메뉴 건너뛰기




Volumn 21, Issue 7, 2015, Pages 850-857

The opposing roles of NOTCH signalling in head and neck cancer: A mini review

Author keywords

NOTCH; Head and neck cancer; Mutations; Oncogene; Tumour suppressor

Indexed keywords

NOTCH RECEPTOR; TUMOR SUPPRESSOR PROTEIN;

EID: 84941620711     PISSN: 1354523X     EISSN: 16010825     Source Type: Journal    
DOI: 10.1111/odi.12309     Document Type: Review
Times cited : (61)

References (58)
  • 1
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N, Frederick MJ, Pickering CR et al (2011). Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154-1157.
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3
  • 2
    • 0028973380 scopus 로고
    • Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity
    • Bailey AM, Posakony JW (1995). Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity. Genes Dev 9: 2609-2622.
    • (1995) Genes Dev , vol.9 , pp. 2609-2622
    • Bailey, A.M.1    Posakony, J.W.2
  • 3
    • 70349642839 scopus 로고    scopus 로고
    • Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia
    • Baldus CD, Thibaut J, Goekbuget N et al (2009). Prognostic implications of NOTCH1 and FBXW7 mutations in adult acute T-lymphoblastic leukemia. Haematologica 94: 1383-1390.
    • (2009) Haematologica , vol.94 , pp. 1383-1390
    • Baldus, C.D.1    Thibaut, J.2    Goekbuget, N.3
  • 4
    • 33747623018 scopus 로고    scopus 로고
    • Notch signalling: a simple pathway becomes complex
    • Bray SJ (2006). Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7: 678-689.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 678-689
    • Bray, S.J.1
  • 5
    • 84880306937 scopus 로고    scopus 로고
    • The Notch signaling pathway as a mediator of tumor survival
    • Capaccione KM, Pine SR (2013). The Notch signaling pathway as a mediator of tumor survival. Carcinogenesis 34: 1420-1430.
    • (2013) Carcinogenesis , vol.34 , pp. 1420-1430
    • Capaccione, K.M.1    Pine, S.R.2
  • 6
    • 84878575235 scopus 로고    scopus 로고
    • Notch3 functions as a tumor suppressor by controlling cellular senescence
    • Cui H, Kong Y, Xu M et al (2013). Notch3 functions as a tumor suppressor by controlling cellular senescence. Cancer Res 73: 3451-3459.
    • (2013) Cancer Res , vol.73 , pp. 3451-3459
    • Cui, H.1    Kong, Y.2    Xu, M.3
  • 7
    • 67649304460 scopus 로고    scopus 로고
    • Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
    • Demehri S, Turkoz A, Kopan R (2009). Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16: 55-66.
    • (2009) Cancer Cell , vol.16 , pp. 55-66
    • Demehri, S.1    Turkoz, A.2    Kopan, R.3
  • 8
    • 22344436360 scopus 로고    scopus 로고
    • p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation
    • Devgan V, Mammucari C, Millar SE et al (2005). p21WAF1/Cip1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev 19: 1485-1495.
    • (2005) Genes Dev , vol.19 , pp. 1485-1495
    • Devgan, V.1    Mammucari, C.2    Millar, S.E.3
  • 9
  • 10
    • 33747014859 scopus 로고    scopus 로고
    • Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells
    • Duan L, Yao J, Wu X et al (2006). Growth suppression induced by Notch1 activation involves Wnt-beta-catenin down-regulation in human tongue carcinoma cells. Biol Cell 98: 479-490.
    • (2006) Biol Cell , vol.98 , pp. 479-490
    • Duan, L.1    Yao, J.2    Wu, X.3
  • 11
    • 0025856717 scopus 로고
    • TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
    • Ellisen LW, Bird J, West DC et al (1991). TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66: 649-661.
    • (1991) Cell , vol.66 , pp. 649-661
    • Ellisen, L.W.1    Bird, J.2    West, D.C.3
  • 12
    • 84884136226 scopus 로고    scopus 로고
    • Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition
    • Espinoza I, Pochampally R, Xing F et al (2013). Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition. Onco Targets Ther 6: 1249-1259.
    • (2013) Onco Targets Ther , vol.6 , pp. 1249-1259
    • Espinoza, I.1    Pochampally, R.2    Xing, F.3
  • 13
    • 0030920376 scopus 로고    scopus 로고
    • The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4)
    • Gallahan D, Callahan R (1997). The mouse mammary tumor associated gene INT3 is a unique member of the NOTCH gene family (NOTCH4). Oncogene 14: 1883-1890.
    • (1997) Oncogene , vol.14 , pp. 1883-1890
    • Gallahan, D.1    Callahan, R.2
  • 14
    • 0023226698 scopus 로고
    • A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17
    • Gallahan D, Kozak C, Callahan R (1987). A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17. J Virol 61: 218-220.
    • (1987) J Virol , vol.61 , pp. 218-220
    • Gallahan, D.1    Kozak, C.2    Callahan, R.3
  • 15
    • 84904275495 scopus 로고    scopus 로고
    • Expression pattern of Notch intracellular domain (NICD) and Hes-1 in preneoplastic and neoplastic human oral squamous epithelium: their correlation with c-Myc, clinicopathological factors and prognosis in oral cancer
    • Gokulan R, Halagowder D (2014). Expression pattern of Notch intracellular domain (NICD) and Hes-1 in preneoplastic and neoplastic human oral squamous epithelium: their correlation with c-Myc, clinicopathological factors and prognosis in oral cancer. Med Oncol 31: 126.
    • (2014) Med Oncol , vol.31 , pp. 126
    • Gokulan, R.1    Halagowder, D.2
  • 16
    • 55449135598 scopus 로고    scopus 로고
    • The molecular logic of Notch signaling-a structural and biochemical perspective
    • Gordon WR, Arnett KL, Blacklow SC (2008). The molecular logic of Notch signaling-a structural and biochemical perspective. J Cell Sci 121: 3109-3119.
    • (2008) J Cell Sci , vol.121 , pp. 3109-3119
    • Gordon, W.R.1    Arnett, K.L.2    Blacklow, S.C.3
  • 17
    • 77349109465 scopus 로고    scopus 로고
    • Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
    • Gu F, Ma Y, Zhang Z et al (2010). Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep 23: 671-676.
    • (2010) Oncol Rep , vol.23 , pp. 671-676
    • Gu, F.1    Ma, Y.2    Zhang, Z.3
  • 18
    • 77749333021 scopus 로고    scopus 로고
    • Upregulation of Notch pathway molecules in oral squamous cell carcinoma
    • Hijioka H, Setoguchi T, Miyawaki A et al (2010). Upregulation of Notch pathway molecules in oral squamous cell carcinoma. Int J Oncol 36: 817-822.
    • (2010) Int J Oncol , vol.36 , pp. 817-822
    • Hijioka, H.1    Setoguchi, T.2    Miyawaki, A.3
  • 19
  • 20
    • 0031785161 scopus 로고    scopus 로고
    • Delta-1 activation of notch-1 signaling results in HES-1 transactivation
    • Jarriault S, Le Bail O, Hirsinger E et al (1998). Delta-1 activation of notch-1 signaling results in HES-1 transactivation. Mol Cell Biol 18: 7423-7431.
    • (1998) Mol Cell Biol , vol.18 , pp. 7423-7431
    • Jarriault, S.1    Le Bail, O.2    Hirsinger, E.3
  • 21
    • 62849127179 scopus 로고    scopus 로고
    • Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer
    • Joo YH, Jung CK, Kim MS et al (2009). Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer. Otolaryngol Head Neck Surg 140: 512-518.
    • (2009) Otolaryngol Head Neck Surg , vol.140 , pp. 512-518
    • Joo, Y.H.1    Jung, C.K.2    Kim, M.S.3
  • 22
    • 84939871526 scopus 로고    scopus 로고
    • Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities
    • [Epub ahead of print].
    • Kagawa S, Natsuizaka M, Whelan KA et al (2014). Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene doi: 10.1038/onc.2014.169. [Epub ahead of print].
    • (2014) Oncogene
    • Kagawa, S.1    Natsuizaka, M.2    Whelan, K.A.3
  • 23
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
    • Kamangar F, Dores GM, Anderson WF (2006). Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J Clin Oncol 24: 2137-2150.
    • (2006) J Clin Oncol , vol.24 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 24
    • 84885735554 scopus 로고    scopus 로고
    • Mutational landscape and significance across 12 major cancer types
    • Kandoth C, McLellan MD, Vandin F et al (2013). Mutational landscape and significance across 12 major cancer types. Nature 502: 333-339.
    • (2013) Nature , vol.502 , pp. 333-339
    • Kandoth, C.1    McLellan, M.D.2    Vandin, F.3
  • 25
    • 0032145527 scopus 로고    scopus 로고
    • A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
    • Kao HY, Ordentlich P, Koyano-Nakagawa N et al (1998). A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12: 2269-2277.
    • (1998) Genes Dev , vol.12 , pp. 2269-2277
    • Kao, H.Y.1    Ordentlich, P.2    Koyano-Nakagawa, N.3
  • 26
    • 79955915582 scopus 로고    scopus 로고
    • A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia
    • Klinakis A, Lobry C, Abdel-Wahab O et al (2011). A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia. Nature 473: 230-233.
    • (2011) Nature , vol.473 , pp. 230-233
    • Klinakis, A.1    Lobry, C.2    Abdel-Wahab, O.3
  • 27
    • 50849125368 scopus 로고    scopus 로고
    • More complicated than it looks: assembly of Notch pathway transcription complexes
    • Kovall RA (2008). More complicated than it looks: assembly of Notch pathway transcription complexes. Oncogene 27: 5099-5109.
    • (2008) Oncogene , vol.27 , pp. 5099-5109
    • Kovall, R.A.1
  • 28
    • 84864087971 scopus 로고    scopus 로고
    • TNFalpha enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells
    • Lee SH, Hong HS, Liu ZX et al (2012). TNFalpha enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells. Biochem Biophys Res Commun 424: 58-64.
    • (2012) Biochem Biophys Res Commun , vol.424 , pp. 58-64
    • Lee, S.H.1    Hong, H.S.2    Liu, Z.X.3
  • 30
    • 0034729760 scopus 로고    scopus 로고
    • Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays
    • Leethanakul C, Patel V, Gillespie J et al (2000). Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene 19: 3220-3224.
    • (2000) Oncogene , vol.19 , pp. 3220-3224
    • Leethanakul, C.1    Patel, V.2    Gillespie, J.3
  • 31
    • 0037663379 scopus 로고    scopus 로고
    • Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain
    • McGill MA, McGlade CJ (2003). Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain. J Biol Chem 278: 23196-23203.
    • (2003) J Biol Chem , vol.278 , pp. 23196-23203
    • McGill, M.A.1    McGlade, C.J.2
  • 32
    • 0036024023 scopus 로고    scopus 로고
    • Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma
    • Nickoloff BJ, Qin JZ, Chaturvedi V et al (2002). Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ 9: 842-855.
    • (2002) Cell Death Differ , vol.9 , pp. 842-855
    • Nickoloff, B.J.1    Qin, J.Z.2    Chaturvedi, V.3
  • 33
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas M, Wolfer A, Raj K et al (2003). Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33: 416-421.
    • (2003) Nat Genet , vol.33 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3
  • 34
    • 33845306813 scopus 로고    scopus 로고
    • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero T, Lim WK, Odom DT et al (2006). NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci USA 103: 18261-18266.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 18261-18266
    • Palomero, T.1    Lim, W.K.2    Odom, D.T.3
  • 35
    • 84880281635 scopus 로고    scopus 로고
    • Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers
    • Pickering CR, Zhang J, Yoo SY et al (2013). Integrative genomic characterization of oral squamous cell carcinoma identifies frequent somatic drivers. Cancer Discov 3: 770-781.
    • (2013) Cancer Discov , vol.3 , pp. 770-781
    • Pickering, C.R.1    Zhang, J.2    Yoo, S.Y.3
  • 36
    • 84919769544 scopus 로고    scopus 로고
    • Mutational landscape of aggressive cutaneous squamous cell carcinoma
    • Pickering CR, Zhou JH, Lee JJ et al (2014). Mutational landscape of aggressive cutaneous squamous cell carcinoma. Clin Cancer Res 20: 6582-6592.
    • (2014) Clin Cancer Res , vol.20 , pp. 6582-6592
    • Pickering, C.R.1    Zhou, J.H.2    Lee, J.J.3
  • 37
    • 0346365362 scopus 로고    scopus 로고
    • Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis
    • Qi R, An H, Yu Y et al (2003). Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res 63: 8323-8329.
    • (2003) Cancer Res , vol.63 , pp. 8323-8329
    • Qi, R.1    An, H.2    Yu, Y.3
  • 38
    • 25444492595 scopus 로고    scopus 로고
    • Highly conserved O-fucose sites have distinct effects on Notch1 function
    • Rampal R, Arboleda-Velasquez JF, Nita-Lazar A et al (2005). Highly conserved O-fucose sites have distinct effects on Notch1 function. J Biol Chem 280: 32133-32140.
    • (2005) J Biol Chem , vol.280 , pp. 32133-32140
    • Rampal, R.1    Arboleda-Velasquez, J.F.2    Nita-Lazar, A.3
  • 39
    • 79955460636 scopus 로고    scopus 로고
    • Notch signalling in solid tumours: a little bit of everything but not all the time
    • Ranganathan P, Weaver KL, Capobianco AJ (2011). Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 11: 338-351.
    • (2011) Nat Rev Cancer , vol.11 , pp. 338-351
    • Ranganathan, P.1    Weaver, K.L.2    Capobianco, A.J.3
  • 40
    • 17844384528 scopus 로고    scopus 로고
    • Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation
    • Rangarajan A, Talora C, Okuyama R et al (2001). Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J 20: 3427-3436.
    • (2001) EMBO J , vol.20 , pp. 3427-3436
    • Rangarajan, A.1    Talora, C.2    Okuyama, R.3
  • 41
    • 24944506696 scopus 로고    scopus 로고
    • High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    • Reedijk M, Odorcic S, Chang L et al (2005). High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res 65: 8530-8537.
    • (2005) Cancer Res , vol.65 , pp. 8530-8537
    • Reedijk, M.1    Odorcic, S.2    Chang, L.3
  • 42
    • 0034902568 scopus 로고    scopus 로고
    • Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic)
    • Ronchini C, Capobianco AJ (2001). Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic). Mol Cell Biol 21: 5925-5934.
    • (2001) Mol Cell Biol , vol.21 , pp. 5925-5934
    • Ronchini, C.1    Capobianco, A.J.2
  • 43
    • 84860273352 scopus 로고    scopus 로고
    • Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms
    • Sakamoto K, Fujii T, Kawachi H et al (2012). Reduction of NOTCH1 expression pertains to maturation abnormalities of keratinocytes in squamous neoplasms. Lab Invest 92: 688-702.
    • (2012) Lab Invest , vol.92 , pp. 688-702
    • Sakamoto, K.1    Fujii, T.2    Kawachi, H.3
  • 44
    • 84893448476 scopus 로고    scopus 로고
    • Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma
    • Song X, Xia R, Li J et al (2014). Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma. Clin Cancer Res 20: 701-710.
    • (2014) Clin Cancer Res , vol.20 , pp. 701-710
    • Song, X.1    Xia, R.2    Li, J.3
  • 45
    • 84922391333 scopus 로고    scopus 로고
    • NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis
    • South AP, Purdie KJ, Watt SA et al (2014). NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis. J Invest Dermatol 134: 2630-2638.
    • (2014) J Invest Dermatol , vol.134 , pp. 2630-2638
    • South, A.P.1    Purdie, K.J.2    Watt, S.A.3
  • 46
    • 0035300448 scopus 로고    scopus 로고
    • Notch signaling induces cell cycle arrest in small cell lung cancer cells
    • Sriuranpong V, Borges MW, Ravi RK et al (2001). Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res 61: 3200-3205.
    • (2001) Cancer Res , vol.61 , pp. 3200-3205
    • Sriuranpong, V.1    Borges, M.W.2    Ravi, R.K.3
  • 47
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • Stransky N, Egloff AM, Tward AD et al (2011). The mutational landscape of head and neck squamous cell carcinoma. Science 333: 1157-1160.
    • (2011) Science , vol.333 , pp. 1157-1160
    • Stransky, N.1    Egloff, A.M.2    Tward, A.D.3
  • 48
    • 84894281594 scopus 로고    scopus 로고
    • Activation of the NOTCH pathway in head and neck cancer
    • Sun W, Gaykalova DA, Ochs MF et al (2014). Activation of the NOTCH pathway in head and neck cancer. Cancer Res 74: 1091-1104.
    • (2014) Cancer Res , vol.74 , pp. 1091-1104
    • Sun, W.1    Gaykalova, D.A.2    Ochs, M.F.3
  • 49
    • 33846048039 scopus 로고    scopus 로고
    • Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    • Vilimas T, Mascarenhas J, Palomero T et al (2007). Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat Med 13: 70-77.
    • (2007) Nat Med , vol.13 , pp. 70-77
    • Vilimas, T.1    Mascarenhas, J.2    Palomero, T.3
  • 50
    • 78649466892 scopus 로고    scopus 로고
    • Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
    • Wang Z, Li Y, Ahmad A et al (2010). Targeting Notch signaling pathway to overcome drug resistance for cancer therapy. Biochim Biophys Acta 1806: 258-267.
    • (2010) Biochim Biophys Acta , vol.1806 , pp. 258-267
    • Wang, Z.1    Li, Y.2    Ahmad, A.3
  • 51
    • 80055092549 scopus 로고    scopus 로고
    • Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
    • Wang NJ, Sanborn Z, Arnett KL et al (2011). Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci USA 108: 17761-17766.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 17761-17766
    • Wang, N.J.1    Sanborn, Z.2    Arnett, K.L.3
  • 52
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W et al (2004). Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306: 269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 53
    • 0034791336 scopus 로고    scopus 로고
    • SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
    • Wu G, Lyapina S, Das I et al (2001). SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 21: 7403-7415.
    • (2001) Mol Cell Biol , vol.21 , pp. 7403-7415
    • Wu, G.1    Lyapina, S.2    Das, I.3
  • 54
    • 35349020430 scopus 로고    scopus 로고
    • Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells
    • Yao J, Duan L, Fan M et al (2007). Gamma-secretase inhibitors exerts antitumor activity via down-regulation of Notch and Nuclear factor kappa B in human tongue carcinoma cells. Oral Dis 13: 555-563.
    • (2007) Oral Dis , vol.13 , pp. 555-563
    • Yao, J.1    Duan, L.2    Fan, M.3
  • 55
    • 84884892535 scopus 로고    scopus 로고
    • The pathological significance of Notch1 in oral squamous cell carcinoma
    • Yoshida R, Nagata M, Nakayama H et al (2013). The pathological significance of Notch1 in oral squamous cell carcinoma. Lab Invest 93: 1068-1081.
    • (2013) Lab Invest , vol.93 , pp. 1068-1081
    • Yoshida, R.1    Nagata, M.2    Nakayama, H.3
  • 56
    • 22244460522 scopus 로고    scopus 로고
    • Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
    • Zeng Q, Li S, Chepeha DB et al (2005). Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling. Cancer Cell 8: 13-23.
    • (2005) Cancer Cell , vol.8 , pp. 13-23
    • Zeng, Q.1    Li, S.2    Chepeha, D.B.3
  • 57
    • 78650783278 scopus 로고    scopus 로고
    • Activation of Notch signaling in human tongue carcinoma
    • Zhang TH, Liu HC, Zhu LJ et al (2011). Activation of Notch signaling in human tongue carcinoma. J Oral Pathol Med 40: 37-45.
    • (2011) J Oral Pathol Med , vol.40 , pp. 37-45
    • Zhang, T.H.1    Liu, H.C.2    Zhu, L.J.3
  • 58
    • 0032972372 scopus 로고    scopus 로고
    • Beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion
    • Zhu AJ, Watt FM (1999). Beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development 126: 2285-2298.
    • (1999) Development , vol.126 , pp. 2285-2298
    • Zhu, A.J.1    Watt, F.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.