-
1
-
-
0037219411
-
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
-
Butler A.E., Janson J., Bonner-Weir S., Ritzel R., Rizza R.A., Butler P.C. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes 2003, 52:102-110.
-
(2003)
Diabetes
, vol.52
, pp. 102-110
-
-
Butler, A.E.1
Janson, J.2
Bonner-Weir, S.3
Ritzel, R.4
Rizza, R.A.5
Butler, P.C.6
-
2
-
-
33745863033
-
Islet beta cell failure in type 2 diabetes
-
Prentki M., Nolan C.J. Islet beta cell failure in type 2 diabetes. J. Clin. Invest. 2006, 116:1802-1812.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1802-1812
-
-
Prentki, M.1
Nolan, C.J.2
-
3
-
-
84884193035
-
Beta cell dysfunction and insulin resistance
-
Cerf M.E. Beta cell dysfunction and insulin resistance. Front. Endocrinol. 2013, 4:37.
-
(2013)
Front. Endocrinol.
, vol.4
, pp. 37
-
-
Cerf, M.E.1
-
4
-
-
84896495719
-
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
-
Kahn S.E., Cooper M.E., Del Prato S. Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet 2014, 383:1068-1083.
-
(2014)
Lancet
, vol.383
, pp. 1068-1083
-
-
Kahn, S.E.1
Cooper, M.E.2
Del Prato, S.3
-
5
-
-
33748675684
-
On the role of IRS2 in the regulation of functional beta-cell mass
-
Niessen M. On the role of IRS2 in the regulation of functional beta-cell mass. Archiv. Physiol. Biochem. 2006, 112:65-73.
-
(2006)
Archiv. Physiol. Biochem.
, vol.112
, pp. 65-73
-
-
Niessen, M.1
-
6
-
-
0032567937
-
Disruption of IRS-2 causes type 2 diabetes in mice
-
4
-
Withers D.J., Gutierrez J.S., Towery H., Burks D.J., Ren J.M., Previs S., Zhang Y., Bernal D., Pons S., Shulman G.I., Bonner-Weir S., White M.F. Disruption of IRS-2 causes type 2 diabetes in mice. Nature 1998, 391:900. 4.
-
(1998)
Nature
, vol.391
, pp. 900
-
-
Withers, D.J.1
Gutierrez, J.S.2
Towery, H.3
Burks, D.J.4
Ren, J.M.5
Previs, S.6
Zhang, Y.7
Bernal, D.8
Pons, S.9
Shulman, G.I.10
Bonner-Weir, S.11
White, M.F.12
-
7
-
-
0033755408
-
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia
-
Kubota N., Tobe K., Terauchi Y., Eto K., Yamauchi T., Suzuki R., Tsubamoto Y., Komeda K., Nakano R., Miki H., Satoh S., Sekihara H., Sciacchitano S., Lesniak M., Aizawa S., Nagai R., Kimura S., Akanuma Y., Taylor S.I., Kadowaki T. Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes 2000, 49:1880-1889.
-
(2000)
Diabetes
, vol.49
, pp. 1880-1889
-
-
Kubota, N.1
Tobe, K.2
Terauchi, Y.3
Eto, K.4
Yamauchi, T.5
Suzuki, R.6
Tsubamoto, Y.7
Komeda, K.8
Nakano, R.9
Miki, H.10
Satoh, S.11
Sekihara, H.12
Sciacchitano, S.13
Lesniak, M.14
Aizawa, S.15
Nagai, R.16
Kimura, S.17
Akanuma, Y.18
Taylor, S.I.19
Kadowaki, T.20
more..
-
8
-
-
0345618266
-
Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes
-
Hennige A.M., Burks D.J., Ozcan U., Kulkarni R.N., Ye J., Park S., Schubert M., Fisher T.L., Dow M.A., Leshan R., Zakaria M., Mossa-Basha M., White M.F. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. J. Clin. Invest. 2003, 112:1521-1532.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1521-1532
-
-
Hennige, A.M.1
Burks, D.J.2
Ozcan, U.3
Kulkarni, R.N.4
Ye, J.5
Park, S.6
Schubert, M.7
Fisher, T.L.8
Dow, M.A.9
Leshan, R.10
Zakaria, M.11
Mossa-Basha, M.12
White, M.F.13
-
9
-
-
9644268058
-
Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis
-
Mohanty S., Spinas G.A., Maedler K., Zuellig R.A., Lehmann R., Donath M.Y., Trub T., Niessen M. Overexpression of IRS2 in isolated pancreatic islets causes proliferation and protects human beta-cells from hyperglycemia-induced apoptosis. Exp. Cell Res. 2005, 303:68-78.
-
(2005)
Exp. Cell Res.
, vol.303
, pp. 68-78
-
-
Mohanty, S.1
Spinas, G.A.2
Maedler, K.3
Zuellig, R.A.4
Lehmann, R.5
Donath, M.Y.6
Trub, T.7
Niessen, M.8
-
10
-
-
84859057520
-
PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis
-
Schultze S.M., Hemmings B.A., Niessen M., Tschopp O. PI3K/AKT, MAPK and AMPK signalling: protein kinases in glucose homeostasis. Expert Rev. Mol. Med. 2012, 14:e1.
-
(2012)
Expert Rev. Mol. Med.
, vol.14
-
-
Schultze, S.M.1
Hemmings, B.A.2
Niessen, M.3
Tschopp, O.4
-
11
-
-
79953674220
-
Promiscuous affairs of PKB/AKT isoforms in metabolism
-
Schultze S.M., Jensen J., Hemmings B.A., Tschopp O., Niessen M. Promiscuous affairs of PKB/AKT isoforms in metabolism. Arch. Physiol. Biochem. 2011, 117:70-77.
-
(2011)
Arch. Physiol. Biochem.
, vol.117
, pp. 70-77
-
-
Schultze, S.M.1
Jensen, J.2
Hemmings, B.A.3
Tschopp, O.4
Niessen, M.5
-
12
-
-
75149152059
-
Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass
-
Buzzi F., Xu L., Zuellig R.A., Boller S.B., Spinas G.A., Hynx D., Chang Z., Yang Z., Hemmings B.A., Tschopp O., Niessen M. Differential effects of protein kinase B/Akt isoforms on glucose homeostasis and islet mass. Mol. Cell. Biol. 2010, 30:601-612.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 601-612
-
-
Buzzi, F.1
Xu, L.2
Zuellig, R.A.3
Boller, S.B.4
Spinas, G.A.5
Hynx, D.6
Chang, Z.7
Yang, Z.8
Hemmings, B.A.9
Tschopp, O.10
Niessen, M.11
-
13
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)
-
Cho H., Mu J., Kim J.K., Thorvaldsen J.L., Chu Q., Crenshaw E.B., Kaestner K.H., Bartolomei M.S., Shulman G.I., Birnbaum M.J. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 2001, 292:1728-1731.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
14
-
-
0035914388
-
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice
-
Cho H., Thorvaldsen J.L., Chu Q., Feng F., Birnbaum M.J. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J. Biol. Chem. 2001, 276:38349-383452.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38349-383452
-
-
Cho, H.1
Thorvaldsen, J.L.2
Chu, Q.3
Feng, F.4
Birnbaum, M.J.5
-
15
-
-
20044382806
-
Role for Akt3/protein kinase B gamma in attainment of normal brain size
-
Easton R.M., Cho H., Roovers K., Shineman D.W., Mizrahi M., Forman M.S., Lee V.M., Szabolcs M., de Jong R., Oltersdorf T., Ludwig T., Efstratiadis A., Birnbaum M.J. Role for Akt3/protein kinase B gamma in attainment of normal brain size. Mol. Cell. Biol. 2005, 25:1869-1878.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.7
Szabolcs, M.8
de Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
16
-
-
85047693348
-
Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta
-
Garofalo R.S., Orena S.J., Rafidi K., Torchia A.J., Stock J.L., Hildebrandt A.L., Coskran T., Black S.C., Brees D.J., Wicks J.R., McNeish J.D., Coleman K.G. Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta. J. Clin. Investig. 2003, 112:197-208.
-
(2003)
J. Clin. Investig.
, vol.112
, pp. 197-208
-
-
Garofalo, R.S.1
Orena, S.J.2
Rafidi, K.3
Torchia, A.J.4
Stock, J.L.5
Hildebrandt, A.L.6
Coskran, T.7
Black, S.C.8
Brees, D.J.9
Wicks, J.R.10
McNeish, J.D.11
Coleman, K.G.12
-
17
-
-
77952043635
-
The critical role of AKT2 in hepatic steatosis induced by PTEN loss
-
He L., Hou X., Kanel G., Zeng N., Galicia V., Wang Y., Yang J., Wu H., Birnbaum M.J., Stiles B.L. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am. J. Pathol. 2010, 176:2302-2308.
-
(2010)
Am. J. Pathol.
, vol.176
, pp. 2302-2308
-
-
He, L.1
Hou, X.2
Kanel, G.3
Zeng, N.4
Galicia, V.5
Wang, Y.6
Yang, J.7
Wu, H.8
Birnbaum, M.J.9
Stiles, B.L.10
-
18
-
-
70350417158
-
Akt2 is required for hepatic lipid accumulation in models of insulin resistance
-
Leavens K.F., Easton R.M., Shulman G.I., Previs S.F., Birnbaum M.J. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metabol. 2009, 10:405-418.
-
(2009)
Cell Metabol.
, vol.10
, pp. 405-418
-
-
Leavens, K.F.1
Easton, R.M.2
Shulman, G.I.3
Previs, S.F.4
Birnbaum, M.J.5
-
19
-
-
23144449547
-
Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis
-
Tschopp O., Yang Z.Z., Brodbeck D., Dummler B.A., Hemmings-Mieszczak M., Watanabe T., Michaelis T., Frahm J., Hemmings B.A. Essential role of protein kinase B gamma (PKB gamma/Akt3) in postnatal brain development but not in glucose homeostasis. Development 2005, 132:2943-2954.
-
(2005)
Development
, vol.132
, pp. 2943-2954
-
-
Tschopp, O.1
Yang, Z.Z.2
Brodbeck, D.3
Dummler, B.A.4
Hemmings-Mieszczak, M.5
Watanabe, T.6
Michaelis, T.7
Frahm, J.8
Hemmings, B.A.9
-
20
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice
-
Yang Z.Z., Tschopp O., Di-Poi N., Bruder E., Baudry A., Dummler B., Wahli W., Hemmings B.A. Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol. Cell. Biol. 2005, 25:10407-10418.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10407-10418
-
-
Yang, Z.Z.1
Tschopp, O.2
Di-Poi, N.3
Bruder, E.4
Baudry, A.5
Dummler, B.6
Wahli, W.7
Hemmings, B.A.8
-
21
-
-
0042357084
-
Protein kinase B alpha/Akt1 regulates placental development and fetal growth
-
Yang Z.Z., Tschopp O., Hemmings-Mieszczak M., Feng J., Brodbeck D., Perentes E., Hemmings B.A. Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 2003, 278:32124-32131.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32124-32131
-
-
Yang, Z.Z.1
Tschopp, O.2
Hemmings-Mieszczak, M.3
Feng, J.4
Brodbeck, D.5
Perentes, E.6
Hemmings, B.A.7
-
22
-
-
0035210374
-
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
-
Bernal-Mizrachi E., Wen W., Stahlhut S., Welling C.M., Permutt M.A. Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J. Clin. Investig. 2001, 108:1631-1638.
-
(2001)
J. Clin. Investig.
, vol.108
, pp. 1631-1638
-
-
Bernal-Mizrachi, E.1
Wen, W.2
Stahlhut, S.3
Welling, C.M.4
Permutt, M.A.5
-
23
-
-
0037147215
-
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1)
-
Wrede C.E., Dickson L.M., Lingohr M.K., Briaud I., Rhodes C.J. Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1). J. Biol. Chem. 2002, 277:49676-49684.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 49676-49684
-
-
Wrede, C.E.1
Dickson, L.M.2
Lingohr, M.K.3
Briaud, I.4
Rhodes, C.J.5
-
24
-
-
9644270397
-
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
-
Bernal-Mizrachi E., Fatrai S., Johnson J.D., Ohsugi M., Otani K., Han Z., Polonsky K.S., Permutt M.A. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J. Clin. Investig. 2004, 114:928-936.
-
(2004)
J. Clin. Investig.
, vol.114
, pp. 928-936
-
-
Bernal-Mizrachi, E.1
Fatrai, S.2
Johnson, J.D.3
Ohsugi, M.4
Otani, K.5
Han, Z.6
Polonsky, K.S.7
Permutt, M.A.8
-
25
-
-
0026091234
-
Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose
-
Kaiser N., Corcos A.P., Sarel I., Cerasi E. Monolayer culture of adult rat pancreatic islets on extracellular matrix: modulation of B-cell function by chronic exposure to high glucose. Endocrinology 1991, 129:2067-2076.
-
(1991)
Endocrinology
, vol.129
, pp. 2067-2076
-
-
Kaiser, N.1
Corcos, A.P.2
Sarel, I.3
Cerasi, E.4
-
26
-
-
0030988289
-
Improved human islet isolation using a new enzyme blend, liberase
-
Linetsky E., Bottino R., Lehmann R., Alejandro R., Inverardi L., Ricordi C. Improved human islet isolation using a new enzyme blend, liberase. Diabetes 1997, 46:1120-1123.
-
(1997)
Diabetes
, vol.46
, pp. 1120-1123
-
-
Linetsky, E.1
Bottino, R.2
Lehmann, R.3
Alejandro, R.4
Inverardi, L.5
Ricordi, C.6
-
27
-
-
51349133256
-
Interleukin-6 regulates pancreatic alpha-cell mass expansion
-
Ellingsgaard H., Ehses J.A., Hammar E.B., Van Lommel L., Quintens R., Martens G., Kerr-Conte J., Pattou F., Berney T., Pipeleers D., Halban P.A., Schuit F.C., Donath M.Y. Interleukin-6 regulates pancreatic alpha-cell mass expansion. Proc. Natl. Acad. Sci. USA 2008, 105:13163-13168.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13163-13168
-
-
Ellingsgaard, H.1
Ehses, J.A.2
Hammar, E.B.3
Van Lommel, L.4
Quintens, R.5
Martens, G.6
Kerr-Conte, J.7
Pattou, F.8
Berney, T.9
Pipeleers, D.10
Halban, P.A.11
Schuit, F.C.12
Donath, M.Y.13
-
28
-
-
0023856499
-
Morphometry of Rambourg-positive and Rambourg-negative beta-cell granules after culture with low and high glucose concentrations
-
Norlund R., Norlund L., Taljedal I.B. Morphometry of Rambourg-positive and Rambourg-negative beta-cell granules after culture with low and high glucose concentrations. Diabetes 1988, 37:194-199.
-
(1988)
Diabetes
, vol.37
, pp. 194-199
-
-
Norlund, R.1
Norlund, L.2
Taljedal, I.B.3
-
30
-
-
84856788284
-
Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity
-
Wan M., Easton R.M., Gleason C.E., Monks B.R., Ueki K., Kahn C.R., Birnbaum M.J. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Mol. Cell. Biol. 2012, 32:96-106.
-
(2012)
Mol. Cell. Biol.
, vol.32
, pp. 96-106
-
-
Wan, M.1
Easton, R.M.2
Gleason, C.E.3
Monks, B.R.4
Ueki, K.5
Kahn, C.R.6
Birnbaum, M.J.7
-
31
-
-
33745668478
-
SiRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle
-
Bouzakri K., Zachrisson A., Al-Khalili L., Zhang B.B., Koistinen H.A., Krook A., Zierath J.R. siRNA-based gene silencing reveals specialized roles of IRS-1/Akt2 and IRS-2/Akt1 in glucose and lipid metabolism in human skeletal muscle. Cell Metabol. 2006, 4:89-96.
-
(2006)
Cell Metabol.
, vol.4
, pp. 89-96
-
-
Bouzakri, K.1
Zachrisson, A.2
Al-Khalili, L.3
Zhang, B.B.4
Koistinen, H.A.5
Krook, A.6
Zierath, J.R.7
-
32
-
-
20044384383
-
Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice
-
Rao P., Roccisana J., Takane K.K., Bottino R., Zhao A., Trucco M., Garcia-Ocana A. Gene transfer of constitutively active Akt markedly improves human islet transplant outcomes in diabetic severe combined immunodeficient mice. Diabetes 2005, 54:1664-1675.
-
(2005)
Diabetes
, vol.54
, pp. 1664-1675
-
-
Rao, P.1
Roccisana, J.2
Takane, K.K.3
Bottino, R.4
Zhao, A.5
Trucco, M.6
Garcia-Ocana, A.7
-
33
-
-
84876253516
-
Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts beta-cell survival and proliferation differentially in vitro and in vivo
-
Bone R.N., Icyuz M., Zhang Y., Zhang Y., Cui W., Wang H., Peng J.B., Matthews Q.L., Siegal G.P., Wu H. Gene transfer of active Akt1 by an infectivity-enhanced adenovirus impacts beta-cell survival and proliferation differentially in vitro and in vivo. Islets 2012, 4:366-378.
-
(2012)
Islets
, vol.4
, pp. 366-378
-
-
Bone, R.N.1
Icyuz, M.2
Zhang, Y.3
Zhang, Y.4
Cui, W.5
Wang, H.6
Peng, J.B.7
Matthews, Q.L.8
Siegal, G.P.9
Wu, H.10
-
34
-
-
0032146564
-
IL-1 produced and released endogenously within human islets inhibits beta cell function
-
Arnush M., Heitmeier M.R., Scarim A.L., Marino M.H., Manning P.T., Corbett J.A. IL-1 produced and released endogenously within human islets inhibits beta cell function. J. Clin. Investig. 1998, 102:516-526.
-
(1998)
J. Clin. Investig.
, vol.102
, pp. 516-526
-
-
Arnush, M.1
Heitmeier, M.R.2
Scarim, A.L.3
Marino, M.H.4
Manning, P.T.5
Corbett, J.A.6
-
35
-
-
0032521025
-
Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes
-
Arnush M., Scarim A.L., Heitmeier M.R., Kelly C.B., Corbett J.A. Potential role of resident islet macrophage activation in the initiation of autoimmune diabetes. J. Immunol. 1998, 160:2684-2691.
-
(1998)
J. Immunol.
, vol.160
, pp. 2684-2691
-
-
Arnush, M.1
Scarim, A.L.2
Heitmeier, M.R.3
Kelly, C.B.4
Corbett, J.A.5
|