Immunomodulatory dendritic cells in intestinal lamina propria

European Journal of Immunology

Volumn 35, Issue 6, 2005, Pages 1831-1840

  Chirdo, Fernando G ^a,b   Millington, Owain R ^a   Beacock Sharp, Helen ^a,c   Mowat, Allan McI ^a  

^a WESTERN INFIRMARY   (United Kingdom)

^b FACULTAD DE CIENCIAS EXACTAS   (Argentina)

^c Celldex Therapeutics Inc   (United Kingdom)

Author keywords

Dendritic cells; Intestinal mucosa; Lamina propria; Oral tolerance

Indexed keywords

ANTIGEN; B7 ANTIGEN; CD11B ANTIGEN; CD4 ANTIGEN; CD40 ANTIGEN; CD45 ANTIGEN; CD86 ANTIGEN; CD8ALPHA ANTIGEN; GLYCOPROTEIN P 15095; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; OVALBUMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; CELL POPULATION; CELL SELECTION; CONTROLLED STUDY; DENDRITIC CELL; ENDOCYTOSIS; ENZYME ACTIVATION; FEMALE; IMMUNOMODULATION; IMMUNOREGULATION; IN VITRO STUDY; IN VIVO STUDY; LAMINA PROPRIA; MAGNETISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECIPIENT; SMALL INTESTINE; UPREGULATION;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD11B; ANTIGENS, CD11C; CYTOKINES; DENDRITIC CELLS; FEMALE; IMMUNOPHENOTYPING; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OVALBUMIN;

EID: 20844443715     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200425882     Document Type: Article

References (36)

1. Mowat, A. McI., Oral tolerance; Physiology and Clinical Implications. Curr. Opin. Gastroenterol. 1999. 15: 546-556.
2. Faria, A. M. C. and Weiner, H. L., Oral tolerance: mechanisms and therapeutic applications. Adv. Immunol. 1999. 73: 153-264.
3. Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. and Amigorena, S., Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 2002. 20: 621-667.
4. Viney, J. L., Mowat, A. McI., O'Malley, J. M., Williamson, E. and Fanger, N., Expanding dendritic cells in vivo enhances the induction of oral tolerance. J. Immunol. 1998. 160: 5815-5825.
5. Mowat, A. McI., Anatomical basis of tolerance and immunity to intestinal antigens. Nat. Rev. Immunol. 2003. 3: 331-341.
6. + dendritic cell population in mouse Peyer's patches. Eur. J. Immunol. 1996. 26: 1801-1806.
7. Spahn, T. W., Weiner, H. L., Rennert, P. D., Lugering, N., Fontana, A., Domschke, W. and Kucharzik, T., Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches. Eur. J. Immunol. 2002. 32: 1109-1113.
8. Spahn, T. W., Fontana, A., Faria, A. M., Slavin, A. J., Eugster, H. P., Zhang, X., Koni, P. A., Ruddle, N. H., Flavell, R. A., Rennert, P. D. and Weiner, H. L., Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur. J. Immunol. 2001. 31: 1278-1287.
9. Alpan, O., Rudomen, G. and Matzinger, P., The role of dendritic cells, B cells and M cells in gut-oriented immune responses. J. Immunol. 2001. 166: 4843-4852.
10. Fujihashi, K., Dohi, T., Rennert, P. D., Yamamoto, M., Koga, Y., Kiyono, H. and McGhee, J. R., Peyer's patches are required for oral tolerance to proteins. Proc. Natl. Acad. Sci. USA 2001. 98: 3310-3315.
11. Zimmer, K. P., Buning, J., Weber, P., Kaiserlian, D. and Strobel, S., Modulation of antigen trafficking to MHC class II-positive late endosomes of enterocytes. Gastroenterology 2000. 118: 128-137.
12. Mayrhofer, G., Pugh, C. W. and Barclay, A. N., The distribution, ontogeny and origin in the rat of Ia-positive cells with dendritic morphology and of Ia antigen in epithelia, with special reference to the intestine. Eur. J. Immunol. 1983. 13: 112-122.
13. Maric, I., Holt, P. G., Perdue, M. H. and Bienenstock, J., Class II MHC antigen (Ia)-bearing dendritic cells in the epithelium of the rat intestine. J. Immunol. 1996. 156: 1408-1414.
14. Iwasaki, A. and Kelsall, B. L., Freshly isolated Peyer's patch, but not spleen, dendritic cells produce interleukin 10 and induce the differentiation of T helper type 2 cells. J. Exp. Med. 1999. 190: 229-239.
15. + and double negative Peyer's patch dendritic cells. J. Immunol. 2001. 166: 4884-4890.
16. + T cells in vivo. J. Immunol. 1995. 154: 5684-5693.
17. Harper, H., Cochrane, L. and Williams, N. A., The role of small intestinal antigen-presenting cells in the induction of T cell reactivity to soluble protein antigens: association between aberrant presentation in the lamina propria and oral tolerance. Immunology 1996. 89: 449-456.
18. Becker, C., Wirtz, S., Blessing, M., Pirhonen, J., Strand, D., Bechthold, O., Frick, J., Galle, P. R., Autenrieth, I. and Neurath, M. F., Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J. Clin. Invest. 2003. 112: 693-706.
19. Wakkach, A., Fournier, N., Brun, V., Breittmayer, J. P., Cottrez, F. and Groux, H., Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo. Immunity 2003. 18: 605-617.
20. O'Keeffe, M., Hochrein, H., Vremec, D., Caminschi, I., Miller, J. L., Anders, E. M., Wu, L., Lahoud, M. H., Henri, S., Scott, B., Hertzog, P., Tatarczuch, L. and Shortman, K., Mouse plasmacytoid cells: long-lived cells, heterogeneous in surface phenotype and function, that differentiate into CD8(+) dendritic cells only after microbial stimulus. J. Exp. Med. 2002. 196: 1307-1319.
21. Kelsall, B. L. and Rescigno, M., Mucosal dendritic cells in immunity and inflammation. Nat. Immunol. 2004. 5: 1091-1095.
22. + DC, with a plasmacytoid phenotype, induce differentiation and support function of T cells with regulatory properties. Immunology 2003. 108: 481-492.
23. Bell, S. J., Rigby, R., English, N., Mann, S. D., Knight, S. C., Kamm, M. A. and Stagg, A. J., Migration and maturation of human colonic dendritic cells. J. Immunol. 2001. 166: 4958-4967.
24. + dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 2002. 100: 383-390.
25. + T cell subset inhibits antigen-specific T cell responses and prevents colitis. Nature 1997. 389: 737-742.
26. Moser, M., Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity 2003. 19: 5-8.
27. Williamson, E., Westrich, G. M. and Viney, J. L., Modulating dendritic cells to optimize mucosal immunization protocols. J. Immunol. 1999. 163: 3668-3675.
28. Williamson, E., Bilsborough, J. M. and Viney, J. L., Regulation of mucosal dendritic cell function by receptor activator of NF-κ B (RANK)/RANK ligand interactions: impact on tolerance induction. J. Immunol. 2002. 169: 3606-3612.
29. Alpan, O., Bachelder, E., Isil, E., Arnheiter, H. and Matzinger, P., 'Educated' dendritic cells act as messengers from memory to naive T helper cells. Nat. Immunol. 2004. 5: 615-622.
30. Bilsborough, J. and Viney, J. L., Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology 2004. 127: 300-309.
31. Akbari, O., DeKruyff, R. H. and Umetsu, D. T., Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2001. 2: 725-731.
32. Liu, L. and MacPherson, G., Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 1993. 177: 1299-1307
33. Scheinecker, C., McHugh, R., Shevach, E. M. and Germain, R. N., Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med. 2002. 196: 1079-1090.
34. Wilson, N. S., El-Sukkari, D., Belz, G. T., Smith, C. M., Steptoe, R. J., Heath, W. R., Shortman, K. and Villadangos, J. A., Most lymphoid organ dendritic cell types are phenotypically and functionally immature. Blood 2003. 103: 2187-2195.
35. Carbone, F. R., Belz, G. T. and Heath, W. R., Transfer of antigen between migrating and lymph node-resident DCs in peripheral T cell tolerance and immunity. Trends Immunol. 2004. 25: 655-658.
36. Garside, P., Steel, M., Worthey, E. A., Satoskar, A., Alexander, J., Bluethmann, H., Liew, F. Y. and Mowat, A. McI., Th2 cells are subject to high dose oral tolerance and are not essential for its induction. J. Immunol. 1995. 154: 5649-5655.