메뉴 건너뛰기




Volumn 36, Issue 4, 2015, Pages 2893-2905

Targeting prostate cancer cell metabolism: impact of hexokinase and CPT-1 enzymes

Author keywords

Apoptosis; ATP; Caspase 3; Glycolysis; LNCaP FGC 10; Mitochondrial membrane potential; PC3; Prostate cancer; Oxidation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARNITINE PALMITOYLTRANSFERASE; CASPASE 3; HEXOKINASE;

EID: 84936760075     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2919-4     Document Type: Article
Times cited : (42)

References (50)
  • 1
    • 34250912278 scopus 로고
    • Über den stoffwechsel menschlicher tumorzellen
    • Warburg O. Über den stoffwechsel menschlicher tumorzellen. J Mol Med. 1925;4:2396–7.
    • (1925) J Mol Med , vol.4 , pp. 2396-2397
    • Warburg, O.1
  • 2
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • PID: 16724055
    • Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature. 2006;441:437–43.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 3
    • 31544445490 scopus 로고    scopus 로고
    • Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma
    • COI: 1:CAS:528:DC%2BD28XlsFOmuw%3D%3D, PID: 16423989
    • Koukourakis MI, Giatromanolaki A, Harris AL, Sivridis E. Comparison of metabolic pathways between cancer cells and stromal cells in colorectal carcinomas: a metabolic survival role for tumor-associated stroma. Cancer Res. 2006;66:632–7.
    • (2006) Cancer Res , vol.66 , pp. 632-637
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Harris, A.L.3    Sivridis, E.4
  • 4
    • 34447547148 scopus 로고    scopus 로고
    • Regulation of tumor pH and the role of carbonic anhydrase 9
    • COI: 1:CAS:528:DC%2BD2sXotFWrtLc%3D, PID: 17415526
    • Swietach P, Vaughan-Jones RD, Harris AL. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev. 2007;26:299–310.
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 299-310
    • Swietach, P.1    Vaughan-Jones, R.D.2    Harris, A.L.3
  • 5
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • COI: 1:CAS:528:DC%2BD2cXptFegt7w%3D, PID: 15516961
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 2004;4:891–9.
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 6
    • 77950191479 scopus 로고    scopus 로고
    • Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
    • COI: 1:CAS:528:DC%2BC3cXjtFygtbo%3D, PID: 20215500
    • Ben Sahra I, Laurent K, Giuliano S, Larbret F, Ponzio G, Gounon P, et al. Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. Cancer Res. 2010;70:2465–75.
    • (2010) Cancer Res , vol.70 , pp. 2465-2475
    • Ben Sahra, I.1    Laurent, K.2    Giuliano, S.3    Larbret, F.4    Ponzio, G.5    Gounon, P.6
  • 7
    • 56249134557 scopus 로고    scopus 로고
    • A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death
    • COI: 1:CAS:528:DC%2BD1cXhtlGgs77N, PID: 19001437
    • Wood TE, Dalili S, Simpson CD, Hurren R, Mao X, Saiz FS, et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther. 2008;7:3546–55.
    • (2008) Mol Cancer Ther , vol.7 , pp. 3546-3555
    • Wood, T.E.1    Dalili, S.2    Simpson, C.D.3    Hurren, R.4    Mao, X.5    Saiz, F.S.6
  • 8
    • 0032767974 scopus 로고    scopus 로고
    • Regulation of prostate cancer cell division by glucose
    • COI: 1:CAS:528:DyaK1MXks1WntL4%3D, PID: 10430183
    • Singh G, Lakkis CL, Laucirica R, Epner DE. Regulation of prostate cancer cell division by glucose. J Cell Physiol. 1999;180:431–8.
    • (1999) J Cell Physiol , vol.180 , pp. 431-438
    • Singh, G.1    Lakkis, C.L.2    Laucirica, R.3    Epner, D.E.4
  • 9
    • 33748260777 scopus 로고    scopus 로고
    • Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
    • COI: 1:CAS:528:DC%2BD28XovVyhu78%3D, PID: 16683009
    • Liu Y. Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer. Prostate Cancer Prostatic Dis. 2006;9:230–4.
    • (2006) Prostate Cancer Prostatic Dis , vol.9 , pp. 230-234
    • Liu, Y.1
  • 10
    • 77950546594 scopus 로고    scopus 로고
    • Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach
    • PID: 20332441
    • Liu Y, Zuckier LS, Ghesani NV. Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach. Anticancer Res. 2010;30:369–74.
    • (2010) Anticancer Res , vol.30 , pp. 369-374
    • Liu, Y.1    Zuckier, L.S.2    Ghesani, N.V.3
  • 11
    • 10744221806 scopus 로고    scopus 로고
    • Elevated α-methylacyl-CoA racemase enzymatic activity
    • Sinha K. Elevated α-methylacyl-CoA racemase enzymatic activity. Am J Pathol2004;164:787-793
    • Am J Pathol2004 , vol.164 , pp. 787-793
    • Sinha, K.1
  • 12
    • 0037012476 scopus 로고    scopus 로고
    • α-Methylacyl-CoA racemase as tissue biomarker of PC
    • Rubin M, Zhou M, Dhanasekaran SM. α-Methylacyl-CoA racemase as tissue biomarker of PC. JAMA 2002;287:1662-1670
    • (2002) JAMA , vol.287 , pp. 1662-1670
    • Rubin, M.1    Zhou, M.2    Dhanasekaran, S.M.3
  • 13
    • 17344393447 scopus 로고    scopus 로고
    • Dunn TA, et al. α-Methylacyl-CoA racemase; a new molecular marker for prostate cancer
    • Luo J, Zha S, Gage WR, Dunn TA, et al. α-Methylacyl-CoA racemase; a new molecular marker for prostate cancer. Cancer Res 2002; 62:2220–2226.
    • (2002) Cancer Res , vol.62 , pp. 2220-2226
    • Luo, J.1    Zha, S.2    Gage, W.R.3
  • 14
    • 0034765524 scopus 로고
    • W.B.A., Rock K L, Xu Y, Savas L, Khan A, et al., P504S: a new molecular marker for the detection of prostate carcinoma
    • Jiang Z, W.B.A., Rock K L, Xu Y, Savas L, Khan A, et al., P504S: a new molecular marker for the detection of prostate carcinoma. Am J Surg Pathol 2001; 25:13971404.
    • (1404) Am J Surg Pathol , vol.25 , Issue.1397 , pp. 2001
    • Jiang, Z.1
  • 15
    • 0036306325 scopus 로고    scopus 로고
    • Alpha-methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions
    • Zhou M, Chinnaiyan AM, Kleer CG, Lucas PC, Rubin MA. Alpha-methylacyl-CoA racemase: a novel tumor marker over-expressed in several human cancers and their precursor lesions. Am J Surg Pathol 2002; 26:926-931.
    • (2002) Am J Surg Pathol , vol.26 , pp. 926-931
    • Zhou, M.1    Chinnaiyan, A.M.2    Kleer, C.G.3    Lucas, P.C.4    Rubin, M.A.5
  • 16
    • 18644382720 scopus 로고    scopus 로고
    • Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer
    • COI: 1:CAS:528:DC%2BD2MXltV2ru7g%3D, PID: 15599942
    • Zha S, Ferdinandusse S, Hicks JL, Denis S, Dunn TA, Wanders RJ, et al. Peroxisomal branched chain fatty acid beta-oxidation pathway is upregulated in prostate cancer. Prostate. 2005;63:316–23.
    • (2005) Prostate , vol.63 , pp. 316-323
    • Zha, S.1    Ferdinandusse, S.2    Hicks, J.L.3    Denis, S.4    Dunn, T.A.5    Wanders, R.J.6
  • 17
    • 33645124651 scopus 로고    scopus 로고
    • Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders
    • PID: 16986057
    • Brawer MK. Lonidamine: basic science and rationale for treatment of prostatic proliferative disorders. Rev Urol. 2005;7(7):S21–6.
    • (2005) Rev Urol , vol.7 , Issue.7 , pp. 21-26
    • Brawer, M.K.1
  • 19
    • 0019868629 scopus 로고
    • Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells
    • COI: 1:CAS:528:DyaL38Xktl0%3D, PID: 7306982
    • Floridi A, Paggi MG, D'Atri S, De Martino C, Marcante ML, Silvestrini B, et al. Effect of lonidamine on the energy metabolism of Ehrlich ascites tumor cells. Cancer Res. 1981;41:4661–6.
    • (1981) Cancer Res , vol.41 , pp. 4661-4666
    • Floridi, A.1    Paggi, M.G.2    D'Atri, S.3    De Martino, C.4    Marcante, M.L.5    Silvestrini, B.6
  • 20
    • 0042575733 scopus 로고
    • High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase
    • COI: 1:CAS:528:DyaE2sXlvVahsr4%3D, PID: 198801
    • Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proc Natl Acad Sci. 1977;74:3735–9.
    • (1977) Proc Natl Acad Sci , vol.74 , pp. 3735-3739
    • Bustamante, E.1    Pedersen, P.L.2
  • 21
    • 0142091721 scopus 로고    scopus 로고
    • Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells
    • COI: 1:CAS:528:DC%2BD3sXhsFWlsLY%3D, PID: 12576524
    • Xu FY, Taylor WA, Hurd JA, Hatch GM. Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 2003;44:415–23.
    • (2003) J Lipid Res , vol.44 , pp. 415-423
    • Xu, F.Y.1    Taylor, W.A.2    Hurd, J.A.3    Hatch, G.M.4
  • 22
    • 0034667655 scopus 로고    scopus 로고
    • Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues
    • COI: 1:CAS:528:DC%2BD3cXnvFSqtbo%3D, PID: 11023836
    • Morillas M, Clotet J, Rubí B, Serra D, Arino J, Hegardt F, et al. Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Biochem J. 2000;351:495–502.
    • (2000) Biochem J , vol.351 , pp. 495-502
    • Morillas, M.1    Clotet, J.2    Rubí, B.3    Serra, D.4    Arino, J.5    Hegardt, F.6
  • 23
    • 0023692752 scopus 로고
    • Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes
    • COI: 1:CAS:528:DyaL1cXktlWqs70%3D, PID: 3421940
    • Gerondaes P, Alberti K, Agius L. Interactions of inhibitors of carnitine palmitoyltransferase I and fibrates in cultured hepatocytes. Biochem J. 1988;253:169–73.
    • (1988) Biochem J , vol.253 , pp. 169-173
    • Gerondaes, P.1    Alberti, K.2    Agius, L.3
  • 24
    • 0035805629 scopus 로고    scopus 로고
    • Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    • COI: 1:CAS:528:DC%2BD3MXjs1Orsro%3D, PID: 11278654
    • Listenberger LL, Ory DS, Schaffer JE. Palmitate-induced apoptosis can occur through a ceramide-independent pathway. J Biol Chem. 2001;276:14890–5.
    • (2001) J Biol Chem , vol.276 , pp. 14890-14895
    • Listenberger, L.L.1    Ory, D.S.2    Schaffer, J.E.3
  • 25
    • 0034120475 scopus 로고    scopus 로고
    • Thrombin is a novel regulator of hexokinase activity in mesangial cells
    • COI: 1:CAS:528:DC%2BD3cXkt1Cgtb0%3D, PID: 10844601
    • Robey RB, Raval BJ, Ma J, Santos AV. Thrombin is a novel regulator of hexokinase activity in mesangial cells. Kidney Int. 2000;57:2308–18.
    • (2000) Kidney Int , vol.57 , pp. 2308-2318
    • Robey, R.B.1    Raval, B.J.2    Ma, J.3    Santos, A.V.4
  • 26
    • 0036146821 scopus 로고    scopus 로고
    • Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats
    • COI: 1:CAS:528:DC%2BD38XhtV2ht70%3D, PID: 11799139
    • Karlic H, Lohninger S, Koeck T, Lohninger A. Dietary l-carnitine stimulates carnitine acyltransferases in the liver of aged rats. J Histochem Cytochem. 2002;50:205–12.
    • (2002) J Histochem Cytochem , vol.50 , pp. 205-212
    • Karlic, H.1    Lohninger, S.2    Koeck, T.3    Lohninger, A.4
  • 27
    • 0037841605 scopus 로고    scopus 로고
    • Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines
    • COI: 1:CAS:528:DC%2BD3sXks1ejsbk%3D, PID: 12810152
    • Salami S, Karami-Tehrani F. Biochemical studies of apoptosis induced by tamoxifen in estrogen receptor positive and negative breast cancer cell lines. Clin Biochem. 2003;36:247–53.
    • (2003) Clin Biochem , vol.36 , pp. 247-253
    • Salami, S.1    Karami-Tehrani, F.2
  • 28
    • 79951571474 scopus 로고    scopus 로고
    • Mitochondrial membrane potential probes and the proton gradient: a practical usage guide
    • COI: 1:CAS:528:DC%2BC3MXhvFGrtb0%3D, PID: 21486251
    • Perry SW, Norman JP, Barbieri J, Brown EB, Gelbard HA. Mitochondrial membrane potential probes and the proton gradient: a practical usage guide. Biotechniques. 2011;50:98.
    • (2011) Biotechniques , vol.50 , pp. 98
    • Perry, S.W.1    Norman, J.P.2    Barbieri, J.3    Brown, E.B.4    Gelbard, H.A.5
  • 29
    • 0033760829 scopus 로고    scopus 로고
    • Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction
    • COI: 1:CAS:528:DC%2BD3cXnvVOmtL0%3D, PID: 11078462
    • Srinivasan S, Stevens M, Wiley JW. Diabetic peripheral neuropathy: evidence for apoptosis and associated mitochondrial dysfunction. Diabetes. 2000;49:1932–8.
    • (2000) Diabetes , vol.49 , pp. 1932-1938
    • Srinivasan, S.1    Stevens, M.2    Wiley, J.W.3
  • 30
    • 0028875706 scopus 로고
    • OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate
    • COI: 1:STN:280:DyaK2M7hslagsw%3D%3D, PID: 7817483
    • Epstein JI, Carmichael M, Partin AW. OA-519 (fatty acid synthase) as an independent predictor of pathologic state in adenocarcinoma of the prostate. Urology. 1995;45:81–6.
    • (1995) Urology , vol.45 , pp. 81-86
    • Epstein, J.I.1    Carmichael, M.2    Partin, A.W.3
  • 31
    • 0042429210 scopus 로고    scopus 로고
    • Fatty acid synthase expression defines distinct molecular signatures in prostate cancer
    • COI: 1:CAS:528:DC%2BD3sXms1Glurg%3D, PID: 12939396
    • Rossi S, Graner E, Febbo P, Weinstein L, Bhattacharya N, Onody T, et al. Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res. 2003;1:707–15.
    • (2003) Mol Cancer Res , vol.1 , pp. 707-715
    • Rossi, S.1    Graner, E.2    Febbo, P.3    Weinstein, L.4    Bhattacharya, N.5    Onody, T.6
  • 32
    • 0029148289 scopus 로고
    • Mitochondria-bound hexokinase as target for therapy of malignant gliomas
    • COI: 1:CAS:528:DyaK2MXnt1yktr4%3D, PID: 7622299
    • Oudard S, Poirson F, Miccoli L, Bourgeois Y, Vassault A, Poisson M, et al. Mitochondria-bound hexokinase as target for therapy of malignant gliomas. Int J Cancer. 1995;62:216–22.
    • (1995) Int J Cancer , vol.62 , pp. 216-222
    • Oudard, S.1    Poirson, F.2    Miccoli, L.3    Bourgeois, Y.4    Vassault, A.5    Poisson, M.6
  • 33
    • 0038714272 scopus 로고    scopus 로고
    • Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function
    • COI: 1:CAS:528:DC%2BD3sXlslaltbw%3D, PID: 12756287
    • Wilson JE. Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J Exp Biol. 2003;206:2049–57.
    • (2003) J Exp Biol , vol.206 , pp. 2049-2057
    • Wilson, J.E.1
  • 34
    • 0027375410 scopus 로고
    • Comparison of the active sites of the purified carnitine acyltransferases from peroxisomes and mitochondria by using a reaction-intermediate analogue
    • PID: 8379919
    • Kumaravel G, Gandour R, Krueger M, Ramsay R. Comparison of the active sites of the purified carnitine acyltransferases from peroxisomes and mitochondria by using a reaction-intermediate analogue. Biochem J. 1993;294:645–51.
    • (1993) Biochem J , vol.294 , pp. 645-651
    • Kumaravel, G.1    Gandour, R.2    Krueger, M.3    Ramsay, R.4
  • 35
    • 0343505447 scopus 로고
    • Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane
    • COI: 1:CAS:528:DyaL2sXhsFWksrw%3D, PID: 3540964
    • Murthy M, Pande SV. Malonyl-CoA binding site and the overt carnitine palmitoyltransferase activity reside on the opposite sides of the outer mitochondrial membrane. Proc Natl Acad Sci. 1987;84:378–82.
    • (1987) Proc Natl Acad Sci , vol.84 , pp. 378-382
    • Murthy, M.1    Pande, S.V.2
  • 36
    • 51449103367 scopus 로고    scopus 로고
    • Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells
    • COI: 1:CAS:528:DC%2BD1cXht1elt77I, PID: 18561258
    • Pimenta AS, Gaidhu MP, Habib S, So M, Fediuc S, Mirpourian M, et al. Prolonged exposure to palmitate impairs fatty acid oxidation despite activation of AMP-activated protein kinase in skeletal muscle cells. J Cell Physiol. 2008;217:478–85.
    • (2008) J Cell Physiol , vol.217 , pp. 478-485
    • Pimenta, A.S.1    Gaidhu, M.P.2    Habib, S.3    So, M.4    Fediuc, S.5    Mirpourian, M.6
  • 37
    • 79960939546 scopus 로고    scopus 로고
    • Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer
    • COI: 1:CAS:528:DC%2BC3MXpsFarur4%3D, PID: 21802006
    • Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, et al. Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol. 2011;18:846–56.
    • (2011) Chem Biol , vol.18 , pp. 846-856
    • Nomura, D.K.1    Lombardi, D.P.2    Chang, J.W.3    Niessen, S.4    Ward, A.M.5    Long, J.Z.6
  • 39
    • 79956326256 scopus 로고    scopus 로고
    • Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress
    • COI: 1:CAS:528:DC%2BC3MXmslOgsbw%3D, PID: 21576264
    • Zaugg K, Yao Y, Reilly PT, Kannan K, Kiarash R, Mason J, et al. Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress. Genes Dev. 2011;25:1041–51.
    • (2011) Genes Dev , vol.25 , pp. 1041-1051
    • Zaugg, K.1    Yao, Y.2    Reilly, P.T.3    Kannan, K.4    Kiarash, R.5    Mason, J.6
  • 40
    • 0032465992 scopus 로고    scopus 로고
    • Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle
    • COI: 1:CAS:528:DyaK1MXitVynt7g%3D, PID: 10212840
    • Ruderman NB, Dean D. Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle. J Basic Clin Physiol Pharmacol. 1998;9:295–308.
    • (1998) J Basic Clin Physiol Pharmacol , vol.9 , pp. 295-308
    • Ruderman, N.B.1    Dean, D.2
  • 41
    • 79955601028 scopus 로고    scopus 로고
    • Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells
    • COI: 1:CAS:528:DC%2BC3MXlsFSitrc%3D
    • Pike LS, Smift AL, Croteau NJ, Ferrick DA, Wu M. Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta (BBA)-Bioenerg. 2011;1807:726–34.
    • (2011) Biochim Biophys Acta (BBA)-Bioenerg , vol.1807 , pp. 726-734
    • Pike, L.S.1    Smift, A.L.2    Croteau, N.J.3    Ferrick, D.A.4    Wu, M.5
  • 42
    • 84874741888 scopus 로고    scopus 로고
    • Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs
    • Kim C, Wong J, Wen J, Wang S, Wang C, Spiering S, et al. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs. Nature. 2013;105–10.
    • (2013) Nature , pp. 105-110
    • Kim, C.1    Wong, J.2    Wen, J.3    Wang, S.4    Wang, C.5    Spiering, S.6
  • 43
    • 77956516647 scopus 로고    scopus 로고
    • Cancer metabolism: is glutamine sweeter than glucose?
    • COI: 1:CAS:528:DC%2BC3cXhtFGht7nF, PID: 20832746
    • Lu W, Pelicano H, Huang P. Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell. 2010;18:199–200.
    • (2010) Cancer Cell , vol.18 , pp. 199-200
    • Lu, W.1    Pelicano, H.2    Huang, P.3
  • 44
    • 0019172128 scopus 로고
    • Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts
    • COI: 1:CAS:528:DyaL3MXisl2gtg%3D%3D, PID: 7432468
    • Pouyssegur J, Franchi A, Silvestre P. Relationship between increased aerobic glycolysis and DNA synthesis initiation studied using glycolytic mutant fibroblasts. Nature. 1980;287:445–7.
    • (1980) Nature , vol.287 , pp. 445-447
    • Pouyssegur, J.1    Franchi, A.2    Silvestre, P.3
  • 46
    • 0028345074 scopus 로고
    • Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (de novo phospholipid synthesis) of rat adipocytes
    • COI: 1:CAS:528:DyaK2cXivFCrtL0%3D, PID: 8182122
    • Farese RV, Standaert ML, Arnold TP, Yamada K, Musunuru K, Hernandez H, et al. Preferential activation of microsomal diacylglycerol/protein kinase C signaling during glucose treatment (de novo phospholipid synthesis) of rat adipocytes. J Clin Investig. 1994;93:1894–9.
    • (1994) J Clin Investig , vol.93 , pp. 1894-1899
    • Farese, R.V.1    Standaert, M.L.2    Arnold, T.P.3    Yamada, K.4    Musunuru, K.5    Hernandez, H.6
  • 47
    • 36148955071 scopus 로고    scopus 로고
    • Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization
    • COI: 1:CAS:528:DC%2BD2sXht1WlsrbL, PID: 17675299
    • Miele C, Paturzo F, Teperino R, Sakane F, Fiory F, Oriente F, et al. Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol kinase subcellular localization. J Biol Chem. 2007;282:31835–43.
    • (2007) J Biol Chem , vol.282 , pp. 31835-31843
    • Miele, C.1    Paturzo, F.2    Teperino, R.3    Sakane, F.4    Fiory, F.5    Oriente, F.6
  • 48
    • 84977817361 scopus 로고    scopus 로고
    • Glucose controls phosphoregulation of HMG-CoA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast
    • Burg JS, Espenshade PJ. Glucose controls phosphoregulation of HMG-CoA reductase through the PP2A-related phosphatase Ppe1 and Insig in fission yeast. J Biol Chem. 2011;111:233452.
    • (2011) J Biol Chem , vol.111 , pp. 233452
    • Burg, J.S.1    Espenshade, P.J.2
  • 49
    • 78651106477 scopus 로고    scopus 로고
    • High-glycolytic cancers and their interplay with the body’s glucose demand and supply cycle
    • COI: 1:CAS:528:DC%2BC3MXjsVGjtw%3D%3D, PID: 20950942
    • Mathews EH, Liebenberg L, Pelzer R. High-glycolytic cancers and their interplay with the body’s glucose demand and supply cycle. Med Hypotheses. 2011;76:157–65.
    • (2011) Med Hypotheses , vol.76 , pp. 157-165
    • Mathews, E.H.1    Liebenberg, L.2    Pelzer, R.3
  • 50
    • 33747513057 scopus 로고    scopus 로고
    • Apoptosis—a brief review
    • COI: 1:CAS:528:DC%2BD2MXhtFeqtLzJ
    • Zhang A, Wu Y, Lai H, Yew D. Apoptosis—a brief review. Neuroembryol Aging. 2005;3:47–59.
    • (2005) Neuroembryol Aging , vol.3 , pp. 47-59
    • Zhang, A.1    Wu, Y.2    Lai, H.3    Yew, D.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.