological Chemistry. , vol.285 , pp. 18727-18736
    • Fletcher, T.C.1    DiGiandomenico, A.2    Hawiger, J.3
  • 86
    • 67650733009 scopus 로고    scopus 로고
    • Natural course of neonatal progeroid syndrome
    • Hou JW. Natural course of neonatal progeroid syndrome. Pediatrics and Neonatology. 2009; 50: 102-9.
    • (2009) Pediatrics and Neonatology. , vol.50 , pp. 102-109
    • Hou, J.W.1
  • 88
    • 84880835807 scopus 로고    scopus 로고
    • The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling
    • Sethman CR, Hawiger J. The innate immunity adaptor SARM translocates to the nucleus to stabilize lamins and prevent DNA fragmentation in response to pro-apoptotic signaling. PLoS One 2013; 8: e70994.
    • (2013) PLoS One , vol.8 , pp. e70994
    • Sethman, C.R.1    Hawiger, J.2
  • 89
    • 84896376445 scopus 로고    scopus 로고
    • Proresolving lipid mediators and mechanisms in the resolution of acute inflammation
    • Buckley CD, Gilroy DW, Serhan CN. Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. Immunity 2014; 40: 315-27.
    • (2014) Immunity , vol.40 , pp. 315-327
    • Buckley, C.D.1    Gilroy, D.W.2    Serhan, C.N.3
  • 90
    • 84899853191 scopus 로고    scopus 로고
    • Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells
    • Jung TW, Hwang HJ, Hong HC, Choi HY, Yoo HJ, Baik SH, Choi KM. Resolvin D1 reduces ER stress-induced apoptosis and triglyceride accumulation through JNK pathway in HepG2 cells. Mol Cell Endocrinol 2014; 391: 30-40.
    • (2014) Mol Cell Endocrinol , vol.391 , pp. 30-40
    • Jung, T.W.1    Hwang, H.J.2    Hong, H.C.3    Choi, H.Y.4    Yoo, H.J.5    Baik, S.H.6    Choi, K.M.7
  • 94
    • 84921727957 scopus 로고    scopus 로고
    • Genomic responses in mouse models greatly mimic human inflammatory diseases
    • published ahead of print August 4, 2014)
    • Takao K, Miyakawa T. Genomic responses in mouse models greatly mimic human inflammatory diseases. Proc Natl Acad Sci USA. 2015 (published ahead of print August 4, 2014); 112: 1167-72.
    • (2015) Proc Natl Acad Sci USA , vol.112 , pp. 1167-1172
    • Takao, K.1    Miyakawa, T.2
  • 97
    • 84901621128 scopus 로고    scopus 로고
    • National inpatient hospital costs: the most expensive conditions by payer, 2011: statistical brief #160
    • In:, Rockville, MD: Agency for Health Care Policy and Research (US), Aug.. Accessed August 2013.
    • Torio CM, Andrews RM. National inpatient hospital costs: the most expensive conditions by payer, 2011: statistical brief #160. In: Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet], Rockville, MD: Agency for Health Care Policy and Research (US), 2013 Aug. www.ncbi.nlm.nih.gov/books/NBK169005/. Accessed August 2013.
    • (2013) Healthcare Cost and Utilization Project (HCUP) Statistical Briefs [Internet]
    • Torio, C.M.1    Andrews, R.M.2
  • 98
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001; 29: 1303-10.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 100
    • 84876665421 scopus 로고    scopus 로고
    • Benchmarking the incidence and mortality of severe sepsis in the United States
    • Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 2013; 41: 1167-74.
    • (2013) Crit Care Med , vol.41 , pp. 1167-1174
    • Gaieski, D.F.1    Edwards, J.M.2    Kallan, M.J.3    Carr, B.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.