Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 39, 2012, Pages 15894-15899

  Cao, Renhai ^a   Ji, Hong ^a   Feng, Ninghan ^a   Zhang, Yin ^a   Yang, Xiaojuan ^a   Andersson, Patrik ^a   Sun, Yuping ^b   Tritsaris, Katerina ^c   Hansen, Anker Jon ^d,e   Dissing, Steen ^c   Cao, Yihai ^a,f  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SHANDONG UNIVERSITY   (China)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e NOVO NORDISK A S   (Denmark)

^f LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Antiangiogenic therapy; Cancer spread; Growth factors; Neovascularization; Signaling interplay

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR RECEPTOR 1; NEUTRALIZING ANTIBODY; VASCULOTROPIN C; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORNEAL ANGIOGENESIS; ENDOTHELIUM CELL; LUNG METASTASIS; LYMPH NODE METASTASIS; LYMPH VESSEL ENDOTHELIUM; LYMPHANGIOGENESIS; METASTASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR MICROENVIRONMENT;

ANIMALS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; HUMANS; LYMPHOMA; MICE; MICE, SCID; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS; TUMOR MICROENVIRONMENT; VASCULAR ENDOTHELIAL GROWTH FACTOR C; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3;

EID: 84866856702     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208324109     Document Type: Article

References (32)

1. Fidler IJ, Ellis LM (1994) The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell 79:185-188. (Pubitemid 24324908)
2. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: The next generation. Cell 144: 646-674.
3. Rouhi P, et al. (2010) Hypoxia-induced metastasis model in embryonic zebrafish. Nat Protoc 5:1911-1918.
4. Lee SL, et al. (2009) Hypoxia-induced pathological angiogenesis mediates tumor cell dissemination, invasion, and metastasis in a zebrafish tumor model. Proc Natl Acad Sci USA 106:19485-19490.
5. Cao Y (2005) Opinion: Emerging mechanisms of tumour lymphangiogenesis and lymphatic metastasis. Nat Rev Cancer 5:735-743.
6. Alitalo K, Carmeliet P (2002) Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 1:219-227. (Pubitemid 41039145)
7. Stacker SA, Achen MG, Jussila L, Baldwin ME, Alitalo K (2002) Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2:573-583. (Pubitemid 37328924)
8. Kedrin D, et al. (2008) Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods 5:1019-1021.
9. Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP (2008) The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell 13:221-234. (Pubitemid 351318371)
10. Kienast Y, et al. (2010) Real-time imaging reveals the single steps of brain metastasis formation. Nat Med 16:116-122.
11. Kaplan RN, et al. (2005) VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438:820-827. (Pubitemid 41753060)
12. Cao Y, et al. (1998) Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases. J Clin Invest 101:1055-1063. (Pubitemid 28125284)
13. Cao Y, et al. (1998) Vascular endothelial growth factor C induces angiogenesis in vivo. Proc Natl Acad Sci USA 95:14389-14394. (Pubitemid 28549377)
14. Cao Y (2008) Why and how do tumors stimulate lymphangiogenesis? Lymphat Res Biol 6:145-148.
15. Cao Y, Zhong W (2007) Tumor-derived lymphangiogenic factors and lymphatic metastasis. Biomed Pharmacother 61:534-539. (Pubitemid 47562689)
16. Cao R, et al. (2006) Hepatocyte growth factor is a lymphangiogenic factor with an indirect mechanism of action. Blood 107:3531-3536.
17. Björndahl M, et al. (2005) Insulin-like growth factors 1 and 2 induce lymphangiogenesis in vivo. Proc Natl Acad Sci USA 102:15593-15598. (Pubitemid 41528101)
18. Cao Y (2005) Direct role of PDGF-BB in lymphangiogenesis and lymphatic metastasis. Cell Cycle 4:228-230.
19. Morisada T, et al. (2005) Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood 105:4649-4656. (Pubitemid 40807284)
20. Veikkola T, Alitalo K (2002) Dual role of Ang2 in postnatal angiogenesis and lymphangiogenesis. Dev Cell 3:302-304.
21. Xue Y, et al. (2011) PDGF-BB modulates hematopoiesis and tumor angiogenesis by inducing erythropoietin production in stromal cells. Nat Med 18:100-110.
22. Nguyen M, Watanabe H, Budson AE, Richie JP, Folkman J (1993) Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients. J Natl Cancer Inst 85:241-242. (Pubitemid 23046901)
23. Van der Auwera I, et al. (2006) First international consensus on the methodology of lymphangiogenesis quantification in solid human tumours. Br J Cancer 95:1611-1625.
24. Cao R, et al. (2011) Mouse corneal lymphangiogenesis model. Nat Protoc 6:817-826.
25. Kubo H, et al. (2002) Blockade of vascular endothelial growth factor receptor-3 signaling inhibits fibroblast growth factor-2-induced lymphangiogenesis in mouse cornea. Proc Natl Acad Sci USA 99:8868-8873. (Pubitemid 34693650)
26. Pytowski B, et al. (2005) Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. J Natl Cancer Inst 97:14-21.
27. Tammela T, et al. (2011) VEGFR-3 controls tip to stalk conversion at vessel fusion sites by reinforcing Notch signalling. Nat Cell Biol 13:1202-1213.
28. Tammela T, et al. (2008) Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation. Nature 454:656-660.
29. Hellström M, et al. (2001) Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 153:543- 553.
30. Nissen LJ, et al. (2007) Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. J Clin Invest 117:2766-2777. (Pubitemid 47529608)
31. Shin JW, et al. (2006) Prox1 promotes lineage-specific expression of fibroblast growth factor (FGF) receptor-3 in lymphatic endothelium: A role for FGF signaling in lymphangiogenesis. Mol Biol Cell 17(2):576-584. (Pubitemid 43191094)
32. Nico B, de Falco G, Vacca A, Roncali L, Ribatti D (2001) In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor. J Hematother Stem Cell Res 10:905-912. (Pubitemid 34081319)