Crystallization of the receptor binding domain of vascular endothelial growth factor

Proteins: Structure, Function and Genetics

Volumn 26, Issue 3, 1996, Pages 353-357

  Christinger, Hans W ^a   Muller, Yves A ^a   Berleau, Lea T ^a   Keyt, Bruce A ^a   Cunningham, Brian C ^a   Ferrara, Napoleone ^a   De Vos, Abraham M ^a  

^a GENENTECH INC   (United States)

Author keywords

angiogenesis; crystals; cysteine mutants; inclusion bodies; tumor vascularization; VEGF; X ray crystallography

Indexed keywords

VASCULOTROPIN;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ESCHERICHIA COLI; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; ENDOTHELIAL GROWTH FACTORS; ESCHERICHIA COLI; LYMPHOKINES; MODELS, MOLECULAR; MUTAGENESIS; PEPTIDE FRAGMENTS; PROTEIN FOLDING; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; RECOMBINANT PROTEINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

ESCHERICHIA COLI;

EID: 0029851571     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(199611)26:3<353::AID-PROT9>3.0.CO;2-E     Document Type: Article

References (19)

1. Ferrara, N. The role of vascular endothelial growth factor in phatological angiogenesis. Breast Cancer Res. Treat. 36:127-137, 1995.
2. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1:27-31, 1995.
3. Dvorak, H.F., Brown, L.F., Detmar, M., Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am. J. Pathol. 146:1029-1039, 1995.
4. Neufeld, G., Tessler, S., Gitay-Goren, H., Cohen, T., Levi, B.Z. Vascular endothelial growth factor and its receptors. Prog. Growth Factor Res. 5:89-97, 1994.
5. Aiello, L.P., Avery, R.L., Arrigg, P.G., Keyt, B.A., Jampel, H.D., Shah, S.T., Pasquale, L.R., Thieme, H., Iwamoto, M.A., Park, J.E., Nguyen, H., Aiello, L.M., Ferrara, N., King, G.L. Vascular endothelial growth in occular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331:1480-1487, 1994.
6. Kim, K.J., Li, B., Winer, J., Armanini, M., Gillet, N., Phillips, H.S., Ferrara, N. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362:841-844, 1993.
7. Park, J.E., Keller, G.A., Ferrara, N. The vascular endothelial growth factor (VEGF) isoforms: Differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF. Mol. Biol. Cell. 4:1317-1326, 1993.
8. Keyt, B.A., Berleau, L.T., Nguyen, H.V., Chen, Heinsohn, H., Vandlen, R., Ferrara, N. The carboxyl-terminal domain of vascular endothelial growth factor is critical for its mitogenic potency. J. Biol. Chem. 271:7788-7795, 1996.
9. Sun, P.D., Davies, D.H. The cystine-knot growth-factor superfamily. Annu. Rev. Biophys. Biomol. Struct. 24:269-291, 1995.
10. Isaacs, N.W. Cystine knots. Curr. Opin. Struct. Biol. 5:391-395, 1995.
11. McDonald, N.Q., Lapatto, R., Murray-Rust, J., Gunning, J., Wlodawer, A., Blundell, T.L. New protein fold revealed by a 2.3 A resolution crystal structure of nerve growth factor. Nature 354:411-414, 1991.
12. Schlunegger, M.P., Grutter, M.G. Refined crystal structure of human transforming growth factor-β2 at 1.95 Å resolution. J. Mol. Biol. 231:445-458, 1993.
13. Daopin, S., Li, M., Davies, D.R. Crystal structure of TGF-β2 refined at 1.8 A resolution. Proteins 17:176-192, 1993.
14. Oefner, C., D'Arcy, A., Winkler, F.K., Eggimann, B., Hosang, M. Crystal structure of human platelet-derived growth factor BB. EMBO J. 11:3921-3926, 1992.
15. Lapthorn, A.J., Harris, D.C., Littlejohn, A., Lustbader, J.W., Canfield, R.E., Machin, K.J. Morgan, F.J., Isaacs, N.W. Crystal structure of human chorionic gonadotropin. Nature 369:455-461, 1994.
16. Wu, H., Lustbader, J.W., Liu, Y., Canfield, R.E., Hendrickson, W.A. Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein. Structure 2:545-558, 1994.
17. Jancarik, J., Kim, S.H. Sparse matrix sampling: A screening method for crystallization of proteins. J. Appl. Crystallogr. 24:409-411, 1991.
18. Kabsch, W. Evaluation of single crystal X-ray diffraction data from a position sensitive detector. J. Appl. Crystallogr. 21:916-924, 1988.
19. Otwinowski, Z. Oscillation data reduction program. In: Proceedings of the CCP4 Study Weekend: "Data Collection and Processing." Sawyer, L., Isaacs, N., Bailey, S. (eds.). UK: SERC Daresbury Laboratory, Warrington, 1993:56-62.