High affinity antigen recognition of the dual specific variants of Herceptin is entropy-driven in spite of structural plasticity

PLoS ONE

Volumn 6, Issue 4, 2011, Pages

  Bostrom, Jenny ^a   Haber, Lauric ^a   Koenig, Patrick ^a   Kelley, Robert F ^a   Fuh, Germaine ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; BH1 44 ANTIBODY; BH1 ANTIBODY; EPIDERMAL GROWTH FACTOR RECEPTOR 2; TRASTUZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN; ANTIGEN; MONOCLONAL ANTIBODY; MUTANT PROTEIN; VASCULOTROPIN A;

ANTIBODY COMBINING SITE; ANTIGEN BINDING; ANTIGEN RECOGNITION; ARTICLE; BINDING AFFINITY; BINDING KINETICS; BIOPHYSICS; CRYSTAL STRUCTURE; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG SPECIFICITY; ENTROPY; HYDROPHOBICITY; PLASTICITY; STRUCTURAL PLASTICITY; THERMODYNAMICS; THERMOSTABILITY; AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; CHEMICAL PHENOMENA; CHEMICAL STRUCTURE; CHEMISTRY; COMPLEMENTARITY DETERMINING REGION; HUMAN; IMMUNOLOGY; KINETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ALIGNMENT; TEMPERATURE;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGENS; COMPLEMENTARITY DETERMINING REGIONS; CONSERVED SEQUENCE; ENTROPY; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN INTERACTION MAPPING; RECEPTOR, ERBB-2; SEQUENCE ALIGNMENT; TEMPERATURE; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79955545620     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017887     Document Type: Article

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