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Volumn 231, Issue 1, 2016, Pages 94-105

Endotoxin-stimulated Rat Hepatic Stellate Cells Induce Autophagy in Hepatocytes as a Survival Mechanism

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CASPASE 3; ENDOTOXIN; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; JANUS KINASE 1; JANUS KINASE 2; LACTATE DEHYDROGENASE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; CULTURE MEDIUM; CYTOKINE; LIPOPOLYSACCHARIDE;

EID: 84942357850     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.25055     Document Type: Article
Times cited : (21)

References (68)
  • 1
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear Factor-kB: The enemy within
    • Aggarwal BB 2004. Nuclear Factor-kB: The enemy within. Cancer Cell 6:203-208.
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 2
    • 4644333142 scopus 로고    scopus 로고
    • Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
    • Aikin R, Maysinger D, Rosenberg L. 2004. Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets. Endocrinology 145:4522-4531.
    • (2004) Endocrinology , vol.145 , pp. 4522-4531
    • Aikin, R.1    Maysinger, D.2    Rosenberg, L.3
  • 3
    • 0036709920 scopus 로고    scopus 로고
    • Cell-specific regulation of apoptosis by glucocorticoids: Implication to their anti-inflammatory action
    • Amsterdam A, Tajima K, Sasson R. 2002. Cell-specific regulation of apoptosis by glucocorticoids: Implication to their anti-inflammatory action. Biochem Pharmacol 64:843-850.
    • (2002) Biochem Pharmacol , vol.64 , pp. 843-850
    • Amsterdam, A.1    Tajima, K.2    Sasson, R.3
  • 4
    • 0028841166 scopus 로고
    • IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury
    • Arai T, Hiromatsu K, Kobayashi N, Takano M, Ishida H, Nimura Y, Yoshikai Y. 1995. IL-10 is involved in the protective effect of dibutyryl cyclic adenosine monophosphate on endotoxin-induced inflammatory liver injury. J Immunol 155:5743-5749.
    • (1995) J Immunol , vol.155 , pp. 5743-5749
    • Arai, T.1    Hiromatsu, K.2    Kobayashi, N.3    Takano, M.4    Ishida, H.5    Nimura, Y.6    Yoshikai, Y.7
  • 5
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer M, Roggel F, Gerbes AL. 2006. Role of Kupffer cells in host defense and liver disease. Liver Int 26:1175-1186.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 6
    • 20644465187 scopus 로고    scopus 로고
    • Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
    • Camargo CA, Jr, Madden JF, Gao W, Selvan RS, Clavien PA. 1997. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 26:1513-1520.
    • (1997) Hepatology , vol.26 , pp. 1513-1520
    • Camargo, C.A.1    Madden, J.F.2    Gao, W.3    Selvan, R.S.4    Clavien, P.A.5
  • 8
    • 84896106296 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates p62-dependent autophagy-like aggregate clearance in hepatocytes
    • Chen C, Deng M, Sun Q, Loughran P, Billiar TR, Scott MJ. 2014. Lipopolysaccharide stimulates p62-dependent autophagy-like aggregate clearance in hepatocytes. Biomed Res Int 2014:267350.
    • (2014) Biomed Res Int , vol.2014 , pp. 267350
    • Chen, C.1    Deng, M.2    Sun, Q.3    Loughran, P.4    Billiar, T.R.5    Scott, M.J.6
  • 11
  • 12
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 13
    • 0032018598 scopus 로고    scopus 로고
    • The response of liver macrophages to inflammatory stimulation
    • Decker K 1998. The response of liver macrophages to inflammatory stimulation. Keio J Med 47:1-9.
    • (1998) Keio J Med , vol.47 , pp. 1-9
    • Decker, K.1
  • 14
    • 79952175742 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 mediates acetylation and release of high mobility group box-1 from hepatocytes during murine liver ischemia-reperfusion injury
    • Dhupar R, Klune JR, Evankovich J, Cardinal J, Zhang M, Ross M, Murase N, Geller DA, Billiar TR, Tsung A. 2011. Interferon regulatory factor-1 mediates acetylation and release of high mobility group box-1 from hepatocytes during murine liver ischemia-reperfusion injury. Shock 35:293-301.
    • (2011) Shock , vol.35 , pp. 293-301
    • Dhupar, R.1    Klune, J.R.2    Evankovich, J.3    Cardinal, J.4    Zhang, M.5    Ross, M.6    Murase, N.7    Geller, D.A.8    Billiar, T.R.9    Tsung, A.10
  • 15
    • 0031666828 scopus 로고    scopus 로고
    • The effect of non-genotoxic carcinogens, Phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis
    • Diez-Fernandez C, Sanz N, Alvarez AM, Wolf A, Cascales M. 1998. The effect of non-genotoxic carcinogens, Phenobarbital and clofibrate, on the relationship between reactive oxygen species, antioxidant enzyme expression and apoptosis. Carcinogenesis 19:1715-1722.
    • (1998) Carcinogenesis , vol.19 , pp. 1715-1722
    • Diez-Fernandez, C.1    Sanz, N.2    Alvarez, A.M.3    Wolf, A.4    Cascales, M.5
  • 17
    • 16644383355 scopus 로고    scopus 로고
    • Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury
    • Ding WX, Yin XM. 2004. Dissection of the multiple mechanisms of TNF-alpha-induced apoptosis in liver injury. J Cell Mol Med 8:445-454.
    • (2004) J Cell Mol Med , vol.8 , pp. 445-454
    • Ding, W.X.1    Yin, X.M.2
  • 18
    • 0030110910 scopus 로고    scopus 로고
    • Supplementation of oral nutrition with pancreatic enzymes improves the nutritional status of aged endotoxemic rats
    • Farges MC, Vasson MP, Davot P, Villie F, Meunier MT, Marcollet M, Cynober L. 1996. Supplementation of oral nutrition with pancreatic enzymes improves the nutritional status of aged endotoxemic rats. Nutrition 112:189-194.
    • (1996) Nutrition , vol.112 , pp. 189-194
    • Farges, M.C.1    Vasson, M.P.2    Davot, P.3    Villie, F.4    Meunier, M.T.5    Marcollet, M.6    Cynober, L.7
  • 19
    • 0029557319 scopus 로고
    • Role of growth factors and cytokines in hepatic regeneration
    • Fausto N, Laird AD, Webber EM. 1995. Role of growth factors and cytokines in hepatic regeneration. FASEB J 9:1527-1536.
    • (1995) FASEB J , vol.9 , pp. 1527-1536
    • Fausto, N.1    Laird, A.D.2    Webber, E.M.3
  • 20
    • 32044448775 scopus 로고    scopus 로고
    • Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure
    • Fukui H 2005. Relation of endotoxin, endotoxin binding proteins and macrophages to severe alcoholic liver injury and multiple organ failure. Alcohol Clin Exp Res 29: 172S-179S.
    • (2005) Alcohol Clin Exp Res , vol.29 , pp. 172S-179S
    • Fukui, H.1
  • 21
    • 0035145603 scopus 로고    scopus 로고
    • Endotoxin treatment causes up-regulation of endothelin system in the liver: Amelioration of increased portal resistance by endothelin receptor antagonism
    • Gandhi CR, Kuddus RH, Nemoto EM, Murase N. 2001. Endotoxin treatment causes up-regulation of endothelin system in the liver: Amelioration of increased portal resistance by endothelin receptor antagonism. J Gastroenterol Hepatol 6:61-69.
    • (2001) J Gastroenterol Hepatol , vol.6 , pp. 61-69
    • Gandhi, C.R.1    Kuddus, R.H.2    Nemoto, E.M.3    Murase, N.4
  • 22
    • 84942319210 scopus 로고    scopus 로고
    • Monga SP, editor. Springer: Molecular Pathology of Liver Diseases
    • Gandhi CR 2010. In: Monga SP, editor. Hepatic Stellate Cells. Springer: Molecular Pathology of Liver Diseases. pp 53-80.
    • (2010) Hepatic Stellate Cells , pp. 53-80
    • Gandhi, C.R.1
  • 25
    • 33745962325 scopus 로고    scopus 로고
    • Nitric oxide and endoplasmic reticulum stress
    • Gotoh T, Mori M. 2006. Nitric oxide and endoplasmic reticulum stress. Arterioscler Thromb Vasc Biol 26:1439-1446.
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 1439-1446
    • Gotoh, T.1    Mori, M.2
  • 29
    • 80053303830 scopus 로고    scopus 로고
    • Autophagy and cytokines
    • Harris J 2011. Autophagy and cytokines. Cytokine 56:140-144.
    • (2011) Cytokine , vol.56 , pp. 140-144
    • Harris, J.1
  • 30
    • 84891916013 scopus 로고    scopus 로고
    • The transcriptomic response of rat hepatic stellate cells to endotoxin: Implications for hepatic inflammation and immune regulation
    • Harvey SAK, Dangi A, Tandon A, Gandhi CR. 2013. The transcriptomic response of rat hepatic stellate cells to endotoxin: Implications for hepatic inflammation and immune regulation. PLoS ONE 8:e82159.
    • (2013) PLoS ONE , vol.8 , pp. e82159
    • Harvey, S.A.K.1    Dangi, A.2    Tandon, A.3    Gandhi, C.R.4
  • 31
    • 79960716001 scopus 로고    scopus 로고
    • Akt signalling in health and disease
    • Hers I, Vincent EE, Tavaré JM. 2011. Akt signalling in health and disease. Cell Signal 23:1515-1527.
    • (2011) Cell Signal , vol.23 , pp. 1515-1527
    • Hers, I.1    Vincent, E.E.2    Tavaré, J.M.3
  • 32
    • 84892473066 scopus 로고    scopus 로고
    • The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells
    • Jia G, Kong R, Ma ZB, Han B, Wang YW, Pan SH, Li YH, Sun B. 2014. The activation of c-Jun NH2-terminal kinase is required for dihydroartemisinin-induced autophagy in pancreatic cancer cells. J Exp Clin Cancer Res 33:8.
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 8
    • Jia, G.1    Kong, R.2    Ma, Z.B.3    Han, B.4    Wang, Y.W.5    Pan, S.H.6    Li, Y.H.7    Sun, B.8
  • 33
    • 34047179973 scopus 로고    scopus 로고
    • Ubiquitinated-protein aggregates form in pancreatic b-cells during diabetes-induced oxidative stress and are regulated by autophagy
    • Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH. 2007. Ubiquitinated-protein aggregates form in pancreatic b-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56:930-939.
    • (2007) Diabetes , vol.56 , pp. 930-939
    • Kaniuk, N.A.1    Kiraly, M.2    Bates, H.3    Vranic, M.4    Volchuk, A.5    Brumell, J.H.6
  • 34
    • 84882658193 scopus 로고    scopus 로고
    • A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells
    • Kim AD, Kang KA, Kim HS, Kim DH, Choi YH, Lee SJ, Kim HS, Hyun JW. 2013. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis 4:e750.
    • (2013) Cell Death Dis , vol.4 , pp. e750
    • Kim, A.D.1    Kang, K.A.2    Kim, H.S.3    Kim, D.H.4    Choi, Y.H.5    Lee, S.J.6    Kim, H.S.7    Hyun, J.W.8
  • 37
    • 38949108670 scopus 로고    scopus 로고
    • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
    • Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, et al. 2008. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151-175.
    • (2008) Autophagy , vol.4 , pp. 151-175
    • Klionsky, D.J.1    Abeliovich, H.2    Agostinis, P.3    Agrawal, D.K.4    Aliev, G.5    Askew, D.S.6
  • 38
    • 70349838737 scopus 로고    scopus 로고
    • Cytoprotective effects of human interleukin-10 gene transfer against necrosis and apoptosis induced by hepatic cold ischemia/reperfusion injury
    • Li JQ, Qi HZ, He ZJ, Hu W, Si ZZ, Li YN, Li DB. 2009. Cytoprotective effects of human interleukin-10 gene transfer against necrosis and apoptosis induced by hepatic cold ischemia/reperfusion injury. J Surg Res 157:e71-e78.
    • (2009) J Surg Res , vol.157 , pp. e71-e78
    • Li, J.Q.1    Qi, H.Z.2    He, Z.J.3    Hu, W.4    Si, Z.Z.5    Li, Y.N.6    Li, D.B.7
  • 39
    • 75149146637 scopus 로고    scopus 로고
    • Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy
    • Lorin S, Pierron G, Ryan KM, Codogno P, Djavaheri-Mergny M. 2010. Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy. Autophagy 6:153-154.
    • (2010) Autophagy , vol.6 , pp. 153-154
    • Lorin, S.1    Pierron, G.2    Ryan, K.M.3    Codogno, P.4    Djavaheri-Mergny, M.5
  • 40
    • 0036556684 scopus 로고    scopus 로고
    • The mammalian endoplasmic reticulum as a sensor for cellular stress
    • Ma Y, Hendershot LM. 2002. The mammalian endoplasmic reticulum as a sensor for cellular stress. Cell Stress Chaperones 7:222-229.
    • (2002) Cell Stress Chaperones , vol.7 , pp. 222-229
    • Ma, Y.1    Hendershot, L.M.2
  • 45
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. 2010. Methods in mammalian autophagy research. Cell 140:313-326.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 46
    • 53149111140 scopus 로고    scopus 로고
    • Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice
    • Ni HM, Chen X, Ding WX, Schuchmann M, Yin XM. 2008. Differential roles of JNK in ConA/GalN and ConA-induced liver injury in mice. Am J Pathol 173:962-972.
    • (2008) Am J Pathol , vol.173 , pp. 962-972
    • Ni, H.M.1    Chen, X.2    Ding, W.X.3    Schuchmann, M.4    Yin, X.M.5
  • 47
    • 84155194923 scopus 로고    scopus 로고
    • Activation of autophagy protects against acetaminophen-induced hepatotoxicity
    • Ni HM, Bockus A, Boggess N, Jaeschke H, Ding WX. 2012. Activation of autophagy protects against acetaminophen-induced hepatotoxicity. Hepatology 55:222-232.
    • (2012) Hepatology , vol.55 , pp. 222-232
    • Ni, H.M.1    Bockus, A.2    Boggess, N.3    Jaeschke, H.4    Ding, W.X.5
  • 49
    • 84893141250 scopus 로고    scopus 로고
    • Hepatic stellate cells and liver fibrosis
    • Puche JE, Saiman Y, Friedman SL. 2013. Hepatic stellate cells and liver fibrosis. Compr Physiol 3:1473-1492.
    • (2013) Compr Physiol , vol.3 , pp. 1473-1492
    • Puche, J.E.1    Saiman, Y.2    Friedman, S.L.3
  • 50
    • 0037405649 scopus 로고    scopus 로고
    • Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes
    • Qiao L, Han SI, Fang Y, Park JS, Gupta S, Gilfor D, Amorino G, Valerie K, Sealy L, Engelhardt JF, Grant S, Hylemon PB, Dent P. 2003. Bile acid regulation of C/EBPbeta, CREB, and c-Jun function, via the extracellular signal-regulated kinase and c-Jun NH2-terminal kinase pathways, modulates the apoptotic response of hepatocytes. Mol Cell Biol 23:3052-3066.
    • (2003) Mol Cell Biol , vol.23 , pp. 3052-3066
    • Qiao, L.1    Han, S.I.2    Fang, Y.3    Park, J.S.4    Gupta, S.5    Gilfor, D.6    Amorino, G.7    Valerie, K.8    Sealy, L.9    Engelhardt, J.F.10    Grant, S.11    Hylemon, P.B.12    Dent, P.13
  • 52
    • 0033950358 scopus 로고    scopus 로고
    • The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis
    • Roberts RA, James NH, Cosulich SC. 2000. The role of protein kinase B and mitogen-activated protein kinase in epidermal growth factor and tumor necrosis factor alpha-mediated rat hepatocyte survival and apoptosis. Hepatology 31:420-427.
    • (2000) Hepatology , vol.31 , pp. 420-427
    • Roberts, R.A.1    James, N.H.2    Cosulich, S.C.3
  • 53
    • 4444341881 scopus 로고    scopus 로고
    • Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    • Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. 2004. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 15:713-725.
    • (2004) Mol Cell , vol.15 , pp. 713-725
    • Sabapathy, K.1    Hochedlinger, K.2    Nam, S.Y.3    Bauer, A.4    Karin, M.5    Wagner, E.F.6
  • 54
    • 79957537223 scopus 로고    scopus 로고
    • Effect of quercetin on lipopolysaccharide induced-sickness behavior and oxidative stress in rats
    • Sah SP, Tirkey N, Kuhad A, Chopra K. 2011. Effect of quercetin on lipopolysaccharide induced-sickness behavior and oxidative stress in rats. Indian J Pharmacol 43:192-196.
    • (2011) Indian J Pharmacol , vol.43 , pp. 192-196
    • Sah, S.P.1    Tirkey, N.2    Kuhad, A.3    Chopra, K.4
  • 58
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner D. 2006. Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: Role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol 290:G583-G589.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G583-G589
    • Schwabe, R.F.1    Brenner, D.2
  • 59
    • 84855838193 scopus 로고    scopus 로고
    • Fructose protects murine hepatocytes from tumor necrosis factor-induced apoptosis by modulating JNK signaling
    • Speicher T, Köhler UA, Choukèr A, Werner S, Weiland T, Wendel A. 2012. Fructose protects murine hepatocytes from tumor necrosis factor-induced apoptosis by modulating JNK signaling. J Biol Chem 287:1837-1846.
    • (2012) J Biol Chem , vol.287 , pp. 1837-1846
    • Speicher, T.1    Köhler, U.A.2    Choukèr, A.3    Werner, S.4    Weiland, T.5    Wendel, A.6
  • 60
    • 84892535822 scopus 로고    scopus 로고
    • A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury
    • Stewart R, Dangi A, Huang C, Murase N, Kimura S, Stolz DB, Wilson GC, Lentsch AB, Gandhi CR. 2014. A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. J Hepatol 60:298-305.
    • (2014) J Hepatol , vol.60 , pp. 298-305
    • Stewart, R.1    Dangi, A.2    Huang, C.3    Murase, N.4    Kimura, S.5    Stolz, D.B.6    Wilson, G.C.7    Lentsch, A.B.8    Gandhi, C.R.9
  • 61
    • 30044439839 scopus 로고    scopus 로고
    • NFκB: Cell survival or cell death?
    • Strozyk E, Kulms D. 2005. NFκB: Cell survival or cell death? Signal Transduction 6:334-339.
    • (2005) Signal Transduction , vol.6 , pp. 334-339
    • Strozyk, E.1    Kulms, D.2
  • 63
    • 21644434942 scopus 로고    scopus 로고
    • Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes
    • Thirunavukkarasu C, Uemura T, Wang LF, Watkins SC, Gandhi CR. 2005. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes. J Cell Physiol 204:654-665.
    • (2005) J Cell Physiol , vol.204 , pp. 654-665
    • Thirunavukkarasu, C.1    Uemura, T.2    Wang, L.F.3    Watkins, S.C.4    Gandhi, C.R.5
  • 64
    • 33747075792 scopus 로고    scopus 로고
    • Mechanisms of endotoxin-induced nitric oxide, interleukin-6 and tumor necrosis factor-a production in activated rat hepatic stellate cells: Role of p38MAPK
    • Thirunavukkarasu C, Watkins S, Gandhi CR. 2006. Mechanisms of endotoxin-induced nitric oxide, interleukin-6 and tumor necrosis factor-a production in activated rat hepatic stellate cells: Role of p38MAPK. Hepatology 44:389-398.
    • (2006) Hepatology , vol.44 , pp. 389-398
    • Thirunavukkarasu, C.1    Watkins, S.2    Gandhi, C.R.3
  • 67
    • 0034888217 scopus 로고    scopus 로고
    • Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-β- and nitric oxide-independent
    • Uemura T, Gandhi CR. 2001. Inhibition of DNA synthesis in cultured hepatocytes by endotoxin-conditioned medium of activated stellate cells is transforming growth factor-β- and nitric oxide-independent. Br J Pharmacol 133:1125-1133.
    • (2001) Br J Pharmacol , vol.133 , pp. 1125-1133
    • Uemura, T.1    Gandhi, C.R.2


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