Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: The acetaminophen for the reduction of oxidative injury in severe sepsis trial

Critical Care Medicine

Volumn 43, Issue 3, 2015, Pages 534-541

  Janz, David R ^a   Bastarache, Julie A ^b   Rice, Todd W ^b   Bernard, Gordon R ^b   Warren, Melissa A ^b   Wickersham, Nancy ^b   Sills, Gillian ^b   Oates, John A ^b   Roberts, L Jackson ^b   Ware, Lorraine B ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acetaminophen; ACetaminophen for the Reduction of Oxidative injury in Severe Sepsis; Cell free hemoglobin; F2 isoprostanes; Sepsis

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CREATININE; HEMOGLOBIN; ISOPROSTANE DERIVATIVE; PARACETAMOL; PLACEBO; ANALGESIC AGENT; PROPOFOL;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHRONOTHERAPY; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CRITICALLY ILL PATIENT; DOSE RESPONSE; DRUG EFFICACY; DRUG ERUPTION; DRUG HYPERSENSITIVITY; ENTERAL DRUG ADMINISTRATION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HUMAN; INFECTION PREVENTION; INTENSIVE CARE UNIT; INTERVENTION STUDY; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; MEDICATION COMPLIANCE; MIDDLE AGED; MORTALITY; OXIDATIVE STRESS; PATIENT COMPLIANCE; PHASE 2 CLINICAL TRIAL; PLASMA; PRIORITY JOURNAL; PROSTAGLANDIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; TERTIARY HEALTH CARE; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT REFUSAL; TREATMENT RESPONSE; UNIVERSITY HOSPITAL; ARTIFICIAL VENTILATION; BLOOD; CELL FREE SYSTEM; CLINICAL TRIAL; CRITICAL ILLNESS; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; HOSPITAL MORTALITY; OXIDATION REDUCTION REACTION; PATHOPHYSIOLOGY;

ACETAMINOPHEN; ADULT; ANALGESICS, NON-NARCOTIC; CELL-FREE SYSTEM; CREATININE; CRITICAL ILLNESS; DOUBLE-BLIND METHOD; F2-ISOPROSTANES; FEMALE; HEMOGLOBINS; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; OXIDATION-REDUCTION; PROPOFOL; RESPIRATION, ARTIFICIAL; SEPSIS;

EID: 84924265176     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000000718     Document Type: Article

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