The role of vindesine and lonidamine in the treatment of elderly patients with advanced non-small cell lung cancer: A phase III randomized fonicap trial

Tumori

Volumn 85, Issue 3, 1999, Pages 177-182

  De Marinis, Filippo ^a   Rinaldi, Massimo ^b   Ardizzoni, Andrea ^c   Bruzzi, Paolo ^c   Pennucci, Maria Cristina ^c   Portalone, Luigi ^a   D'Aprile, Modesto ^d   Ripanti, Paola ^a   Romano, Francesco ^e   Belli, Massimo ^f   Altavilla, Giuseppe ^g   Migliorino, Maria Rita ^a   Rosso, Riccardo ^c   Salvati, Franco ^a  

^a SAN CAMILLO FORLANINI HOSPITAL   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d SANTA MARIA GORETTI HOSPITAL   (Italy)

^e Osp Civ Annunziata   (Italy)

^f Ospedale Civile   (Italy)

^g UNIVERSITY OF MESSINA   (Italy)

Author keywords

Chemotherapy; Elderly patients; Non small cell lung cancer; NSCLC

Indexed keywords

ANALGESIC AGENT; GESTAGEN; LONIDAMINE; STEROID; VINDESINE;

ADVANCED CANCER; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FATIGUE; FEMALE; FEVER; FLU LIKE SYNDROME; GASTROINTESTINAL TOXICITY; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LEUKOPENIA; LUNG NON SMALL CELL CANCER; MAJOR CLINICAL STUDY; MALE; MYALGIA; ORAL DRUG ADMINISTRATION; PAIN; PHASE 3 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; TESTIS;

EID: 0032813958     PISSN: 03008916     EISSN: None     Source Type: Journal    
DOI: 10.1177/030089169908500306     Document Type: Article

References (23)

1. Bakowsky M.T., Crouch J.C.: Chemotherapy of non small cell lung cancer: a reappraisal and a loss to the future. Cancer Treat. Rev., 10: 159-172, 1983.
2. Band P.R., Deschamps M., Besner J.G.: Phase I toxicologic study of lonidamine in cancer patients. In: Lonidamine. Proceedings of the 2nd International Symposium, Vancouver 1982, Silvestrini B., Band P.R., Caputo A., Young C.W. (Eds.). Oncology, 41 (Suppl. 1): 56-59, 1984 .
3. Contu A., Olmeo N.A., Pani P.: Lonidamine in non small cell lung cancer. Phase II study. Tumori, 77: 52-55, 1991.
4. Einhorn L.H., Loehrer P.J., Williams S.D.: Random prospective study of vindesine versus vindesine plus high-dose cisplatin versus vindesine plus cisplatin plus mitomycin C in advanced non-small cell lung cancer. J. Clin. Oncol., 4: 1037-1043, 1986.
5. Finkelstein D.M., Ettinger D.S., Ruckdeschel J.C.: Long-term survivors in metastatic non small cell lung cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol., 4: 702-709, 1986.
6. Floridi A., Bellocci M., Paggi M.G.: Changes of energy metabolism in the germ cells and Ehrlich ascites tumor cells. In: Lonidamine. A new pharmacological approach to the study and control of spermatogenesis and tumors, B. Silvestrini, A. Caputo (Eds.), Chemotherapy, 27 (Suppl. 2): 50-60, 1981.
7. Gatzemeier U., Cavalli F., Haussinger K.: Phase III trial with and without lonidamine in non-small cell lung cancer. Sem. Oncol., 18 (Suppl. 4): 42-48, 1991.
8. Giaccone G., Bagattella M., Donadio M.: Lonidamine versus polychemotherapy in advanced non small cell lung cancer. A preliminary analysis. Tumori, 75: 43-46, 1989.
9. Hahn G., Vankersen I., Silvestrini B.: Inhibition of the recovery from potentially lethal damage by lonidamine. Br. J. Cancer, 50: 657-660, 1984.
10. Horm J.W., Asire A.J., Young J.L.: SEER program: Cancer incidence and mortality in the United States 1973-1981, U.S. Department of Health Education and Welfare Publication (NIH) 85-1837. Bethesda, National Cancer Institute, 1984.
11. Jensen O.M., Estève J., Moller A.: Cancer in the European Community and its member states. Eur. J. Cancer , 26: 1167-1172, 1990.
12. Kokron O., Maca S., De Gregorio M.: Phase II study of lonidamine in non small cell lung cancer: final report. Br. J. Cancer, 61: 316-318, 1990.
13. Leslie W., Bonomi P., Gale M.: Combined modality therapy for stage III NSCLC: comparison of geriatric and younger patients. Proceedings of American Society of Clinical Oncology annual meeting (abstract # 904), 1991.
14. Luedke D.W., Einhorn L., Omura G.A.: Randomized comparison of two combination regimens versus minimal chemotherapy in non-small cell lung cancer: a Southeastern Cancer Study Group trial. J. Clin. Oncol., 8: 886-891, 1990.
15. Minna J.D., Higgins G.A., Glastein E.J.: Cancer in the lung. In: Cancer: principles and practice of oncology, V.T. DeVita, S. Hellmann, S.A. Rosenberg (Eds.), pp. 396-474, J.B. Lippincott Company, Philadelphia, 1982.
16. Monfardini S., Yancik R.M.: Cancer and aging. Meeting the challenges of an aging population. J. Natl. Cancer Inst., 85: 532-539, 1993.
17. O'Rourke M., Feussner J.R., Feigl P.: Age trends of lung cancer stage at diagnosis. JAMA, 258: 921-927, 1987.
18. Paesmans M., Sculier J.P., Libert P.: Prognostic factors for survival in advanced non-small cell lung cancer: univariate and multivariate analysis including recursive partitioning and amalgamation alghorithms in 1052 patients. J. Clin. Oncol., 13: 1221-1230, 1995.
19. Rinaldi M., De Marinis F., Ardizzoni A.: Correlation between age and prognosis in patients with advanced non small cell lung cancer treated with cisplatin containing chemotherapy: a retrospective multicenter study. Ann. Oncol., 5 (Suppl. 8): 58, 1994.
20. Scagliotti G.V., Gozzellino F., Albera C.: Chronic administration of lonidamine in untreated non small cell lung cancer of stage III M0-1. Chemotherapy, 35: 64-68, 1989.
21. Thatcher N., Ranson M., Anderson H.: Chemotherapy in advanced non-small cell lung cancer. Changes in performance status and tumor-related symptoms. In: Innovative antimetabolites in solid tumors (European School of Oncolgy Monographs), M.S. Aapro (Ed.), pp. 47-52, Springer-Verlag, Berlin, 1994.
22. Veronesi A., Zagonel V., Serraino D.: Clinical characteristics, diagnosis and treatment of elderly patients with lung cancer at non surgical institutions: a multicenter study. Tumori, 76: 429-435, 1990.
23. Young C.W., Currie V.E., Kim J.H.: Phase I and clinical pharmacologic evaluation of lonidamine in patients with advanced cancer. In: Lonidamine. Proceedings of the 2nd International Symposium, Vancouver 1982, B. Silvestrini, P.R. Band, A. Caputo, C.W. Young (Eds.). Oncology, 41 (Suppl. 1): 60-65, 1984.