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Volumn 9, Issue SUPPL. 3, 2006, Pages 101-115

Alzheimer's disease-related alterations in synaptic density: Neocortex and hippocampus

Author keywords

Cognition; Limbic; Plasticity; Synapse; Ultrastructure

Indexed keywords

ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

EID: 84880185901     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2006-9s312     Document Type: Review
Times cited : (236)

References (105)
  • 1
    • 0023272355 scopus 로고
    • Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: A quantitative ultrastructural study
    • I. Adams, Comparison of synaptic changes in the precentral and postcentral cerebral cortex of aging humans: a quantitative ultrastructural study, Neurobiol Aging 8 (1987), 203-212.
    • (1987) Neurobiol Aging , vol.8 , pp. 203-212
    • Adams, I.1
  • 2
    • 0023589151 scopus 로고
    • Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans
    • I. Adams, Plasticity of the synaptic contact zone following loss of synapses in the cerebral cortex of aging humans, Brain Res 424 (1987), 343-351.
    • (1987) Brain Res , vol.424 , pp. 343-351
    • Adams, I.1
  • 3
    • 1642618227 scopus 로고    scopus 로고
    • United States life tables, 2002
    • E. Arias, United States life tables, 2002, Nutl Vital Stat Rep 53 (2004), 1-38.
    • (2004) Nutl Vital Stat Rep , vol.53 , pp. 1-38
    • Arias, E.1
  • 4
    • 0026743110 scopus 로고
    • Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
    • P.V. Arriagada, K. Marzloff and B.T. Hyman, Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease, Neurology 42 (1992), 1681-1688.
    • (1992) Neurology , vol.42 , pp. 1681-1688
    • Arriagada, P.V.1    Marzloff, K.2    Hyman, B.T.3
  • 5
    • 0031020840 scopus 로고    scopus 로고
    • Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly: The preclinical stage of Alzheimer's disease?
    • T.G. Beach, W.G. Honer and L.H. Hughes, Cholinergic fibre loss associated with diffuse plaques in the non-demented elderly: the preclinical stage of Alzheimer's disease? Acta Neuropathol (Berl) 93 (1997), 146-153.
    • (1997) Acta Neuropathol (Berl) , vol.93 , pp. 146-153
    • Beach, T.G.1    Honer, W.G.2    Hughes, L.H.3
  • 6
    • 0024839699 scopus 로고
    • Computer-assisted morphometry of synaptic plasticity during aging and dementia
    • C. Bertoni-Freddari and P. Fattoretti, Computer-assisted morphometry of synaptic plasticity during aging and dementia, Path Res Pract 185 (1989), 799-802.
    • (1989) Path Res Pract , vol.185 , pp. 799-802
    • Bertoni-Freddari, C.1    Fattoretti, P.2
  • 7
    • 0025283380 scopus 로고
    • Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease
    • C. Bertoni-Freddari, P. Fattoretti, T. Casoli, W. Meier-Ruge and J. Ulrich, Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease, Brain Res 517 (1990), 69-75.
    • (1990) Brain Res , vol.517 , pp. 69-75
    • Bertoni-Freddari, C.1    Fattoretti, P.2    Casoli, T.3    Meier-Ruge, W.4    Ulrich, J.5
  • 8
    • 0014313861 scopus 로고
    • The association between quantitatiave measures of dementia and of senile changes in cerebral grey matter of elderly subjects
    • G. Blessed, B. Tomlinson and M. Roth, The association between quantitatiave measures of dementia and of senile changes in cerebral grey matter of elderly subjects, Br J Psychiatry 114 (1968), 797-811.
    • (1968) Br J Psychiatry , vol.114 , pp. 797-811
    • Blessed, G.1    Tomlinson, B.2    Roth, M.3
  • 9
    • 0025106123 scopus 로고
    • Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presinile and senile dementia
    • H. Braak and E. Braak, Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presinile and senile dementia, Acta Neuropathol 80 (1990), 479-486.
    • (1990) Acta Neuropathol , vol.80 , pp. 479-486
    • Braak, H.1    Braak, E.2
  • 10
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • H. Braak and E. Braak, Neuropathological stageing of Alzheimer-related changes, Acta Neuropathol 82 (1991), 239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 11
    • 0001815909 scopus 로고
    • Pathology of Alzheimer's disease
    • D.B. Calne, ed., W.B. Saunders, Co., Philadelphia
    • H. Braak and E. Braak, Pathology of Alzheimer's disease, in: Neurodegenerative Diseases, D.B. Calne, ed., Vol., W.B. Saunders, Co., Philadelphia, 1994, pp. 585-613.
    • (1994) Neurodegenerative Diseases , pp. 585-613
    • Braak, H.1    Braak, E.2
  • 12
    • 0027490614 scopus 로고
    • Staging of Alzheimer-related cortical destruction
    • H. Braak, E. Braak and J. Bohl, Staging of Alzheimer-related cortical destruction, Euro Neurol 33 (1993), 403-408.
    • (1993) Euro Neurol , vol.33 , pp. 403-408
    • Braak, H.1    Braak, E.2    Bohl, J.3
  • 13
    • 0026549426 scopus 로고
    • Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions
    • L.M. Cabalka, B.T. Hyman, C.R. Goodlett, T.C. Ritchie and G.W. Van Hoesen, Alteration in the pattern of nerve terminal protein immunoreactivity in the perforant pathway in Alzheimer's disease and in rats after entorhinal lesions, Neurobiol Aging 13 (1992), 283-291.
    • (1992) Neurobiol Aging , vol.13 , pp. 283-291
    • Cabalka, L.M.1    Hyman, B.T.2    Goodlett, C.R.3    Ritchie, T.C.4    Van Hoesen, G.W.5
  • 14
    • 0007621806 scopus 로고
    • Plasticity in the central nervous system: Do synapses divide?
    • R.K. Carlin and P. Siekevitz, Plasticity in the central nervous system: do synapses divide? Proc Natl Acatl Sci USA 80 (1983), 3517-3521.
    • (1983) Proc Natl Acatl Sci USA , vol.80 , pp. 3517-3521
    • Carlin, R.K.1    Siekevitz, P.2
  • 15
    • 0036733145 scopus 로고    scopus 로고
    • Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: Dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71
    • A. Castegna, M. Aksenov, V. Thongboonkerd, J.B. Klein, W.M. Pierce, R. Booze, W.R. Markesbery and D.A. Butterfield, Proteomic identification of oxidatively modified proteins in Alzheimer's disease brain. Part II: dihydropyrimidinase-related protein 2, alpha-enolase and heat shock cognate 71, J Neurochem 82 (2002), 1524-1532.
    • (2002) J Neurochem , vol.82 , pp. 1524-1532
    • Castegna, A.1    Aksenov, M.2    Thongboonkerd, V.3    Klein, J.B.4    Pierce, W.M.5    Booze, R.6    Markesbery, W.R.7    Butterfield, D.A.8
  • 17
    • 0023106967 scopus 로고
    • A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
    • C.A. Davies, D.M.A. Mann, P.W. Sumpter and P.O. Yates, A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease, J Neurol Sci 78 (1987), 151-164.
    • (1987) J Neurol Sci , vol.78 , pp. 151-164
    • Davies, C.A.1    Mann, D.M.A.2    Sumpter, P.W.3    Yates, P.O.4
  • 18
    • 0014723027 scopus 로고
    • Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients
    • A.D. Dayan, Quantitative histological studies on the aged human brain. I. Senile plaques and neurofibrillary tangles in "normal" patients, Acta Neuropathol (Berl) 16 (1970), 85-94.
    • (1970) Acta Neuropathol (Berl) , vol.16 , pp. 85-94
    • Dayan, A.D.1
  • 19
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • S.T. DeKosky and S.W. Scheff, Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity, Ann Neurol 27 (1990), 457-464.
    • (1990) Ann Neurol , vol.27 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 20
    • 0021970688 scopus 로고
    • Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer's disease
    • S.T. DeKosky, S.W. Scheff and W.R. Markesbery, Laminar organization of cholinergic circuits in human frontal cortex in Alzheimer's disease, Neurol 35 (1985), 1425-1431.
    • (1985) Neurol , vol.35 , pp. 1425-1431
    • DeKosky, S.T.1    Scheff, S.W.2    Markesbery, W.R.3
  • 21
    • 0022385709 scopus 로고
    • Age-related dendritic growth in dentate gyms of human brain is followed by regression in the 'oldest old'
    • D.G. Flood, S.J. Buell, C.H. Defiore, G.J. Horwitz and P.D. Coleman, Age-related dendritic growth in dentate gyms of human brain is followed by regression in the 'oldest old', Brain Res 345 (1985), 366-368.
    • (1985) Brain Res , vol.345 , pp. 366-368
    • Flood, D.G.1    Buell, S.J.2    Defiore, C.H.3    Horwitz, G.J.4    Coleman, P.D.5
  • 22
    • 0023156372 scopus 로고
    • Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia
    • D.G. Flood, S.J. Buell, G.J. Horwitz and P.D. Coleman, Dendritic extent in human dentate gyrus granule cells in normal aging and senile dementia, Brain Res 402 (1987), 205-216.
    • (1987) Brain Res , vol.402 , pp. 205-216
    • Flood, D.G.1    Buell, S.J.2    Horwitz, G.J.3    Coleman, P.D.4
  • 23
    • 0022397573 scopus 로고
    • Plasticity of hippocampal circuitry in Alzheimer's disease
    • J. Geddes, D. Monahan, C. Cotman, I.T. Lott, R. Kim and H. Chui, Plasticity of hippocampal circuitry in Alzheimer's disease, Science 230 (1985), 1179-1181.
    • (1985) Science , vol.230 , pp. 1179-1181
    • Geddes, J.1    Monahan, D.2    Cotman, C.3    Lott, I.T.4    Kim, R.5    Chui, H.6
  • 24
    • 0032191016 scopus 로고    scopus 로고
    • Selective vulnerability of neocortical association areas in Alzheimer's disease
    • P. Giannakopoulos, P.R. Hof and C. Bouras, Selective vulnerability of neocortical association areas in Alzheimer's disease, Microsc Res Tech 43 (1998), 16-23.
    • (1998) Microsc Res Tech , vol.43 , pp. 16-23
    • Giannakopoulos, P.1    Hof, P.R.2    Bouras, C.3
  • 25
    • 0028884524 scopus 로고
    • Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients
    • P. Giannakopoulos, P.R. Hof, A.S. Giannakopoulos, F.R. Herrmann, J.P. Michel and C. Bouras, Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of very old patients, Arch Neurol 52 (1995), 1150-1159.
    • (1995) Arch Neurol , vol.52 , pp. 1150-1159
    • Giannakopoulos, P.1    Hof, P.R.2    Giannakopoulos, A.S.3    Herrmann, F.R.4    Michel, J.P.5    Bouras, C.6
  • 26
    • 0030780381 scopus 로고    scopus 로고
    • Cerebral cortex pathology in aging and Alzheimer's disease: A quantitative survey of large hospital-based geriatric and psychiatric cohorts
    • P. Giannakopoulos, P.R. Hof, J.P. Michel, J. Guimon and C. Bouras, Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts, Brain Res Rev 25 (1997), 217-245.
    • (1997) Brain Res Rev , vol.25 , pp. 217-245
    • Giannakopoulos, P.1    Hof, P.R.2    Michel, J.P.3    Guimon, J.4    Bouras, C.5
  • 27
    • 0021063927 scopus 로고
    • EM study of the numbers of cortical synapses in the brains of aging people and people with Alzheimer-type dementia
    • P.H. Gibson, EM study of the numbers of cortical synapses in the brains of aging people and people with Alzheimer-type dementia, Acta Neuropathol (Berl) 62 (1983), 127-133.
    • (1983) Acta Neuropathol (Berl) , vol.62 , pp. 127-133
    • Gibson, P.H.1
  • 29
    • 0025218566 scopus 로고
    • Neuronal inputs to hippocampal formation in Alzheimer's disease and in parkinsonism-dementia complex on Guam
    • S. Goto and A. Hirano, Neuronal inputs to hippocampal formation in Alzheimer's disease and in parkinsonism-dementia complex on Guam, Acta Neuropathol 79 (1990), 545-550.
    • (1990) Acta Neuropathol , vol.79 , pp. 545-550
    • Goto, S.1    Hirano, A.2
  • 32
    • 0024595972 scopus 로고
    • Synaptic loss in Alzheimer's disease and other dementias
    • J. Hamos, L. DeGennaro and D. Drachman, Synaptic loss in Alzheimer's disease and other dementias, Neurology 39 (1989), 355-361.
    • (1989) Neurology , vol.39 , pp. 355-361
    • Hamos, J.1    DeGennaro, L.2    Drachman, D.3
  • 33
    • 0025878695 scopus 로고
    • Entorhinal neurofibrillary tangles in Alzheimer disease with Lewy bodies
    • L.A. Hansen, E. Masliah, S. Quijada-Fawcett and D. Rexin, Entorhinal neurofibrillary tangles in Alzheimer disease with Lewy bodies, Neurosci Lett 129 (1991), 269-272.
    • (1991) Neurosci Lett , vol.129 , pp. 269-272
    • Hansen, L.A.1    Masliah, E.2    Quijada-Fawcett, S.3    Rexin, D.4
  • 34
    • 0024432819 scopus 로고
    • Intracerebroventricular bethanechol chloride infustion in Alzheimer's disease: Results of a collaborative, double-blind study
    • R.E. Harbaugh, T.M. Reeder and H.J. Senter, Intracerebroventricular bethanechol chloride infustion in Alzheimer's disease: results of a collaborative, double-blind study, J Neurosurg 71 (1989), 481-486.
    • (1989) J Neurosurg , vol.71 , pp. 481-486
    • Harbaugh, R.E.1    Reeder, T.M.2    Senter, H.J.3
  • 35
    • 0028801680 scopus 로고
    • Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
    • O. Heinonen, H. Soininen, H. Sorvari, O. Kosunen, L. Paljarvi, E. Koivisto and P.J. Riekkinen, Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease, Neuroscience 64 (1995), 375-384.
    • (1995) Neuroscience , vol.64 , pp. 375-384
    • Heinonen, O.1    Soininen, H.2    Sorvari, H.3    Kosunen, O.4    Paljarvi, L.5    Koivisto, E.6    Riekkinen, P.J.7
  • 36
    • 0019748551 scopus 로고
    • Plasticity of synaptic size with constancy of total synaptic contact area on Purkinje cells in the cerebellum
    • D.E. Hillman and S. Chen, Plasticity of synaptic size with constancy of total synaptic contact area on Purkinje cells in the cerebellum, Prog Clin Biol Res 59A (1981), 229-245.
    • (1981) Prog Clin Biol Res , vol.59 A , pp. 229-245
    • Hillman, D.E.1    Chen, S.2
  • 38
    • 2642525455 scopus 로고    scopus 로고
    • Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment
    • C. Huang, L.O. Wahlund, L. Svensson, B. Winblad and P. Julin, Cingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment, BMC Neurol 2 (2002), 9.
    • (2002) BMC Neurol , vol.2 , pp. 9
    • Huang, C.1    Wahlund, L.O.2    Svensson, L.3    Winblad, B.4    Julin, P.5
  • 39
    • 0025240790 scopus 로고
    • A quantitative histological study of early clinical and preclinical Alzheimer's disease
    • B.M. Hubbard, G. W. Fenton and J.M. Anderson, A quantitative histological study of early clinical and preclinical Alzheimer's disease, Neuropathol Appl Neurobiol 16 (1990), 111-121.
    • (1990) Neuropathol Appl Neurobiol , vol.16 , pp. 111-121
    • Hubbard, B.M.1    Fenton, G.W.2    Anderson, J.M.3
  • 40
    • 0022535539 scopus 로고
    • Perforant pathway changes and memory impairment of Alzheimer's disease
    • B. Hyman, G. Van Hoesen, L. Kromer and A. Damasio, Perforant pathway changes and memory impairment of Alzheimer's disease, Ann Neurol 20 (1986), 472-481.
    • (1986) Ann Neurol , vol.20 , pp. 472-481
    • Hyman, B.1    Van Hoesen, G.2    Kromer, L.3    Damasio, A.4
  • 41
    • 0025107676 scopus 로고
    • Memory-related neural systems in Alzheimer's disease: An anatomic study
    • B.T. Hyman, G.W. Van Hoesen and A.R. Damasio, Memory-related neural systems in Alzheimer's disease: an anatomic study, Neurology 40 (1990), 1721-1730.
    • (1990) Neurology , vol.40 , pp. 1721-1730
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3
  • 42
    • 84903495965 scopus 로고    scopus 로고
    • Hippocampal formation
    • G. Paxinos and J.K. Mai, eds, Elsevier, San Diego
    • R. Insausti and D.G. Amaral, Hippocampal formation, in: The Human Nervous System, G. Paxinos and J.K. Mai, eds, Vol., Elsevier, San Diego, 2004, pp. 871-914.
    • (2004) The Human Nervous System , pp. 871-914
    • Insausti, R.1    Amaral, D.G.2
  • 43
    • 0023905906 scopus 로고
    • Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
    • R. Katzman, R. Terry, R. DeTeresa, T. Brown, P. Davies, P. Fuld, X. Renbing and A. Peck, Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques, Ann Neurol 23 (1988), 138-144.
    • (1988) Ann Neurol , vol.23 , pp. 138-144
    • Katzman, R.1    Terry, R.2    DeTeresa, R.3    Brown, T.4    Davies, P.5    Fuld, P.6    Renbing, X.7    Peck, A.8
  • 44
    • 0032229652 scopus 로고    scopus 로고
    • Alzheimer's disease pathology in non-demented elderly
    • A.M. Kazee and E.M. Johnson, Alzheimer's disease pathology in non-demented elderly, J Alz Dis 1 (1998), 81-89.
    • (1998) J Alz Dis , vol.1 , pp. 81-89
    • Kazee, A.M.1    Johnson, E.M.2
  • 45
    • 0022414054 scopus 로고
    • Diagnosis of Alzheimer's disease
    • Z.D. Khachaturian, Diagnosis of Alzheimer's disease, Arch Neurol 42 (1985), 1097-1105.
    • (1985) Arch Neurol , vol.42 , pp. 1097-1105
    • Khachaturian, Z.D.1
  • 46
    • 0035131830 scopus 로고    scopus 로고
    • Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
    • J.H. Kordower, Y. Chu, G.T. Stebbins, S.T. DeKosky, E.J. Cochran, D. Bennett and E.J. Mufson, Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment, Ann Neurol 49 (2001), 202-213.
    • (2001) Ann Neurol , vol.49 , pp. 202-213
    • Kordower, J.H.1    Chu, Y.2    Stebbins, G.T.3    DeKosky, S.T.4    Cochran, E.J.5    Bennett, D.6    Mufson, E.J.7
  • 47
    • 0028609448 scopus 로고
    • The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma
    • A. Koudinov, E. Matsubara, B. Frangione and J. Ghiso, The soluble form of Alzheimer's amyloid beta protein is complexed to high density lipoprotein 3 and very high density lipoprotein in normal human plasma, Biochem Biophys Res Commun 205 (1994), 1164-1171.
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1164-1171
    • Koudinov, A.1    Matsubara, E.2    Frangione, B.3    Ghiso, J.4
  • 48
    • 0030601055 scopus 로고    scopus 로고
    • Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: Association with high density lipoproteins
    • A.R. Koudinov, N.V. Koudinova, A. Kumar, R.C. Beavis and J. Ghiso, Biochemical characterization of Alzheimer's soluble amyloid beta protein in human cerebrospinal fluid: association with high density lipoproteins, Biochem Biophys Res Commun 223 (1996), 592-597.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 592-597
    • Koudinov, A.R.1    Koudinova, N.V.2    Kumar, A.3    Beavis, R.C.4    Ghiso, J.5
  • 49
    • 0034925118 scopus 로고    scopus 로고
    • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: The role of Abetal-42
    • C.M. Lauderback, J.M. Hackett, F.F. Huang, J.N. Keller, L.I. Szweda, W.R. Markesbery and D.A. Butterfield, The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abetal-42, J Neurochem 78 (2001), 413-416.
    • (2001) J Neurochem , vol.78 , pp. 413-416
    • Lauderback, C.M.1    Hackett, J.M.2    Huang, F.F.3    Keller, J.N.4    Szweda, L.I.5    Markesbery, W.R.6    Butterfield, D.A.7
  • 50
    • 0141505031 scopus 로고    scopus 로고
    • Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: A brain SPECT finding by statistical parametric mapping
    • Y.C. Liao, R.S. Liu, Y.C. Lee, C.M. Sun, C.Y. Liu, P.S. Wang, P.N. Wang and H.C. Liu, Selective hypoperfusion of anterior cingulate gyrus in depressed AD patients: a brain SPECT finding by statistical parametric mapping, Dement Geriatr Cogn Disord 16 (2003), 238-244.
    • (2003) Dement Geriatr Cogn Disord , vol.16 , pp. 238-244
    • Liao, Y.C.1    Liu, R.S.2    Lee, Y.C.3    Sun, C.M.4    Liu, C.Y.5    Wang, P.S.6    Wang, P.N.7    Liu, H.C.8
  • 52
    • 0027511788 scopus 로고
    • Quantal analysis and synaptic anatomy - Integrating two views of hippocampal plasticity
    • J.E. Lisman and K.M. Harris, Quantal analysis and synaptic anatomy - integrating two views of hippocampal plasticity, Trends Neurosci 16 (1993), 141-147.
    • (1993) Trends Neurosci , vol.16 , pp. 141-147
    • Lisman, J.E.1    Harris, K.M.2
  • 53
    • 0028989692 scopus 로고
    • Synaptophysin immunoreactivity is stable 36 h postmortem
    • X. Liu and A. Brun, Synaptophysin immunoreactivity is stable 36 h postmortem, Dementia 6 (1995), 211-217.
    • (1995) Dementia , vol.6 , pp. 211-217
    • Liu, X.1    Brun, A.2
  • 54
    • 0029981501 scopus 로고    scopus 로고
    • Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration
    • X. Liu, C. Erikson and A. Brun, Cortical synaptic changes and gliosis in normal aging, Alzheimer's disease and frontal lobe degeneration, Dementia 7 (1996), 128-134.
    • (1996) Dementia , vol.7 , pp. 128-134
    • Liu, X.1    Erikson, C.2    Brun, A.3
  • 56
    • 0032902974 scopus 로고    scopus 로고
    • Oxidative alterations in Alzheimer's disease
    • W.R. Markesbery and J.M. Carney, Oxidative alterations in Alzheimer's disease, Brain Pathol 9 (1999), 133-146.
    • (1999) Brain Pathol , vol.9 , pp. 133-146
    • Markesbery, W.R.1    Carney, J.M.2
  • 57
    • 0027390458 scopus 로고
    • Quantitative synaptic alterations in the human neocortex during normal aging
    • E. Masliah, M. Mallory, L. Hansen, R. DeTeresa and R.D. Terry, Quantitative synaptic alterations in the human neocortex during normal aging, Neurology 43 (1993), 192-197.
    • (1993) Neurology , vol.43 , pp. 192-197
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    DeTeresa, R.4    Terry, R.D.5
  • 58
    • 0024364877 scopus 로고
    • Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
    • E. Masliah, R. Terry, R. DeTeresa and L. Hansen, Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease, Neurosci Lett 103 (1989), 234-239.
    • (1989) Neurosci Lett , vol.103 , pp. 234-239
    • Masliah, E.1    Terry, R.2    DeTeresa, R.3    Hansen, L.4
  • 59
    • 0026032039 scopus 로고
    • Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease
    • E. Masliah, R.D. Terry, M. Alford, R. DeTeresa and L.A. Hansen, Cortical and subcortical patterns of synaptophysin-like immunoreactivity in Alzheimer's disease, Am J Pathol 138 (1991), 235-246.
    • (1991) Am J Pathol , vol.138 , pp. 235-246
    • Masliah, E.1    Terry, R.D.2    Alford, M.3    DeTeresa, R.4    Hansen, L.A.5
  • 60
    • 0025600931 scopus 로고
    • Diffuse plaques do not accentuate synapse loss in Alzheimer's disease
    • E. Masliah, R.D. Terry, M. Mallory, M. Alford and L.A. Hansen, Diffuse plaques do not accentuate synapse loss in Alzheimer's disease, Am J Pathol 137 (1990), 1293-1297.
    • (1990) Am J Pathol , vol.137 , pp. 1293-1297
    • Masliah, E.1    Terry, R.D.2    Mallory, M.3    Alford, M.4    Hansen, L.A.5
  • 62
    • 0035103864 scopus 로고    scopus 로고
    • Stress and hippocampal plasticity: Implications for the pathophysiology of affective disorders
    • B.S. McEwen and A.M. Magarinos, Stress and hippocampal plasticity: implications for the pathophysiology of affective disorders, Hum Psychopharmacol 16 (2001), S7-S19.
    • (2001) Hum Psychopharmacol , vol.16
    • McEwen, B.S.1    Magarinos, A.M.2
  • 64
    • 0030874251 scopus 로고    scopus 로고
    • Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
    • S. Minoshima, B. Giordani, S. Berent, K.A. Frey, N.L. Foster and D.E. Kuhl, Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease, Ann Neurol 42 (1997), 85-94.
    • (1997) Ann Neurol , vol.42 , pp. 85-94
    • Minoshima, S.1    Giordani, B.2    Berent, S.3    Frey, K.A.4    Foster, N.L.5    Kuhl, D.E.6
  • 65
    • 0029892175 scopus 로고    scopus 로고
    • Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease
    • J.C. Morris, M. Storandt, S.W. McKeel, E.H. Rubin, J.L. Price, E.A. Grant and L. Berg, Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease, Neurology 46 (1996), 707-719.
    • (1996) Neurology , vol.46 , pp. 707-719
    • Morris, J.C.1    Storandt, M.2    McKeel, S.W.3    Rubin, E.H.4    Price, J.L.5    Grant, E.A.6    Berg, L.7
  • 66
    • 0034213718 scopus 로고    scopus 로고
    • High-level neuronal expression of a beta 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
    • L. Mucke, E. Masliah, G.Q. Yu, M. Mallory, E.M. Rockenstein, G. Tatsuno, K. Hu, D. Kholodenko, K. Johnson-Wood and L. McConlogue, High-level neuronal expression of A beta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation, J Neurosci 20 (2000), 4050-4058.
    • (2000) J Neurosci , vol.20 , pp. 4050-4058
    • Mucke, L.1    Masliah, E.2    Yu, G.Q.3    Mallory, M.4    Rockenstein, E.M.5    Tatsuno, G.6    Hu, K.7    Kholodenko, D.8    Johnson-Wood, K.9    McConlogue, L.10
  • 68
    • 0030929886 scopus 로고    scopus 로고
    • Neocortical neuron number in humans: Effect of sex and age
    • B. Pakkenberg and J.G. Gundersen, Neocortical neuron number in humans: effect of sex and age, J Comp Neurol 384 (1997), 312-320.
    • (1997) J Comp Neurol , vol.384 , pp. 312-320
    • Pakkenberg, B.1    Gundersen, J.G.2
  • 69
    • 0023024547 scopus 로고
    • Alzheimer's disease: Maintenance of neuronal and synaptic densities in frontal cortical layers II and III
    • M.M. Paula-Barbosa, A. Saraiva, M.A. Tavares, M.M. Borges and R.W.H. Verwer, Alzheimer's disease: maintenance of neuronal and synaptic densities in frontal cortical layers II and III, Acta Neurol Scand 74 (1986), 404-408.
    • (1986) Acta Neurol Scand , vol.74 , pp. 404-408
    • Paula-Barbosa, M.M.1    Saraiva, A.2    Tavares, M.A.3    Borges, M.M.4    Verwer, R.W.H.5
  • 70
    • 0021191259 scopus 로고
    • Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia
    • E. Perdahl, R. Adolfsson, I. Alafuzoff, K.A. Albert, E.J. Nestler, P. Greengard and B. Winblad, Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multiinfarct dementia, J Neural Trans 60 (1984), 133-141.
    • (1984) J Neural Trans , vol.60 , pp. 133-141
    • Perdahl, E.1    Adolfsson, R.2    Alafuzoff, I.3    Albert, K.A.4    Nestler, E.J.5    Greengard, P.6    Winblad, B.7
  • 71
  • 74
    • 0034849725 scopus 로고    scopus 로고
    • Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
    • J.L. Price, A.I. Ko, M.J. Wade, S.K. Tsou, D.W. McKeel and J.C. Morris, Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease, Arch Neurol 58 (2001), 1395-1402.
    • (2001) Arch Neurol , vol.58 , pp. 1395-1402
    • Price, J.L.1    Ko, A.I.2    Wade, M.J.3    Tsou, S.K.4    McKeel, D.W.5    Morris, J.C.6
  • 75
    • 0025770134 scopus 로고
    • The distribution of tangles, plaques and related immunohistochemical markers in health aging and Alzheimer's disease
    • L.J. Price, P.B. Davis, J.C. Morris and D.L. White, The distribution of tangles, plaques and related immunohistochemical markers in health aging and Alzheimer's disease, Neurobiol Aging 12 (1991), 295-312.
    • (1991) Neurobiol Aging , vol.12 , pp. 295-312
    • Price, L.J.1    Davis, P.B.2    Morris, J.C.3    White, D.L.4
  • 76
    • 0019967975 scopus 로고
    • The Global Deterioration Scale for assessment of primary degenerative dementia
    • B. Reisberg, S.H. Ferris, M.J. de Leon and T. Crook, The Global Deterioration Scale for assessment of primary degenerative dementia, Am J Psychiatry 139 (1982), 1136-1139.
    • (1982) Am J Psychiatry , vol.139 , pp. 1136-1139
    • Reisberg, B.1    Ferris, S.H.2    De Leon, M.J.3    Crook, T.4
  • 77
    • 0023734831 scopus 로고
    • Is senile dementia of the Alzheimer type associted with hippocampal plasticity
    • A. Represa, C. Duychaerts, E. Tremblay, J.J. Hauw and Y. Ben-Ari, Is senile dementia of the Alzheimer type associted with hippocampal plasticity, Brain Res 457 (1988), 355-359.
    • (1988) Brain Res , vol.457 , pp. 355-359
    • Represa, A.1    Duychaerts, C.2    Tremblay, E.3    Hauw, J.J.4    Ben-Ari, Y.5
  • 78
    • 0002691008 scopus 로고    scopus 로고
    • Synaptic reorganization after injury: The hippocampus as a model system
    • F.J. Seil, ed., Alan R. Liss, New York
    • S.W. Scheff, Synaptic reorganization after injury: the hippocampus as a model system, in: Neural Regeneration and Transplantation, F.J. Seil, ed., Vol., Alan R. Liss, New York, 1989, pp. 137-156.
    • Neural Regeneration and Transplantation , vol.1989 , pp. 137-156
    • Scheff, S.W.1
  • 79
    • 0025217385 scopus 로고
    • Quantitative assessment of cortical synaptic density in Alzheimer's disease
    • S.W. Scheff, S.T. DeKosky and D.A. Price, Quantitative assessment of cortical synaptic density in Alzheimer's disease, Neurobiol Aging 11 (1990), 29-37.
    • (1990) Neurobiol Aging , vol.11 , pp. 29-37
    • Scheff, S.W.1    DeKosky, S.T.2    Price, D.A.3
  • 80
    • 0027400026 scopus 로고
    • Synapse loss in the temporal lobe in Alzheimer's disease
    • S.W. Scheff and D. Price, Synapse loss in the temporal lobe in Alzheimer's disease, Ann Neurol 33 (1993), 190-199.
    • (1993) Ann Neurol , vol.33 , pp. 190-199
    • Scheff, S.W.1    Price, D.2
  • 81
    • 0034766709 scopus 로고    scopus 로고
    • Alzheimer's disease-related synapse loss in the cingulate cortex
    • S.W. Scheff and D.A. Price, Alzheimer's disease-related synapse loss in the cingulate cortex, J Alz Dis 3 (2001), 495-505.
    • (2001) J Alz Dis , vol.3 , pp. 495-505
    • Scheff, S.W.1    Price, D.A.2
  • 82
    • 0031743132 scopus 로고    scopus 로고
    • Synaptic density in the inner molecular layer of the hippocampal dentate gyrus in Alzheimer disease
    • S.W. Scheff and D.A. Price, Synaptic density in the inner molecular layer of the hippocampal dentate gyrus in Alzheimer disease, J Neuropathol Exp Neurol 57 (1998), 1146-1153.
    • (1998) J Neuropathol Exp Neurol , vol.57 , pp. 1146-1153
    • Scheff, S.W.1    Price, D.A.2
  • 83
    • 0345276568 scopus 로고    scopus 로고
    • Synaptic pathology in Alzheimer's disease: A review of ultrastructural studies
    • S.W. Scheff and D.A. Price, Synaptic pathology in Alzheimer's disease: a review of ultrastructural studies, Neurobiol Aging 24 (2003), 1029-1046.
    • (2003) Neurobiol Aging , vol.24 , pp. 1029-1046
    • Scheff, S.W.1    Price, D.A.2
  • 84
    • 0034990224 scopus 로고    scopus 로고
    • Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex
    • S.W. Scheff, D.A. Price and D.L. Sparks, Quantitative assessment of possible age-related change in synaptic numbers in the human frontal cortex, Neurobiol Aging 22 (2001), 355-365.
    • (2001) Neurobiol Aging , vol.22 , pp. 355-365
    • Scheff, S.W.1    Price, D.A.2    Sparks, D.L.3
  • 85
    • 0027261146 scopus 로고
    • Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease
    • S.W. Scheff, D.L. Sparks and D.A. Price, Quantitative assessment of synaptic density in the entorhinal cortex in Alzheimer's disease, Ann Neurol 34 (1993), 356-361.
    • (1993) Ann Neurol , vol.34 , pp. 356-361
    • Scheff, S.W.1    Sparks, D.L.2    Price, D.A.3
  • 86
    • 0029793008 scopus 로고    scopus 로고
    • Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease
    • S.W. Scheff, D.L. Sparks and D.A. Price, Quantitative assessment of synaptic density in the outer molecular layer of the hippocampal dentate gyrus in Alzheimer's disease, Dementia 7 (1996), 213-220.
    • (1996) Dementia , vol.7 , pp. 213-220
    • Scheff, S.W.1    Sparks, D.L.2    Price, D.A.3
  • 88
    • 0017173036 scopus 로고
    • Progressive dendritic changes in the aging human limbic system
    • M.E. Scheibel, R.D. Lindsay, U. Tomiyasu and A.B. Scheibel, Progressive dendritic changes in the aging human limbic system, Exp Neurol 53 (1976), 420-430.
    • (1976) Exp Neurol , vol.53 , pp. 420-430
    • Scheibel, M.E.1    Lindsay, R.D.2    Tomiyasu, U.3    Scheibel, A.B.4
  • 93
    • 0027394978 scopus 로고
    • Temporal sequence of plaque formation in the cerebral cortex of non-demented individuals
    • D.L. Sparks, L. Huaichen, S.W. Scheff, C.M. Coyne and J.C. Hunsaker, Temporal sequence of plaque formation in the cerebral cortex of non-demented individuals, J Neuropath Exp Neurol 52 (1993), 135-142.
    • (1993) J Neuropath Exp Neurol , vol.52 , pp. 135-142
    • Sparks, D.L.1    Huaichen, L.2    Scheff, S.W.3    Coyne, C.M.4    Hunsaker, J.C.5
  • 95
    • 0021234096 scopus 로고
    • The unbiased estimation of number and sizes of arbitrary particles using the disector
    • D.C. Sterio, The unbiased estimation of number and sizes of arbitrary particles using the disector, J Microsc 134 (1984), 127-136.
    • (1984) J Microsc , vol.134 , pp. 127-136
    • Sterio, D.C.1
  • 96
    • 0030872413 scopus 로고    scopus 로고
    • Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
    • C.I. Sze, J.C. Troncoso, C. Kawas, P. Mouton, D.L. Price and L.J. Martin, Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease, J Neuropathol Exp Neurol 56 (1997), 933-944.
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 933-944
    • Sze, C.I.1    Troncoso, J.C.2    Kawas, C.3    Mouton, P.4    Price, D.L.5    Martin, L.J.6
  • 97
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • R.D. Terry, E. Masliah, D.P. Salmon, N. Butters, R. DeTeresa, R. Hill, L.A. Hansen and R. Katzman, Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment, Ann Neurol 30 (1991), 572-580.
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    DeTeresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 98
    • 0000664142 scopus 로고
    • The parahippocampal gyrus: New observations regarding its cortical connections in the monkey
    • G.W. Van Hoesen, The parahippocampal gyrus: new observations regarding its cortical connections in the monkey, Trends Neurosci (1982), 345-350.
    • (1982) Trends Neurosci , pp. 345-350
    • Van Hoesen, G.W.1
  • 99
    • 0025717403 scopus 로고
    • Entorhinal cortex pathology in Alzheimer's disease
    • G.W. Van Hoesen, B.T. Hyman and A.R. Damasio, Entorhinal cortex pathology in Alzheimer's disease, Hippocampus 1 (1991), 1-8.
    • (1991) Hippocampus , vol.1 , pp. 1-8
    • Van Hoesen, G.W.1    Hyman, B.T.2    Damasio, A.R.3
  • 100
    • 33747418316 scopus 로고
    • Functional Heterogeneity in Cingulate Cortex: The Anterior Executive and Posterior Evaluative Regions
    • B.A. Vogt, F.D. M. and O.C. R., Functional Heterogeneity in Cingulate Cortex: The Anterior Executive and Posterior Evaluative Regions, Cerebral Cortex 443 (1992), 1047-3211.
    • (1992) Cerebral Cortex , vol.443 , pp. 1047-3211
    • Vogt, B.A.1    Mo, F.D.2    Ro, O.C.3
  • 101
    • 0023184512 scopus 로고
    • Cingulate Cortex of the Rhesus Monkey: II. Cortical Afferents
    • B.A. Vogt and P.D. N., Cingulate Cortex of the Rhesus Monkey: II. Cortical Afferents, J Comp Neurol 262 (1987), 271-289.
    • (1987) J Comp Neurol , vol.262 , pp. 271-289
    • Vogt, B.A.1    No, P.D.2
  • 102
    • 0023202546 scopus 로고
    • Cingulate Cortex of the Rhesus Monkey: I. Cytoarchitecture and Thalamic Afferents
    • B.A. Vogt, P.D. N. and R. D., Cingulate Cortex of the Rhesus Monkey: I. Cytoarchitecture and Thalamic Afferents, J Comp Neurol 262 (1987), 256-270.
    • (1987) J Comp Neurol , vol.262 , pp. 256-270
    • Vogt, B.A.1    No, P.D.2    Do, R.3
  • 103
    • 0025172064 scopus 로고
    • Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease
    • B.A. Vogt, G.W. Van Hoesen and L.J. Vogt, Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease, Acta Neuropath 80 (1990), 581-589.
    • (1990) Acta Neuropath , vol.80 , pp. 581-589
    • Vogt, B.A.1    Van Hoesen, G.W.2    Vogt, L.J.3
  • 104
    • 0028587094 scopus 로고
    • Synapse alterations in the hippocampal-entorhinal function in Alzheimer's disease with and without Lewy body disease
    • K. Wakabayaski, W.G. Honer and E. Masliah, Synapse alterations in the hippocampal-entorhinal function in Alzheimer's disease with and without Lewy body disease, Brain Res 667 (1994), 24-32.
    • (1994) Brain Res , vol.667 , pp. 24-32
    • Wakabayaski, K.1    Honer, W.G.2    Masliah, E.3
  • 105
    • 0027229615 scopus 로고
    • Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia
    • S.-S. Zhan, K. Beyreuther and H.P. Schmitt, Quantitative assessment of the synaptophysin immuno-reactivity of the cortical neuropil in various neurodegenerative disorders with dementia, Dementia 4 (1993), 66-74.
    • (1993) Dementia , vol.4 , pp. 66-74
    • Zhan, S.-S.1    Beyreuther, K.2    Schmitt, H.P.3


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