The relationship between delirium duration, white matter integrity, and cognitive impairment in intensive care unit survivors as determined by diffusion tensor imaging: The VISIONS prospective cohort magnetic resonance imaging study

Critical Care Medicine

Volumn 40, Issue 7, 2012, Pages 2182-2189

  Morandi, Alessandro ^a,b,c   Rogers, Baxter P ^a,d,e   Gunther, Max L ^a,d   Merkle, Kristen ^d   Pandharipande, Pratik ^c,f   Girard, Timothy D ^a,b,c,f   Jackson, James C ^a,b,d,f   Thompson, Jennifer ^c   Shintani, Ayumi K ^c   Geevarghese, Sunil ^c   Miller, Russell R ^g   Canonico, Angelo ^h   Cannistraci, Christopher J ^a   Gore, John C ^a,d,e   Wesley Ely, E ^a,b,c,f   Hopkins, Ramona O ^g,i  

^a VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^b DENVER HEALTH AND HOSPITAL AUTHORITY   (United States)

^c VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY   (United States)

^e VANDERBILT UNIVERSITY   (United States)

^f VETERANS AFFAIRS MEDICAL CENTER   (United States)

^g INTERMOUNTAIN MEDICAL CENTER   (United States)

^h SAINT THOMAS HOSPITAL   (United States)

ⁱ BRIGHAM YOUNG UNIVERSITY   (United States)

Author keywords

Critical care; delirium; diffusion tensor imaging; geriatrics; magnetic resonance imaging; neuroimaging; white matter integrity

Indexed keywords

ADULT; AGE DISTRIBUTION; AGED; CLINICAL ARTICLE; COGNITIVE DEFECT; DELIRIUM; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; DISEASE DURATION; FEMALE; FOLLOW UP; FRACTIONAL ANISOTROPY; HOSPITAL DISCHARGE; HUMAN; INTENSIVE CARE UNIT; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; REVIEW; SEPSIS; SURVIVOR; WHITE MATTER;

AGED; ANISOTROPY; COGNITION DISORDERS; CORPUS CALLOSUM; DELIRIUM; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMAGING, THREE-DIMENSIONAL; INTENSIVE CARE UNITS; INTERNAL CAPSULE; LINEAR MODELS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PILOT PROJECTS; PROSPECTIVE STUDIES; SAMPLING STUDIES; SURVIVORS; TIME FACTORS;

EID: 84862727616     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e318250acdc     Document Type: Review

References (67)

1. Girard TD, Jackson JC, Pandharipande PP, et al: Delirium as a predictor of long-term cognitive impairment in survivors of critical illness. Crit Care Med 2010; 38:1513-1520
2. Andrew MK, Freter SH, Rockwood K: Incomplete functional recovery after delirium in elderly people: A prospective cohort study. BMC Geriatr 2005; 5:5
3. McAvay GJ, Van Ness PH, Bogardus ST Jr, et al: Depressive symptoms and the risk of incident delirium in older hospitalized adults. J Am Geriatr Soc 2007; 55:684-691 (Pubitemid 46668969)
4. Ehlenbach WJ, Hough CL, Crane PK, et al: Association between acute care and critical illness hospitalization and cognitive function in older adults. JAMA 2010; 303:763-770
5. Iwashyna TJ, Ely EW, Smith DM, et al: Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA 2010; 304:1787-1794
6. Suchyta MR, Jephson A, Hopkins RO: Neurologic changes during critical illness: Brain imaging findings and neurobehavioral outcomes. Brain Imaging Behav 2010; 4:22-34
7. Ely EW, Gautam S, Margolin R, et al: The impact of delirium in the intensive care unit on hospital length of stay. Intensive Care Med 2001; 27:1892-1900 (Pubitemid 33145075)
8. Girard TD, Shintani A, Pun BT, et al: The effect of delirium on mortality appears greater in severe sepsis than in non-infectious critical illness. Proc Am Thorac Soc 2006; 3:A501
9. Lin SM, Liu CY, Wang CH, et al: The impact of delirium on the survival of mechanically ventilated patients. Crit Care Med 2004; 32:2254-2259
10. Ely EW, Shintani A, Truman B, et al: Delirium as a predictor of mortality in mechanically ventilated patients in the intensive care unit. JAMA 2004; 291:1753-1762 (Pubitemid 38489897)
11. Shehabi Y, Riker RR, Bokesch PM, et al: Delirium duration and mortality in lightly sedated, mechanically ventilated intensive care patients. Crit Care Med 2010; 38: 2311-2318
12. Dubois MJ, Bergeron N, Dumont M, et al: Delirium in an intensive care unit: A study of risk factors. Intensive Care Med 2001; 27:1297-1304 (Pubitemid 32758927)
13. Salam A, Tilluckdharry L, Amoateng-Adjepong Y, et al: Neurologic status, cough, secretions and extubation outcomes. Intensive Care Med 2004; 30:1334-1339 (Pubitemid 38951715)
14. Pisani MA, Kong SY, Kasl SV, et al: Days of delirium are associated with 1-year mortality in an older intensive care unit population. Am J Respir Crit Care Med 2009; 180:1092-1097
15. Yokota H, Ogawa S, Kurokawa A, et al: Regional cerebral blood flow in delirium patients. Psychiatry Clin Neurosci 2003; 57:337-339 (Pubitemid 36644422)
16. Fong TG, Bogardus ST Jr, Daftary A, et al: Cerebral perfusion changes in older delirious patients using 99mTc HMPAO SPECT. J Gerontol A Biol Sci Med Sci 2006; 61: 1294-1299 (Pubitemid 46147785)
17. Sharshar T, Carlier R, Bernard F, et al: Brain lesions in septic shock: A magnetic resonance imaging study. Intensive Care Med 2007; 33:798-806 (Pubitemid 46675332)
18. Shioiri A, Kurumaji A, Takeuchi T, et al: White matter abnormalities as a risk factor for postoperative delirium revealed by diffusion tensor imaging. Am J Geriatr Psychiatry 2010; 18:743-753
19. Little DM, Kraus MF, Jiam C, et al: Neuroimaging of hypoxic-ischemic brain injury. NeuroRehabilitation 2010; 26:15-25
20. Arfanakis K, Haughton VM, Carew JD, et al: Diffusion tensor MR imaging in diffuse axonal injury. AJNR Am J Neuroradiol 2002; 23:794-802 (Pubitemid 34525695)
21. Xu J, Rasmussen IA, Lagopoulos J, et al: Diffuse axonal injury in severe traumatic brain injury visualized using high-resolution diffusion tensor imaging. J Neurotrauma 2007; 24:753-765 (Pubitemid 46799268)
22. Huisman TA, Schwamm LH, Schaefer PW, et al: Diffusion tensor imaging as potential biomarker of white matter injury in diffuse axonal injury. AJNR Am J Neuroradiol 2004; 25:370-376 (Pubitemid 38374913)
23. Lee JW, Choi CG, Chun MH: Usefulness of diffusion tensor imaging for evaluation of motor function in patients with traumatic brain injury: Three case studies. J Head Trauma Rehabil 2006; 21:272-278 (Pubitemid 44309960)
24. Wilde EA, McCauley SR, Hunter JV, et al: Diffusion tensor imaging of acute mild traumatic brain injury in adolescents. Neurology 2008; 70:948-955 (Pubitemid 351430744)
25. Levin HS, Wilde EA, Chu Z, et al: Diffusion tensor imaging in relation to cognitive and functional outcome of traumatic brain injury in children. J Head Trauma Rehabil 2008; 23:197-208
26. Suskauer SJ: The promise of evolving neuroimaging techniques for pediatric Traumatic Brain Injury. J Pediatr Rehabil Med 2009; 2:249-253
27. Kraus MF, Susmaras T, Caughlin BP, et al: White matter integrity and cognition in chronic traumatic brain injury: A diffusion tensor imaging study. Brain 2007; 130(Pt 10):2508-2519 (Pubitemid 47511721)
28. Kumar R, Saksena S, Husain M, et al: Serial changes in diffusion tensor imaging metrics of corpus callosum in moderate traumatic brain injury patients and their correlation with neuropsychometric tests: A 2-year follow-up study. J Head Trauma Rehabil 2010; 25:31-42
29. Lo C, Shifteh K, Gold T, et al: Diffusion tensor imaging abnormalities in patients with mild traumatic brain injury and neurocognitive impairment. J Comput Assist Tomogr 2009; 33:293-297
30. Jorm AF: A short form of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): Development and cross-validation. Psychol Med 1994; 24:145-153 (Pubitemid 24083690)
31. Hughes CP, Berg L, Danziger WL, et al: A new clinical scale for the staging of dementia. Br J Psychiatry 1982; 140:566-572 (Pubitemid 12124384)
32. Berg L: Clinical Dementia Rating (CDR). Psychopharmacol Bull 1988; 24:637-639 (Pubitemid 19054369)
33. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification system. Crit Care Med 1985; 13:818-829 (Pubitemid 15250137)
34. Vincent JL, Moreno R, Takala J, et al: The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996; 22:707-710 (Pubitemid 26254283)
35. Ely EW, Inouye SK, Bernard GR, et al: Delirium in mechanically ventilated patients: Validity and reliability of the confusion assessment method for the intensive care unit (CAM-ICU). JAMA 2001; 286:2703-2710 (Pubitemid 33135077)
36. Ely EW, Margolin R, Francis J, et al: Evaluation of delirium in critically ill patients: Validation of the Confusion Assessment Method for the Intensive Care Unit (CAM-ICU). Crit Care Med 2001; 29:1370-1379 (Pubitemid 32641799)
37. Sessler CN, Gosnell MS, Grap MJ, et al: The Richmond Agitation-Sedation Scale: Validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002; 166:1338-1344 (Pubitemid 35292699)
38. Ely EW, Gautam S, May L, et al: A comparison of different sedation scales in the ICU and validation of the Richmond Agitation Sedation Scale (RASS). Am J Respir Crit Care Med 2001; 163:A954
39. Ely EW, Truman B, Shintani A, et al: Monitoring sedation status over time in ICU patients: Reliability and validity of the Richmond Agitation-Sedation Scale (RASS). JAMA 2003; 289:2983-2991 (Pubitemid 37430101)
40. Levy MM, Fink MP, Marshall JC, et al: SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003; 31:1250-1256 (Pubitemid 36444440)
41. Randolph C, Tierney MC, Mohr E, et al: The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): Preliminary clinical validity. J Clin Exp Neuropsychol 1998; 20:310-319 (Pubitemid 28539551)
42. McKay C, Casey JE, Wertheimer J, et al: Reliability and validity of the RBANS in a traumatic brain injured sample. Arch Clin Neuropsychol 2007; 22:91-98 (Pubitemid 46209594)
43. Smith SM, Jenkinson M, Woolrich MW, et al: Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 2004; 23 (Suppl 1):S208-S219 (Pubitemid 39421720)
44. Woolrich MW, Jbabdi S, Patenaude B, et al: Bayesian analysis of neuroimaging data in FSL. Neuroimage 2009; 45(Suppl 1):S173-S186
45. Hua K, Zhang J, Wakana S, et al: Tract probability maps in stereotaxic spaces: Analyses of white matter anatomy and tract-specific quantification. Neuroimage 2008; 39:336-347 (Pubitemid 350102194)
46. Mori S, Wakana S, Nagae-Poetscher LM, et al: MRI Atlas of Human White Matter. Elsevier, Amsterdam, 2005
47. Wakana S, Caprihan A, Panzenboeck MM, et al: Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 2007; 36:630-644 (Pubitemid 46907616)
48. Ihaka R, Gentleman R: A language for data analysis and graphics. J Comput Graph Stat 1996; 5:299-314
49. Salat DH, Tuch DS, Greve DN, et al: Age-related alterations in white matter microstructure measured by diffusion tensor imaging. Neurobiol Aging 2005; 26:1215-1227 (Pubitemid 40726015)
50. Trzepacz PT: The neuropathogenesis of delirium. A need to focus our research. Psychosomatics 1994; 35:374-391 (Pubitemid 24206400)
51. Gunther ML, Morandi A, Ely EW: Pathophysiology of delirium in the intensive care unit. Crit Care Clin 2008; 24:45-65, viii (Pubitemid 351172684)
52. Maclullich AM, Ferguson KJ, Miller T, et al: Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses. J Psychosom Res 2008; 65:229-238
53. Maldonado JR: Pathoetiological model of delirium: A comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment. Crit Care Clin 2008; 24:789-856, ix
54. Morandi A, Gunther ML, Vasilevskis EE, et al: Neuroimaging in delirious intensive care unit patients: A preliminary case series report. Psychiatry (Edgmont) 2010; 7:28-33
55. Bigler ED, Lowry CM, Kerr B, et al: Role of white matter lesions, cerebral atrophy, and APOE on cognition in older persons with and without dementia: The Cache County, Utah, study of memory and aging. Neuropsychology 2003; 17:339-352 (Pubitemid 37013145)
56. Fork M, Bartels C, Ebert AD, et al: Neuropsychological sequelae of diffuse traumatic brain injury. Brain Inj 2005; 19:101-108 (Pubitemid 40259748)
57. Gennarelli TA, Thibault LE, Adams JH, et al: Diffuse axonal injury and traumatic coma in the primate. Ann Neurol 1982; 12:564-574 (Pubitemid 13250413)
58. Rapoport MJ, Herrmann N, Shammi P, et al: Outcome after traumatic brain injury sustained in older adulthood: A one-year longitudinal study. Am J Geriatr Psychiatry 2006; 14: 456-465
59. Wallesch CW, Curio N, Galazky I, et al: The neuropsychology of blunt head injury in the early postacute stage: Effects of focal lesions and diffuse axonal injury. J Neurotrauma 2001; 18:11-20 (Pubitemid 32055452)
60. Gunther ML, Jackson JC, Ely EW: The cognitive consequences of critical illness: Practical recommendations for screening and assessment. Crit Care Clin 2007; 23:491-506 (Pubitemid 47454696)
61. Jackson JC, Hart RP, Gordon SM, et al: Six-month neuropsychological outcome of medical intensive care unit patients. Crit Care Med 2003; 31:1226-1234 (Pubitemid 36444437)
62. Jones C, Griffiths RD, Slater T, et al: Significant cognitive dysfunction in non-delirious patients identified during and persisting following critical illness. Intensive Care Med 2006; 32: 923-926 (Pubitemid 43781378)
63. Sukantarat KT, Burgess PW, Williamson RC, et al: Prolonged cognitive dysfunction in survivors of critical illness. Anaesthesia 2005; 60:847-853 (Pubitemid 41200655)
64. Jackson JC, Girard TD, Gordon SM, et al: Long-term cognitive and psychological outcomes in the awakening and breathing controlled trial. Am J Respir Crit Care Med 2010; 182:183-191
65. Kumar R, Husain M, Gupta RK, et al: Serial changes in the white matter diffusion tensor imaging metrics in moderate traumatic brain injury and correlation with neuro-cognitive function. J Neurotrauma 2009; 26:481-495
66. Matsushita M, Hosoda K, Naitoh Y, et al: Utility of diffusion tensor imaging in the acute stage of mild to moderate traumatic brain injury for detecting white matter lesions and predicting 510 long-term cognitive function in adults. J Neurosurg 2011; 115:130-139
67. Palacios EM, Fernandez-Espejo D, Junque C, et al: Diffusion tensor imaging differences relate to memory deficits in diffuse traumatic brain injury. BMC Neurol 2011; 11:24