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Volumn 50, Issue 9, 2015, Pages 928-939

A breakthrough in probiotics: Clostridium butyricum regulates gut homeostasis and anti-inflammatory response in inflammatory bowel disease

Author keywords

Clostridium butyricum; Interleukin 10; Macrophages; Probiotics

Indexed keywords

INTERLEUKIN 10; PROBIOTIC AGENT; TOLL LIKE RECEPTOR 2; IL10 PROTEIN, HUMAN;

EID: 84941261312     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-015-1084-x     Document Type: Review
Times cited : (121)

References (143)
  • 1
    • 79959216005 scopus 로고    scopus 로고
    • Genetics and pathogenesis of inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BC3MXnsFOrsr4%3D, PID: 21677747
    • Khor B, Gardet A, Xavier RJ. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011;474(7351):307–17.
    • (2011) Nature , vol.474 , Issue.7351 , pp. 307-317
    • Khor, B.1    Gardet, A.2    Xavier, R.J.3
  • 2
    • 84939949671 scopus 로고    scopus 로고
    • The microbiota in inflammatory bowel disease
    • Sheehan D, Moran C, Shanahan F. The microbiota in inflammatory bowel disease. J Gastroenterol. 2015. doi:10.1007/s00535-015-1064-1.
    • (2015) J Gastroenterol
    • Sheehan, D.1    Moran, C.2    Shanahan, F.3
  • 3
    • 84862276328 scopus 로고    scopus 로고
    • Structure, function and diversity of the healthy human microbiome
    • Human Microbiome Project Consortium. Structure, function and diversity of the healthy human microbiome. Nature. 2012;486(7402):207–14.
    • (2012) Nature , vol.486 , Issue.7402 , pp. 207-214
    • Human Microbiome Project Consortium1
  • 4
    • 33745594044 scopus 로고    scopus 로고
    • The gut flora as a forgotten organ
    • PID: 16819463
    • O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Rep. 2006;7(7):688–93.
    • (2006) EMBO Rep , vol.7 , Issue.7 , pp. 688-693
    • O’Hara, A.M.1    Shanahan, F.2
  • 5
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • COI: 1:CAS:528:DC%2BD2sXpvVGjsbg%3D, PID: 17699621
    • Frank DN, St Amand AL, Feldman RA, et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104(34):13780–5.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , Issue.34 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3
  • 6
    • 20544444045 scopus 로고    scopus 로고
    • Diversity of the human intestinal microbial flora
    • PID: 15831718
    • Eckburg PB, Bik EM, Bernstein CN, et al. Diversity of the human intestinal microbial flora. Science. 2005;308(5728):1635–8.
    • (2005) Science , vol.308 , Issue.5728 , pp. 1635-1638
    • Eckburg, P.B.1    Bik, E.M.2    Bernstein, C.N.3
  • 7
    • 34848889673 scopus 로고    scopus 로고
    • Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
    • COI: 1:CAS:528:DC%2BD2sXht1CntLjF, PID: 17923086
    • Garrett WS, Lord GM, Punit S, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007;131(1):33–45.
    • (2007) Cell , vol.131 , Issue.1 , pp. 33-45
    • Garrett, W.S.1    Lord, G.M.2    Punit, S.3
  • 8
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
    • COI: 1:CAS:528:DC%2BC3MXmvFWhtLo%3D, PID: 21565393
    • Elinav E, Strowig T, Kau AL, et al. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell. 2011;145(5):745–57.
    • (2011) Cell , vol.145 , Issue.5 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3
  • 9
    • 84881477044 scopus 로고    scopus 로고
    • Treg induction by a rationally selected mixture of clostridia strains from the human microbiota
    • COI: 1:CAS:528:DC%2BC3sXhtFShsbfJ, PID: 23842501
    • Atarashi K, Tanoue T, Oshima K, et al. Treg induction by a rationally selected mixture of clostridia strains from the human microbiota. Nature. 2013;500(7461):232–6.
    • (2013) Nature , vol.500 , Issue.7461 , pp. 232-236
    • Atarashi, K.1    Tanoue, T.2    Oshima, K.3
  • 10
    • 85027947787 scopus 로고    scopus 로고
    • Induction of colonic regulatory T cells by indigenous Clostridium species
    • COI: 1:CAS:528:DC%2BC3MXmsVCjsw%3D%3D, PID: 21205640
    • Atarashi K, Tanoue T, Shima T, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science. 2011;331(6015):337–41.
    • (2011) Science , vol.331 , Issue.6015 , pp. 337-341
    • Atarashi, K.1    Tanoue, T.2    Shima, T.3
  • 11
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • COI: 1:CAS:528:DC%2BC3cXovFyit7s%3D, PID: 20566854
    • Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A. 2010;107(27):12204–9.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.27 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 12
    • 79956311926 scopus 로고    scopus 로고
    • The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
    • COI: 1:CAS:528:DC%2BC3MXmtFSgurY%3D, PID: 21512004
    • Round JL, Lee SM, Li J, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science. 2011;332(6032):974–7.
    • (2011) Science , vol.332 , Issue.6032 , pp. 974-977
    • Round, J.L.1    Lee, S.M.2    Li, J.3
  • 13
    • 84879109909 scopus 로고    scopus 로고
    • A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice
    • COI: 1:CAS:528:DC%2BC3sXpsFSjtbg%3D, PID: 23768495
    • Hayashi A, Sato T, Kamada N, et al. A single strain of Clostridium butyricum induces intestinal IL-10-producing macrophages to suppress acute experimental colitis in mice. Cell Host Microbe. 2013;13(6):711–22.
    • (2013) Cell Host Microbe , vol.13 , Issue.6 , pp. 711-722
    • Hayashi, A.1    Sato, T.2    Kamada, N.3
  • 14
    • 0026432216 scopus 로고
    • Inflammatory bowel disease
    • COI: 1:STN:280:DyaK3MzltFamsQ%3D%3D, PID: 1881418
    • Podolsky DK. Inflammatory bowel disease. N Engl J Med. 1991;325(13):928–37.
    • (1991) N Engl J Med , vol.325 , Issue.13 , pp. 928-937
    • Podolsky, D.K.1
  • 15
    • 84901422463 scopus 로고    scopus 로고
    • The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications
    • COI: 1:CAS:528:DC%2BC2cXkslWntLw%3D, PID: 24652102
    • Goldsmith JR, Sartor RB. The role of diet on intestinal microbiota metabolism: downstream impacts on host immune function and health, and therapeutic implications. J Gastroenterol. 2014;49(5):785–98.
    • (2014) J Gastroenterol , vol.49 , Issue.5 , pp. 785-798
    • Goldsmith, J.R.1    Sartor, R.B.2
  • 16
    • 46049086230 scopus 로고    scopus 로고
    • Analysis of bacterial bowel communities of IBD patients: what has it revealed?
    • PID: 18275077
    • Sokol H, Lay C, Seksik P, et al. Analysis of bacterial bowel communities of IBD patients: what has it revealed? Inflamm Bowel Dis. 2008;14(6):858–67.
    • (2008) Inflamm Bowel Dis , vol.14 , Issue.6 , pp. 858-867
    • Sokol, H.1    Lay, C.2    Seksik, P.3
  • 17
    • 55949124035 scopus 로고    scopus 로고
    • Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
    • COI: 1:CAS:528:DC%2BD1cXhtleks7%2FI, PID: 18936492
    • Sokol H, Pigneur B, Watterlot L, et al. Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci U S A. 2008;105(43):16731–6.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , Issue.43 , pp. 16731-16736
    • Sokol, H.1    Pigneur, B.2    Watterlot, L.3
  • 18
    • 34547934812 scopus 로고    scopus 로고
    • Mycobacterium avium subspecies paratuberculosis and Crohn’s disease: a systematic review and meta-analysis
    • PID: 17714674
    • Feller M, Huwiler K, Stephan R, et al. Mycobacterium avium subspecies paratuberculosis and Crohn’s disease: a systematic review and meta-analysis. Lancet Infect Dis. 2007;7(9):607–13.
    • (2007) Lancet Infect Dis , vol.7 , Issue.9 , pp. 607-613
    • Feller, M.1    Huwiler, K.2    Stephan, R.3
  • 19
    • 34250030068 scopus 로고    scopus 로고
    • Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2sXnvFOhtLg%3D, PID: 17570206
    • Selby W, Pavli P, Crotty B, et al. Two-year combination antibiotic therapy with clarithromycin, rifabutin, and clofazimine for Crohn’s disease. Gastroenterology. 2007;132(7):2313–9.
    • (2007) Gastroenterology , vol.132 , Issue.7 , pp. 2313-2319
    • Selby, W.1    Pavli, P.2    Crotty, B.3
  • 20
    • 0033679199 scopus 로고    scopus 로고
    • Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls
    • COI: 1:CAS:528:DC%2BD3cXosl2qs74%3D, PID: 11106094
    • Chen W, Li D, Paulus B, et al. Detection of Listeria monocytogenes by polymerase chain reaction in intestinal mucosal biopsies from patients with inflammatory bowel disease and controls. J Gastroenterol Hepatol. 2000;15(10):1145–50.
    • (2000) J Gastroenterol Hepatol , vol.15 , Issue.10 , pp. 1145-1150
    • Chen, W.1    Li, D.2    Paulus, B.3
  • 21
    • 84938288390 scopus 로고    scopus 로고
    • Listeria monocytogenes y su relacion con terapia no biologica en la enfermedad inflamatoria intestinal
    • Ontanilla Clavijo G, Trigo Salado C, Leo Carnerero E, et al. Listeria monocytogenes y su relacion con terapia no biologica en la enfermedad inflamatoria intestinal. Gastroenterol Hepatol. 2014. doi:10.1016/j.gastrohep.2014.07.001.
    • (2014) Gastroenterol Hepatol
    • Ontanilla Clavijo, G.1    Trigo Salado, C.2    Leo Carnerero, E.3
  • 22
    • 35348982432 scopus 로고    scopus 로고
    • Adherent-invasive Escherichia coli in inflammatory bowel disease
    • PID: 17476674
    • Rolhion N, Darfeuille-Michaud A. Adherent-invasive Escherichia coli in inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(10):1277–83.
    • (2007) Inflamm Bowel Dis , vol.13 , Issue.10 , pp. 1277-1283
    • Rolhion, N.1    Darfeuille-Michaud, A.2
  • 23
    • 0036378418 scopus 로고    scopus 로고
    • Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody
    • PID: 12164960
    • Ohkusa T, Sato N, Ogihara T, et al. Fusobacterium varium localized in the colonic mucosa of patients with ulcerative colitis stimulates species-specific antibody. J Gastroenterol Hepatol. 2002;17(8):849–53.
    • (2002) J Gastroenterol Hepatol , vol.17 , Issue.8 , pp. 849-853
    • Ohkusa, T.1    Sato, N.2    Ogihara, T.3
  • 24
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • COI: 1:STN:280:DyaK3c7ivVSnuw%3D%3D, PID: 1688816
    • Okayasu I, Hatakeyama S, Yamada M, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 1990;98(3):694–702.
    • (1990) Gastroenterology , vol.98 , Issue.3 , pp. 694-702
    • Okayasu, I.1    Hatakeyama, S.2    Yamada, M.3
  • 25
    • 0028006855 scopus 로고
    • Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice
    • COI: 1:CAS:528:DyaK2MXivFSls7s%3D, PID: 7958674
    • Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology. 1994;107(6):1643–52.
    • (1994) Gastroenterology , vol.107 , Issue.6 , pp. 1643-1652
    • Dieleman, L.A.1    Ridwan, B.U.2    Tennyson, G.S.3
  • 26
    • 0029918501 scopus 로고    scopus 로고
    • +-cell depleted, athymic and NK-cell depleted SCID mice
    • COI: 1:CAS:528:DyaK28XislCisbc%3D, PID: 8741008
    • +-cell depleted, athymic and NK-cell depleted SCID mice. Inflamm Res. 1996;45(4):181–91.
    • (1996) Inflamm Res , vol.45 , Issue.4 , pp. 181-191
    • Axelsson, L.G.1    Landstrom, E.2    Goldschmidt, T.J.3
  • 27
    • 0036950810 scopus 로고    scopus 로고
    • 1 regulates intestinal inflammation in experimental colitis
    • COI: 1:CAS:528:DC%2BD38XpslWmsLs%3D, PID: 12488427
    • 1 regulates intestinal inflammation in experimental colitis. J Clin Investig. 2002;110(12):1773–82.
    • (2002) J Clin Investig , vol.110 , Issue.12 , pp. 1773-1782
    • Krieglstein, C.F.1    Cerwinka, W.H.2    Sprague, A.G.3
  • 28
    • 33644752099 scopus 로고    scopus 로고
    • Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis
    • PID: 16482634
    • Kim TW, Seo JN, Suh YH, et al. Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis. World J Gastroenterol. 2006;12(2):302–5.
    • (2006) World J Gastroenterol , vol.12 , Issue.2 , pp. 302-305
    • Kim, T.W.1    Seo, J.N.2    Suh, Y.H.3
  • 29
    • 84891736162 scopus 로고    scopus 로고
    • Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis
    • COI: 1:CAS:528:DC%2BC2cXkslartrg%3D, PID: 23426893
    • Johansson ME, Gustafsson JK, Holmen-Larsson J, et al. Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis. Gut. 2014;63(2):281–91.
    • (2014) Gut , vol.63 , Issue.2 , pp. 281-291
    • Johansson, M.E.1    Gustafsson, J.K.2    Holmen-Larsson, J.3
  • 30
    • 77957906400 scopus 로고    scopus 로고
    • Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model
    • PID: 20805871
    • Johansson ME, Gustafsson JK, Sjoberg KE, et al. Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS One. 2010;5(8):e12238.
    • (2010) PLoS One , vol.5 , Issue.8 , pp. e12238
    • Johansson, M.E.1    Gustafsson, J.K.2    Sjoberg, K.E.3
  • 31
    • 66149137296 scopus 로고    scopus 로고
    • Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis
    • PID: 18942757
    • Alex P, Zachos NC, Nguyen T, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009;15(3):341–52.
    • (2009) Inflamm Bowel Dis , vol.15 , Issue.3 , pp. 341-352
    • Alex, P.1    Zachos, N.C.2    Nguyen, T.3
  • 32
    • 0031736096 scopus 로고    scopus 로고
    • Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines
    • COI: 1:CAS:528:DyaK1MXhslGqtA%3D%3D, PID: 9844047
    • Dieleman LA, Palmen MJ, Akol H, et al. Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immunol. 1998;114(3):385–91.
    • (1998) Clin Exp Immunol , vol.114 , Issue.3 , pp. 385-391
    • Dieleman, L.A.1    Palmen, M.J.2    Akol, H.3
  • 33
    • 0037216498 scopus 로고    scopus 로고
    • Increased expression of interleukin 17 in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD3sXmtVyqsw%3D%3D, PID: 12477762
    • Fujino S, Andoh A, Bamba S, et al. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 2003;52(1):65–70.
    • (2003) Gut , vol.52 , Issue.1 , pp. 65-70
    • Fujino, S.1    Andoh, A.2    Bamba, S.3
  • 34
    • 0842324613 scopus 로고    scopus 로고
    • Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
    • COI: 1:CAS:528:DC%2BD2cXhtV2hur4%3D, PID: 14962796
    • Ogawa A, Andoh A, Araki Y, et al. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin Immunol. 2004;110(1):55–62.
    • (2004) Clin Immunol. , vol.110 , Issue.1 , pp. 55-62
    • Ogawa, A.1    Andoh, A.2    Araki, Y.3
  • 35
    • 3242664636 scopus 로고    scopus 로고
    • Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis
    • COI: 1:CAS:528:DC%2BD2cXmtlKntrg%3D, PID: 15260992
    • Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, et al. Recognition of commensal microflora by Toll-like receptors is required for intestinal homeostasis. Cell. 2004;118(2):229–41.
    • (2004) Cell , vol.118 , Issue.2 , pp. 229-241
    • Rakoff-Nahoum, S.1    Paglino, J.2    Eslami-Varzaneh, F.3
  • 36
    • 20444373390 scopus 로고    scopus 로고
    • MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
    • COI: 1:CAS:528:DC%2BD2MXhtVamsbg%3D, PID: 15692785
    • Araki A, Kanai T, Ishikura T, et al. MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J Gastroenterol. 2005;40(1):16–23.
    • (2005) J Gastroenterol , vol.40 , Issue.1 , pp. 16-23
    • Araki, A.1    Kanai, T.2    Ishikura, T.3
  • 37
    • 34848893583 scopus 로고    scopus 로고
    • Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study
    • PID: 17919486, quiz 1340–1341
    • Gupta RB, Harpaz N, Itzkowitz S, et al. Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study. Gastroenterology. 2007;133(4):1099–105; quiz 1340–1.
    • (2007) Gastroenterology. , vol.133 , Issue.4 , pp. 1099-1105
    • Gupta, R.B.1    Harpaz, N.2    Itzkowitz, S.3
  • 38
    • 0344237231 scopus 로고    scopus 로고
    • A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    • COI: 1:CAS:528:DC%2BD2cXhsF2nuw%3D%3D, PID: 14611673
    • Tanaka T, Kohno H, Suzuki R, et al. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci. 2003;94(11):965–73.
    • (2003) Cancer Sci , vol.94 , Issue.11 , pp. 965-973
    • Tanaka, T.1    Kohno, H.2    Suzuki, R.3
  • 39
    • 33847060965 scopus 로고    scopus 로고
    • Interleukin-1β-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors
    • COI: 1:CAS:528:DC%2BD2sXht1yns7k%3D, PID: 17283139
    • Krelin Y, Voronov E, Dotan S, et al. Interleukin-1β-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res. 2007;67(3):1062–71.
    • (2007) Cancer Res , vol.67 , Issue.3 , pp. 1062-1071
    • Krelin, Y.1    Voronov, E.2    Dotan, S.3
  • 40
    • 0036854732 scopus 로고    scopus 로고
    • IL18 polymorphism is associated with an increased risk of Crohn’s disease
    • COI: 1:CAS:528:DC%2BD38Xpsleqtb8%3D, PID: 12572878
    • Tamura K, Fukuda Y, Sashio H, et al. IL18 polymorphism is associated with an increased risk of Crohn’s disease. J Gastroenterol. 2002;37(Suppl 14):111–6.
    • (2002) J Gastroenterol , vol.37 , pp. 111-116
    • Tamura, K.1    Fukuda, Y.2    Sashio, H.3
  • 41
    • 77955350419 scopus 로고    scopus 로고
    • MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18
    • COI: 1:CAS:528:DC%2BC3cXhtVejt7bN, PID: 20624890
    • Salcedo R, Worschech A, Cardone M, et al. MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. J Exp Med. 2010;207(8):1625–36.
    • (2010) J Exp Med , vol.207 , Issue.8 , pp. 1625-1636
    • Salcedo, R.1    Worschech, A.2    Cardone, M.3
  • 42
    • 84899631135 scopus 로고    scopus 로고
    • Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis
    • COI: 1:CAS:528:DC%2BC2cXnt1Ohuw%3D%3D, PID: 24424523
    • Wang Y, Wang K, Han GC, et al. Neutrophil infiltration favors colitis-associated tumorigenesis by activating the interleukin-1 (IL-1)/IL-6 axis. Mucosal Immunol. 2014;7(5):1106–15.
    • (2014) Mucosal Immunol , vol.7 , Issue.5 , pp. 1106-1115
    • Wang, Y.1    Wang, K.2    Han, G.C.3
  • 43
    • 0032538915 scopus 로고    scopus 로고
    • Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4
    • COI: 1:CAS:528:DyaK1cXnsVKksrg%3D, PID: 9815270
    • Boirivant M, Fuss IJ, Chu A, et al. Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med. 1998;188(10):1929–39.
    • (1998) J Exp Med , vol.188 , Issue.10 , pp. 1929-1939
    • Boirivant, M.1    Fuss, I.J.2    Chu, A.3
  • 44
    • 0036850908 scopus 로고    scopus 로고
    • Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells
    • COI: 1:CAS:528:DC%2BD38XovF2lsrY%3D, PID: 12433369
    • Heller F, Fuss IJ, Nieuwenhuis EE, et al. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity. 2002;17(5):629–38.
    • (2002) Immunity , vol.17 , Issue.5 , pp. 629-638
    • Heller, F.1    Fuss, I.J.2    Nieuwenhuis, E.E.3
  • 45
    • 0028861975 scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • COI: 1:CAS:528:DyaK2MXovFWru7s%3D, PID: 7595199
    • Neurath MF, Fuss I, Kelsall BL, et al. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med. 1995;182(5):1281–90.
    • (1995) J Exp Med , vol.182 , Issue.5 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3
  • 46
    • 0033638507 scopus 로고    scopus 로고
    • Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12
    • COI: 1:CAS:528:DC%2BD3cXovV2ht7c%3D, PID: 11114383
    • Oppmann B, Lesley R, Blom B, et al. Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity. 2000;13(5):715–25.
    • (2000) Immunity , vol.13 , Issue.5 , pp. 715-725
    • Oppmann, B.1    Lesley, R.2    Blom, B.3
  • 47
    • 33646397611 scopus 로고    scopus 로고
    • IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6
    • COI: 1:CAS:528:DC%2BD28XksVWns78%3D, PID: 16670770
    • Yen D, Cheung J, Scheerens H, et al. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. J Clin Investig. 2006;116(5):1310–6.
    • (2006) J Clin Investig , vol.116 , Issue.5 , pp. 1310-1316
    • Yen, D.1    Cheung, J.2    Scheerens, H.3
  • 48
    • 33747777440 scopus 로고    scopus 로고
    • Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis
    • COI: 1:CAS:528:DC%2BD28Xot1equ7s%3D, PID: 16920909
    • Becker C, Dornhoff H, Neufert C, et al. Cutting edge: IL-23 cross-regulates IL-12 production in T cell-dependent experimental colitis. J Immunol. 2006;177(5):2760–4.
    • (2006) J Immunol , vol.177 , Issue.5 , pp. 2760-2764
    • Becker, C.1    Dornhoff, H.2    Neufert, C.3
  • 49
    • 0027521572 scopus 로고
    • Interleukin-10-deficient mice develop chronic enterocolitis
    • COI: 1:STN:280:DyaK2c%2Fgs1Gmug%3D%3D, PID: 8402911
    • Kuhn R, Lohler J, Rennick D, et al. Interleukin-10-deficient mice develop chronic enterocolitis. Cell. 1993;75(2):263–74.
    • (1993) Cell , vol.75 , Issue.2 , pp. 263-274
    • Kuhn, R.1    Lohler, J.2    Rennick, D.3
  • 50
    • 0032412057 scopus 로고    scopus 로고
    • Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice
    • COI: 1:CAS:528:DyaK1cXntFWmsLk%3D, PID: 9784526
    • Sellon RK, Tonkonogy S, Schultz M, et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect Immun. 1998;66(11):5224–31.
    • (1998) Infect Immun , vol.66 , Issue.11 , pp. 5224-5231
    • Sellon, R.K.1    Tonkonogy, S.2    Schultz, M.3
  • 51
    • 0027517545 scopus 로고
    • Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice
    • COI: 1:STN:280:DyaK2c%2Fotlektg%3D%3D, PID: 7903159
    • Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol. 1993;5(11):1461–71.
    • (1993) Int Immunol , vol.5 , Issue.11 , pp. 1461-1471
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3
  • 52
    • 34247157433 scopus 로고    scopus 로고
    • IL-7 Is essential for the development and the persistence of chronic colitis
    • COI: 1:CAS:528:DC%2BD2sXjslWjsrg%3D, PID: 17404253
    • Totsuka T, Kanai T, Nemoto Y, et al. IL-7 Is essential for the development and the persistence of chronic colitis. J Immunol. 2007;178(8):4737–48.
    • (2007) J Immunol , vol.178 , Issue.8 , pp. 4737-4748
    • Totsuka, T.1    Kanai, T.2    Nemoto, Y.3
  • 54
    • 0032530697 scopus 로고    scopus 로고
    • IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice
    • COI: 1:CAS:528:DyaK1cXmtVGmu7o%3D, PID: 9743382
    • Davidson NJ, Hudak SA, Lesley RE, et al. IL-12, but not IFN-γ, plays a major role in sustaining the chronic phase of colitis in IL-10-deficient mice. J Immunol. 1998;161(6):3143–9.
    • (1998) J Immunol , vol.161 , Issue.6 , pp. 3143-3149
    • Davidson, N.J.1    Hudak, S.A.2    Lesley, R.E.3
  • 55
    • 0033523607 scopus 로고    scopus 로고
    • An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation
    • COI: 1:CAS:528:DyaK1MXmsVClt7s%3D, PID: 10510089
    • Asseman C, Mauze S, Leach MW, et al. An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation. J Exp Med. 1999;190(7):995–1004.
    • (1999) J Exp Med , vol.190 , Issue.7 , pp. 995-1004
    • Asseman, C.1    Mauze, S.2    Leach, M.W.3
  • 56
    • 0037029649 scopus 로고    scopus 로고
    • The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn’s disease
    • COI: 1:CAS:528:DC%2BD38Xjs1Wnu74%3D, PID: 11994418
    • Neurath MF, Weigmann B, Finotto S, et al. The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn’s disease. J Exp Med. 2002;195(9):1129–43.
    • (2002) J Exp Med , vol.195 , Issue.9 , pp. 1129-1143
    • Neurath, M.F.1    Weigmann, B.2    Finotto, S.3
  • 57
    • 0032550312 scopus 로고    scopus 로고
    • T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells
    • COI: 1:CAS:528:DyaK1cXis1Cru7g%3D, PID: 9547334
    • Simpson SJ, Shah S, Comiskey M, et al. T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells. J Exp Med. 1998;187(8):1225–34.
    • (1998) J Exp Med , vol.187 , Issue.8 , pp. 1225-1234
    • Simpson, S.J.1    Shah, S.2    Comiskey, M.3
  • 58
    • 65749091607 scopus 로고    scopus 로고
    • A protective function for interleukin 17A in T cell-mediated intestinal inflammation
    • PID: 19448631
    • O’Connor W Jr, Kamanaka M, Booth CJ, et al. A protective function for interleukin 17A in T cell-mediated intestinal inflammation. Nat Immunol. 2009;10(6):603–9.
    • (2009) Nat Immunol , vol.10 , Issue.6 , pp. 603-609
    • O’Connor, W.1    Kamanaka, M.2    Booth, C.J.3
  • 59
    • 59849114998 scopus 로고    scopus 로고
    • RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F
    • COI: 1:CAS:528:DC%2BD1MXht1Cqs7s%3D, PID: 18992745
    • Leppkes M, Becker C, Ivanov II, et al. RORγ-expressing Th17 cells induce murine chronic intestinal inflammation via redundant effects of IL-17A and IL-17F. Gastroenterology. 2009;136(1):257–67.
    • (2009) Gastroenterology , vol.136 , Issue.1 , pp. 257-267
    • Leppkes, M.1    Becker, C.2    Ivanov, I.I.3
  • 60
    • 77953293952 scopus 로고    scopus 로고
    • Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis
    • COI: 1:CAS:528:DC%2BC3cXnt1Kls7w%3D, PID: 20493732
    • Durant L, Watford WT, Ramos HL, Laurence A, Vahedi G, Wei L, et al. Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis. Immunity. 2010;32(5):605–15.
    • (2010) Immunity , vol.32 , Issue.5 , pp. 605-615
    • Durant, L.1    Watford, W.T.2    Ramos, H.L.3    Laurence, A.4    Vahedi, G.5    Wei, L.6
  • 61
    • 77956456087 scopus 로고    scopus 로고
    • Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis
    • COI: 1:CAS:528:DC%2BC3cXhtV2gurbL, PID: 20706984
    • Mikami Y, Kanai T, Sujino T, et al. Competition between colitogenic Th1 and Th17 cells contributes to the amelioration of colitis. Eur J Immunol. 2010;40(9):2409–22.
    • (2010) Eur J Immunol , vol.40 , Issue.9 , pp. 2409-2422
    • Mikami, Y.1    Kanai, T.2    Sujino, T.3
  • 62
    • 80052122798 scopus 로고    scopus 로고
    • Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells
    • COI: 1:CAS:528:DC%2BC3MXhtFSru7zK, PID: 21699791
    • Sujino T, Kanai T, Ono Y, et al. Regulatory T cells suppress development of colitis, blocking differentiation of T-helper 17 into alternative T-helper 1 cells. Gastroenterology. 2011;141(3):1014–23.
    • (2011) Gastroenterology , vol.141 , Issue.3 , pp. 1014-1023
    • Sujino, T.1    Kanai, T.2    Ono, Y.3
  • 63
    • 84925815225 scopus 로고    scopus 로고
    • Classical Th1 cells obtain colitogenicity by co-existence of RORgammat-expressing T cells in experimental colitis
    • PID: 25167215
    • Saigusa K, Hisamatsu T, Handa T, et al. Classical Th1 cells obtain colitogenicity by co-existence of RORgammat-expressing T cells in experimental colitis. Inflamm Bowel Dis. 2014;20(10):1820–7.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.10 , pp. 1820-1827
    • Saigusa, K.1    Hisamatsu, T.2    Handa, T.3
  • 64
    • 79956315886 scopus 로고    scopus 로고
    • Intestinal bacterial colonization induces mutualistic regulatory T cell responses
    • COI: 1:CAS:528:DC%2BC3MXms12rsLk%3D, PID: 21596591
    • Geuking MB, Cahenzli J, Lawson MA, et al. Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity. 2011;34(5):794–806.
    • (2011) Immunity , vol.34 , Issue.5 , pp. 794-806
    • Geuking, M.B.1    Cahenzli, J.2    Lawson, M.A.3
  • 65
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • COI: 1:CAS:528:DC%2BC38XhtleqsrzI, PID: 22972297
    • Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature. 2012;489(7415):242–9.
    • (2012) Nature , vol.489 , Issue.7415 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 66
    • 80053025965 scopus 로고    scopus 로고
    • The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment
    • COI: 1:CAS:528:DC%2BC3MXhtFymt7bJ, PID: 21925113
    • Sczesnak A, Segata N, Qin X, et al. The genome of Th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe. 2011;10(3):260–72.
    • (2011) Cell Host Microbe , vol.10 , Issue.3 , pp. 260-272
    • Sczesnak, A.1    Segata, N.2    Qin, X.3
  • 67
    • 53349173070 scopus 로고    scopus 로고
    • Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
    • COI: 1:CAS:528:DC%2BD1cXht12iurbO, PID: 18854238
    • Ivanov II, Frutos Rde L, Manel N, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008;4(4):337–49.
    • (2008) Cell Host Microbe , vol.4 , Issue.4 , pp. 337-349
    • Ivanov, I.I.1    Frutos Rde, L.2    Manel, N.3
  • 68
    • 70349742524 scopus 로고    scopus 로고
    • The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
    • COI: 1:CAS:528:DC%2BD1MXhsVChtLrF, PID: 19833089
    • Gaboriau-Routhiau V, Rakotobe S, Lecuyer E, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity. 2009;31(4):677–89.
    • (2009) Immunity , vol.31 , Issue.4 , pp. 677-689
    • Gaboriau-Routhiau, V.1    Rakotobe, S.2    Lecuyer, E.3
  • 69
    • 70350343544 scopus 로고    scopus 로고
    • Induction of intestinal Th17 cells by segmented filamentous bacteria
    • COI: 1:CAS:528:DC%2BD1MXhsFKltL%2FL, PID: 19836068
    • Ivanov II, Atarashi K, Manel N, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 2009;139(3):485–98.
    • (2009) Cell , vol.139 , Issue.3 , pp. 485-498
    • Ivanov, I.I.1    Atarashi, K.2    Manel, N.3
  • 70
    • 84901979873 scopus 로고    scopus 로고
    • Focused specificity of intestinal TH17 cells towards commensal bacterial antigens
    • COI: 1:CAS:528:DC%2BC2cXhtFygsrfL, PID: 24739972
    • Yang Y, Torchinsky MB, Gobert M, et al. Focused specificity of intestinal TH17 cells towards commensal bacterial antigens. Nature. 2014;510(7503):152–6.
    • (2014) Nature , vol.510 , Issue.7503 , pp. 152-156
    • Yang, Y.1    Torchinsky, M.B.2    Gobert, M.3
  • 71
    • 84898679249 scopus 로고    scopus 로고
    • Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation
    • COI: 1:CAS:528:DC%2BC2cXltFCkt7c%3D, PID: 24684957
    • Goto Y, Panea C, Nakato G, et al. Segmented filamentous bacteria antigens presented by intestinal dendritic cells drive mucosal Th17 cell differentiation. Immunity. 2014;40(4):594–607.
    • (2014) Immunity , vol.40 , Issue.4 , pp. 594-607
    • Goto, Y.1    Panea, C.2    Nakato, G.3
  • 72
    • 59649099774 scopus 로고    scopus 로고
    • A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity
    • COI: 1:CAS:528:DC%2BD1MXht1eiu7c%3D, PID: 18978771
    • Cella M, Fuchs A, Vermi W, et al. A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity. Nature. 2009;457(7230):722–5.
    • (2009) Nature , vol.457 , Issue.7230 , pp. 722-725
    • Cella, M.1    Fuchs, A.2    Vermi, W.3
  • 73
    • 84924625632 scopus 로고    scopus 로고
    • The brave new world of innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC2cXitFKltL3J, PID: 25521670
    • Eberl G, Di Santo JP, Vivier E. The brave new world of innate lymphoid cells. Nat Immunol. 2015;16(1):1–5.
    • (2015) Nat Immunol , vol.16 , Issue.1 , pp. 1-5
    • Eberl, G.1    Di Santo, J.P.2    Vivier, E.3
  • 74
    • 84923525743 scopus 로고    scopus 로고
    • Profiling the diversity of innate lymphoid cells
    • COI: 1:CAS:528:DC%2BC2MXivVSktrY%3D, PID: 25689434
    • Diefenbach A. Profiling the diversity of innate lymphoid cells. Nat Immunol. 2015;16(3):222–4.
    • (2015) Nat Immunol , vol.16 , Issue.3 , pp. 222-224
    • Diefenbach, A.1
  • 75
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells—a proposal for uniform nomenclature
    • COI: 1:CAS:528:DC%2BC3sXjslGjtg%3D%3D, PID: 23348417
    • Spits H, Artis D, Colonna M, et al. Innate lymphoid cells—a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13(2):145–9.
    • (2013) Nat Rev Immunol , vol.13 , Issue.2 , pp. 145-149
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 76
    • 84905439631 scopus 로고    scopus 로고
    • Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn’s disease
    • PID: 24991784
    • Mizuno S, Mikami Y, Kamada N, et al. Cross-talk between RORγt+ innate lymphoid cells and intestinal macrophages induces mucosal IL-22 production in Crohn’s disease. Inflamm Bowel Dis. 2014;20(8):1426–34.
    • (2014) Inflamm Bowel Dis , vol.20 , Issue.8 , pp. 1426-1434
    • Mizuno, S.1    Mikami, Y.2    Kamada, N.3
  • 77
    • 77956190936 scopus 로고    scopus 로고
    • + natural killer cells in the intestinal mucosa of patients with Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3cXhtV2iurvL, PID: 20638936
    • + natural killer cells in the intestinal mucosa of patients with Crohn’s disease. Gastroenterology. 2010;139(3):882–92.e3.
    • (2010) Gastroenterology. , vol.139 , Issue.3 , pp. 882
    • Takayama, T.1    Kamada, N.2    Chinen, H.3
  • 78
    • 4143095716 scopus 로고    scopus 로고
    • IL-22 increases the innate immunity of tissues
    • COI: 1:CAS:528:DC%2BD2cXnsVKlt7k%3D, PID: 15308104
    • Wolk K, Kunz S, Witte E. IL-22 increases the innate immunity of tissues. Immunity. 2004;21(2):241–54.
    • (2004) Immunity , vol.21 , Issue.2 , pp. 241-254
    • Wolk, K.1    Kunz, S.2    Witte, E.3
  • 79
    • 84864966419 scopus 로고    scopus 로고
    • Healing of intestinal inflammation by IL-22
    • PID: 22359410
    • Mizoguchi A. Healing of intestinal inflammation by IL-22. Inflamm Bowel Dis. 2012;18(9):1777–84.
    • (2012) Inflamm Bowel Dis , vol.18 , Issue.9 , pp. 1777-1784
    • Mizoguchi, A.1
  • 80
    • 79952584368 scopus 로고    scopus 로고
    • Recent advances in IL-22 biology
    • COI: 1:CAS:528:DC%2BC3MXjtFWgurY%3D, PID: 21393631
    • Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol. 2011;23(3):159–63.
    • (2011) Int Immunol , vol.23 , Issue.3 , pp. 159-163
    • Zenewicz, L.A.1    Flavell, R.A.2
  • 81
    • 84868204017 scopus 로고    scopus 로고
    • Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis
    • COI: 1:CAS:528:DC%2BC38XhsFKns7zI, PID: 23022186
    • Kimura K, Kanai T, Hayashi A, et al. Dysregulated balance of retinoid-related orphan receptor γt-dependent innate lymphoid cells is involved in the pathogenesis of chronic DSS-induced colitis. Biochem Biophys Res Commun. 2012;427(4):694–700.
    • (2012) Biochem Biophys Res Commun , vol.427 , Issue.4 , pp. 694-700
    • Kimura, K.1    Kanai, T.2    Hayashi, A.3
  • 82
    • 84870876967 scopus 로고    scopus 로고
    • Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria
    • COI: 1:CAS:528:DC%2BC38XhslGku7nF, PID: 23200827
    • Basu R, O’Quinn DB, Silberger DJ, et al. Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. 2012;37(6):1061–75.
    • (2012) Immunity , vol.37 , Issue.6 , pp. 1061-1075
    • Basu, R.1    O’Quinn, D.B.2    Silberger, D.J.3
  • 83
    • 78751706261 scopus 로고    scopus 로고
    • + lymphoid tissue-inducer cells promote innate immunity in the gut
    • COI: 1:CAS:528:DC%2BC3MXht1Wlu7w%3D, PID: 21194981
    • + lymphoid tissue-inducer cells promote innate immunity in the gut. Immunity. 2011;34(1):122–34.
    • (2011) Immunity , vol.34 , Issue.1 , pp. 122-134
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Elloso, M.M.3
  • 84
    • 40049083827 scopus 로고    scopus 로고
    • Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
    • COI: 1:CAS:528:DC%2BD1cXivFOrtLw%3D, PID: 18264109
    • Zheng Y, Valdez PA, Danilenko DM, et al. Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat Med. 2008;14(3):282–9.
    • (2008) Nat Med , vol.14 , Issue.3 , pp. 282-289
    • Zheng, Y.1    Valdez, P.A.2    Danilenko, D.M.3
  • 85
    • 84861989207 scopus 로고    scopus 로고
    • Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria
    • COI: 1:CAS:528:DC%2BC38XnvFektrc%3D, PID: 22674331
    • Sonnenberg GF, Monticelli LA, Alenghat T, et al. Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science. 2012;336(6086):1321–5.
    • (2012) Science , vol.336 , Issue.6086 , pp. 1321-1325
    • Sonnenberg, G.F.1    Monticelli, L.A.2    Alenghat, T.3
  • 86
    • 1242296822 scopus 로고    scopus 로고
    • Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut
    • COI: 1:CAS:528:DC%2BD2cXhs1Skurk%3D, PID: 14766966
    • Suzuki K, Meek B, Doi Y. Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut. Proc Natl Acad Sci U S A. 2004;101(7):1981–6.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , Issue.7 , pp. 1981-1986
    • Suzuki, K.1    Meek, B.2    Doi, Y.3
  • 87
    • 35848931007 scopus 로고    scopus 로고
    • IgA response to symbiotic bacteria as a mediator of gut homeostasis
    • COI: 1:CAS:528:DC%2BD2sXhtlyhtL3L, PID: 18005754
    • Peterson DA, McNulty NP, Guruge JL, et al. IgA response to symbiotic bacteria as a mediator of gut homeostasis. Cell Host Microbe. 2007;2(5):328–39.
    • (2007) Cell Host Microbe , vol.2 , Issue.5 , pp. 328-339
    • Peterson, D.A.1    McNulty, N.P.2    Guruge, J.L.3
  • 88
    • 84904384753 scopus 로고    scopus 로고
    • + T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis
    • COI: 1:CAS:528:DC%2BC2cXhtFeqsb%2FK, PID: 25017466
    • + T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. Immunity. 2014;41(1):152–65.
    • (2014) Immunity , vol.41 , Issue.1 , pp. 152-165
    • Kawamoto, S.1    Maruya, M.2    Kato, L.M.3
  • 89
    • 22144490199 scopus 로고    scopus 로고
    • An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
    • COI: 1:CAS:528:DC%2BD2MXmsFeiurw%3D, PID: 16009137
    • Mazmanian SK, Liu CH, Tzianabos AO, et al. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107–18.
    • (2005) Cell , vol.122 , Issue.1 , pp. 107-118
    • Mazmanian, S.K.1    Liu, C.H.2    Tzianabos, A.O.3
  • 90
    • 44449106055 scopus 로고    scopus 로고
    • A microbial symbiosis factor prevents intestinal inflammatory disease
    • COI: 1:CAS:528:DC%2BD1cXmsVKqurw%3D, PID: 18509436
    • Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature. 2008;453(7195):620–5.
    • (2008) Nature , vol.453 , Issue.7195 , pp. 620-625
    • Mazmanian, S.K.1    Round, J.L.2    Kasper, D.L.3
  • 91
    • 84875612653 scopus 로고    scopus 로고
    • Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn’s disease
    • COI: 1:CAS:528:DC%2BC3sXkvFOgt70%3D, PID: 23216550
    • Fujimoto T, Imaeda H, Takahashi K, et al. Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn’s disease. J Gastroenterol Hepatol. 2013;28(4):613–9.
    • (2013) J Gastroenterol Hepatol , vol.28 , Issue.4 , pp. 613-619
    • Fujimoto, T.1    Imaeda, H.2    Takahashi, K.3
  • 92
    • 70350666634 scopus 로고    scopus 로고
    • Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43
    • COI: 1:CAS:528:DC%2BD1MXhtlOjt7vI, PID: 19865172
    • Maslowski KM, Vieira AT, Ng A, et al. Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature. 2009;461(7268):1282–6.
    • (2009) Nature , vol.461 , Issue.7268 , pp. 1282-1286
    • Maslowski, K.M.1    Vieira, A.T.2    Ng, A.3
  • 93
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • COI: 1:CAS:528:DC%2BC3sXhvFOltr3F, PID: 24226770
    • Furusawa Y, Obata Y, Fukuda S, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 2013;504(7480):446–50.
    • (2013) Nature , vol.504 , Issue.7480 , pp. 446-450
    • Furusawa, Y.1    Obata, Y.2    Fukuda, S.3
  • 94
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • COI: 1:CAS:528:DC%2BC3sXhvFOmtrrJ, PID: 24226773
    • Arpaia N, Campbell C, Fan X, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 2013;504(7480):451–5.
    • (2013) Nature , vol.504 , Issue.7480 , pp. 451-455
    • Arpaia, N.1    Campbell, C.2    Fan, X.3
  • 95
    • 0030930368 scopus 로고    scopus 로고
    • Intestinal distribution and intraluminal localization of orally administered Clostridium butyricum in rats
    • PID: 9343816
    • Sato R, Tanaka M. Intestinal distribution and intraluminal localization of orally administered Clostridium butyricum in rats. Microbiol Immunol. 1997;41(9):665–71.
    • (1997) Microbiol Immunol , vol.41 , Issue.9 , pp. 665-671
    • Sato, R.1    Tanaka, M.2
  • 96
    • 0242515998 scopus 로고    scopus 로고
    • Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI
    • PID: 12654076
    • Seki H, Shiohara M, Matsumura T, et al. Prevention of antibiotic-associated diarrhea in children by Clostridium butyricum MIYAIRI. Pediatr Int. 2003;45(1):86–90.
    • (2003) Pediatr Int , vol.45 , Issue.1 , pp. 86-90
    • Seki, H.1    Shiohara, M.2    Matsumura, T.3
  • 97
    • 31144447912 scopus 로고    scopus 로고
    • Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy
    • PID: 16437727
    • Shimbo I, Yamaguchi T, Odaka T, et al. Effect of Clostridium butyricum on fecal flora in Helicobacter pylori eradication therapy. World J Gastroenterol. 2005;11(47):7520–4.
    • (2005) World J Gastroenterol , vol.11 , Issue.47 , pp. 7520-7524
    • Shimbo, I.1    Yamaguchi, T.2    Odaka, T.3
  • 98
    • 0034091384 scopus 로고    scopus 로고
    • Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats
    • COI: 1:CAS:528:DC%2BD3cXktVensLc%3D, PID: 10832668
    • Okamoto T, Sasaki M, Tsujikawa T, et al. Preventive efficacy of butyrate enemas and oral administration of Clostridium butyricum M588 in dextran sodium sulfate-induced colitis in rats. J Gastroenterol. 2000;35(5):341–6.
    • (2000) J Gastroenterol , vol.35 , Issue.5 , pp. 341-346
    • Okamoto, T.1    Sasaki, M.2    Tsujikawa, T.3
  • 99
    • 84877798095 scopus 로고    scopus 로고
    • Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis
    • COI: 1:CAS:528:DC%2BC3sXosFGjsb4%3D, PID: 23696823
    • Endo H, Niioka M, Kobayashi N, et al. Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis. PLoS One. 2013;8(5):e63388.
    • (2013) PLoS One , vol.8 , Issue.5 , pp. e63388
    • Endo, H.1    Niioka, M.2    Kobayashi, N.3
  • 100
    • 84890125493 scopus 로고    scopus 로고
    • Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats
    • PID: 24166662
    • Seo M, Inoue I, Tanaka M, et al. Clostridium butyricum MIYAIRI 588 improves high-fat diet-induced non-alcoholic fatty liver disease in rats. Dig Dis Sci. 2013;58(12):3534–44.
    • (2013) Dig Dis Sci , vol.58 , Issue.12 , pp. 3534-3544
    • Seo, M.1    Inoue, I.2    Tanaka, M.3
  • 101
    • 2942545832 scopus 로고    scopus 로고
    • The effect of probiotic treatment with Clostridium butyricum on enterohemorrhagic Escherichia coli O157:H7 infection in mice
    • COI: 1:CAS:528:DC%2BD2cXkvVKksL0%3D, PID: 15196571
    • Takahashi M, Taguchi H, Yamaguchi H, et al. The effect of probiotic treatment with Clostridium butyricum on enterohemorrhagic Escherichia coli O157:H7 infection in mice. FEMS Immunol Med Microbiol. 2004;41(3):219–26.
    • (2004) FEMS Immunol Med Microbiol , vol.41 , Issue.3 , pp. 219-226
    • Takahashi, M.1    Taguchi, H.2    Yamaguchi, H.3
  • 102
    • 80053516398 scopus 로고    scopus 로고
    • Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain
    • COI: 1:CAS:528:DC%2BC3MXhs1Slt7fI, PID: 21700738
    • Woo TD, Oka K, Takahashi M, et al. Inhibition of the cytotoxic effect of Clostridium difficile in vitro by Clostridium butyricum MIYAIRI 588 strain. J Med Microbiol. 2011;60(Pt 11):1617–25.
    • (2011) J Med Microbiol , vol.60 , pp. 1617-1625
    • Woo, T.D.1    Oka, K.2    Takahashi, M.3
  • 103
    • 0024408824 scopus 로고
    • Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones
    • COI: 1:CAS:528:DyaK3cXhtFKqtL0%3D, PID: 2531194
    • Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med. 1989;170(6):2081–95.
    • (1989) J Exp Med , vol.170 , Issue.6 , pp. 2081-2095
    • Fiorentino, D.F.1    Bond, M.W.2    Mosmann, T.R.3
  • 104
    • 0025335354 scopus 로고
    • Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein–Barr virus gene BCRFI
    • COI: 1:CAS:528:DyaK3cXlvVGlurc%3D, PID: 2161559
    • Moore KW, Vieira P, Fiorentino DF, et al. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein–Barr virus gene BCRFI. Science. 1990;248(4960):1230–4.
    • (1990) Science , vol.248 , Issue.4960 , pp. 1230-1234
    • Moore, K.W.1    Vieira, P.2    Fiorentino, D.F.3
  • 105
    • 33847144180 scopus 로고    scopus 로고
    • − Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection
    • COI: 1:CAS:528:DC%2BD2sXitVekt7Y%3D, PID: 17283209
    • − Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med. 2007;204(2):273–83.
    • (2007) J Exp Med , vol.204 , Issue.2 , pp. 273-283
    • Jankovic, D.1    Kullberg, M.C.2    Feng, C.G.3
  • 106
    • 41549159660 scopus 로고    scopus 로고
    • Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    • COI: 1:CAS:528:DC%2BD1cXkvV2it7c%3D, PID: 18387831
    • Rubtsov YP, Rasmussen JP, Chi EY, et al. Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity. 2008;28(4):546–58.
    • (2008) Immunity , vol.28 , Issue.4 , pp. 546-558
    • Rubtsov, Y.P.1    Rasmussen, J.P.2    Chi, E.Y.3
  • 107
    • 33645077332 scopus 로고    scopus 로고
    • + natural regulatory T cells are specific for microbial antigens
    • COI: 1:CAS:528:DC%2BD28XjsVSqu78%3D, PID: 16533885
    • + natural regulatory T cells are specific for microbial antigens. J Exp Med. 2006;203(3):777–88.
    • (2006) J Exp Med , vol.203 , Issue.3 , pp. 777-788
    • Suffia, I.J.1    Reckling, S.K.2    Piccirillo, C.A.3
  • 108
    • 1042269477 scopus 로고    scopus 로고
    • + regulatory T cells
    • COI: 1:CAS:528:DC%2BD2cXmtlyqug%3D%3D, PID: 14734610
    • + regulatory T cells. Int Immunol. 2004;16(2):249–56.
    • (2004) Int Immunol , vol.16 , Issue.2 , pp. 249-256
    • Zhang, X.1    Koldzic, D.N.2    Izikson, L.3
  • 109
  • 110
    • 0026506870 scopus 로고
    • Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10
    • PID: 1547817
    • O’Garra A, Chang R, Go N, et al. Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. Eur J Immunol. 1992;22(3):711–7.
    • (1992) Eur J Immunol , vol.22 , Issue.3 , pp. 711-717
    • O’Garra, A.1    Chang, R.2    Go, N.3
  • 111
    • 0036795531 scopus 로고    scopus 로고
    • B cells regulate autoimmunity by provision of IL-10
    • COI: 1:CAS:528:DC%2BD38XnsVGrs7g%3D, PID: 12244307
    • Fillatreau S, Sweenie CH, McGeachy MJ, et al. B cells regulate autoimmunity by provision of IL-10. Nat Immunol. 2002;3(10):944–50.
    • (2002) Nat Immunol , vol.3 , Issue.10 , pp. 944-950
    • Fillatreau, S.1    Sweenie, C.H.2    McGeachy, M.J.3
  • 112
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • COI: 1:CAS:528:DC%2BD2sXhtVCkurnN, PID: 17873879
    • Denning TL, Wang YC, Patel SR, et al. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol. 2007;8(10):1086–94.
    • (2007) Nat Immunol , vol.8 , Issue.10 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3
  • 113
    • 84856815290 scopus 로고    scopus 로고
    • Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon
    • COI: 1:CAS:528:DC%2BC38XhtFSqu70%3D, PID: 22231304
    • Rivollier A, He J, Kole A, et al. Inflammation switches the differentiation program of Ly6Chi monocytes from antiinflammatory macrophages to inflammatory dendritic cells in the colon. J Exp Med. 2012;209(1):139–55.
    • (2012) J Exp Med , vol.209 , Issue.1 , pp. 139-155
    • Rivollier, A.1    He, J.2    Kole, A.3
  • 114
    • 1642526354 scopus 로고    scopus 로고
    • CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages
    • COI: 1:CAS:528:DC%2BD2cXptlyktw%3D%3D, PID: 14734716
    • Katakura T, Miyazaki M, Kobayashi M, et al. CCL17 and IL-10 as effectors that enable alternatively activated macrophages to inhibit the generation of classically activated macrophages. J Immunol. 2004;172(3):1407–13.
    • (2004) J Immunol , vol.172 , Issue.3 , pp. 1407-1413
    • Katakura, T.1    Miyazaki, M.2    Kobayashi, M.3
  • 115
    • 0035313447 scopus 로고    scopus 로고
    • Regulatory activity of autocrine IL-10 on dendritic cell functions
    • COI: 1:CAS:528:DC%2BD3MXit1Oksb4%3D, PID: 11254683
    • Corinti S, Albanesi C, la Sala A, et al. Regulatory activity of autocrine IL-10 on dendritic cell functions. J Immunol. 2001;166(7):4312–8.
    • (2001) J Immunol , vol.166 , Issue.7 , pp. 4312-4318
    • Corinti, S.1    Albanesi, C.2    la Sala, A.3
  • 116
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • COI: 1:CAS:528:DC%2BD38XosFCnsQ%3D%3D, PID: 11805149
    • McGuirk P, McCann C, Mills KH. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J Exp Med. 2002;195(2):221–31.
    • (2002) J Exp Med , vol.195 , Issue.2 , pp. 221-231
    • McGuirk, P.1    McCann, C.2    Mills, K.H.3
  • 117
    • 20844443715 scopus 로고    scopus 로고
    • Immunomodulatory dendritic cells in intestinal lamina propria
    • COI: 1:CAS:528:DC%2BD2MXls1GqtLY%3D, PID: 16010704
    • Chirdo FG, Millington OR, Beacock-Sharp H, et al. Immunomodulatory dendritic cells in intestinal lamina propria. Eur J Immunol. 2005;35(6):1831–40.
    • (2005) Eur J Immunol , vol.35 , Issue.6 , pp. 1831-1840
    • Chirdo, F.G.1    Millington, O.R.2    Beacock-Sharp, H.3
  • 118
    • 0031157030 scopus 로고    scopus 로고
    • Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice
    • COI: 1:CAS:528:DyaK2sXjtl2mtrY%3D, PID: 9164955
    • Romani L, Mencacci A, Cenci E, et al. Neutrophil production of IL-12 and IL-10 in candidiasis and efficacy of IL-12 therapy in neutropenic mice. J Immunol. 1997;158(11):5349–56.
    • (1997) J Immunol , vol.158 , Issue.11 , pp. 5349-5356
    • Romani, L.1    Mencacci, A.2    Cenci, E.3
  • 119
    • 0035879238 scopus 로고    scopus 로고
    • Human eosinophils and human high affinity IgE receptor transgenic mouse eosinophils express low levels of high affinity IgE receptor, but release IL-10 upon receptor activation
    • COI: 1:CAS:528:DC%2BD3MXotFWktLg%3D, PID: 11441108
    • Kayaba H, Dombrowicz D, Woerly G, et al. Human eosinophils and human high affinity IgE receptor transgenic mouse eosinophils express low levels of high affinity IgE receptor, but release IL-10 upon receptor activation. J Immunol. 2001;167(2):995–1003.
    • (2001) J Immunol , vol.167 , Issue.2 , pp. 995-1003
    • Kayaba, H.1    Dombrowicz, D.2    Woerly, G.3
  • 120
    • 17144383927 scopus 로고    scopus 로고
    • Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria
    • COI: 1:CAS:528:DC%2BD2MXjvV2qt78%3D, PID: 15825073
    • Kim SC, Tonkonogy SL, Albright CA, et al. Variable phenotypes of enterocolitis in interleukin 10-deficient mice monoassociated with two different commensal bacteria. Gastroenterology. 2005;128(4):891–906.
    • (2005) Gastroenterology , vol.128 , Issue.4 , pp. 891-906
    • Kim, S.C.1    Tonkonogy, S.L.2    Albright, C.A.3
  • 121
    • 0344665570 scopus 로고    scopus 로고
    • Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice
    • COI: 1:CAS:528:DC%2BD2cXhtlSgtw%3D%3D, PID: 14633949
    • Hoentjen F, Harmsen HJ, Braat H, et al. Antibiotics with a selective aerobic or anaerobic spectrum have different therapeutic activities in various regions of the colon in interleukin 10 gene deficient mice. Gut. 2003;52(12):1721–7.
    • (2003) Gut , vol.52 , Issue.12 , pp. 1721-1727
    • Hoentjen, F.1    Harmsen, H.J.2    Braat, H.3
  • 122
    • 0034116557 scopus 로고    scopus 로고
    • Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice
    • COI: 1:CAS:528:DC%2BD3cXktlaiurk%3D, PID: 10833484
    • Madsen KL, Doyle JS, Tavernini MM, et al. Antibiotic therapy attenuates colitis in interleukin 10 gene-deficient mice. Gastroenterology. 2000;118(6):1094–105.
    • (2000) Gastroenterology , vol.118 , Issue.6 , pp. 1094-1105
    • Madsen, K.L.1    Doyle, J.S.2    Tavernini, M.M.3
  • 123
    • 0036087411 scopus 로고    scopus 로고
    • Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice
    • COI: 1:CAS:528:DC%2BD38XltFOrsb4%3D, PID: 12057927
    • Balish E, Warner T. Enterococcus faecalis induces inflammatory bowel disease in interleukin-10 knockout mice. Am J Pathol. 2002;160(6):2253–7.
    • (2002) Am J Pathol , vol.160 , Issue.6 , pp. 2253-2257
    • Balish, E.1    Warner, T.2
  • 124
    • 55049111426 scopus 로고    scopus 로고
    • Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility
    • COI: 1:CAS:528:DC%2BD1cXhtlSkurjI, PID: 18836448
    • Franke A, Balschun T, Karlsen TH, et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet. 2008;40(11):1319–23.
    • (2008) Nat Genet , vol.40 , Issue.11 , pp. 1319-1323
    • Franke, A.1    Balschun, T.2    Karlsen, T.H.3
  • 125
    • 84882683958 scopus 로고    scopus 로고
    • The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3
    • COI: 1:CAS:528:DC%2BC3sXhtlCnsrbE, PID: 23973223
    • Chen Z, Barbi J, Bu S, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 2013;39(2):272–85.
    • (2013) Immunity , vol.39 , Issue.2 , pp. 272-285
    • Chen, Z.1    Barbi, J.2    Bu, S.3
  • 126
    • 84896704750 scopus 로고    scopus 로고
    • Homeostatic control of regulatory T cell diversity
    • COI: 1:CAS:528:DC%2BC2cXhs1Smtb4%3D, PID: 24481337
    • Liston A, Gray DH. Homeostatic control of regulatory T cell diversity. Nat Rev Immunol. 2014;14(3):154–65.
    • (2014) Nat Rev Immunol , vol.14 , Issue.3 , pp. 154-165
    • Liston, A.1    Gray, D.H.2
  • 127
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • COI: 1:CAS:528:DC%2BD1cXntFaltrg%3D, PID: 18510923
    • Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell. 2008;133(5):775–87.
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3
  • 128
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: critical proteins linking innate and acquired immunity
    • COI: 1:CAS:528:DC%2BD3MXlslGjtLs%3D, PID: 11477402
    • Akira S, Takeda K, Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat Immunol. 2001;2(8):675–80.
    • (2001) Nat Immunol , vol.2 , Issue.8 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 129
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • COI: 1:CAS:528:DC%2BD38XlvF2qu74%3D, PID: 11905821
    • Medzhitov R. Toll-like receptors and innate immunity. Nat Rev Immunol. 2001;1(2):135–45.
    • (2001) Nat Rev Immunol , vol.1 , Issue.2 , pp. 135-145
    • Medzhitov, R.1
  • 130
    • 33751563152 scopus 로고    scopus 로고
    • Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals
    • COI: 1:CAS:528:DC%2BD28Xht1WrsL7P, PID: 17114424
    • Boonstra A, Rajsbaum R, Holman M, et al. Macrophages and myeloid dendritic cells, but not plasmacytoid dendritic cells, produce IL-10 in response to MyD88- and TRIF-dependent TLR signals, and TLR-independent signals. J Immunol. 2006;177(11):7551–8.
    • (2006) J Immunol , vol.177 , Issue.11 , pp. 7551-7558
    • Boonstra, A.1    Rajsbaum, R.2    Holman, M.3
  • 131
    • 0026094306 scopus 로고
    • Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B, et al. Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med. 1991;174(5):1209–20.
    • (1991) J Exp Med , vol.174 , Issue.5 , pp. 1209-1220
    • de Waal, M.R.1    Abrams, J.2    Bennett, B.3
  • 132
    • 33845574337 scopus 로고    scopus 로고
    • Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    • COI: 1:CAS:528:DC%2BD28XhtlCnsrzP, PID: 17111348
    • Siewe L, Bollati-Fogolin M, Wickenhauser C, et al. Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA. Eur J Immunol. 2006;36(12):3248–55.
    • (2006) Eur J Immunol , vol.36 , Issue.12 , pp. 3248-3255
    • Siewe, L.1    Bollati-Fogolin, M.2    Wickenhauser, C.3
  • 133
    • 1842477227 scopus 로고    scopus 로고
    • A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells
    • COI: 1:CAS:528:DC%2BD2cXivVSiur0%3D, PID: 15067049
    • Dillon S, Agrawal A, Van Dyke T, et al. A Toll-like receptor 2 ligand stimulates Th2 responses in vivo, via induction of extracellular signal-regulated kinase mitogen-activated protein kinase and c-Fos in dendritic cells. J Immunol. 2004;172(8):4733–43.
    • (2004) J Immunol , vol.172 , Issue.8 , pp. 4733-4743
    • Dillon, S.1    Agrawal, A.2    Van Dyke, T.3
  • 134
    • 77953644572 scopus 로고    scopus 로고
    • An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation
    • COI: 1:CAS:528:DC%2BC3cXmvFejs74%3D, PID: 20483766
    • Platt AM, Bain CC, Bordon Y, et al. An independent subset of TLR expressing CCR2-dependent macrophages promotes colonic inflammation. J Immunol. 2010;184(12):6843–54.
    • (2010) J Immunol , vol.184 , Issue.12 , pp. 6843-6854
    • Platt, A.M.1    Bain, C.C.2    Bordon, Y.3
  • 135
    • 80054882496 scopus 로고    scopus 로고
    • Mucosal macrophages in intestinal homeostasis and inflammation
    • PID: 22025201
    • Mowat AM, Bain CC. Mucosal macrophages in intestinal homeostasis and inflammation. J Innate Immun. 2011;3(6):550–64.
    • (2011) J Innate Immun , vol.3 , Issue.6 , pp. 550-564
    • Mowat, A.M.1    Bain, C.C.2
  • 136
    • 13744256812 scopus 로고    scopus 로고
    • Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
    • COI: 1:CAS:528:DC%2BD2MXis1eksQ%3D%3D, PID: 15630445
    • Smythies LE, Sellers M, Clements RH, et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J Clin Investig. 2005;115(1):66–75.
    • (2005) J Clin Investig , vol.115 , Issue.1 , pp. 66-75
    • Smythies, L.E.1    Sellers, M.2    Clements, R.H.3
  • 137
    • 0029056024 scopus 로고
    • Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis
    • COI: 1:STN:280:DyaK2M3mt1artQ%3D%3D, PID: 7538056
    • Grimm MC, Pavli P, Van de Pol E, et al. Evidence for a CD14+ population of monocytes in inflammatory bowel disease mucosa—implications for pathogenesis. Clin Exp Immunol. 1995;100(2):291–7.
    • (1995) Clin Exp Immunol , vol.100 , Issue.2 , pp. 291-297
    • Grimm, M.C.1    Pavli, P.2    Van de Pol, E.3
  • 138
    • 0035451799 scopus 로고    scopus 로고
    • Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities
    • COI: 1:CAS:528:DC%2BD3MXmtlSjt7o%3D, PID: 11509607
    • Smith PD, Smythies LE, Mosteller-Barnum M, et al. Intestinal macrophages lack CD14 and CD89 and consequently are down-regulated for LPS- and IgA-mediated activities. J Immunol. 2001;167(5):2651–6.
    • (2001) J Immunol , vol.167 , Issue.5 , pp. 2651-2656
    • Smith, P.D.1    Smythies, L.E.2    Mosteller-Barnum, M.3
  • 139
    • 45749107055 scopus 로고    scopus 로고
    • + intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
    • COI: 1:CAS:528:DC%2BD1cXntVClsr4%3D, PID: 18497880
    • + intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis. J Clin Investig. 2008;118(6):2269–80.
    • (2008) J Clin Investig , vol.118 , Issue.6 , pp. 2269-2280
    • Kamada, N.1    Hisamatsu, T.2    Okamoto, S.3
  • 140
    • 56549104968 scopus 로고    scopus 로고
    • IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease
    • COI: 1:CAS:528:DC%2BD1cXhsFCrsrnN, PID: 18653729
    • Kobayashi T, Okamoto S, Hisamatsu T, et al. IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease. Gut. 2008;57(12):1682–9.
    • (2008) Gut , vol.57 , Issue.12 , pp. 1682-1689
    • Kobayashi, T.1    Okamoto, S.2    Hisamatsu, T.3
  • 141
    • 84920541630 scopus 로고    scopus 로고
    • Fecal microbiota transplantation for gastrointestinal diseases
    • PID: 25500625
    • Matsuoka K, Mizuno S, Hayashi A, et al. Fecal microbiota transplantation for gastrointestinal diseases. Keio J Med. 2014;63(4):69–74.
    • (2014) Keio J Med , vol.63 , Issue.4 , pp. 69-74
    • Matsuoka, K.1    Mizuno, S.2    Hayashi, A.3
  • 142
    • 2442453484 scopus 로고    scopus 로고
    • Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics
    • PID: 15168372
    • Sartor RB. Therapeutic manipulation of the enteric microflora in inflammatory bowel diseases: antibiotics, probiotics, and prebiotics. Gastroenterology. 2004;126(6):1620–33.
    • (2004) Gastroenterology , vol.126 , Issue.6 , pp. 1620-1633
    • Sartor, R.B.1
  • 143
    • 84873019302 scopus 로고    scopus 로고
    • Duodenal infusion of donor feces for recurrent Clostridium difficile
    • PID: 23323867
    • van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile. N Engl J Med. 2013;368(5):407–15.
    • (2013) N Engl J Med , vol.368 , Issue.5 , pp. 407-415
    • van Nood, E.1    Vrieze, A.2    Nieuwdorp, M.3


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