Evaluation of hippocampal injury and cognitive function induced by embolization in the rat brain

Anatomical Record

Volumn 296, Issue 8, 2013, Pages 1207-1214

  Zhang, Heng Ai ^a,b,c   Gao, Mei ^a,b   Chen, Bainian ^a,b   Shi, Lili ^a,b   Wang, Qiaoyun ^d   Yu, Xiaoyan ^a,b   Xuan, Zhaohong ^a,b   Gao, Li ^a,b   Du, Guanhua ^a,b  

^a Beijing Key Laboratory of Drug Target Identification and Drug Screening   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

^c INSTITUTE OF ZOOLOGY   (China)

^d BINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cerebral thromboembolism; Cognitive function; Different sizes of emboli; Hippocampal injury

Indexed keywords

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFICIAL EMBOLISM; BLOOD CLOTTING; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN TISSUE; CEREBROVASCULAR ACCIDENT; COGNITION; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CONTROLLED STUDY; CORRELATION ANALYSIS; EXTERNAL CAROTID ARTERY; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA2 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; MALE; MOTOR PERFORMANCE; NEUROLOGIC EXAMINATION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SCORING SYSTEM; SPATIAL LEARNING; THROMBOEMBOLISM; VAGUS NERVE;

CEREBRAL THROMBOEMBOLISM; COGNITIVE FUNCTION; DIFFERENT SIZES OF EMBOLI; HIPPOCAMPAL INJURY;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CA2 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; COGNITION; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INTRACRANIAL THROMBOSIS; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEVERITY OF ILLNESS INDEX; STROKE; THROMBOEMBOLISM; TIME FACTORS;

ANIMALIA; RATTUS;

EID: 84880329643     PISSN: 19328486     EISSN: 19328494     Source Type: Journal    
DOI: 10.1002/ar.22715     Document Type: Article

References (24)

1. Barth AM, Mody I. 2011. Changes in hippocampal neuronal activity during and after unilateral selective hippocampal ischemia in vivo. J Neurosci 31:851-860.
2. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. 1986. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476.
3. Chao X, Zhou J, Chen T, Liu W, Dong W, Qu Y, Jiang X, Ji X, Zhen H, Fei Z. 2010. Neuroprotective effect of osthole against acute ischemic stroke on middle cerebral ischemia occlusion in rats. Brain Res 1363:206-211.
4. De Jong GI, Farkas E, Stienstra CM, Plass JR, Keijser JN, de la Torre JC, Luiten PG. 1999. Cerebral hypoperfusion yields capillary damage in the hippocampal CA1 area that correlates with spatial memory impairment. Neuroscience 91:203-210.
5. Dorr A, Sled JG, Kabani N. 2007. Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study. Neuroimage 35:1409-1423.
6. Ferri CP, Schoenborn C, Kalra L, Acosta D, Guerra M, Huang Y, Jacob KS, Llibre RJJ, Salas A, Sosa AL, et al. 2011. Prevalence of stroke and related burden among older people living in Latin America, India and China. J Neurol Neurosurg Psychiatry 82:1074-1082.
7. Fujioka M, Nishio K, Miyamoto S, Hiramatsu KI, Sakaki T, Okuchi K, Taoka T, Fujioka S. 2000. Hippocampal damage in the human brain after cardiac arrest. Cerebrovasc Dis 10:2-7.
8. Kim AS, Johnston SC. 2011. Global variation in the relative burden of stroke and ischemic heart disease. Circulation 124:314-323.
9. Kokmen E, Whisnant JP, O'Fallon WM, Chu CP, Beard CM. 1996. Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960-1984). Neurology 46:154-159.
10. Krakovsky M, Polianski V, Nimrod A, Higazi A, Leker RR, Lamensdorf I. 2011. THR-18, a 18-mer peptide derived from PAI-1, is neuroprotective and improves thrombolysis by tPA in rat stroke models. Neurol Res 33:983-990.
11. Kuang X, Du JR, Liu YX, Zhang GY, Peng HY. 2008. Post ischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats. Pharmacol Biochem Behav 88:213-221.
12. Kudo M, Aoyama A, Ichimori S, Fukunaga N. 1982. An animal model of cerebral infarction. Homologous blood clot emboli in rats. Stroke 13:505-508.
13. Orset C, Macrez R, Young AR, Panthou D, Angles-Cano E, Maubert E, Agin V, Vivien D. 2007. Mouse model of in situ thromboembolic stroke and reperfusion. Stroke 38:2771-2778.
14. Pulsinelli WA, Brierley JB. 1979. A new model of bilateral hemispheric ischemia in the unanesthetized rat. Stroke 10:267-272.
15. Rapp JH, Pan XM, Yu B, Swanson RA, Higashida RT, Simpson P, Saloner D. 2003. Cerebral ischemia and infarction from atheroemboli <100 microm in Size. Stroke 34:1976-1980.
16. Rasmussen RS, Overgaard K, Hildebrandt-Eriksen ES, Boysen G. 2006. D-amphetamine improves cognitive deficits and physical therapy promotes fine motor rehabilitation in a rat embolic stroke model. Acta Neurol Scand 113:189-198.
17. Savva GM, Stephan BC. 2010. Epidemiological studies of the effect of stroke on incident dementia: a systematic review. Stroke 41:e41-e46.
18. Schneider AT, Kissela B, Woo D, Kleindorfer D, Alwell K, Miller R, Szaflarski J, Gebel J, Khoury J, Shukla R, et al. 2004. Ischemic stroke subtypes: a population-based study of incidence rates among blacks and whites. Stroke 35:1552-1556.
19. Sugawara T, Lewen A, Noshita N, Gasche Y, Chan PH. 2002. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98.
20. Tsai MJ, Tsai YH, Kuo YM. 2011. Characterization of the pattern of ischemic stroke induced by artificial particle embolization in the rat brain. Biomaterials 32:6381-6388.
21. Walvick RP, Bratane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. 2011. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke 42:1110-1115.
22. Wang D, Hao Z, Tao W, Kong F, Zhang S, Wu B, Lin S, Liu M. 2011. Acute ischemic stroke in the very elderly Chinese: risk factors, hospital management and one-year outcome. Clin Neurol Neurosurg 113:442-446.
23. Zhang RL, Chopp M, Zhang ZG, Jiang Q, Ewing JR. 1997. A rat model of focal embolic cerebral ischemia. Brain Res 766:83-92.
24. Zang YQ, Sun L, Du GH. 2006. Improvement and Evaluation of Multi-Infarction Dementia Animal Model. Chin Pharm J 41:347-350.