Genome-wide ENU mutagenesis to reveal immune regulators

Immunity

Volumn 15, Issue 3, 2001, Pages 409-418

  Nelms, Keats A ^a   Goodnow, Christopher C ^a  

^a Biology and Environment   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ETHYLNITROSOUREA;

ANALYTIC METHOD; CHEMICAL MUTAGENESIS; GENE FUNCTION; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENOME; HUMAN; IMMUNE SYSTEM; IMMUNOREGULATION; LETHAL MUTANT; MOLECULAR GENETICS; NONHUMAN; PHENOMENOLOGY; PHENOTYPE; PRIORITY JOURNAL; PRODUCTIVITY; REVIEW;

EID: 0034813659     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-7613(01)00199-6     Document Type: Review

References (37)

1. Ethylnitrosourea mutagenesis and the isolation of mutant alleles for specific genes located in the T region of mouse chromosome 17
2. hph-1: A mouse mutant with hereditary hyperphenylalaninemia induced by ethylnitrosourea mutagenesis
3. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor
4. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection
5. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45
6. The induction of forward and reverse specific-locus mutations and dominant cataract mutations in spermatogonia of treated strain DBA/2 mice by ethylnitrosourea
7. How self-tolerance and the immunosuppressive drug FK506 prevent B-cell mitogenesis
8. B-lymphocyte quiescence, tolerance and activation as viewed by global gene expression profiling on microarrays
9. Genomic-scale gene expression analysis of lymphocyte growth, tolerance and malignancy
10. The FLP recombinase of yeast catalyzes site-specific recombination in the Drosophila genome
11. sar: A genetic mouse model for human sarcosinemia generated by ethylnitrosourea mutagenesis
12. Dose-repetition increases the mutagenic effectiveness of N-ethyl-N-nitrosourea in mouse spermatogonia
13. Genome-wide, large-scale production of mutant mice by ENU mutagenesis
14. Mouse ENU mutagenesis
15. A phenotype-based screen for embryonic lethal mutations in the mouse
16. Three murine cataract mutants (Cat2) are defective in different γ-crystallin genes
17. ENU mutagenesis in the mouse electrophoretic specific-locus test, 1. Dose-response relationship of electrophoretically-detected mutations arising from mouse spermatogonia treated with ethylnitrosourea
18. From mouse to man: Generating megabase chromosome rearrangements
19. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse
20. A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse
21. Mutations affecting segment number and polarity in Drosophila
22. Independent regulation of the two Pax5 alleles during B-cell development
23. + T cells
24. Expansion or elimination of B cells in vivo: Dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor
25. A strategy for fine-structure functional analysis of a 6- to 11-centimorgan region of mouse chromosome 7 by high-efficiency mutagenesis
26. Specific-locus test shows ethylnitrosourea to be the most potent mutagen in the mouse
27. Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development
28. Saturation germ line mutagenesis of the murine t region including a lethal allele at the quaking locus
29. Mouse models of human phenylketonuria
30. Ras1 and a putative guanine nucleotide exchange factor perform crucial steps in signaling by the sevenless protein tyrosine kinase
31. Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreas
32. Use of FLP/FRT system to study Drosophila development
33. Single epitope multiple staining to detect ultralow frequency B cells
34. Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior
35. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells
36. Neurodegeneration in Lurcher mice caused by mutation in δ2 glutamate receptor gene