Growth suppression induced by Notch1 activation involves Wnt - β-catenin down-regulation in human tongue carcinoma cells

Biology of the Cell

Volumn 98, Issue 8, 2006, Pages 479-490

  Duan, Li ^a   Yao, Jun ^b   Wu, Xinxing ^b   Fan, Mingwen ^a  

^a WUHAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

Author keywords

catenin; Apoptosis; Cell cycle arrest; Notch1; Transfection; Wnt.

Indexed keywords

BETA CATENIN; CYCLIN DEPENDENT KINASE INHIBITOR 1; NOTCH1 RECEPTOR; PROTEIN BCL 2; PROTEIN P52; S PHASE KINASE ASSOCIATED PROTEIN 2; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOMA CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVATION; GENE ACTIVITY; GENE OVEREXPRESSION; GENETIC CODE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTO ONCOGENE; SIGNAL TRANSDUCTION; TONGUE CARCINOMA;

ANIMALS; APOPTOSIS; BETA CATENIN; BLOTTING, WESTERN; CELL CYCLE; CELL LINE, TUMOR; CELL NUCLEUS; CELL PROLIFERATION; CELL SHAPE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DOWN-REGULATION; GENE EXPRESSION; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTOR, NOTCH1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TONGUE NEOPLASMS; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 33747014859     PISSN: 02484900     EISSN: None     Source Type: Journal    
DOI: 10.1042/BC20060020     Document Type: Article

References (45)

1. Allenspach, E.J., Maillard, I., Aster, J.C. and Pear, W.S. (2002) Notch signaling in cancer. Cancer Biol. Ther. 1, 466-476
2. Andrews, G.A., Xi, S., Pomerantz, R.G., Lin, C.J., Gooding, W.E., Wentzel, A.L., Wu, L., Sidransky, D. and Grandis, J.R. (2004) Mutation of p53 in head and neck squamous cell carcinoma correlates with BCL-2 expression and increased susceptibility to cisplatin-induced apoptosis. Head Neck 26, 870-877
3. Artavanis-Tsakonas, S., Rand, M.D. and Lake, R.J. (1999) Notch signaling: cell fate control and signal integration in development. Science 284, 770-776
4. Axelrod, J.D., Matsuno, K., Artavanis-Tsakonas, S. and Perrimon, N. (1996) Interaction between wingless and Notch signaling pathways mediated by disheveled. Science 271, 1826-1832
5. Axelson, H. (2004) Notch signaling and cancer: emerging complexity. Semin. Cancer Biol. 14,317-319
6. Baldi, A., De Falco, M., De Luca, L., Cottone, G., Paggi, M.G., Nickoloff, B.J., Miele, L. and De Luca, A. (2004) Characterization of tissue specific expression of Notch-1 in human tissues. Biol. Cell 96, 303-311
7. Balint, K., Xiao, M., Pinnix, C.C., Soma, A., Veres, I., Juhasz, I., Brown, E.J., Capobianco, A.J., Herlyn, M. and Liu, Z.-J. (2005) Activation of Notch1 signaling is required for β-catenin-mediated human primary melanoma progression. J. Clin. Invest. 115, 3166-3176
8. Benchimol, S. (2001) p53-dependent pathways of apoptosis. Cell Death Differ. 8,1049-1051
9. CIP1 is a negative transcriptional regulator of Wnt4 expression downstream of Notch1 activation. Genes Dev. 19, 1485-1495
10. Dumont, E., Fuchs, K.P., Bommer, G., Christoph, B., Kremmer, E. and Kempkes, B. (2000) Neoplastic transformation by Notch is independent of transcriptional activation by RBP-J signaling. Oncogene 19, 556-561
11. Duncan, A.W., Rattis, F.M., DiMascio, L.N., Congdon, K.L., Pazianos, G., Zhao, C., Yoon, K., Cook, J.M., Willert, K., Gaiano, N. and Reya, T. (2005) Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat. Immunol. 6, 314-322
12. Gstaiger, M., Jordan, R., Lim, M., Catzavelos, C., Mestan, J., Slingerland, J. and Krek, W. (2001) Skp2 is oncogenic and overexpressed in human cancers. Proc. Natl. Acad. Sci. U.S.A. 98, 5043-5048
13. Hayward, P., Brennan, K., Sanders, P., Balayo, T, DasGupta, R., Perrimon, N. and Martinez Arias, A. (2005) Notch modulates Wnt signaling by associating with Armadillo/Β-catenin and regulating its transcriptional activity. Development 132,1819-1830
14. He, B., You, L., Uematsu, K., Xu, Z., Lee, A.Y., Matsangou, M., McCormick, F and Jablons, D.M. (2004) A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. Neoplasia 6,7-14
15. Iso, T., Kedes, L. and Hamamori, Y. (2003) HES and HERP families: Multiple effectors of the Notch signaling pathway. J. Cell. Physiol. 194,237-255
16. Kitajima, S., Kudo, Y, Ogawa, I., Bashir, T, Kitagawa, M., Miyauchi, M, Pagano, M. and Takata, T. (2004) Role of Cks1 overexpression in oral squamous cell carcinomas: cooperation with Skp2 in promoting p27 degradation. Am. J. Pathol. 165, 2147-2155
17. Kudo, Y., Kitajima, S., Ogawa, I., Kitagawa, M., Miyauchi, M. and Takata, T. (2005) Small interfering RNA targeting of S-phase kinase-interacting protein 2 inhibits cell growth of oral cancer cells by inhibiting p27 degradation. Mol. Cancer Ther. 4, 471-476
18. Lathion, S., Schaper, J., Beard, P. and Raj, K. (2003) Notch1 can contribute to viral-induced transformation of primary human keratinocytes. Cancer Res. 63, 8687-8694
19. Lefort, K. and Dotto, G.P. (2004) Notch signaling in the integrated control of keratinocyte growth/differentiation and tumor suppression. Semin. Cancer Biol. 14, 374-386
20. Lin, J.-G., Chen, G.-W., Li, T.-M., Chouh, S.-T, Tan, T.-W. and Chung, J.-G. (2006) Aloe-Emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. J. Urol. 175, 343-347
21. Lo Muzio, L., Pannone, G., Staibano, S., Mignogna, M.D., Grieco, M., Ramires, P, Maria, Romito, A., De, Rosa, G. and Piattelli, A. (2002) Wnt-1 expression in basal cell carcinoma of head and neck. An immunolhistochemical and confocal study with regard to the intracellular distribution of β-catenin. Anticancer Res. 22, 565-576
22. Maillard, I. and Pear, W.S. (2003) Notch and cancer: best to avoid the ups and downs. Cancer Cell 3, 203-205
23. Miele, L. and Osborne, B. (1999) Arbiter of differentiation and death: Notch signaling meets apoptosis. J. Cell. Physiol. 181, 393-409
24. Morimura, T, Goitsuka, R., Zhang, Y., Saito, I., Reth, M. and Kitamura, D. (2000) Cell cycle arrest and apoptosis induced by Notch1 in B cells. J. Biol. Chem. 275, 36523-36531
25. Nair, P, Somasundaram, K. and Krishna, S. (2003) Activated Notch1 inhibits p53-induced apoptosis and sustains transformation by human papillomavirus type 16 E6 and E7 oncogenes; through a PI3K-PKB/ Akt-dependent pathway. J. Virol. 77, 7106-7112
26. Nicolas, M., Wolfer, A., Raj, K., Kummer, J.A., Mill, R, Van Noort, M., Hui, C.-C., Clevers, H. and Dotto, G.P. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat. Genet. 33, 416-421
27. Pear, W.S. and Aster, J.C. (2004) T cell acute lymphoblastic leukemia/ lymphoma: A human cancer commonly associated with aberrant NOTCH1 signaling. Curr. Opin. Hematol. 11, 426-433
28. Politi, K., Feirt, N., Kitajewski, J., Brennan, K. and Brown, A.M.C. (2003) Is there a role for Notch signaling in human breast cancer? Breast Cancer Res. 5, 69-75
29. Qi, R., An, H., Yu, Y, Zhang, M., Liu, S., Xu, H., Guo, Z., Cheng, T. and Cao, X. (2003) Notch1 signaling inhibits growth of human hepatocellular carcinoma through induction of cell cycle arrest and apoptosis. Cancer Res. 63, 8323-8329
30. Radtke, F. and Raj, K. (2003) The role of Notch in tumorigenesis: oncogene or tumor suppressor? Nat. Rev. Cancer 3, 756-767
31. Rangarajan, A., Talora, C., Okuyama, R., Nicolas, M., Mammucari, C., Oh, H., Aster, J.C., Krishna, S., Metzger, D., Chambon, P, Miele, L., Aguet, M., Radtke, F. and Dotto, G.P. (2001) Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation. EMBO J. 20, 3427-3436
32. Reedijk, M., Odorcic, S., Chang, L., Zhang, H., Miller, N., McCready, D.R., Lockwood, G. and Sean, E. (2005) High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. Cancer Res. 65, 8530-8537
33. Sasaki, Y, Ishida, S., Morimoto, I., Yamashita, T, Kojima, T., Kihara, C., Tanaka, T., Imai, K., Nakamura, Y. and Tokino, T. (2002) The p53 family member genes are involved in the Notch signal pathway. J. Biol. Chem. 277, 719-724
34. 1-phase progression. Genes Dev. 13, 1501-1512
35. Sjølund, J., Manetopoulos, C., Stockhausen, M.-T. and Axelson, H. (2005) The Notch pathway in cancer: differentiation gone awry. Eur. J. Cancer 41, 2620-2629
36. Sriuranpong, V., Borges, M.W., Ravi, R.K., Arnold, D.R., Nelkin, B.D. and Baylin, S.B. (2001) Notch signaling induces cell cycle arrest in small cell lung cancer cells. Cancer Res. 61, 3200-3205
37. Talora, C., Sgroi, D.C., Crum, C.R and Dotto, G.P. (2002) Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation. Genes Dev. 16, 2252-2263
38. Talora, C., Cialfi, S., Segatto, O., Morrone, S., Kim Choi, J., Frati, L., Dotto, G.P, Gulino, A. and Screpanti, I. (2005) Constitutively active Notch1 induces growth arrest of HPV-positive cervical cancer cells via separate signaling pathways. Exp. Cell Res. 305, 343-354
39. Weijzen, S., Rizzo, P, Braid, M., Vaishnav, R., Jonkheer, S.M., Zlobin, A., Osborne, B.A., Gottipati, S., Aster, J.C., Hahn, W.C., Rudolf, M., Siziopikou, K., Martin Kast, W. and Miele, L. (2002) Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat. Med. 8, 979-986
40. Weijzen, S., Zlobin, A., Braid, M., Miele, L. and Kast, W.M. (2003) HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation. J. Cell. Physiol. 194, 356-362
41. Weng, A.P. and Aster, J.C. (2004) Multiple niches for Notch in cancer: context is everything. Curr. Opin. Genet. Dev. 14, 48-54
42. Wesley, C.S. (1999) Notch and Wingless regulate expression of cuticle patterning genes. Mol. Cell. Biol. 19, 5743-5758
43. Wu, L. and Griffin, J.D. (2004) Modulation of Notch signaling by mastermind-like (MAML) transcriptional co-activators and their involvement in tumorigenesis. Semin. Cancer Biol. 14, 348-356
44. Wu, L., Aster, J.C., Blacklow, S.C., Lake, R., Artavanis-Tsakonas, S. and Griffin, J.D. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat. Genet. 26, 484-489
45. Yang, X., Klein, R., Tian, X., Cheng, H.-T, Kopan, R. and Shen, J.M. (2004) Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev. Biol. 269, 81-94