Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification

Journal of Neuro-Oncology

Volumn 36, Issue 2, 1998, Pages 149-157

  Ben Yoseph, Oded ^a   Lyons, John C ^b   Song, Chang W ^b   Ross, Brian D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

9L brain tumor; 31P magnetic resonance spectroscopy; Acidosis; Lonidamine; Radiation and hypothermia sensitizer

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENT; CREATINE PHOSPHATE; HEXOKINASE; LACTIC ACID; LONIDAMINE; PHOSPHATE;

ACIDIFICATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TUMOR; DRUG MECHANISM; ENERGY METABOLISM; GLIOSARCOMA; HIGH ENERGY PHOSPHATE; MEAN ARTERIAL PRESSURE; MUSCLE METABOLISM; NONHUMAN; PENTOSE PHOSPHATE CYCLE; RAT; TUMOR BLOOD FLOW; TUMOR MODEL;

EID: 0031883221     PISSN: 0167594X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1005819604858     Document Type: Article

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