Synaptic genes are extensively downregulated across multiple brain regions in normal human aging and Alzheimer's disease

Neurobiology of Aging

Volumn 34, Issue 6, 2013, Pages 1653-1661

  Berchtold, Nicole C ^a   Coleman, Paul D ^b,c   Cribbs, David H ^a,d   Rogers, Joseph ^b   Gillen, Daniel L ^a,e   Cotman, Carl W ^a,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SUN HEALTH RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Ringgold Standard Institution Informatics   (United States)

Author keywords

Cortex; Limbic; Microarray; Molecular reprogramming; Neurotransmitter receptors; Scaffolding molecules; Synaptic vesicle trafficking

Indexed keywords

MUSCARINIC M3 RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NEUROTRANSMITTER RECEPTOR; SEROTONIN 2A RECEPTOR; SOMATOSTATIN; SYNAPTOBREVIN 2; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 25;

ADULT; AGE DISTRIBUTION; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; BRAIN REGION; CELL ADHESION; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE FUNCTION; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; MALE; NEUROMODULATION; PRIORITY JOURNAL; PROTEIN TRANSPORT; SYNAPSE; SYNAPSE VESICLE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; BRAIN CHEMISTRY; DOWN-REGULATION; FEMALE; GENE EXPRESSION PROFILING; HUMANS; MALE; MIDDLE AGED; SYNAPSES; SYNAPTIC VESICLES; YOUNG ADULT;

EID: 84875262338     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.11.024     Document Type: Article

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