메뉴 건너뛰기




Volumn 1847, Issue 11, 2015, Pages 1347-1353

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Author keywords

Aging; DNA; Mitochondrial

Indexed keywords

MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE;

EID: 84941734879     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2015.05.022     Document Type: Article
Times cited : (270)

References (107)
  • 1
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • T.B. Kirkwood Understanding the odd science of aging Cell 120 2005 437 447
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 2
    • 38949145803 scopus 로고    scopus 로고
    • A systematic look at an old problem
    • T.B.L. Kirkwood A systematic look at an old problem Nature 451 2008 644 647
    • (2008) Nature , vol.451 , pp. 644-647
    • Kirkwood, T.B.L.1
  • 3
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • D. Harman Aging: a theory based on free radical and radiation chemistry J. Gerontol. 11 1956 298 300
    • (1956) J. Gerontol. , vol.11 , pp. 298-300
    • Harman, D.1
  • 4
    • 33646351299 scopus 로고    scopus 로고
    • Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
    • Y. Kraytsberg, E. Kudryavtseva, A.C. McKee, C. Geula, N.W. Kowall, and K. Khrapko Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons Nat. Genet. 38 2006 518 520
    • (2006) Nat. Genet. , vol.38 , pp. 518-520
    • Kraytsberg, Y.1    Kudryavtseva, E.2    McKee, A.C.3    Geula, C.4    Kowall, N.W.5    Khrapko, K.6
  • 5
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • A.W. Linnane, S. Marzuki, T. Ozawa, and M. Tanaka Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases Lancet 1 1989 642 645
    • (1989) Lancet , vol.1 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 8
    • 0026671245 scopus 로고
    • Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease
    • M. Corral-Debrinski, J.M. Shoffner, M.T. Lott, and D.C. Wallace Association of mitochondrial DNA damage with aging and coronary atherosclerotic heart disease Mutat. Res. 275 1992 169 180
    • (1992) Mutat. Res. , vol.275 , pp. 169-180
    • Corral-Debrinski, M.1    Shoffner, J.M.2    Lott, M.T.3    Wallace, D.C.4
  • 9
    • 3242668604 scopus 로고    scopus 로고
    • Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication
    • P.E. Coskun, M.F. Beal, and D.C. Wallace Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication Proc. Natl. Acad. Sci. U. S. A. 101 2004 10726 10731
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 10726-10731
    • Coskun, P.E.1    Beal, M.F.2    Wallace, D.C.3
  • 10
    • 0026471872 scopus 로고
    • Accumulation of deletions in human mitochondrial DNA during normal aging: Analysis by quantitative PCR
    • S. Simonetti, X. Chen, S. DiMauro, and E.A. Schon Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR Biochim. Biophys. Acta 1180 1992 113 122
    • (1992) Biochim. Biophys. Acta , vol.1180 , pp. 113-122
    • Simonetti, S.1    Chen, X.2    DiMauro, S.3    Schon, E.A.4
  • 11
    • 0031885843 scopus 로고    scopus 로고
    • Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
    • E.J. Brierley, M.A. Johnson, R.N. Lightowlers, O.F. James, and D.M. Turnbull Role of mitochondrial DNA mutations in human aging: implications for the central nervous system and muscle Ann. Neurol. 43 1998 217 223
    • (1998) Ann. Neurol. , vol.43 , pp. 217-223
    • Brierley, E.J.1    Johnson, M.A.2    Lightowlers, R.N.3    James, O.F.4    Turnbull, D.M.5
  • 12
    • 0033595684 scopus 로고    scopus 로고
    • Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
    • (New York, N.Y.)
    • Y. Michikawa, F. Mazzucchelli, N. Bresolin, G. Scarlato, and G. Attardi Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication Science 286 1999 774 779 (New York, N.Y.)
    • (1999) Science , vol.286 , pp. 774-779
    • Michikawa, Y.1    Mazzucchelli, F.2    Bresolin, N.3    Scarlato, G.4    Attardi, G.5
  • 14
    • 0037081814 scopus 로고    scopus 로고
    • High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain
    • M.T. Lin, D.K. Simon, C.H. Ahn, L.M. Kim, and M.F. Beal High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain Hum. Mol. Genet. 11 2002 133 145
    • (2002) Hum. Mol. Genet. , vol.11 , pp. 133-145
    • Lin, M.T.1    Simon, D.K.2    Ahn, C.H.3    Kim, L.M.4    Beal, M.F.5
  • 19
    • 0037972522 scopus 로고    scopus 로고
    • Mitochondrial respiratory-chain diseases
    • S. DiMauro, and E.A. Schon Mitochondrial respiratory-chain diseases N. Engl. J. Med. 348 2003 2656 2668
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2656-2668
    • DiMauro, S.1    Schon, E.A.2
  • 23
    • 0029116061 scopus 로고
    • Oxidative damage to mitochondrial DNA and its relationship to ageing
    • C. Richter Oxidative damage to mitochondrial DNA and its relationship to ageing Int. J. Biochem. Cell Biol. 27 1995 647 653
    • (1995) Int. J. Biochem. Cell Biol. , vol.27 , pp. 647-653
    • Richter, C.1
  • 26
    • 33748643416 scopus 로고    scopus 로고
    • Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers
    • E. Bua, J. Johnson, A. Herbst, B. Delong, D. McKenzie, S. Salamat, and J.M. Aiken Mitochondrial DNA-deletion mutations accumulate intracellularly to detrimental levels in aged human skeletal muscle fibers Am. J. Hum. Genet. 79 2006 469 480
    • (2006) Am. J. Hum. Genet. , vol.79 , pp. 469-480
    • Bua, E.1    Johnson, J.2    Herbst, A.3    Delong, B.4    McKenzie, D.5    Salamat, S.6    Aiken, J.M.7
  • 28
    • 1942454211 scopus 로고    scopus 로고
    • Mitochondrial DNA repeats constrain the life span of mammals
    • D.C. Samuels Mitochondrial DNA repeats constrain the life span of mammals Trends Genet. 20 2004 226 229
    • (2004) Trends Genet. , vol.20 , pp. 226-229
    • Samuels, D.C.1
  • 29
    • 4143081492 scopus 로고    scopus 로고
    • Two direct repeats cause most human mtDNA deletions
    • D.C. Samuels, E.A. Schon, and P.F. Chinnery Two direct repeats cause most human mtDNA deletions Trends Genet. 20 2004 393 398
    • (2004) Trends Genet. , vol.20 , pp. 393-398
    • Samuels, D.C.1    Schon, E.A.2    Chinnery, P.F.3
  • 31
    • 0027166063 scopus 로고
    • In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria
    • C.S. Madsen, S.C. Ghivizzani, and W.W. Hauswirth In vivo and in vitro evidence for slipped mispairing in mammalian mitochondria Proc. Natl. Acad. Sci. U. S. A. 90 1993 7671 7675
    • (1993) Proc. Natl. Acad. Sci. U. S. A. , vol.90 , pp. 7671-7675
    • Madsen, C.S.1    Ghivizzani, S.C.2    Hauswirth, W.W.3
  • 32
    • 34047095284 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and aging: A case closed?
    • K. Khrapko, and J. Vijg Mitochondrial DNA mutations and aging: a case closed? Nat. Genet. 39 2007 445 446
    • (2007) Nat. Genet. , vol.39 , pp. 445-446
    • Khrapko, K.1    Vijg, J.2
  • 33
    • 59349086549 scopus 로고    scopus 로고
    • Mitochondrial DNA mutations and aging: Devils in the details?
    • K. Khrapko, and J. Vijg Mitochondrial DNA mutations and aging: devils in the details? Trends Genet. 25 2009 91 98
    • (2009) Trends Genet. , vol.25 , pp. 91-98
    • Khrapko, K.1    Vijg, J.2
  • 37
    • 0036258718 scopus 로고    scopus 로고
    • Ageing muscle: Clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function
    • G. Fayet, M. Jansson, D. Sternberg, A.R. Moslemi, P. Blondy, A. Lombes, M. Fardeau, and A. Oldfors Ageing muscle: clonal expansions of mitochondrial DNA point mutations and deletions cause focal impairment of mitochondrial function Neuromuscul. Disord. 12 2002 484 493
    • (2002) Neuromuscul. Disord. , vol.12 , pp. 484-493
    • Fayet, G.1    Jansson, M.2    Sternberg, D.3    Moslemi, A.R.4    Blondy, P.5    Lombes, A.6    Fardeau, M.7    Oldfors, A.8
  • 38
    • 0036848145 scopus 로고    scopus 로고
    • Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control
    • F. Diaz, M.P. Bayona-Bafaluy, M. Rana, M. Mora, H. Hao, and C.T. Moraes Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control Nucleic Acids Res. 30 2002 4626 4633
    • (2002) Nucleic Acids Res. , vol.30 , pp. 4626-4633
    • Diaz, F.1    Bayona-Bafaluy, M.P.2    Rana, M.3    Mora, M.4    Hao, H.5    Moraes, C.T.6
  • 39
    • 0014690248 scopus 로고
    • Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat
    • N.J. Gross, G.S. Getz, and M. Rabinowitz Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat J. Biol. Chem. 244 1969 1552 1562
    • (1969) J. Biol. Chem. , vol.244 , pp. 1552-1562
    • Gross, N.J.1    Getz, G.S.2    Rabinowitz, M.3
  • 40
    • 0033358580 scopus 로고    scopus 로고
    • Relaxed replication of mtDNA: A model with implications for the expression of disease
    • P.F. Chinnery, and D.C. Samuels Relaxed replication of mtDNA: a model with implications for the expression of disease Am. J. Hum. Genet. 64 1999 1158 1165
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 1158-1165
    • Chinnery, P.F.1    Samuels, D.C.2
  • 41
    • 0035097502 scopus 로고    scopus 로고
    • Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age
    • J.L. Elson, D.C. Samuels, D.M. Turnbull, and P.F. Chinnery Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age Am. J. Hum. Genet. 68 2001 802 806
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 802-806
    • Elson, J.L.1    Samuels, D.C.2    Turnbull, D.M.3    Chinnery, P.F.4
  • 42
    • 79960918493 scopus 로고    scopus 로고
    • The timing of mitochondrial DNA mutations in aging
    • K. Khrapko The timing of mitochondrial DNA mutations in aging Nat. Genet. 43 2011 726 727
    • (2011) Nat. Genet. , vol.43 , pp. 726-727
    • Khrapko, K.1
  • 45
    • 0036570159 scopus 로고    scopus 로고
    • Oxidatively modified proteins in aging and disease
    • M.F. Beal Oxidatively modified proteins in aging and disease Free Radic. Biol. Med. 32 2002 797 803
    • (2002) Free Radic. Biol. Med. , vol.32 , pp. 797-803
    • Beal, M.F.1
  • 48
    • 0028070138 scopus 로고
    • Dietary restriction attenuates age-related increases in rat skeletal muscle antioxidant enzyme activities
    • T.A. Luhtala, E.B. Roecker, T. Pugh, R.J. Feuers, and R. Weindruch Dietary restriction attenuates age-related increases in rat skeletal muscle antioxidant enzyme activities J. Gerontol. 49 1994 B231 B238
    • (1994) J. Gerontol. , vol.49 , pp. B231-B238
    • Luhtala, T.A.1    Roecker, E.B.2    Pugh, T.3    Feuers, R.J.4    Weindruch, R.5
  • 52
    • 77956271188 scopus 로고    scopus 로고
    • Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults
    • A. Safdar, M.J. Hamadeh, J.J. Kaczor, S. Raha, J. Debeer, and M.A. Tarnopolsky Aberrant mitochondrial homeostasis in the skeletal muscle of sedentary older adults PLoS ONE 5 2010 e10778
    • (2010) PLoS ONE , vol.5 , pp. e10778
    • Safdar, A.1    Hamadeh, M.J.2    Kaczor, J.J.3    Raha, S.4    Debeer, J.5    Tarnopolsky, M.A.6
  • 53
    • 35648947912 scopus 로고    scopus 로고
    • Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans
    • S.L. Rea, N. Ventura, and T.E. Johnson Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans PLoS Biol. 5 2007 e259
    • (2007) PLoS Biol. , vol.5 , pp. e259
    • Rea, S.L.1    Ventura, N.2    Johnson, T.E.3
  • 54
  • 55
    • 33847378451 scopus 로고    scopus 로고
    • Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis
    • G. Bjelakovic, D. Nikolova, L.L. Gluud, R.G. Simonetti, and C. Gluud Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis JAMA 297 2007 842 857
    • (2007) JAMA , vol.297 , pp. 842-857
    • Bjelakovic, G.1    Nikolova, D.2    Gluud, L.L.3    Simonetti, R.G.4    Gluud, C.5
  • 60
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - An age-related phenomenon. A histochemical ultracytochemical study
    • J. Muller-Hocker Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study Am. J. Pathol. 134 1989 1167 1173
    • (1989) Am. J. Pathol. , vol.134 , pp. 1167-1173
    • Muller-Hocker, J.1
  • 61
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
    • J. Muller-Hocker Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: an age-related alteration J. Neurol. Sci. 100 1990 14 21
    • (1990) J. Neurol. Sci. , vol.100 , pp. 14-21
    • Muller-Hocker, J.1
  • 62
    • 0026728212 scopus 로고
    • Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing - A cytochemical-immunohistochemical study
    • J. Muller-Hocker, K. Schneiderbanger, F.H. Stefani, and B. Kadenbach Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing - a cytochemical-immunohistochemical study Mutat. Res. 275 1992 115 124
    • (1992) Mutat. Res. , vol.275 , pp. 115-124
    • Muller-Hocker, J.1    Schneiderbanger, K.2    Stefani, F.H.3    Kadenbach, B.4
  • 63
    • 0030009436 scopus 로고    scopus 로고
    • Effects of physical activity and age on mitochondrial function
    • E.J. Brierley, M.A. Johnson, O.F. James, and D.M. Turnbull Effects of physical activity and age on mitochondrial function QJM 89 1996 251 258
    • (1996) QJM , vol.89 , pp. 251-258
    • Brierley, E.J.1    Johnson, M.A.2    James, O.F.3    Turnbull, D.M.4
  • 66
    • 0034234773 scopus 로고    scopus 로고
    • Oxidative capacity and ageing in human muscle
    • K.E. Conley, S.A. Jubrias, and P.C. Esselman Oxidative capacity and ageing in human muscle J. Physiol. 526 Pt 1 2000 203 210
    • (2000) J. Physiol. , vol.526 , pp. 203-210
    • Conley, K.E.1    Jubrias, S.A.2    Esselman, P.C.3
  • 67
    • 0030824415 scopus 로고    scopus 로고
    • Ageing: Effects on oxidative function of skeletal muscle in vivo
    • D.J. Taylor, G.J. Kemp, C.H. Thompson, and G.K. Radda Ageing: effects on oxidative function of skeletal muscle in vivo Mol. Cell. Biochem. 174 1997 321 324
    • (1997) Mol. Cell. Biochem. , vol.174 , pp. 321-324
    • Taylor, D.J.1    Kemp, G.J.2    Thompson, C.H.3    Radda, G.K.4
  • 68
    • 0027328441 scopus 로고
    • Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles
    • K.K. McCully, R.A. Fielding, W.J. Evans, J.S. Leigh Jr., and J.D. Posner Relationships between in vivo and in vitro measurements of metabolism in young and old human calf muscles J. Appl. Physiol. 75 1993 813 819
    • (1993) J. Appl. Physiol. , vol.75 , pp. 813-819
    • McCully, K.K.1    Fielding, R.A.2    Evans, W.J.3    Leigh, J.S.4    Posner, J.D.5
  • 75
    • 0034234773 scopus 로고    scopus 로고
    • Oxidative capacity and ageing in human muscle
    • K.E. Conley, S.A. Jubrias, and P.C. Esselman Oxidative capacity and ageing in human muscle J. Physiol. 526 2000 203 210
    • (2000) J. Physiol. , vol.526 , pp. 203-210
    • Conley, K.E.1    Jubrias, S.A.2    Esselman, P.C.3
  • 78
    • 0034141765 scopus 로고    scopus 로고
    • The effects of aging on enzyme activities and metabolite concentrations in skeletal muscle from sedentary male and female subjects
    • O. Pastoris, F. Boschi, M. Verri, P. Baiardi, G. Felzani, J. Vecchiet, M. Dossena, and M. Catapano The effects of aging on enzyme activities and metabolite concentrations in skeletal muscle from sedentary male and female subjects Exp. Gerontol. 35 2000 95 104
    • (2000) Exp. Gerontol. , vol.35 , pp. 95-104
    • Pastoris, O.1    Boschi, F.2    Verri, M.3    Baiardi, P.4    Felzani, G.5    Vecchiet, J.6    Dossena, M.7    Catapano, M.8
  • 80
    • 84856569690 scopus 로고    scopus 로고
    • Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior
    • R.G. Larsen, D.M. Callahan, S.A. Foulis, and J.A. Kent-Braun Age-related changes in oxidative capacity differ between locomotory muscles and are associated with physical activity behavior Appl. Physiol. Nutr. Metab. 37 2012 88 99
    • (2012) Appl. Physiol. Nutr. Metab. , vol.37 , pp. 88-99
    • Larsen, R.G.1    Callahan, D.M.2    Foulis, S.A.3    Kent-Braun, J.A.4
  • 82
    • 66349120223 scopus 로고    scopus 로고
    • Endurance exercise is protective for mice with mitochondrial myopathy
    • T. Wenz, F. Diaz, D. Hernandez, and C.T. Moraes Endurance exercise is protective for mice with mitochondrial myopathy J. Appl. Physiol. 106 2009 1712 1719
    • (2009) J. Appl. Physiol. , vol.106 , pp. 1712-1719
    • Wenz, T.1    Diaz, F.2    Hernandez, D.3    Moraes, C.T.4
  • 84
    • 0042266366 scopus 로고    scopus 로고
    • Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity
    • K.R. Short, J.L. Vittone, M.L. Bigelow, D.N. Proctor, R.A. Rizza, J.M. Coenen-Schimke, and K.S. Nair Impact of aerobic exercise training on age-related changes in insulin sensitivity and muscle oxidative capacity Diabetes 52 2003 1888 1896
    • (2003) Diabetes , vol.52 , pp. 1888-1896
    • Short, K.R.1    Vittone, J.L.2    Bigelow, M.L.3    Proctor, D.N.4    Rizza, R.A.5    Coenen-Schimke, J.M.6    Nair, K.S.7
  • 85
    • 84876288029 scopus 로고    scopus 로고
    • Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle
    • N. Psilander, P. Frank, M. Flockhart, and K. Sahlin Exercise with low glycogen increases PGC-1α gene expression in human skeletal muscle Eur. J. Appl. Physiol. 113 2013 951 963
    • (2013) Eur. J. Appl. Physiol. , vol.113 , pp. 951-963
    • Psilander, N.1    Frank, P.2    Flockhart, M.3    Sahlin, K.4
  • 86
    • 73949099327 scopus 로고    scopus 로고
    • Increased muscle PGC-1Î ± expression protects from sarcopenia and metabolic disease during aging
    • T. Wenz, S.G. Rossi, R.L. Rotundo, B.M. Spiegelman, and C.T. Moraes Increased muscle PGC-1Î ± expression protects from sarcopenia and metabolic disease during aging Proc. Natl. Acad. Sci. 106 2009 20405 20410
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 20405-20410
    • Wenz, T.1    Rossi, S.G.2    Rotundo, R.L.3    Spiegelman, B.M.4    Moraes, C.T.5
  • 89
    • 49349102894 scopus 로고    scopus 로고
    • Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
    • G. Twig, B. Hyde, and O.S. Shirihai Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view Biochim. Biophys. Acta 1777 2008 1092 1097
    • (2008) Biochim. Biophys. Acta , vol.1777 , pp. 1092-1097
    • Twig, G.1    Hyde, B.2    Shirihai, O.S.3
  • 90
    • 33745756805 scopus 로고    scopus 로고
    • Mitochondrial dynamics and aging: Mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA
    • A. Sato, K. Nakada, and J.I. Hayashi Mitochondrial dynamics and aging: mitochondrial interaction preventing individuals from expression of respiratory deficiency caused by mutant mtDNA Biochim. Biophys. Acta Mol. Cell Res. 1763 2006 473 481
    • (2006) Biochim. Biophys. Acta Mol. Cell Res. , vol.1763 , pp. 473-481
    • Sato, A.1    Nakada, K.2    Hayashi, J.I.3
  • 91
    • 79959940178 scopus 로고    scopus 로고
    • Evolution of the mitochondrial fusion-fission cycle and its role in aging
    • A. Kowald, and T.B.L. Kirkwood Evolution of the mitochondrial fusion-fission cycle and its role in aging Proc. Natl. Acad. Sci. 108 2011 10237 10242
    • (2011) Proc. Natl. Acad. Sci. , vol.108 , pp. 10237-10242
    • Kowald, A.1    Kirkwood, T.B.L.2
  • 94
    • 75049085555 scopus 로고    scopus 로고
    • Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise
    • S.E. Wohlgemuth, A.Y. Seo, E. Marzetti, H.A. Lees, and C. Leeuwenburgh Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise Exp. Gerontol. 45 2010 138 148
    • (2010) Exp. Gerontol. , vol.45 , pp. 138-148
    • Wohlgemuth, S.E.1    Seo, A.Y.2    Marzetti, E.3    Lees, H.A.4    Leeuwenburgh, C.5
  • 95
    • 33846187292 scopus 로고    scopus 로고
    • Evidence for selective mitochondrial autophagy and failure in aging
    • G. Cavallini, A. Donati, M. Taddei, and E. Bergamini Evidence for selective mitochondrial autophagy and failure in aging Autophagy 3 2007 26 27
    • (2007) Autophagy , vol.3 , pp. 26-27
    • Cavallini, G.1    Donati, A.2    Taddei, M.3    Bergamini, E.4
  • 97
    • 33845209693 scopus 로고    scopus 로고
    • Skeletal muscle apoptosis, sarcopenia and frailty at old age
    • E. Marzetti, and C. Leeuwenburgh Skeletal muscle apoptosis, sarcopenia and frailty at old age Exp. Gerontol. 41 2006 1234 1238
    • (2006) Exp. Gerontol. , vol.41 , pp. 1234-1238
    • Marzetti, E.1    Leeuwenburgh, C.2
  • 98
    • 37049016418 scopus 로고    scopus 로고
    • The role of mitochondrial DNA mutations in aging and sarcopenia: Implications for the mitochondrial vicious cycle theory of aging
    • A. Hiona, and C. Leeuwenburgh The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging Exp. Gerontol. 43 2008 24 33
    • (2008) Exp. Gerontol. , vol.43 , pp. 24-33
    • Hiona, A.1    Leeuwenburgh, C.2
  • 99
    • 0035127889 scopus 로고    scopus 로고
    • Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia
    • J. Wanagat, Z. Cao, P. Pathare, and J.M. Aiken Mitochondrial DNA deletion mutations colocalize with segmental electron transport system abnormalities, muscle fiber atrophy, fiber splitting, and oxidative damage in sarcopenia FASEB J. 15 2001 322 332
    • (2001) FASEB J. , vol.15 , pp. 322-332
    • Wanagat, J.1    Cao, Z.2    Pathare, P.3    Aiken, J.M.4
  • 100
    • 25644432770 scopus 로고    scopus 로고
    • Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age
    • S.A. Whitman, M.J. Wacker, S.R. Richmond, and M.P. Godard Contributions of the ubiquitin-proteasome pathway and apoptosis to human skeletal muscle wasting with age Pflugers Arch. Eur. J. Physiol. 450 2005 437 446
    • (2005) Pflugers Arch. Eur. J. Physiol. , vol.450 , pp. 437-446
    • Whitman, S.A.1    Wacker, M.J.2    Richmond, S.R.3    Godard, M.P.4
  • 102
    • 77956553979 scopus 로고    scopus 로고
    • The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle
    • S. Park, H. Kim, J. Lee, K. Yoon, M. Chang, and S. Park The age-dependent induction of apoptosis-inducing factor (AIF) in the human semitendinosus skeletal muscle Cellular and Molecular Biology Letters 2010 1
    • (2010) Cellular and Molecular Biology Letters , pp. 1
    • Park, S.1    Kim, H.2    Lee, J.3    Yoon, K.4    Chang, M.5    Park, S.6
  • 105
    • 33947574775 scopus 로고    scopus 로고
    • Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression
    • N.D. Bonawitz, M. Chatenay-Lapointe, Y. Pan, and G.S. Shadel Reduced TOR signaling extends chronological life span via increased respiration and upregulation of mitochondrial gene expression Cell Metab. 5 2007 265 277
    • (2007) Cell Metab. , vol.5 , pp. 265-277
    • Bonawitz, N.D.1    Chatenay-Lapointe, M.2    Pan, Y.3    Shadel, G.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.