Icariin inhibits corticosterone-induced apoptosis in hypothalamic neurons via the PI3-K/Akt signaling pathway

Molecular Medicine Reports

Volumn 6, Issue 5, 2012, Pages 967-972

  Zhang, Hongying ^a   Liu, Baojun ^a   Wu, Jinfeng ^a   Xu, Changqing ^a   Tao, Jiang ^b   Duan, Xiaohong ^a   Cao, Yuxue ^a   Dong, Jingcheng ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Apoptosis; Corticosterone; Hypothalamus; Icariin; PI3 K Akt pathway

Indexed keywords

CASPASE 3; CORTICOSTERONE; ICARIIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HYPOTHALAMUS; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CORTICOSTERONE; EPIMEDIUM; FLAVONOIDS; HYPOTHALAMUS; MEMBRANE POTENTIAL, MITOCHONDRIAL; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EPIMEDIUM SAGITTATUM;

EID: 84866455174     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2012.1041     Document Type: Article

References (23)

1. Mathers CD and Loncar D: Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3: e442, 2006.
2. Ustun TB, Ayuso-Mateos JL, Chatterji S, Mathers C and Murray CJ: Global burden of depressive disorders in the year 2000. Br J Psychiatry 184: 386-392, 2004. (Pubitemid 38624764)
3. Chopra K, Kumar B and Kuhad A: Pathobiological targets of depression. Expert Opin Ther Targets 15: 379-400, 2011.
4. Pariante CM and Lightman SL: The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31: 464-468, 2008.
5. Snyder JS, Soumier A, Brewer M, Pickel J and Cameron HA: Adult hippocampal neurogenesis buffers stress responses and depressive behaviour. Nature 476: 458-461, 2011.
6. Pariante CM: Risk factors for development of depression and psychosis. Glucocorticoid receptors and pituitary implications for treatment with antidepressant and glucocorticoids. Ann NY Acad Sci 1179: 144-152, 2009.
7. Skynner HA, Amos DP and Murray F, et al: Proteomic analysis identifies alterations in cellular morphology and cell death pathways in mouse brain after chronic corticosterone treatment. Brain Res 1102: 12-26, 2006. (Pubitemid 44092660)
8. Wann BP, Bah TM and Kaloustian S, et al: Behavioural signs of depression and apoptosis in the limbic system following myocardial infarction: effects of sertraline. J Psychopharmacol 23: 451-459, 2009.
9. Kulkarni SK and Dhir A: Current investigational drugs for major depression. Expert Opin Investig Drugs 18: 767-788, 2009.
10. Wu J, Du J and Xu C, et al: Icariin attenuates social defeat-induced down-regulation of glucocorticoid receptor in mice. Pharmacol Biochem Behav 98: 273-278, 2011.
11. Liu B, Zhang H and Xu C, et al: Neuroprotective effects of icariin on corticosterone-induced apoptosis in primary cultured rat hippocampal neurons. Brain Res 1375: 59-67, 2011.
12. Yokosuka M, Ohtani-Kaneko R, Yamashita K, Muraoka D, Kuroda Y and Watanabe C: Estrogen and environmental estrogenic chemicals exert developmental effects on rat hypothalamic neurons and glias. Toxicol In Vitro 22: 1-9, 2008. (Pubitemid 350267097)
13. Wang H, Xu Y and Yan J, et al: Acteoside protects human neuroblastoma SH-SY5Y cells against beta-amyloid-induced cell injury. Brain Res 1283: 139-147, 2009.
14. Kunugi H, Hori H, Adachi N and Numakawa T: Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. Psychiatry Clin Neurosci 64: 447-459, 2010.
15. Keller J, Flores B and Gomez RG, et al: Cortisol circadian rhythm alterations in psychotic major depression. Biol Psychiatry 60: 275-281, 2006. (Pubitemid 44093438)
16. Iijima M, Ito A, Kurosu S and Chaki S: Pharmacological characterization of repeated corticosterone injection-induced depression model in rats. Brain Res 1359: 75-80, 2010.
17. Ago Y, Arikawa S and Yata M, et al: Antidepressant-like effects of the glucocorticoid receptor antagonist RU-43044 are associated with changes in prefrontal dopamine in mouse models of depression. Neuropharmacology 55: 1355-1363, 2008.
18. Gerritsen L, Comijs HC, van der Graaf Y, Knoops AJ, Penninx BW and Geerlings MI: Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes - The SMART Medea Study. Biol Psychiatry 70: 373-380, 2011.
19. de Quervain DJ, Aerni A, Schelling G and Roozendaal B: Glucocorticoids and the regulation of memory in health and disease. Front Neuroendocrinol 30: 358-370, 2009.
20. Xu Y, Zhang C and Wang R, et al: Corticosterone induced morphological changes of hippocampal and amygdaloid cell lines are dependent on 5-HT7 receptor related signal pathway. Neuroscience 182: 71-81, 2011.
21. Fatokun AA, Stone TW and Smith RA: Oxidative stress in neurodegeneration and available means of protection. Front Biosci 13: 3288-3311, 2008. (Pubitemid 351594683)
22. Huang SH, Lin CM and Chiang BH: Protective effects of Angelica sinensis extract on amyloid beta-peptide-induced neurotoxicity. Phytomedicine 15: 710-721, 2008.
23. Zhu ZH, Yang R, Fu X, Wang YQ and Wu GC: Astrocyte-conditioned medium protecting hippocampal neurons in primary cultures against corticosterone- induced damages via PI3-K/Akt signal pathway. Brain Res 1114: 1-10, 2006.