Potential use of additivity of mutational effects in simplifying protein engineering

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 20, 1996, Pages 10753-10757

  Skinner, Matthew M ^a   Terwilliger, Thomas C ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

crystallography; gene V protein; mutational additivity; site specific mutants

Indexed keywords

MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DNA BINDING; GENETIC ENGINEERING; PRIORITY JOURNAL; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

COLIPHAGES; DNA-BINDING PROTEINS; FOURIER ANALYSIS; MODELS, MOLECULAR; POINT MUTATION; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 0029785464     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.20.10753     Document Type: Article

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