A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury

Journal of Hepatology

Volumn 60, Issue 2, 2014, Pages 298-305

  Stewart, Rachel K ^a   Dangi, Anil ^a,b,c   Huang, Chao ^a   Murase, Noriko ^a   Kimura, Shoko ^a   Stolz, Donna B ^d   Wilson, Gregory C ^b   Lentsch, Alex B ^b   Gandhi, Chandrashekhar R ^a,b,c,e  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c Veteran's Administration   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Depletion; Endotoxemia; Hepatic stellate cells; Hepatocytes; Injury; Ischemia reperfusion; Lipopolysaccharide; Liver; Necrosis

Indexed keywords

CARBON TETRACHLORIDE; CXCL1 CHEMOKINE; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTOXIN; GANCICLOVIR; INTERLEUKIN 6; MESSENGER RNA; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; THYMIDINE KINASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; ENDOTOXEMIA; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; LIVER CELL; LIVER CELL DAMAGE; LIVER FIBROSIS; LIVER HISTOLOGY; LIVER INJURY; LIVER SINUSOID; MONOCYTE; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPERFUSION; REPERFUSION INJURY; STELLATE CELL; VASODILATATION;

AB; ALANINE AMINOTRANSFERASE; ALT; ANTIBODY; APOPTOSIS; CARBON TETRACHLORIDE; CCL(4); DEPLETION; ECM; ENDOTHELIN-1; ENDOTOXEMIA; ET-1; EXTRACELLULAR MATRIX; GANCICLOVIR; GCV; GFAP; GLIAL FIBRILLARY ACIDIC PROTEIN; H/E; HEMATOXYLIN AND EOSIN; HEPATIC STELLATE CELL; HEPATIC STELLATE CELLS; HEPATOCYTES; HERPES SIMPLEX VIRUS; HSC; HSV; I/R; IL; INJURY; INTERLEUKIN; INTRAPERITONEAL; IP; ISCHEMIA/REPERFUSION; KCS; KUPFFER CELLS; LIPOPOLYSACCHARIDE; LIVER; LPS; NECROSIS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NO; NOS; PBS; PHOSPHATE-BUFFERED SALINE; QRT-PCR; QUANTITATIVE REAL-TIME POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; ROS; TG; THYMIDINE KINASE; TK; TNF; TRANSGENIC; TUMOR NECROSIS FACTOR; WILD TYPE; WT;

ANIMALS; CARBON TETRACHLORIDE; CHEMOKINE CXCL1; DISEASE MODELS, ANIMAL; DRUG-INDUCED LIVER INJURY; ENDOTHELIN-1; GANCICLOVIR; GENE EXPRESSION; HEPATIC STELLATE CELLS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; REPERFUSION INJURY; THYMIDINE KINASE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84892535822     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.09.013     Document Type: Article

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