Deep sequencing-guided design of a high affinity dual specificity antibody to target two angiogenic factors in neovascular age-related macular degeneration

Journal of Biological Chemistry

Volumn 290, Issue 36, 2015, Pages 21773-21786

  Koenig, Patrick ^a   Lee, Chingwei V ^a   Sanowar, Sarah ^a   Wu, Ping ^c   Stinson, Jeremy ^b   Harris, Seth F ^c   Fuh, Germaine ^a  

^a Antibody Engineering   (United States)

^b Genentech   (United States)

^c GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

AGE-RELATED MACULAR DEGENERATION; ANGIOGENIC FACTOR; BINDING SURFACE; DUAL ACTION; HIGH AFFINITY; NANOMOLAR AFFINITY; THERAPEUTIC POTENTIALS;

BIOLOGY;

ANGIOPOIETIN 2; VASCULOTROPIN; ANGIOGENIC FACTOR; COMPLEMENTARITY DETERMINING REGION; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; PROTEIN BINDING; VASCULOTROPIN A;

AGE RELATED MACULAR DEGENERATION; ANGIOGENESIS; ANIMAL CELL; ANTIBODY COMBINING SITE; ANTIBODY SPECIFICITY; ARTICLE; BINDING AFFINITY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DEPP SEQUENCING; HIGH AFFINITY DUAL ANTIBODY SPECIFICITY; HUMAN; NEOVASCULAR AGE RELATED MACULAR DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SEQUENCE ANALYSIS; ANTAGONISTS AND INHIBITORS; ANTIBODY AFFINITY; CHEMISTRY; DRUG DESIGN; FEASIBILITY STUDY; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGY; KINETICS; MACULAR DEGENERATION; METABOLISM; MOLECULAR MODEL; MOLECULARLY TARGETED THERAPY; MUTATION; PROCEDURES; PROTEIN ENGINEERING; PROTEIN TERTIARY STRUCTURE; REPRODUCIBILITY;

ANGIOGENESIS INDUCING AGENTS; ANGIOPOIETIN-2; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; COMPLEMENTARITY DETERMINING REGIONS; DRUG DESIGN; FEASIBILITY STUDIES; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; KINETICS; MACULAR DEGENERATION; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; MUTATION; PROTEIN BINDING; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; REPRODUCIBILITY OF RESULTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84941333624     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.662783     Document Type: Article

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