Plasminogen is a critical host pathogenicity factor for group A streptococcal infection

Science

Volumn 305, Issue 5688, 2004, Pages 1283-1286

  Sun, Hongmin ^a   Ringdahl, Ulrika ^c   Momeister, Jonathon W ^a   Fay, William P ^a   Engleberg, N Cary ^a   Yang, Angela Y ^a   Rozek, Laura S ^a   Wang, Xixi ^a   Sjöbring, Ulf ^c   Ginsburg, David ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; CATALYST ACTIVITY; ENZYMES; PATHOLOGY;

BLOOD CLOT; MICROBIAL PATHOGENS; PATHOGENECITY; PLASMINOGEN; STREPTOKINASE EXPRESSION;

BACTERIA;

PLASMINOGEN; STREPTOKINASE;

MEDICINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD CLOT LYSIS; BLOOD CLOTTING; CONTROLLED STUDY; ENZYME ACTIVITY; HOST PATHOGEN INTERACTION; HOST RESISTANCE; MOUSE; NONHUMAN; PATHOGENICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES DIFFERENCE; STREPTOCOCCUS GROUP A; STREPTOCOCCUS INFECTION; TRANSGENIC MOUSE;

ANCROD; ANIMALS; ANTICOAGULANTS; BACTERIAL PROTEINS; CARRIER PROTEINS; COLONY COUNT, MICROBIAL; DISEASE SUSCEPTIBILITY; FIBRIN; FIBRINOLYSIS; GENE DELETION; HUMANS; IMMUNITY, NATURAL; MICE; MICE, INBRED C57BL; PLASMIN; PLASMINOGEN; SKIN; SPECIES SPECIFICITY; SPLEEN; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; STREPTOKINASE; TRANSGENES; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA; MUS MUSCULUS; POSIBACTERIA; STREPTOCOCCUS; STREPTOCOCCUS SP. 'GROUP A';

EID: 4344601240     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1101245     Document Type: Article

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26. We thank S. Gruber for advice concerning the statistical analysis. Supported by grants from the National Institute of Health (P01HL057346) (D.G. and W.F.), Swedish Research Council grant no. 9926 (U.S.), and a National Hemophilia Foundation Judith Graham Pool fellowship (H.S.). D.G. is a Howard Hughes Medical Institute investigator.