-
2
-
-
33644839612
-
Signaling mechanisms regulating endothelial permeability
-
Mehta D, Malik AB. Signaling mechanisms regulating endothelial permeability. Physiol Review. 2006;86:279-367.
-
(2006)
Physiol Review
, vol.86
, pp. 279-367
-
-
Mehta, D.1
Malik, A.B.2
-
3
-
-
25644449640
-
Pathophysiological consequences of VEGF-induced vascular permeability
-
DOI 10.1038/nature03987, PII N03987
-
Weis SM, Cheresh DA. Pathophysiological consequences of VEGFinduced vascular permeability. Nature. 2005;437:497-504. (Pubitemid 41613541)
-
(2005)
Nature
, vol.437
, Issue.7058
, pp. 497-504
-
-
Weis, S.M.1
Cheresh, D.A.2
-
4
-
-
79751520659
-
The acute respiratory distress syndrome: Pathogenesis and treatment
-
Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol. 2011;28:147-163.
-
(2011)
Annu Rev Pathol.
, vol.28
, pp. 147-163
-
-
Matthay, M.A.1
Zemans, R.L.2
-
5
-
-
52749098471
-
Possible role of imatinib in clinical pulmonary venoocclusive disease
-
Overbeek MJ, van Nieuw Amerongen GP, Boonstra A, Smit EF, Vonk Noordegraaf A. Possible role of imatinib in clinical pulmonary venoocclusive disease. Eur Respir J. 2008;32:232-235.
-
(2008)
Eur Respir J
, vol.32
, pp. 232-235
-
-
Overbeek, M.J.1
Van Nieuw Amerongen, G.P.2
Boonstra, A.3
Smit, E.F.4
Vonk Noordegraaf, A.5
-
7
-
-
15244339164
-
Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
-
DOI 10.1172/JCI200419603
-
Daniels CE, Wilkes MC, Edens M, Kottom TJ, Murphy SJ, Limper AH, Leof EB. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J Clin Invest. 2004;114:1308-1316. (Pubitemid 40385302)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.9
, pp. 1308-1316
-
-
Daniels, C.E.1
Wilkes, M.C.2
Edens, M.3
Kottom, T.J.4
Murphy, S.J.5
Limper, A.H.6
Leof, E.B.7
-
8
-
-
26444540768
-
Reversal of experimental pulmonary hypertension by PDGF inhibition
-
DOI 10.1172/JCI24838
-
Schermuly RT, Dony E, Ghofrani HA, Pullamsetti S, Savai R, Roth M, Sydykov A, Lai YJ, Weissmann N, Seeger W, Grimmiger F. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest. 2005;115:2811-2821. (Pubitemid 41434408)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.10
, pp. 2811-2821
-
-
Schermuly, R.T.1
Dony, E.2
Ghofrani, H.A.3
Pullamsetti, S.4
Savai, R.5
Roth, M.6
Sydykov, A.7
Lai, Y.J.8
Weissmann, N.9
Seeger, W.10
Grimminger, F.11
-
9
-
-
33746845181
-
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate
-
DOI 10.1038/nm1446, PII NM1446
-
Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, van Etten RA, Alroy J, Durand JB, Force T. Cardiotoxicity of the cancer therapeutic agent imatinib mesylate. Nat Med. 2006;12:908-916. (Pubitemid 44175142)
-
(2006)
Nature Medicine
, vol.12
, Issue.8
, pp. 908-916
-
-
Kerkela, R.1
Grazette, L.2
Yacobi, R.3
Iliescu, C.4
Patten, R.5
Beahm, C.6
Walters, B.7
Shevtsov, S.8
Pesant, S.9
Clubb, F.J.10
Rosenzweig, A.11
Salomon, R.N.12
Van Etten, R.A.13
Alroy, J.14
Durand, J.-B.15
Force, T.16
-
10
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037. (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
11
-
-
80051973850
-
Complete resolution of lifethreatening bleomycin-induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin's lymphoma: Hope for severe chemotherapy-induced toxicity?
-
Carnevale-Schianca F, Gallo S, Rota-Scalabrini D, Sangiolo D, Fizzotti M, Caravelli D, Capaldi A, Anselmetti G, Palesandro E, D'Ambrosio L, Coha V, Obert R, Aglietta M, Grignani G. Complete resolution of lifethreatening bleomycin-induced pneumonitis after treatment with imatinib mesylate in a patient with Hodgkin's lymphoma: hope for severe chemotherapy-induced toxicity? J Clin Oncol. 2011;29:e691-e693.
-
(2011)
J Clin Oncol.
, vol.29
-
-
Carnevale-Schianca, F.1
Gallo, S.2
Rota-Scalabrini, D.3
Sangiolo, D.4
Fizzotti, M.5
Caravelli, D.6
Capaldi, A.7
Anselmetti, G.8
Palesandro, E.9
D'Ambrosio, L.10
Coha, V.11
Obert, R.12
Aglietta, M.13
Grignani, G.14
-
12
-
-
46749118298
-
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
-
Su EJ, Fredriksson L, Geyer M, Folestad E, Cale J, Andrae J, Gao Y, Pietras K, Mann K, Yepes M, Strickland DK, Betsholtz C, Eriksson U, Lawrence DA. Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med. 2008;14:731-737.
-
(2008)
Nat Med.
, vol.14
, pp. 731-737
-
-
Su, E.J.1
Fredriksson, L.2
Geyer, M.3
Folestad, E.4
Cale, J.5
Andrae, J.6
Gao, Y.7
Pietras, K.8
Mann, K.9
Yepes, M.10
Strickland, D.K.11
Betsholtz, C.12
Eriksson, U.13
Lawrence, D.A.14
-
13
-
-
78649467527
-
Pericytes regulate the blood-brain barrier
-
Armulik A, Genové G, Mäe M, Nisancioglu MH, Wallgard E, Niaudet C, He L, Norlin J, Lindblom P, Strittmatter K, Johansson BR, Betsholtz C. Pericytes regulate the blood-brain barrier. Nature. 2010;468:557-561.
-
(2010)
Nature
, vol.468
, pp. 557-561
-
-
Armulik, A.1
Genové, G.2
Mäe, M.3
Nisancioglu, M.H.4
Wallgard, E.5
Niaudet, C.6
He, L.7
Norlin, J.8
Lindblom, P.9
Strittmatter, K.10
Johansson, B.R.11
Betsholtz, C.12
-
14
-
-
0033179025
-
Cell-substrate contact: Another factor may influence transepithelial electrical resistance of cell layers cultured on permeable filters
-
DOI 10.1006/excr.1999.4538
-
Lo CM, Keese CR, Giaever I. Cell-substrate contact: another factor may influence transepithelial electrical resistance of cell layers cultured on permeable filters. Exp Cell Res. 1999;250:576-580. (Pubitemid 29367467)
-
(1999)
Experimental Cell Research
, vol.250
, Issue.2
, pp. 576-580
-
-
Lo, C.-M.1
Keese, C.R.2
Giaever, I.3
-
15
-
-
0034110533
-
Histamine alters endothelial barrier function at cell-cell and cell- matrix sites
-
Moy AB, Winter M, Kamath A, Blackwell K, Reyes G, Giaever I, Keese C, Shasby DM. Histamine alters endothelial barrier function at cell-cell and cell-matrix sites. Am J Physiol Lung Cell Mol Physiol. 2000;278:L888-L898. (Pubitemid 30351043)
-
(2000)
American Journal of Physiology - Lung Cellular and Molecular Physiology
, vol.278
, Issue.5
-
-
Moy, A.B.1
Winter, M.2
Kamath, A.3
Blackwell, K.4
Reyes, G.5
Giaever, I.6
Keese, C.7
Shasby, D.M.8
-
18
-
-
77950376386
-
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture
-
Xu Z, Castellino FJ, Ploplis VA. Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood. 2010;115:2038-2047.
-
(2010)
Blood
, vol.115
, pp. 2038-2047
-
-
Xu, Z.1
Castellino, F.J.2
Ploplis, V.A.3
-
20
-
-
0033770910
-
Opposing views on tensegrity as a structural framework for understanding cell mechanics
-
Ingber DE. Opposing views on tensegrity as a structural framework for understanding cell mechanics. J Appl Physiol. 2000;89:1663-1670.
-
(2000)
J Appl Physiol.
, vol.89
, pp. 1663-1670
-
-
Ingber, D.E.1
-
21
-
-
56149093421
-
Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids
-
Birukova AA, Alekseeva E, Cokic I, Turner CE, Birukov KG. Cross talk between paxillin and Rac is critical for mediation of barrier-protective effects by oxidized phospholipids. Am J Physiol Lung Cell Mol Physiol. 2008;295:L593-L602.
-
(2008)
Am J Physiol Lung Cell Mol Physiol.
, vol.295
-
-
Birukova, A.A.1
Alekseeva, E.2
Cokic, I.3
Turner, C.E.4
Birukov, K.G.5
-
22
-
-
84866436847
-
Rodent models of sepsis found shockingly lacking
-
Raven K. Rodent models of sepsis found shockingly lacking. Nat Med. 2012;18:998.
-
(2012)
Nat Med.
, vol.18
, pp. 998
-
-
Raven, K.1
-
23
-
-
68849113721
-
Drug monitoring of imatinib levels in patients undergoing therapy for chronic myeloid leukaemia: Comparing plasma levels of responders and non-responders
-
Singh N, Kumar L, Meena R, Velpandian T. Drug monitoring of imatinib levels in patients undergoing therapy for chronic myeloid leukaemia: comparing plasma levels of responders and non-responders. Eur J Clin Pharmacol. 2009;65:545-549.
-
(2009)
Eur J Clin Pharmacol.
, vol.65
, pp. 545-549
-
-
Singh, N.1
Kumar, L.2
Meena, R.3
Velpandian, T.4
-
24
-
-
67650306170
-
Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors
-
Demetri GD, Wang Y, Wehrle E, Racine A, Nikolova Z, Blanke CD, Joensuu H, von Mehren M. Imatinib plasma levels are correlated with clinical benefit in patients with unresectable/metastatic gastrointestinal stromal tumors. J Clin Oncol. 2009;27:3141-3147.
-
(2009)
J Clin Oncol.
, vol.27
, pp. 3141-3147
-
-
Demetri, G.D.1
Wang, Y.2
Wehrle, E.3
Racine, A.4
Nikolova, Z.5
Blanke, C.D.6
Joensuu, H.7
Von Mehren, M.8
-
25
-
-
59049091078
-
The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib
-
Oostendorp RL, Buckle T, Beijnen JH, van Tellingen O, Schellens JH. The effect of P-gp (Mdr1a/1b), BCRP (Bcrp1) and P-gp/BCRP inhibitors on the in vivo absorption, distribution, metabolism and excretion of imatinib. Invest New Drugs. 2009;27:31-40.
-
(2009)
Invest New Drugs.
, vol.27
, pp. 31-40
-
-
Oostendorp, R.L.1
Buckle, T.2
Beijnen, J.H.3
Van Tellingen, O.4
Schellens, J.H.5
-
26
-
-
0037370946
-
S1P induces FA remodeling in human pulmonary endothelial cells: Role of Rac, GIT1, FAK, and paxillin
-
Shikata Y, Birukov KG, Garcia JG. S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. J Appl Physiol. 2003;94:1193-1203. (Pubitemid 36232038)
-
(2003)
Journal of Applied Physiology
, vol.94
, Issue.3
, pp. 1193-1203
-
-
Shikata, Y.1
Birukov, K.G.2
Garcia, J.G.N.3
-
27
-
-
34948885066
-
The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin
-
DOI 10.1091/mbc.E07-01-0075
-
Peacock JG, Miller AL, Bradley WD, Rodriguez OC, Webb DJ, Koleske AJ. The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell. 2007;18:3860-3872. (Pubitemid 47519479)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.10
, pp. 3860-3872
-
-
Peacock, J.G.1
Miller, A.L.2
Bradley, W.D.3
Rodriguez, O.C.4
Webb, D.J.5
Koleske, A.J.6
-
28
-
-
78650400825
-
The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts
-
Peacock JG, Couch BA, Koleske AJ. The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts. Cytoskeleton (Hoboken). 2010;67:666-675.
-
(2010)
Cytoskeleton (Hoboken)
, vol.67
, pp. 666-675
-
-
Peacock, J.G.1
Couch, B.A.2
Koleske, A.J.3
-
29
-
-
79551652731
-
Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: Mechanistic similarities with angiopoietin-1
-
Hoang MV, Nagy JA, Senger DR. Active Rac1 improves pathologic VEGF neovessel architecture and reduces vascular leak: mechanistic similarities with angiopoietin-1. Blood. 2011;117:1751-1760.
-
(2011)
Blood
, vol.117
, pp. 1751-1760
-
-
Hoang, M.V.1
Nagy, J.A.2
Senger, D.R.3
-
30
-
-
80053309268
-
Arg kinase regulates epithelial cell polarity by targeting beta1-integrin and small GTPase pathways
-
Li R, Pendergast AM. Arg kinase regulates epithelial cell polarity by targeting beta1-integrin and small GTPase pathways. Curr Biol. 2011;21:1534-1542.
-
(2011)
Curr Biol.
, vol.21
, pp. 1534-1542
-
-
Li, R.1
Pendergast, A.M.2
-
31
-
-
70350379633
-
Regulation of cell migration and morphogenesis by Abl-family kinases: Emerging mechanisms and physiological contexts
-
Bradley WD, Koleske AJ. Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts. J Cell Sci. 2009;122:3441-3454.
-
(2009)
J Cell Sci.
, vol.122
, pp. 3441-3454
-
-
Bradley, W.D.1
Koleske, A.J.2
-
33
-
-
78649661062
-
Abl tyrosine kinase phosphorylates nonmuscle myosin light chain kinase to regulate endothelial barrier function
-
Dudek SM, Chiang ET, Camp SM, Guo Y, Zhao J, Brown ME, Singleton PA, Wang L, Desai A, Arce FT, Lal R, Van Eyk JE, Imam SZ, Garcia JG. Abl tyrosine kinase phosphorylates nonmuscle myosin light chain kinase to regulate endothelial barrier function. Mol Biol Cell. 2010;21:4042-4056.
-
(2010)
Mol Biol Cell.
, vol.21
, pp. 4042-4056
-
-
Dudek, S.M.1
Chiang, E.T.2
Camp, S.M.3
Guo, Y.4
Zhao, J.5
Brown, M.E.6
Singleton, P.A.7
Wang, L.8
Desai, A.9
Arce, F.T.10
Lal, R.11
Van Eyk, J.E.12
Imam, S.Z.13
Garcia, J.G.14
|