Endothelin-1 regulates hypoxia-inducible factor-1α and -2α stability through prolyl hydroxylase domain 2 inhibition in human lymphatic endothelial cells

Life Sciences

Volumn 118, Issue 2, 2014, Pages 185-190

  Caprara, Valentina ^a   Scappa, Silvia ^a   Garrafa, Emirena ^b   Di Castro, Valeriana ^a   Rosanò, Laura ^a   Bagnato, Anna ^a   Spinella, Francesca ^a  

^a REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

Endothelin B receptor; Endothelin 1; Hypoxia inducible factor 1; Lymphatic endothelial cells; Prolyl hydroxylases enzymes

Indexed keywords

ENDOTHELIN 1; ENDOTHELIN B RECEPTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; HYPOXIA INDUCIBLE FACTOR PROLINE DIOXYGENASE; MESSENGER RNA; PROLYL HYDROXYLASE DOMAIN 2; PROTEASOME; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROXYLATION; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; REPORTER GENE; ANGIOGENESIS; CELL MOTION; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; METABOLISM; PROTEIN TERTIARY STRUCTURE;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL MOVEMENT; CELL NUCLEUS; ENDOTHELIAL CELLS; ENDOTHELIN-1; HUMANS; HYDROXYLATION; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, ENDOTHELIN B; RNA, SMALL INTERFERING;

EID: 84942580796     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2014.02.030     Document Type: Article

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