JNK2 is activated during ER stress and promotes cell survival

Cell Death and Disease

Volumn 3, Issue 11, 2012, Pages

  Raciti, M ^a   Lotti, L V ^a   Valia, S ^a   Pulcinelli, F M ^a   Di Renzo, L ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Apoptosis; Autophagy; Endoplasmic reticulum stress; JNK2; Lysosome; Survival pathway

Indexed keywords

CASPASE 3; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MITOGEN ACTIVATED PROTEIN KINASE 9; PROTEIN P62; THAPSIGARGIN; TUNICAMYCIN;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL STRAIN U937; CELL STRESS; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENESCENCE; TUMOR CELL; UNFOLDED PROTEIN RESPONSE; UPREGULATION;

APOPTOSIS; CASPASE 3; CELL SURVIVAL; ENDOPLASMIC RETICULUM STRESS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 9; NEOPLASMS; PROTO-ONCOGENE PROTEINS C-MYC; TRANSCRIPTION FACTOR CHOP; U937 CELLS;

EID: 84870572036     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.167     Document Type: Article

References (43)

1. Kaufman RJ. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev 1999; 13: 1211-1233.
2. Harding HP, Calfan M, Urano F, Novoa I, Ron D. Transcriptional and translational control in the mammalian unfolded protein response. Annu Rev Cell Dev Biol 2002; 18: 575-599.
3. Kozutsumi Y, Segal M, Normington K, Gething MJ, Sambrook J. The presence of malfolded proteins in the endoplasmic reticulum signals the induction of glucose-regulated proteins. Nature (London) 1988; 332: 462-464.
4. Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ et al. Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival and tumor angiogenesis in transgene-induced mammary tumor development. Cancer Res 2008; 68: 498-505.
5. Wang XZ, Lawson B, Brewer JW, Zinszner H, Sanjay A, Mi LJ et al. Signals from the stressed endoplasmic reticulum induce C/EBP homologous protein (CHOP/GADD153). Mol Cell Biol 1996; 16: 4273-4280.
6. Marciniak SJ, Yun CY, Oyadamari S, Novoa I, Zhang Y, Jungreis R et al. CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev 2004; 18: 3066-3077.
7. Ogata M, Hino SI, Saito A, Morikawa K, Kondo S, Kanemoto S et al. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26: 9220-9231.
8. Ding W-X, Ni H-M, Gao W, Yoshimori T, Stolz DB, Ron D et al. Linking of autophagy to ubiquitin-proteasome system is important for the regulation of endoplasmic reticulum stress and cell viability. Am J Pathol 2007; 171: 513-524.
9. Yorimitsu T, Nair U, Yang Z, Klionsky DJ. Endoplasmic reticulum stress triggers autophagy. J Biol Chem 2006; 281: 30299-30304.
10. Bernales S, McDonald KL, Walter P. Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response. PLoS Biol 2006; 4: 2311-2324.
11. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182: 685-701.
12. Alva AS, Gultekin SH, Baehrecke EH. Autophagy in human tumors: cell survival or death? Cell Death Differ 2004; 11: 1046-1048.
13. Gozuacik D, Kimchi A. Autophagy and cell death. Curr Top Dev Biol 2007; 78: 217-245.
14. Eskelinen EL, Tanaka Y, Saftig P. At the acidic edge: emerging functions for lysosomal membrane proteins. Trends Cell Biol 2003; 13: 137-145.
15. Luzio JP, Pryor PR, Bright NA. Lysosomes: fusion and function. Nat Rev Mol Cell Biol 2007; 8: 622-632.
16. Joyce JA, Hanahan D. Multiple roles for cysteine cathepsins in cancer. Cell cycle 2004; 3: 1516-1519.
17. Guicciardi ME, Leist M, Gores GJ. Lysosomes in cell death. Oncogene 2004; 23: 2881-2890.
18. Kroemer G, JäätteläM. Lysosomes and autophagy in cell death control. Nat Rev Cancer 2005; 5: 886-897.
19. Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 2000; 287: 664-666.
20. Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30: 678-688.
21. Li DD, Wang LL, Deng R, Tang J, Shen Y, Guo JF et al. The pivotal role of c-Jun NH2- terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells. Oncogene 2009; 28: 886-898.
22. Oh SH, Lim SC. Endoplasmic reticulum stress-mediated autophagy/apoptosis induced by capsaicin (8-methyl-N-vanillyl-6-nonenamide) and dihydrocapsaicin is regulated by the extent of c-Jun NH2-terminal kinase/extracellular signal-regulated kinase activation in WI38 lung epithelial fibroblast cells. J Pharmacol Exp Ther 2009; 329: 112-122.
23. Shimizu S, Konishi A, Nishida Y, Mizuta T, Yamamoto A, Tsujimoto Y. Involvement of JNK in the regulation of autophagic cell death. Oncogene 2010; 29: 2070-2082.
24. Nakano H, Nakajima A, Sakon-Komazawa S, Piao JH, Xue X, Okumura K. Reactive oxygen species mediate crosstalk between NF-kB and JNK. Cell Death Differ 2006; 13: 730-737.
25. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dé rijard B et al. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996; 15: 2760-2770.
26. Bogoyevitch MA. The isoform-specific functions of the c-Jun N-terminal kinases (JNKs): differences revealed by gene targeting. BioEssays 2006; 28: 923-934.
27. Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 2006; 21: 701-710.
28. Nicoletti I, Migliorati G, Pagliacci MC, Grignani F, Riccardi C. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J Immunol Methods 1991; 139: 271-279.
29. Bennett BL, Sasaki DT, Murray BW, O'Leary EC, Sakata ST, Xu W et al. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001; 98: 13681-13686.
30. Snider JL, Allison C, Bellaire BH, Ferrero RL, Cardelli JA. The b1 integrin activates JNK independent of CagA, and JNK activation is required for Helicobacter pylori CagA+-induced motility of gastric cancer cells. J Biol Chem 2008; 283: 13952-13963.
31. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askow DS et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 2008; 4: 151-175.
32. Gancz D, Donin N, Fishelson Z. Involvement of the c-jun N-terminal kinases JNK1 and JNK2 in complement-mediated cell death. Mol Immunol 2009; 47: 310-317.
33. Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-jun-dependent cell proliferation. Mol Cell 2004; 15: 713-725.
34. Potapova O, Anisimov SV, Gorospe M, Dougherty RH, Gaarde WA, Boheler KR et al. Targets of c-Jun NH2-terminal kinase 2-mediated tumor growth regulation revealed by serial analysis of gene expression. Cancer Res 2002; 62: 3257-3263.
35. Potapova O, Gorospe M, Dougherty RH, Dean NM, Gaarde WA, Holbrook NJ. Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 2000; 20: 1713-1722.
36. Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 2011; 25: 310-322.
37. Jäger S, Bucci C, Tanida I, Ueno T, Kominami E, Saftig P et al. Role for Rab7 in maturation of late autophagic vacuoles. J Cell Sci 2004; 117: 4837-4848.
38. Jahreiss L, Menzies FM, Rubinsztein DC. The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 2008; 9: 574-587.
39. Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 2010; 465: 942-946.
40. Oberle C, Huai J, Reinheckel T, Tacke M, Rassner M, Ekert PG et al. Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes. Cell Death Differ 2010; 17: 1167-1178.
41. Boya P, Kroemer G. Lysosomal membrane permeabilization in cell death. Oncogene 2008; 27: 6434-6451.
42. Matusali G, Arena G, De Leo A, Di Renzo L, Mattia E. Inhibition of p38 MAP kinase pathway induces apoptosis and prevents Epstein-Barr virus reactivation in Raji cells exposed to lytic cycle inducing compounds. Mol Cancer 2009; 8: 18.
43. Marfe' G, Morgante E, Di Stefano C, Di Renzo L, De Martino L, Iovane G et al. Sorbitolinduced apoptosis of human leukemia is mediated by caspase activation and cytochrome c release. Arch toxicol 2008; 6: 371-377.