Evidence for Alzheimer’s disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons

Brain Structure and Function

Volumn 220, Issue 6, 2015, Pages 3143-3165

  Neuman, Krystina M ^a   Molina Campos, Elizabeth ^a   Musial, Timothy F ^a   Price, Andrea L ^a   Oh, Kwang Jin ^a   Wolke, Malerie L ^a   Buss, Eric W ^a   Scheff, Stephen W ^b   Mufson, Elliott J ^a   Nicholson, Daniel A ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer s disease; AMPA receptor; Array tomography; Dendrite; Electron microscopy; EPSP; Hippocampus; Immunogold; Patch clamp physiology; Serial section; Synapse

Indexed keywords

AMPA RECEPTOR;

5XFAD MOUSE; AGED; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITE; ELECTRON MICROSCOPY; GENE MUTATION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL TISSUE; HUMAN; HUMAN TISSUE; IMMUNOGOLD ELECTRON MICROSCOPY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; QUANTITATIVE ANALYSIS; QUANTITATIVE CONVENTIONAL ELECTRON MICROSCOPY; SYNAPSE; TRANSGENIC MOUSE; WHOLE CELL PATCH CLAMP; ANIMAL; AXON; CELL CULTURE; METABOLISM; NERVE CELL; NERVE CELL PLASTICITY; NERVE ENDING; PATHOLOGY;

ALZHEIMER DISEASE; ANIMALS; AXONS; CA1 REGION, HIPPOCAMPAL; CELLS, CULTURED; DENDRITES; HUMANS; MALE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; NEURONAL PLASTICITY; NEURONS; PRESYNAPTIC TERMINALS; PYRAMIDAL CELLS; RECEPTORS, AMPA; SYNAPSES;

EID: 84942374517     PISSN: 18632653     EISSN: 18632661     Source Type: Journal    
DOI: 10.1007/s00429-014-0848-z     Document Type: Article

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