The γ-secretase inhibitor 2-[(1R)-1-[(4-chlorophenyl)sulfonyl](2,5- difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's disease

European Journal of Pharmacology

Volumn 698, Issue 1-3, 2013, Pages 193-199

  Meunier, Johann ^a   Villard, Vanessa ^a   Givalois, Laurent ^b,c,d   Maurice, Tangui ^b,c,d  

^a AMYLGEN   (France)

^b University of Montpellier   (France)

^c UNIV MONTPELLIER   (France)

^d PSL RESEARCH UNIVERSITY   (France)

Author keywords

secretase inhibitor; Alzheimer's disease; Amyloid protein seeding; Amyloid peptide; Drug discovery

Indexed keywords

2 [1 [(4 CHLOROPHENYL)SULFONYL](2,5 DIFLUOROPHENYL)AMINO]ETHYL 5 FLUOROBENZENEBUTANOIC ACID; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID BETA PROTEIN[25-35]; BMS 299897; GAMMA SECRETASE INHIBITOR; UNCLASSIFIED DRUG;

ALTERNATION BEHAVIOR; ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; LIPID PEROXIDATION; LONG TERM MEMORY; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OBJECT RECOGNITION; PASSIVE AVOIDANCE; PRIORITY JOURNAL; SHORT TERM MEMORY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BUTYRATES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HYDROCARBONS, HALOGENATED; MALE; MEMORY DISORDERS; MICE; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; TIME FACTORS;

EID: 84871921315     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.10.033     Document Type: Article

References (31)

1. J.J. Anderson, G. Holtz, P.P. Baskin, M. Turner, B. Rowe, B. Wang, M.Z. Kounnas, B.T. Lamb, D. Barten, K. Felsenstein, I. McDonald, K. Srinivasan, B. Munoz, and S.L. Wagner Reductions in β-amyloid concentrations in vivo by the γ-secretase inhibitors BMS-289948 and BMS-299897 Biochem. Pharmacol. 69 2005 689 698
2. D.M. Barten, V.L. Guss, J.A. Corsa, A. Loo, S.B. Hansel, M. Zheng, B. Munoz, K. Srinivasan, B. Wang, B.J. Robertson, C.T. Polson, J. Wang, S.B. Roberts, J.P. Hendrick, J.J. Anderson, J.K. Loy, R. Denton, T.A. Verdoorn, D.W. Smith, and K.M. Felsenstein Dynamics of β-amyloid reductions in brain, cerebrospinal fluid and plasma of β-amyloid precursor protein transgenic mice treated with a γ-secretase inhibitor J. Pharmacol. Exp. Ther. 312 2005 635 643 (Pubitemid 40189561)
3. C.S. Casley, J.M. Land, M.A. Sharpe, J.B. Clark, M.R. Duchen, and L. Canevari β-amyloid fragment 25-35 causes mitochondrial dysfunction in primary cortical neurons Neurobiol. Dis. 10 2002 258 267 (Pubitemid 35217579)
4. F. Chavant, J. Deguil, S. Pain, I. Ingrand, S. Milin, B. Fauconneau, M.C. Perault-Pochat, and C. Lafay-Chebassier Imipramine, in part through tumor necrosis factor inhibition, prevents cognitive decline and β-amyloid accumulation in a mouse model of Alzheimer's disease J. Pharmacol. Exp. Ther. 332 2010 505 514
5. S. Delobette, A. Privat, and T. Maurice In vitro aggregation facilitates β-amyloid peptide-(25-35)-induced amnesia in the rat Eur. J. Pharmacol. 319 1997 1 4 (Pubitemid 27051308)
6. M. Hermes-Lima, W.G. Willmore, and K.B. Storey Quantification of lipid peroxidation in tissue extracts based on Fe(III)xylenol orange complex formation Free Radic. Biol. Med. 19 1995 271 280
7. K. Hsiao, P. Chapman, S. Nilsen, C. Eckman, Y. Harigaya, S. Younkin, F. Yang, and G. Cole Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice Science 274 1996 99 102 (Pubitemid 26332733)
8. B.P. Imbimbo, and G.A. Giardina γ-secretase inhibitors and modulators for the treatment of Alzheimer's disease: disappointments and hopes Curr. Top. Med. Chem. 11 2011 1555 1570
9. 42(43) Neuron 13 1994 45 53
10. J.T. Jarrett, E.P. Berger, and P.T. Lansbury The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease Biochemistry 32 1993 4693 4697 (Pubitemid 23162022)
11. 25-35 Neuroscience 145 2007 209 224 (Pubitemid 46227730)
12. Y. Lu, Y. Ji, S. Ganesan, R. Schloesser, K. Martinowich, M. Sun, F. Mei, M.V. Chao, and B. Lu TrkB as a potential synaptic and behavioral tag J. Neurosci. 31 2011 11762 11771
13. T. Maurice, B.P. Lockhart, T.P. Su, and A. Privat Amnesia induced in mice by centrally administered β-amyloid peptides involves cholinergic dysfunction Brain Res. 706 1996 181 193 (Pubitemid 26048681)
14. 25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor Br. J. Pharmacol 149 2006 998 1012 (Pubitemid 44950803)
15. L. Minichiello TrkB signalling pathways in LTP and learning Nat. Rev. Neurosci. 10 2009 850 860
16. M. Morán, D. Moreno-Lastres, L. Marín-Buera, J. Arenas, M.A. Martín, and C. Ugalde Mitochondrial respiratory chain dysfunction: implications in neurodegeneration Free Radic. Biol. Med. 53 2012 595 609
17. 25-35 region to aggregation and neurotoxicity J. Neurochem. 64 1995 253 265
18. 42 is associated with cognitive impairment in healthy elderly and subjective cognitive impairment J. Alzheimers Dis. 26 2011 135 142
19. D.J. Selkoe Translating cell biology into therapeutic advances in Alzheimer's disease Nature 399 1999 A23 A31
20. D.J. Selkoe Alzheimer's disease: genes, proteins, and therapy Physiol. Rev. 81 2001 741 766 (Pubitemid 32267077)
21. M. Srivareerat, T.T. Tran, S. Salim, A.M. Aleisa, and K.A. Alkadhi Chronic nicotine restores normal Aβ levels and prevents short-term memory and E-LTP impairment in Aβ rat model of Alzheimer's disease Neurobiol. Aging 32 2011 834 844
22. 25-35: pathomorphological changes in the hippocampus and impairment of spatial memory Neurosci. Behav. Physiol. 36 2006 101 106 (Pubitemid 43149518)
23. 25-35 peptide J. Neurosci. Res. 71 2003 110 120 (Pubitemid 36008407)
24. 25-35- induced memory impairments correlate with cell loss in rat hippocampus Physiol. Behav. 80 2004 647 655 (Pubitemid 38230963)
25. Y. Tang, K. Yamada, Y. Kanou, T. Miyazaki, X. Xiong, F. Kambe, Y. Murata, H. Seo, and T. Nabeshima Spatiotemporal expression of BDNF in the hippocampus induced by the continuous intracerebroventricular infusion of β-amyloid in rats Brain Res. Mol. Brain Res. 80 2000 188 197
26. J.P. Terranova, J.P. Kan, J.J. Storme, P. Perreaut, G. Le Fur, and P. Soubrié Administration of amyloid beta-peptides in the rat medial septum causes memory deficits: reversal by SR 57746A, a non-peptide neurotrophic compound Neurosci. Lett. 213 1996 79 82 (Pubitemid 26252829)
27. 1) ligand ANAVEX2-73, a novel aminotetrahydrofuran derivative J. Psychopharmacol. 25 2011 1101 1117
28. 25-35-induced toxicity in mice Neuropsychopharmacology 34 2009 1552 1566
29. K. Yamada, T. Tanaka, L.B. Zou, K. Senzaki, K. Yano, T. Osada, A. Olariu, X. Ren, T. Kameyama, and T. Nabeshima Long-term deprivation of oestrogens by ovariectomy potentiates beta-amyloid-induced working memory deficits in rats Br. J. Pharmacol. 128 1999 419 427 (Pubitemid 29458602)
30. B.A. Yankner Mechanisms of neuronal degeneration in Alzheimer's disease Neuron 16 1996 921 932 (Pubitemid 26171198)
31. C. Zussy, A. Brureau, B. Delair, S. Marchal, E. Keller, G. Ixart, G. Naert, J. Meunier, N. Chevallier, T. Maurice, and L. Givalois Time-course and regional analyses of the physiopathological changes induced after cerebral injection of an amyloid β fragment in rats Am. J. Pathol. 179 2011 315 334