메뉴 건너뛰기




Volumn 33, Issue 9, 2013, Pages 3989-4001

MicroRNA-195 protects against dementia induced by chronic brain hypoperfusion via its anti-amyloidogenic effect in rats

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 195; UNCLASSIFIED DRUG;

EID: 84874609290     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1997-12.2013     Document Type: Article
Times cited : (98)

References (54)
  • 1
    • 0033029151 scopus 로고    scopus 로고
    • TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: MRNA stabilization
    • CrossRef Medline
    • Amara FM, Junaid A, Clough RR, Liang B (1999) TGF-beta(1), regulation of alzheimer amyloid precursor protein mRNA expression in a normal human astrocyte cell line: mRNA stabilization. Brain Res Mol Brain Res 71:42-49. CrossRef Medline
    • (1999) Brain Res Mol Brain Res , vol.71 , pp. 42-49
    • Amara, F.M.1    Junaid, A.2    Clough, R.R.3    Liang, B.4
  • 2
    • 66149181776 scopus 로고    scopus 로고
    • Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
    • CrossRef Medline
    • Bales KR, Liu F, Wu S, Lin S, Koger D, DeLong C, Hansen JC, Sullivan PM, Paul SM (2009) Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. J Neurosci 29:6771-6779. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 6771-6779
    • Bales, K.R.1    Liu, F.2    Wu, S.3    Lin, S.4    Koger, D.5    DeLong, C.6    Hansen, J.C.7    Sullivan, P.M.8    Paul, S.M.9
  • 3
    • 79958066914 scopus 로고    scopus 로고
    • Thyroid hormone suppression of beta-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events
    • CrossRef Medline
    • Belakavadi M, Dell J, Grover GJ, Fondell JD (2011) Thyroid hormone suppression of beta-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events. Mol Cell Endocrinol 339: 72-80. CrossRef Medline
    • (2011) Mol Cell Endocrinol , vol.339 , pp. 72-80
    • Belakavadi, M.1    Dell, J.2    Grover, G.J.3    Fondell, J.D.4
  • 4
    • 0034603619 scopus 로고    scopus 로고
    • Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion
    • CrossRef Medline
    • Bennett SA, Pappas BA, Stevens WD, Davidson CM, Fortin T, Chen J (2000) Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion. Neurobiol Aging 21:207-214. CrossRef Medline
    • (2000) Neurobiol Aging , vol.21 , pp. 207-214
    • Bennett, S.A.1    Pappas, B.A.2    Stevens, W.D.3    Davidson, C.M.4    Fortin, T.5    Chen, J.6
  • 5
    • 59049087888 scopus 로고    scopus 로고
    • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1
    • Medline
    • Boissonneault V, Plante I, Rivest S, Provost P (2009) MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 284:1971-1981. Medline
    • (2009) J Biol Chem , vol.284 , pp. 1971-1981
    • Boissonneault, V.1    Plante, I.2    Rivest, S.3    Provost, P.4
  • 6
    • 44349140124 scopus 로고    scopus 로고
    • NFkappaBdependent control of BACE1 promoter transactivation by Abeta42
    • CrossRef Medline
    • Buggia-Prevot V, Sevalle J, Rossner S, Checler F (2008) NFkappaBdependent control of BACE1 promoter transactivation by Abeta42. J Biol Chem 283:10037-10047. CrossRef Medline
    • (2008) J Biol Chem , vol.283 , pp. 10037-10047
    • Buggia-Prevot, V.1    Sevalle, J.2    Rossner, S.3    Checler, F.4
  • 8
    • 84863798868 scopus 로고    scopus 로고
    • Nuclear factor-kappaB regulates betaAPP and betaand gamma-secretases differently at physiological and supraphysiological Abeta concentrations
    • CrossRef Medline
    • Chami L, Buggia-Prévot V, Duplan E, Delprete D, Chami M, Peyron JF, Checler F (2012) Nuclear factor-kappaB regulates betaAPP and betaand gamma-secretases differently at physiological and supraphysiological Abeta concentrations. J Biol Chem 287:24573-24584. CrossRef Medline
    • (2012) J Biol Chem , vol.287 , pp. 24573-24584
    • Chami, L.1    Buggia-Prévot, V.2    Duplan, E.3    Delprete, D.4    Chami, M.5    Peyron, J.F.6    Checler, F.7
  • 9
    • 35348914716 scopus 로고    scopus 로고
    • Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430
    • CrossRef Medline
    • Choi WY, Giraldez AJ, Schier AF (2007) Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science 318:271-274. CrossRef Medline
    • (2007) Science , vol.318 , pp. 271-274
    • Choi, W.Y.1    Giraldez, A.J.2    Schier, A.F.3
  • 10
    • 69249212436 scopus 로고    scopus 로고
    • Linking vascular disorders and Alzheimer's disease: Potential involvement of BACE1
    • CrossRef Medline
    • Cole SL, Vassar R (2009) Linking vascular disorders and Alzheimer's disease: potential involvement of BACE1. Neurobiol Aging 30:1535-1544. CrossRef Medline
    • (2009) Neurobiol Aging , vol.30 , pp. 1535-1544
    • Cole, S.L.1    Vassar, R.2
  • 11
    • 0035943345 scopus 로고    scopus 로고
    • A portrait of Alzheimer secretases-new features and familiar faces
    • CrossRef Medline
    • Esler WP, Wolfe MS (2001) A portrait of Alzheimer secretases-new features and familiar faces. Science 293:1449-1454. CrossRef Medline
    • (2001) Science , vol.293 , pp. 1449-1454
    • Esler, W.P.1    Wolfe, M.S.2
  • 12
    • 33947646259 scopus 로고    scopus 로고
    • Permanent, bilateral common carotid artery occlusion in the rat: A model for chronic cerebral hypoperfusionrelated neurodegenerative diseases
    • CrossRef Medline
    • Farkas E, Luiten PG, Bari F (2007) Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusionrelated neurodegenerative diseases. Brain Res Rev 54:162-180. CrossRef Medline
    • (2007) Brain Res Rev , vol.54 , pp. 162-180
    • Farkas, E.1    Luiten, P.G.2    Bari, F.3
  • 13
    • 77956937207 scopus 로고    scopus 로고
    • The miR-15/107 group of microRNA genes: Evolutionary biology, cellular functions, and roles in human diseases
    • CrossRef Medline
    • Finnerty JR, Wang WX, Hébert SS, Wilfred BR, Mao G, Nelson PT (2010) The miR-15/107 group of microRNA genes: evolutionary biology, cellular functions, and roles in human diseases. J Mol Biol 402:491-509. CrossRef Medline
    • (2010) J Mol Biol , vol.402 , pp. 491-509
    • Finnerty, J.R.1    Wang, W.X.2    Hébert, S.S.3    Wilfred, B.R.4    Mao, G.5    Nelson, P.T.6
  • 14
    • 0026354927 scopus 로고
    • MAP2: A sensitive cross-linker and adjustable spacer in dendritic architecture
    • CrossRef Medline
    • Friedrich P, Aszódi A (1991) MAP2: a sensitive cross-linker and adjustable spacer in dendritic architecture. FEBS Lett 295:5-9. CrossRef Medline
    • (1991) FEBS Lett , vol.295 , pp. 5-9
    • Friedrich, P.1    Aszódi, A.2
  • 16
    • 77949426688 scopus 로고    scopus 로고
    • A novel microRNA and transcription factor mediated regulatory network in schizophrenia
    • CrossRef Medline
    • Guo AY, Sun J, Jia P, Zhao Z (2010) A novel microRNA and transcription factor mediated regulatory network in schizophrenia. BMC Syst Biol 4:10. CrossRef Medline
    • (2010) BMC Syst Biol , vol.4 , pp. 10
    • Guo, A.Y.1    Sun, J.2    Jia, P.3    Zhao, Z.4
  • 17
    • 0028178079 scopus 로고
    • The effects of Alzheimer's disease, other dementias, and premortem course on beta-amyloid precursor protein messenger RNA in frontal cortex
    • Medline
    • Harrison PJ, Barton AJ, Procter AW, Bowen DM, Pearson RC (1994) The effects of Alzheimer's disease, other dementias, and premortem course on beta-amyloid precursor protein messenger RNA in frontal cortex. J Neurochem 62:635-644. Medline
    • (1994) J Neurochem , vol.62 , pp. 635-644
    • Harrison, P.J.1    Barton, A.J.2    Procter, A.W.3    Bowen, D.M.4    Pearson, R.C.5
  • 21
    • 67650383731 scopus 로고    scopus 로고
    • Amyloid precursor protein and its homologues: A family of proteolysis-dependent receptors
    • CrossRef Medline
    • Jacobsen KT, Iverfeldt K (2009) Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors. Cell Mol Life Sci 66:2299-2318. CrossRef Medline
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2299-2318
    • Jacobsen, K.T.1    Iverfeldt, K.2
  • 22
    • 0030983079 scopus 로고    scopus 로고
    • Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease
    • CrossRef Medline
    • Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997) Transcription factor NF-kappaB is activated in primary neurons by amyloid beta peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc Natl Acad Sci U S A 94:2642-2647. CrossRef Medline
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 2642-2647
    • Kaltschmidt, B.1    Uherek, M.2    Volk, B.3    Baeuerle, P.A.4    Kaltschmidt, C.5
  • 23
    • 4644307407 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity
    • CrossRef Medline
    • Khoshnan A, Ko J, Watkin EE, Paige LA, Reinhart PH, Patterson PH (2004) Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity. J Neurosci 24:7999-8008. CrossRef Medline
    • (2004) J Neurosci , vol.24 , pp. 7999-8008
    • Khoshnan, A.1    Ko, J.2    Watkin, E.E.3    Paige, L.A.4    Reinhart, P.H.5    Patterson, P.H.6
  • 25
    • 49249120035 scopus 로고    scopus 로고
    • Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats
    • CrossRef Medline
    • Kumaran D, Udayabanu M, Kumar M, Aneja R, Katyal A (2008) Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats. Neuroscience 155:626-639. CrossRef Medline
    • (2008) Neuroscience , vol.155 , pp. 626-639
    • Kumaran, D.1    Udayabanu, M.2    Kumar, M.3    Aneja, R.4    Katyal, A.5
  • 27
    • 79952197721 scopus 로고    scopus 로고
    • Prospects for delaying the rising tide of worldwide, latelife dementias
    • Medline
    • Larson EB (2010) Prospects for delaying the rising tide of worldwide, latelife dementias. Int Psychogeriatr 8:1196-1202. Medline
    • (2010) Int Psychogeriatr , vol.8 , pp. 1196-1202
    • Larson, E.B.1
  • 29
    • 84855806746 scopus 로고    scopus 로고
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
    • CrossRef Medline
    • Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, Qiang B, Yuan J, Peng X (2012) MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice. Neurobiol Aging 33:522-534. CrossRef Medline
    • (2012) Neurobiol Aging , vol.33 , pp. 522-534
    • Liu, W.1    Liu, C.2    Zhu, J.3    Shu, P.4    Yin, B.5    Gong, Y.6    Qiang, B.7    Yuan, J.8    Peng, X.9
  • 30
    • 79151483332 scopus 로고    scopus 로고
    • MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed
    • CrossRef Medline
    • Long JM, Lahiri DK (2011) MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed. Biochem Biophys Res Commun 404:889-895. CrossRef Medline
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 889-895
    • Long, J.M.1    Lahiri, D.K.2
  • 31
    • 60849097262 scopus 로고    scopus 로고
    • Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice
    • CrossRef Medline
    • Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce-Levie K, Cheng IH, Yu GQ, Mucke L (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci 29:1977-1986. CrossRef Medline
    • (2009) J Neurosci , vol.29 , pp. 1977-1986
    • Meilandt, W.J.1    Cisse, M.2    Ho, K.3    Wu, T.4    Esposito, L.A.5    Scearce-Levie, K.6    Cheng, I.H.7    Yu, G.Q.8    Mucke, L.9
  • 32
    • 52949109849 scopus 로고    scopus 로고
    • A set of differentially expressed miRNAs, including miR-30a-5p, act as posttranscriptional inhibitors of BDNF in prefrontal cortex
    • CrossRef Medline
    • Mellios N, Huang HS, Grigorenko A, Rogaev E, Akbarian S (2008) A set of differentially expressed miRNAs, including miR-30a-5p, act as posttranscriptional inhibitors of BDNF in prefrontal cortex. Hum Mol Genet 17:3030-3042. CrossRef Medline
    • (2008) Hum Mol Genet , vol.17 , pp. 3030-3042
    • Mellios, N.1    Huang, H.S.2    Grigorenko, A.3    Rogaev, E.4    Akbarian, S.5
  • 33
    • 77954132249 scopus 로고    scopus 로고
    • Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: From synapses toward neural networks
    • CrossRef Medline
    • Palop JJ, Mucke L (2010) Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks. Nat Neurosci 13:812-818. CrossRef Medline
    • (2010) Nat Neurosci , vol.13 , pp. 812-818
    • Palop, J.J.1    Mucke, L.2
  • 36
    • 71749092463 scopus 로고    scopus 로고
    • MicroRNAs: Novel therapeutic targets in neurodegenerative diseases
    • CrossRef Medline
    • Roshan R, Ghosh T, Scaria V, Pillai B (2009) MicroRNAs: novel therapeutic targets in neurodegenerative diseases. Drug Discov Today 14:1123-1129. CrossRef Medline
    • (2009) Drug Discov Today , vol.14 , pp. 1123-1129
    • Roshan, R.1    Ghosh, T.2    Scaria, V.3    Pillai, B.4
  • 37
    • 33747347875 scopus 로고    scopus 로고
    • Transcriptional and translational regulation of BACE1 expression-Implications for Alzheimer's disease
    • CrossRef Medline
    • Rossner S, Sastre M, Bourne K, Lichtenthaler SF (2006) Transcriptional and translational regulation of BACE1 expression-Implications for Alzheimer's disease. Prog Neurobiol 79:95-111. CrossRef Medline
    • (2006) Prog Neurobiol , vol.79 , pp. 95-111
    • Rossner, S.1    Sastre, M.2    Bourne, K.3    Lichtenthaler, S.F.4
  • 39
    • 77749308402 scopus 로고    scopus 로고
    • Amyloid oligomers: Formation and toxicity of Abeta oligomers
    • CrossRef Medline
    • Sakono M, Zako T (2010) Amyloid oligomers: formation and toxicity of Abeta oligomers. FEBS J 277:1348-1358. CrossRef Medline
    • (2010) FEBS J , vol.277 , pp. 1348-1358
    • Sakono, M.1    Zako, T.2
  • 40
    • 84856293013 scopus 로고    scopus 로고
    • Clinical and Research Diagnostic Criteria for Alzheimer's Disease
    • CrossRef Medline
    • Sarazin M, de Souza LC, Lehéricy S, Dubois B (2012) Clinical and Research Diagnostic Criteria for Alzheimer's Disease. Neuroimaging Clin N Am 22:23-32, viii. CrossRef Medline
    • (2012) Neuroimaging Clin N Am , vol.22
    • Sarazin, M.1    de Souza, L.C.2    Lehéricy, S.3    Dubois, B.4
  • 41
    • 0037111169 scopus 로고    scopus 로고
    • Cognitive impairment and chronic cerebral hypoperfusion: What can be learned from experimental models
    • Sarti C, Pantoni L, Bartolini L, Inzitari D (2002a) Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models. J Neurol Sci 203-204:263-266.
    • (2002) J Neurol Sci , vol.203-204 , pp. 263-266
    • Sarti, C.1    Pantoni, L.2    Bartolini, L.3    Inzitari, D.4
  • 42
    • 0037126173 scopus 로고    scopus 로고
    • Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat
    • CrossRef Medline
    • Sarti C, Pantoni L, Bartolini L, Inzitari D (2002b) Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat. Behav Brain Res 136:13-20. CrossRef Medline
    • (2002) Behav Brain Res , vol.136 , pp. 13-20
    • Sarti, C.1    Pantoni, L.2    Bartolini, L.3    Inzitari, D.4
  • 43
    • 62449201739 scopus 로고    scopus 로고
    • Anoxia-induced NFkappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons
    • CrossRef Medline
    • Sirabella R, Secondo A, Pannaccione A, Scorziello A, Valsecchi V, Adornetto A, Bilo L, Di Renzo G, Annunziato L (2009) Anoxia-induced NFkappaB-dependent upregulation of NCX1 contributes to Ca2+ refilling into endoplasmic reticulum in cortical neurons. Stroke 40:922-929. CrossRef Medline
    • (2009) Stroke , vol.40 , pp. 922-929
    • Sirabella, R.1    Secondo, A.2    Pannaccione, A.3    Scorziello, A.4    Valsecchi, V.5    Adornetto, A.6    Bilo, L.7    Di Renzo, G.8    Annunziato, L.9
  • 44
    • 78650692019 scopus 로고    scopus 로고
    • In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs
    • CrossRef Medline
    • Smith P, Al Hashimi A, Girard J, Delay C, Hébert SS (2011) In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs. J Neurochem 116:240-247. CrossRef Medline
    • (2011) J Neurochem , vol.116 , pp. 240-247
    • Smith, P.1    Al Hashimi, A.2    Girard, J.3    Delay, C.4    Hébert, S.S.5
  • 46
    • 0036219702 scopus 로고    scopus 로고
    • Retinal and optic nerve degeneration after chronic carotid ligation: Time course and role of light exposure
    • CrossRef Medline
    • Stevens WD, Fortin T, Pappas BA (2002) Retinal and optic nerve degeneration after chronic carotid ligation: time course and role of light exposure. Stroke 33:1107-1112. CrossRef Medline
    • (2002) Stroke , vol.33 , pp. 1107-1112
    • Stevens, W.D.1    Fortin, T.2    Pappas, B.A.3
  • 48
    • 33846461062 scopus 로고    scopus 로고
    • Morris water maze: Procedures for assessing spatial and related forms of learning and memory
    • CrossRef
    • Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protocols 1:848-858. CrossRef
    • (2006) Nat Protocols , vol.1 , pp. 848-858
    • Vorhees, C.V.1    Williams, M.T.2
  • 49
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • CrossRef Medline
    • Wang WX, Rajeev BW, Stromberg AJ, Ren N, Tang G, Huang Q, Rigoutsos I, Nelson PT (2008) The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 28:1213-1223. CrossRef Medline
    • (2008) J Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 50
    • 79451474371 scopus 로고    scopus 로고
    • Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: White matter versus gray matter
    • CrossRef Medline
    • Wang WX, Huang Q, Hu Y, Stromberg AJ, Nelson PT (2011) Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter. Acta Neuropathol 121: 193-205. CrossRef Medline
    • (2011) Acta Neuropathol , vol.121 , pp. 193-205
    • Wang, W.X.1    Huang, Q.2    Hu, Y.3    Stromberg, A.J.4    Nelson, P.T.5
  • 51
    • 67651154718 scopus 로고    scopus 로고
    • MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells
    • CrossRef Medline
    • Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM (2009) MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells. Hepatology 50:113-121. CrossRef Medline
    • (2009) Hepatology , vol.50 , pp. 113-121
    • Xu, T.1    Zhu, Y.2    Xiong, Y.3    Ge, Y.Y.4    Yun, J.P.5    Zhuang, S.M.6
  • 52
    • 34548179335 scopus 로고    scopus 로고
    • {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: Implications for Alzheimer disease
    • CrossRef Medline
    • Yin YI, Bassit B, Zhu L, Yang X, Wang C, Li YM (2007) {gamma}-Secretase Substrate Concentration Modulates the Abeta42/Abeta40 Ratio: implications for Alzheimer disease. J Biol Chem 282:23639-23644. CrossRef Medline
    • (2007) J Biol Chem , vol.282 , pp. 23639-23644
    • Yin, Y.I.1    Bassit, B.2    Zhu, L.3    Yang, X.4    Wang, C.5    Li, Y.M.6
  • 53
    • 67349164281 scopus 로고    scopus 로고
    • Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease
    • CrossRef Medline
    • Zhiyou C, Yong Y, Shanquan S, Jun Z, Liangguo H, Ling Y, Jieying L (2009) Upregulation of BACE1 and beta-amyloid protein mediated by chronic cerebral hypoperfusion contributes to cognitive impairment and pathogenesis of Alzheimer's disease. Neurochem Res 34:1226-1235. CrossRef Medline
    • (2009) Neurochem Res , vol.34 , pp. 1226-1235
    • Zhiyou, C.1    Yong, Y.2    Shanquan, S.3    Jun, Z.4    Liangguo, H.5    Ling, Y.6    Jieying, L.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.