메뉴 건너뛰기




Volumn 10, Issue 9, 2015, Pages 741-747

Designing DNA nanodevices for compatibility with the immune system of higher organisms

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL SYSTEMS; IMMUNE SYSTEM; NANOSTRUCTURED MATERIALS; NUCLEIC ACIDS;

EID: 84941137774     PISSN: 17483387     EISSN: 17483395     Source Type: Journal    
DOI: 10.1038/nnano.2015.180     Document Type: Review
Times cited : (190)

References (102)
  • 1
    • 84923309112 scopus 로고    scopus 로고
    • Programmable materials and the nature of the DNA bond
    • Jones, M. R.; Seeman, N. C. and Mirkin, C. A. Programmable materials and the nature of the DNA bond. Science 347, 1260901 (2015). We recommend this paper as an introduction to advances in DNA nanotechnology
    • (2015) Science , vol.347 , pp. 1260901
    • Jones, M.R.1    Seeman, N.C.2    Mirkin, C.A.3
  • 2
    • 84869865149 scopus 로고    scopus 로고
    • Designer nucleic acids to probe and program the cell
    • Krishnan, Y. and Bathe, M. Designer nucleic acids to probe and program the cell. Trends Cell Biol. 22, 624-633 (2012)
    • (2012) Trends Cell Biol. , vol.22 , pp. 624-633
    • Krishnan, Y.1    Bathe, M.2
  • 3
    • 84872268888 scopus 로고    scopus 로고
    • Nucleic acid modifications with epigenetic significance
    • Fu, Y. and He, C. Nucleic acid modifications with epigenetic significance. Curr. Opin. Chem. Biol. 16, 516-524 (2012)
    • (2012) Curr. Opin. Chem. Biol. , vol.16 , pp. 516-524
    • Fu, Y.1    He, C.2
  • 5
    • 0027324744 scopus 로고
    • Biology of DNA restriction
    • Bickle, T. A. and Krüger, D. H. Biology of DNA restriction. Microbiol. Rev. 57, 434-450 (1993)
    • (1993) Microbiol. Rev. , vol.57 , pp. 434-450
    • Bickle, T.A.1    Krüger, D.H.2
  • 6
    • 84877304698 scopus 로고    scopus 로고
    • Comparative genomics of defense systems in archaea and bacteria
    • Makarova, K. S.; Wolf, Y. I. and Koonin, E. V. Comparative genomics of defense systems in archaea and bacteria. Nucleic Acids Res. 41, 4360-4377 (2013)
    • (2013) Nucleic Acids Res. , vol.41 , pp. 4360-4377
    • Makarova, K.S.1    Wolf, Y.I.2    Koonin, E.V.3
  • 7
    • 75149133614 scopus 로고    scopus 로고
    • Chitosan-based formulations for delivery of DNA and siRNA
    • Mao, S.; Sun, W. and Kissel, T. Chitosan-based formulations for delivery of DNA and siRNA. Adv. Drug Deliv. Rev. 62, 12-27 (2010)
    • (2010) Adv. Drug Deliv. Rev. , vol.62 , pp. 12-27
    • Mao, S.1    Sun, W.2    Kissel, T.3
  • 8
    • 84891712597 scopus 로고    scopus 로고
    • V-shaped dinuclear Pt(II) complexes: Selective interaction with human telomeric G-quadruplex and significant inhibition towards telomerase
    • Xu, C.-X. et al. V-shaped dinuclear Pt(II) complexes: selective interaction with human telomeric G-quadruplex and significant inhibition towards telomerase. Sci. Rep. 3, 2060 (2013)
    • (2013) Sci. Rep. , vol.3 , pp. 2060
    • Xu, C.-X.1
  • 11
    • 33645028600 scopus 로고    scopus 로고
    • Folding DNA to create nanoscale shapes and patterns
    • Rothemund, P. W. K. Folding DNA to create nanoscale shapes and patterns. Nature 440, 297-302 (2006)
    • (2006) Nature , vol.440 , pp. 297-302
    • Rothemund, P.W.K.1
  • 12
    • 74249095519 scopus 로고    scopus 로고
    • CRISPR/Cas, the immune system of bacteria and archaea
    • Horvath, P. and Barrangou, R. CRISPR/Cas, the immune system of bacteria and archaea. Science 327, 167-70 (2010)
    • (2010) Science , vol.327 , pp. 167-170
    • Horvath, P.1    Barrangou, R.2
  • 14
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu, J. and Chen, Z. J. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32, 461-488 (2014). References 13 and 14 provide an overview of the mechanisms of detection of nucleic acids and related immune responses
    • (2014) Annu. Rev. Immunol , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 15
    • 84893075305 scopus 로고    scopus 로고
    • Regulation of type i interferon responses
    • Ivashkiv, L. B. and Donlin, L. T. Regulation of type I interferon responses. Nature Rev. Immunol. 14, 36-49 (2014)
    • (2014) Nature Rev. Immunol. , vol.14 , pp. 36-49
    • Ivashkiv, L.B.1    Donlin, L.T.2
  • 16
    • 84920072385 scopus 로고    scopus 로고
    • Antimicrobial inflammasomes: Unified signalling against diverse bacterial pathogens
    • Eldridge, M. J. and Shenoy, A. R. Antimicrobial inflammasomes: unified signalling against diverse bacterial pathogens. Curr. Opin. Microbiol. 23, 32-41 (2015)
    • (2015) Curr. Opin. Microbiol. , vol.23 , pp. 32-41
    • Eldridge, M.J.1    Shenoy, A.R.2
  • 17
    • 84924651472 scopus 로고    scopus 로고
    • Inflammasome control of viral infection
    • Lupfer, C.; Malik, A. and Kanneganti, T.-D. Inflammasome control of viral infection. Curr. Opin. Virol. 12, 38-46 (2015). Host responses to nucleic acids via the interferon and caspase-1 inflammasome pathways are summarized in refs 15-17
    • (2015) Curr. Opin. Virol , vol.12 , pp. 38-46
    • Lupfer, C.1    Malik, A.2    Kanneganti, T.-D.3
  • 18
    • 84862855875 scopus 로고    scopus 로고
    • Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination
    • Desmet, C. J. and Ishii, K. J. Nucleic acid sensing at the interface between innate and adaptive immunity in vaccination. Nature Rev. Immunol. 12, 479-491 (2012)
    • (2012) Nature Rev. Immunol. , vol.12 , pp. 479-491
    • Desmet, C.J.1    Ishii, K.J.2
  • 21
    • 84871218439 scopus 로고    scopus 로고
    • STING and the innate immune response to nucleic acids in the cytosol
    • Burdette, D. L. and Vance, R. E. STING and the innate immune response to nucleic acids in the cytosol. Nature Immunol. 14, 19-26 (2013)
    • (2013) Nature Immunol. , vol.14 , pp. 19-26
    • Burdette, D.L.1    Vance, R.E.2
  • 22
    • 84873711885 scopus 로고    scopus 로고
    • Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type i interferon pathway
    • Sun, L.; Wu, J.; Du, F.; Chen, X. and Chen, Z. J. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339, 786-791 (2013)
    • (2013) Science , vol.339 , pp. 786-791
    • Sun, L.1    Wu, J.2    Du, F.3    Chen, X.4    Chen, Z.J.5
  • 23
    • 84879385334 scopus 로고    scopus 로고
    • CGAS produces a 2-5-linked cyclic dinucleotide second messenger that activates STING
    • Ablasser, A. et al. cGAS produces a 2-5-linked cyclic dinucleotide second messenger that activates STING. Nature 498, 380-384 (2013)
    • (2013) Nature , vol.498 , pp. 380-384
    • Ablasser, A.1
  • 24
    • 84893934506 scopus 로고    scopus 로고
    • Recognition of cytosolic DNA by cGAS and other STING-dependent sensors
    • Bhat, N. and Fitzgerald, K. A. Recognition of cytosolic DNA by cGAS and other STING-dependent sensors. Eur. J. Immunol. 44, 634-640 (2014)
    • (2014) Eur. J. Immunol. , vol.44 , pp. 634-640
    • Bhat, N.1    Fitzgerald, K.A.2
  • 25
    • 68049092912 scopus 로고    scopus 로고
    • RNA polymerase III detects cytosolic DNA and induces type i interferons through the RIG-I pathway
    • Chiu, Y.-H.; Macmillan, J. B. and Chen, Z. J. RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway. Cell 138, 576-591 (2009)
    • (2009) Cell , vol.138 , pp. 576-591
    • Chiu, Y.-H.1    Macmillan, J.B.2    Chen, Z.J.3
  • 26
    • 77952566304 scopus 로고    scopus 로고
    • The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type i interferon via a-catenin-dependent pathway
    • Yang, P. et al. The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a ?-catenin-dependent pathway. Nature Immunol. 11, 487-494 (2010)
    • (2010) Nature Immunol. , vol.11 , pp. 487-494
    • Yang, P.1
  • 27
    • 48549083482 scopus 로고    scopus 로고
    • The sweetness of the DNA backbone drives Toll-like receptor 9
    • Wagner, H. The sweetness of the DNA backbone drives Toll-like receptor 9. Curr. Opin. Immunol. 20, 396-400 (2008)
    • (2008) Curr. Opin. Immunol. , vol.20 , pp. 396-400
    • Wagner, H.1
  • 28
    • 33745946911 scopus 로고    scopus 로고
    • Therapeutic potential of Toll-like receptor 9 activation
    • Krieg, A. M. Therapeutic potential of Toll-like receptor 9 activation. Nature Rev. Drug Discov. 5, 471-484 (2006). Molecular determinants of TLR9-activating dsDNA and their potential application in vaccine design are discussed in refs 27 and 28
    • (2006) Nature Rev. Drug Discov , vol.5 , pp. 471-484
    • Krieg, A.M.1
  • 29
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin, T. et al. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36, 561-571 (2012)
    • (2012) Immunity , vol.36 , pp. 561-571
    • Jin, T.1
  • 30
    • 84884333427 scopus 로고    scopus 로고
    • Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing
    • Gehrke, N. et al. Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing. Immunity 39, 482-495 (2013)
    • (2013) Immunity , vol.39 , pp. 482-495
    • Gehrke, N.1
  • 31
    • 48749085127 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
    • Gilliet, M.; Cao, W. and Liu, Y.-J. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nature Rev. Immunol. 8, 594-606 (2008)
    • (2008) Nature Rev. Immunol. , vol.8 , pp. 594-606
    • Gilliet, M.1    Cao, W.2    Liu, Y.-J.3
  • 32
    • 84885169498 scopus 로고    scopus 로고
    • Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses
    • Huang, L. et al. Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses. J. Immunol. 191, 3509-3513 (2013)
    • (2013) J. Immunol. , vol.191 , pp. 3509-3513
    • Huang, L.1
  • 33
    • 84961288005 scopus 로고    scopus 로고
    • Immunomodulatory spherical nucleic acids
    • Radovic-Moreno, A. F. et al. Immunomodulatory spherical nucleic acids. Proc. Natl Acad. Sci. USA 112, 3892-3897 (2015)
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 3892-3897
    • Radovic-Moreno, A.F.1
  • 34
    • 17644393549 scopus 로고    scopus 로고
    • DNA degradation in development and programmed cell death
    • Nagata, S. DNA degradation in development and programmed cell death. Annu. Rev. Immunol. 23, 853-875 (2005)
    • (2005) Annu. Rev. Immunol. , vol.23 , pp. 853-875
    • Nagata, S.1
  • 35
    • 84874223452 scopus 로고    scopus 로고
    • Molecular basis of DNA recognition in the immune system
    • Atianand, M. K. and Fitzgerald, K. A. Molecular basis of DNA recognition in the immune system. J. Immunol. 190, 1911-1918 (2013)
    • (2013) J. Immunol. , vol.190 , pp. 1911-1918
    • Atianand, M.K.1    Fitzgerald, K.A.2
  • 36
    • 34548327158 scopus 로고    scopus 로고
    • Mutations in the gene encoding the 3-5? DNA exonuclease TREX1 are associated with systemic lupus erythematosus
    • Lee-Kirsch, M. A. et al. Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 are associated with systemic lupus erythematosus. Nature Genet. 39, 1065-1067 (2007)
    • (2007) Nature Genet. , vol.39 , pp. 1065-1067
    • Lee-Kirsch, M.A.1
  • 37
    • 33746581694 scopus 로고    scopus 로고
    • Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus
    • Crow, Y. J. et al. Mutations in the gene encoding the 3?-5? DNA exonuclease TREX1 cause Aicardi-Goutieres syndrome at the AGS1 locus. Nature Genet. 38, 917-920 (2006)
    • (2006) Nature Genet. , vol.38 , pp. 917-920
    • Crow, Y.J.1
  • 38
    • 33750465224 scopus 로고    scopus 로고
    • Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages
    • Kawane, K. et al. Chronic polyarthritis caused by mammalian DNA that escapes from degradation in macrophages. Nature 443, 998-1002 (2006)
    • (2006) Nature , vol.443 , pp. 998-1002
    • Kawane, K.1
  • 39
    • 84856301080 scopus 로고    scopus 로고
    • Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease
    • Gall, A. et al. Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36, 120-131 (2012)
    • (2012) Immunity , vol.36 , pp. 120-131
    • Gall, A.1
  • 40
    • 49549100511 scopus 로고    scopus 로고
    • Trex1 prevents cell-intrinsic initiation of autoimmunity
    • The importance of DNAses in preventing systemic inflammation is discussed in this study
    • Stetson, D. B.; Ko, J. S.; Heidmann, T. and Medzhitov, R. Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell 134, 587-598 (2008). The importance of DNAses in preventing systemic inflammation is discussed in this study
    • (2008) Cell , vol.134 , pp. 587-598
    • Stetson, D.B.1    Ko, J.S.2    Heidmann, T.3    Medzhitov, R.4
  • 41
    • 0019797317 scopus 로고
    • Serum deoxyribonuclease i and clinical activity in systemic lupus erythematosus
    • Chitrabamrung, S.; Rubin, R. L. and Tan, E. M. Serum deoxyribonuclease I and clinical activity in systemic lupus erythematosus. Rheumatol. Int. 1, 55-60 (1981)
    • (1981) Rheumatol. Int. , vol.1 , pp. 55-60
    • Chitrabamrung, S.1    Rubin, R.L.2    Tan, E.M.3
  • 43
    • 12344290452 scopus 로고    scopus 로고
    • Lethal anemia caused by interferon-? Produced in mouse embryos carrying undigested DNA.
    • Yoshida, H.; Okabe, Y.; Kawane, K.; Fukuyama, H. and Nagata, S. Lethal anemia caused by interferon-? produced in mouse embryos carrying undigested DNA. Nature Immunol. 6, 49-56 (2005).
    • (2005) Nature Immunol. , vol.6 , pp. 49-56
    • Yoshida, H.1    Okabe, Y.2    Kawane, K.3    Fukuyama, H.4    Nagata, S.5
  • 44
    • 84869794842 scopus 로고    scopus 로고
    • STING manifests self DNA-dependent inflammatory disease.
    • Ahn, J.; Gutman, D.; Saijo, S. and Barber, G. N. STING manifests self DNA-dependent inflammatory disease. Proc. Natl Acad. Sci. USA 109, 19386-19391 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 19386-19391
    • Ahn, J.1    Gutman, D.2    Saijo, S.3    Barber, G.N.4
  • 45
    • 79958259512 scopus 로고    scopus 로고
    • A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging
    • he first description of tissue-specific cargo delivery in vivo using a DNA nanodevice.
    • Bhatia, D.; Surana, S.; Chakraborty, S.; Koushika, S. P. and Krishnan, Y. A synthetic icosahedral DNA-based host-cargo complex for functional in vivo imaging. Nature Commun. 2, 339 (2011). The first description of tissue-specific cargo delivery in vivo using a DNA nanodevice.
    • (2011) Nature Commun. , vol.2 , pp. 339
    • Bhatia, D.1    Surana, S.2    Chakraborty, S.3    Koushika, S.P.4    Krishnan, Y.5
  • 46
    • 84863726330 scopus 로고    scopus 로고
    • Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery
    • This report describes a DNA nanodevice that delivers RNAi to tumours in vivo.
    • Lee, H. et al. Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery. Nature Nanotech. 7, 389-393 (2012). This report describes a DNA nanodevice that delivers RNAi to tumours in vivo.
    • (2012) Nature Nanotech , vol.7 , pp. 389-393
    • Lee, H.1
  • 47
    • 79958267629 scopus 로고    scopus 로고
    • An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism
    • The first designer DNA nanodevice that was delivered tissue-specifically in vivo where it functioned as a pH reporter.
    • Surana, S.; Bhat, J. M.; Koushika, S. P. and Krishnan, Y. An autonomous DNA nanomachine maps spatiotemporal pH changes in a multicellular living organism. Nature Commun. 2, 340 (2011). The first designer DNA nanodevice that was delivered tissue-specifically in vivo where it functioned as a pH reporter.
    • (2011) Nature Commun. , vol.2 , pp. 340
    • Surana, S.1    Bhat, J.M.2    Koushika, S.P.3    Krishnan, Y.4
  • 48
    • 84886307744 scopus 로고    scopus 로고
    • A method to study in vivo stability of DNA nanostructures.
    • Surana, S.; Bhatia, D. and Krishnan, Y. A method to study in vivo stability of DNA nanostructures. Methods 64, 94-100 (2013).
    • (2013) Methods , vol.64 , pp. 94-100
    • Surana, S.1    Bhatia, D.2    Krishnan, Y.3
  • 49
    • 0029818146 scopus 로고    scopus 로고
    • Folate receptors.
    • Antony, A. C. Folate receptors. Annu. Rev. Nutr. 16, 501-521 (1996).
    • (1996) Annu. Rev. Nutr. , vol.16 , pp. 501-521
    • Antony, A.C.1
  • 50
    • 84864702099 scopus 로고    scopus 로고
    • A DNA nanostructure platform for directed assembly of synthetic vaccines.
    • Liu, X. et al. A DNA nanostructure platform for directed assembly of synthetic vaccines. Nano Lett. 12, 4254-4259 (2012)
    • (2012) Nano Lett. , vol.12 , pp. 4254-4259
    • Liu, X.1
  • 51
    • 84880519156 scopus 로고    scopus 로고
    • Oral delivery of therapeutic proteins and peptides: A review on recent developments
    • Gupta, S. et al. Oral delivery of therapeutic proteins and peptides: a review on recent developments. Drug Deliv. 20, 237-246 (2013)
    • (2013) Drug Deliv. , vol.20 , pp. 237-246
    • Gupta, S.1
  • 52
    • 55949126429 scopus 로고    scopus 로고
    • Clearance properties of nano-sized particles and molecules as imaging agents: Considerations and caveats
    • Longmire, M.; Choyke, P. L. and Kobayashi, H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine 3, 703-717 (2008)
    • (2008) Nanomedicine , vol.3 , pp. 703-717
    • Longmire, M.1    Choyke, P.L.2    Kobayashi, H.3
  • 53
    • 77953916083 scopus 로고    scopus 로고
    • Potential of nanoparticulate drug delivery systems by intranasal administration
    • Ali, J. et al. Potential of nanoparticulate drug delivery systems by intranasal administration. Curr. Pharm. Des. 16, 1644-1653 (2010)
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 1644-1653
    • Ali, J.1
  • 54
    • 77949833508 scopus 로고    scopus 로고
    • Intranasal delivery to the central nervous system: Mechanisms and experimental considerations
    • Dhuria, S. V, Hanson, L. R. and Frey, W. H. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J. Pharm. Sci. 99, 1654-1673 (2010)
    • (2010) J. Pharm. Sci. , vol.99 , pp. 1654-1673
    • Dhuria, S.V.1    Hanson, L.R.2    Frey, W.H.3
  • 55
    • 84899998698 scopus 로고    scopus 로고
    • Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain
    • Harmon, B. T. et al. Intranasal administration of plasmid DNA nanoparticles yields successful transfection and expression of a reporter protein in rat brain. Gene Ther. 21, 514-521 (2014)
    • (2014) Gene Ther. , vol.21 , pp. 514-521
    • Harmon, B.T.1
  • 56
    • 70350733741 scopus 로고    scopus 로고
    • Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina
    • Ding, X.-Q. et al. Ocular delivery of compacted DNA-nanoparticles does not elicit toxicity in the mouse retina. PLoS One 4, e7410 (2009)
    • (2009) PLoS One , vol.4 , pp. e7410
    • Ding, X.-Q.1
  • 57
    • 34248570405 scopus 로고    scopus 로고
    • Efficient non-viral ocular gene transfer with compacted DNA nanoparticles
    • Farjo, R.; Skaggs, J.; Quiambao, A. B.; Cooper, M. J. and Naash, M. I. Efficient non-viral ocular gene transfer with compacted DNA nanoparticles. PLoS One 1, e38 (2006)
    • (2006) PLoS One , vol.1 , pp. e38
    • Farjo, R.1    Skaggs, J.2    Quiambao, A.B.3    Cooper, M.J.4    Naash, M.I.5
  • 58
    • 0347354994 scopus 로고    scopus 로고
    • Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo
    • Ziady, A.-G. et al. Transfection of airway epithelium by stable PEGylated poly-L-lysine DNA nanoparticles in vivo. Mol. Ther. 8, 936-947 (2003)
    • (2003) Mol. Ther. , vol.8 , pp. 936-947
    • Ziady, A.-G.1
  • 59
    • 80053009243 scopus 로고    scopus 로고
    • DNA nanoparticles: Detection of long-term transgene activity in brain using bioluminescence imaging
    • Yurek, D. M. et al. DNA nanoparticles: detection of long-term transgene activity in brain using bioluminescence imaging. Mol. Imaging 10, 327-339 (2011)
    • (2011) Mol. Imaging , vol.10 , pp. 327-339
    • Yurek, D.M.1
  • 60
    • 34447257278 scopus 로고    scopus 로고
    • Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery
    • Dai, H. et al. Chitosan-DNA nanoparticles delivered by intrabiliary infusion enhance liver-targeted gene delivery. Int. J. Nanomedicine 1, 507-522 (2006)
    • (2006) Int. J. Nanomedicine , vol.1 , pp. 507-522
    • Dai, H.1
  • 61
    • 84878526418 scopus 로고    scopus 로고
    • Endocytosis of gene delivery vectors: From clathrin-dependent to lipid raft-mediated endocytosis
    • El-Sayed, A. and Harashima, H. Endocytosis of gene delivery vectors: from clathrin-dependent to lipid raft-mediated endocytosis. Mol. Ther. 21, 1118-1130 (2013)
    • (2013) Mol. Ther. , vol.21 , pp. 1118-1130
    • El-Sayed, A.1    Harashima, H.2
  • 62
    • 84896091512 scopus 로고    scopus 로고
    • ERBB receptors: From oncogene discovery to basic science to mechanism-based cancer therapeutics
    • Arteaga, C. L. and Engelman, J. A. ERBB receptors: from oncogene discovery to basic science to mechanism-based cancer therapeutics. Cancer Cell 25, 282-303 (2014)
    • (2014) Cancer Cell , vol.25 , pp. 282-303
    • Arteaga, C.L.1    Engelman, J.A.2
  • 63
    • 84878944591 scopus 로고    scopus 로고
    • Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell
    • Modi, S.; Nizak, C.; Surana, S.; Halder, S. and Krishnan, Y. Two DNA nanomachines map pH changes along intersecting endocytic pathways inside the same cell. Nature Nanotech. 8, 459-467 (2013)
    • (2013) Nature Nanotech. , vol.8 , pp. 459-467
    • Modi, S.1    Nizak, C.2    Surana, S.3    Halder, S.4    Krishnan, Y.5
  • 64
    • 84944454004 scopus 로고    scopus 로고
    • A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells
    • Saha, S.; Prakash, V.; Halder, S.; Chakraborty, K. and Krishnan, Y. A pH-independent DNA nanodevice for quantifying chloride transport in organelles of living cells. Nature Nanotech. 10, 645-651 (2015)
    • (2015) Nature Nanotech. , vol.10 , pp. 645-651
    • Saha, S.1    Prakash, V.2    Halder, S.3    Chakraborty, K.4    Krishnan, Y.5
  • 65
    • 78649305928 scopus 로고    scopus 로고
    • Cationic liposome-nucleic acid complexes for gene delivery and silencing: Pathways and mechanisms for plasmid DNA and siRNA
    • Ewert, K. K. et al. Cationic liposome-nucleic acid complexes for gene delivery and silencing: pathways and mechanisms for plasmid DNA and siRNA. Top. Curr. Chem. 296, 191-226 (2010)
    • (2010) Top. Curr. Chem. , vol.296 , pp. 191-226
    • Ewert, K.K.1
  • 66
    • 77956304534 scopus 로고    scopus 로고
    • Macrophages recognize size and shape of their targets
    • Doshi, N. and Mitragotri, S. Macrophages recognize size and shape of their targets. PLoS One 5, e10051 (2010)
    • (2010) PLoS One , vol.5 , pp. e10051
    • Doshi, N.1    Mitragotri, S.2
  • 68
    • 70349783777 scopus 로고    scopus 로고
    • Icosahedral DNA nanocapsules by modular assembly
    • Bhatia, D. et al. Icosahedral DNA nanocapsules by modular assembly. Angew. Chem. Int. Ed. 48, 4134-4137 (2009)
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 4134-4137
    • Bhatia, D.1
  • 69
    • 0029261550 scopus 로고
    • Red blood cell magnesium concentrations: Analytical problems and significance
    • Millart, H.; Durlach, V. and Durlach, J. Red blood cell magnesium concentrations: analytical problems and significance. Magnes. Res. 8, 65-76 (1995)
    • (1995) Magnes. Res. , vol.8 , pp. 65-76
    • Millart, H.1    Durlach, V.2    Durlach, J.3
  • 70
    • 84871091378 scopus 로고    scopus 로고
    • Rapid folding of DNA into nanoscale shapes at constant temperature
    • Sobczak, J.-P. J.; Martin, T. G.; Gerling, T. and Dietz, H. Rapid folding of DNA into nanoscale shapes at constant temperature. Science 338, 1458-1461 (2012)
    • (2012) Science , vol.338 , pp. 1458-1461
    • Sobczak, J.-P.J.1    Martin, T.G.2    Gerling, T.3    Dietz, H.4
  • 71
    • 84863186339 scopus 로고    scopus 로고
    • Complex shapes self-assembled from single-stranded DNA tiles
    • Wei, B.; Dai, M. and Yin, P. Complex shapes self-assembled from single-stranded DNA tiles. Nature 485, 623-626 (2012)
    • (2012) Nature , vol.485 , pp. 623-626
    • Wei, B.1    Dai, M.2    Yin, P.3
  • 72
    • 84922211630 scopus 로고    scopus 로고
    • Addressing the instability of DNA nanostructures in tissue culture
    • Hahn, J.; Wickham, S. F. J.; Shih, W. M. and Perrault, S. D. Addressing the instability of DNA nanostructures in tissue culture. ACS Nano 8, 8765-8775 (2014)
    • (2014) ACS Nano , vol.8 , pp. 8765-8775
    • Hahn, J.1    Wickham, S.F.J.2    Shih, W.M.3    Perrault, S.D.4
  • 73
    • 66249137759 scopus 로고    scopus 로고
    • Self-assembly of DNA into nanoscale three-dimensional shapes
    • Douglas, S. M. et al. Self-assembly of DNA into nanoscale three-dimensional shapes. Nature 459, 414-418 (2009)
    • (2009) Nature , vol.459 , pp. 414-418
    • Douglas, S.M.1
  • 74
    • 77955204651 scopus 로고    scopus 로고
    • Self-assembly of three-dimensional prestressed tensegrity structures from DNA
    • Liedl, T.; Högberg, B.; Tytell, J.; Ingber, D. E. and Shih, W. M. Self-assembly of three-dimensional prestressed tensegrity structures from DNA. Nature Nanotech. 5, 520-524 (2010)
    • (2010) Nature Nanotech. , vol.5 , pp. 520-524
    • Liedl, T.1    Högberg, B.2    Tytell, J.3    Ingber, D.E.4    Shih, W.M.5
  • 75
    • 84901660628 scopus 로고    scopus 로고
    • Virus-inspired membrane encapsulation of DNA nanostructures to achieve in vivo stability
    • Perrault, S. and Shih, W. Virus-inspired membrane encapsulation of DNA nanostructures to achieve in vivo stability. ACS Nano 8, 5132-5140 (2014)
    • (2014) ACS Nano , vol.8 , pp. 5132-5140
    • Perrault, S.1    Shih, W.2
  • 76
    • 0025804117 scopus 로고
    • Synthesis from DNA of a molecule with the connectivity of a cube
    • Chen, J. H. and Seeman, N. C. Synthesis from DNA of a molecule with the connectivity of a cube. Nature 350, 631-633 (1991)
    • (1991) Nature , vol.350 , pp. 631-633
    • Chen, J.H.1    Seeman, N.C.2
  • 77
    • 72849118204 scopus 로고    scopus 로고
    • Enhanced resistance of DNA nanostructures to enzymatic digestion
    • Keum, J.-W. and Bermudez, H. Enhanced resistance of DNA nanostructures to enzymatic digestion. Chem. Commun. 45, 7036-7038 (2009)
    • (2009) Chem. Commun. , vol.45 , pp. 7036-7038
    • Keum, J.-W.1    Bermudez, H.2
  • 78
    • 84872349154 scopus 로고    scopus 로고
    • DNA nanostructure serum stability: Greater than the sum of its parts
    • Conway, J. W.; McLaughlin, C. K.; Castor, K. J. and Sleiman, H. DNA nanostructure serum stability: greater than the sum of its parts. Chem. Commun. 49, 1172-1174 (2013)
    • (2013) Chem. Commun. , vol.49 , pp. 1172-1174
    • Conway, J.W.1    McLaughlin, C.K.2    Castor, K.J.3    Sleiman, H.4
  • 79
    • 28444461124 scopus 로고    scopus 로고
    • Stable, specific, and reversible base pairing via Schiff base
    • Dohno, C.; Okamoto, A. and Saito, I. Stable, specific, and reversible base pairing via Schiff base. J. Am. Chem. Soc. 127, 16681-16684 (2005)
    • (2005) J. Am. Chem. Soc. , vol.127 , pp. 16681-16684
    • Dohno, C.1    Okamoto, A.2    Saito, I.3
  • 81
    • 79952714315 scopus 로고    scopus 로고
    • Exploring the role of chirality in nucleic acid recognition
    • DAlonzo, D.; Guaragna, A. and Palumbo, G. Exploring the role of chirality in nucleic acid recognition. Chem. Biodivers. 8, 373-413 (2011)
    • (2011) Chem. Biodivers. , vol.8 , pp. 373-413
    • Dalonzo, D.1    Guaragna, A.2    Palumbo, G.3
  • 82
    • 0029986009 scopus 로고    scopus 로고
    • Peptide nucleic acids (PNA): Syn thesis, properties and potential applications
    • Hyrup, B. and Nielsen, P. E. Peptide nucleic acids (PNA): synthesis, properties and potential applications. Bioorg. Med. Chem. 4, 5-23 (1996)
    • (1996) Bioorg. Med. Chem. , vol.4 , pp. 5-23
    • Hyrup, B.1    Nielsen, P.E.2
  • 83
    • 36048947570 scopus 로고    scopus 로고
    • Sugar modification as a means to increase the biological performance of oligonucleotides
    • Leumann, C. J. Sugar modification as a means to increase the biological performance of oligonucleotides. Vol. 50 Nucleic Acids Symp. Series (Oxf). 55-56 (2006)
    • (2006) 50 Nucleic Acids Symp. Series (Oxf). , pp. 55-56
    • Leumann, C.J.1
  • 84
    • 79955115072 scopus 로고    scopus 로고
    • Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging
    • Liu, J. et al. Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging. ACS Nano 5, 237-246 (2011)
    • (2011) ACS Nano , vol.5 , pp. 237-246
    • Liu, J.1
  • 85
    • 0031669682 scopus 로고    scopus 로고
    • Peptide nucleic acids (PNA) and PNA-DNA chimeras: From high binding affinity towards biological function
    • Uhlmann, E. Peptide nucleic acids (PNA) and PNA-DNA chimeras: from high binding affinity towards biological function. Biol. Chem. 379, 1045-1052 (1998)
    • (1998) Biol. Chem. , vol.379 , pp. 1045-1052
    • Uhlmann, E.1
  • 86
    • 0029121625 scopus 로고
    • Relative thermodynamic stability of DNA, RNA, and DNA:RNA hybrid duplexes: Relationship with base composition and structure
    • Lesnik, E. A. and Freier, S. M. Relative thermodynamic stability of DNA, RNA, and DNA:RNA hybrid duplexes: relationship with base composition and structure. Biochemistry 34, 10807-10815 (1995)
    • (1995) Biochemistry , vol.34 , pp. 10807-10815
    • Lesnik, E.A.1    Freier, S.M.2
  • 87
    • 80055018807 scopus 로고    scopus 로고
    • Stability and mismatch discrimination of locked nucleic acid-DNA duplexes
    • Owczarzy, R.; You, Y.; Groth, C. L. and Tataurov, A. V. Stability and mismatch discrimination of locked nucleic acid-DNA duplexes. Biochemistry 50, 9352-9367 (2011)
    • (2011) Biochemistry , vol.50 , pp. 9352-9367
    • Owczarzy, R.1    You, Y.2    Groth, C.L.3    Tataurov, A.V.4
  • 88
    • 84555177367 scopus 로고    scopus 로고
    • Cellular immunostimulation by CpG-sequence-coated DNA origami structures
    • Schüller, V. J. et al. Cellular immunostimulation by CpG-sequence-coated DNA origami structures. ACS Nano 5, 9696-9702 (2011)
    • (2011) ACS Nano , vol.5 , pp. 9696-9702
    • Schüller, V.J.1
  • 89
    • 34247255391 scopus 로고    scopus 로고
    • Chemical adjuvants for plasmid DNA vaccines
    • Greenland, J. R. and Letvin, N. L. Chemical adjuvants for plasmid DNA vaccines. Vaccine 25, 3731-3741 (2007)
    • (2007) Vaccine , vol.25 , pp. 3731-3741
    • Greenland, J.R.1    Letvin, N.L.2
  • 90
    • 84861175030 scopus 로고    scopus 로고
    • Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells
    • Huang, L. et al. Engineering DNA nanoparticles as immunomodulatory reagents that activate regulatory T cells. J. Immunol. 188, 4913-4920 (2012)
    • (2012) J. Immunol. , vol.188 , pp. 4913-4920
    • Huang, L.1
  • 91
    • 84885157623 scopus 로고    scopus 로고
    • Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation
    • This report identified DNA motifs that could be used to inhibit the AIM2 receptor-dependent inflammatory pathways
    • Kaminski, J. J. et al. Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation. J. Immunol. 191, 3876-3883 (2013). This report identified DNA motifs that could be used to inhibit the AIM2 receptor-dependent inflammatory pathways
    • (2013) J. Immunol , vol.191 , pp. 3876-3883
    • Kaminski, J.J.1
  • 92
    • 84934439394 scopus 로고    scopus 로고
    • Innate immunity in C. Elegans
    • Engelmann, I. and Pujol, N. Innate immunity in C. elegans. Adv. Exp. Med. Biol. 708, 105-121 (2010)
    • (2010) Adv. Exp. Med. Biol. , vol.708 , pp. 105-121
    • Engelmann, I.1    Pujol, N.2
  • 93
    • 0242581687 scopus 로고    scopus 로고
    • The immune response of Drosophila
    • Hoffmann, J. A. The immune response of Drosophila. Nature 426, 33-38 (2003)
    • (2003) Nature , vol.426 , pp. 33-38
    • Hoffmann, J.A.1
  • 95
    • 84887992036 scopus 로고    scopus 로고
    • The antiviral innate immune response in fish: Evolution and conservation of the IFN system
    • Langevin, C. et al. The antiviral innate immune response in fish: evolution and conservation of the IFN system. J. Mol. Biol. 425, 4904-4920 (2013)
    • (2013) J. Mol. Biol. , vol.425 , pp. 4904-4920
    • Langevin, C.1
  • 96
    • 84857335824 scopus 로고    scopus 로고
    • A logic-gated nanorobot for targeted transport of molecular payloads
    • This paper describes a DNA cargo-hold that delivers payloads triggered by molecular logic
    • Douglas, S. M.; Bachelet, I. and Church, G. M. A logic-gated nanorobot for targeted transport of molecular payloads. Science 335, 831-834 (2012). This paper describes a DNA cargo-hold that delivers payloads triggered by molecular logic
    • (2012) Science , vol.335 , pp. 831-834
    • Douglas, S.M.1    Bachelet, I.2    Church, G.M.3
  • 97
    • 84867776387 scopus 로고    scopus 로고
    • DNA Origami delivery system for cancer therapy with tunable release properties
    • Zhao, Y. -X. et al. DNA Origami delivery system for cancer therapy with tunable release properties. ACS Nano 6, 8684-8691 (2012)
    • (2012) ACS Nano , vol.6 , pp. 8684-8691
    • Zhao, Y.-X.1
  • 98
    • 67651222407 scopus 로고    scopus 로고
    • Multifunctional nanoarchitectures from DNA-based ABC monomers
    • Lee, J. B. et al. Multifunctional nanoarchitectures from DNA-based ABC monomers. Nature Nanotech. 4, 430-436 (2009)
    • (2009) Nature Nanotech. , vol.4 , pp. 430-436
    • Lee, J.B.1
  • 99
    • 84860171099 scopus 로고    scopus 로고
    • Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures
    • Kim, D.-N.; Kilchherr, F.; Dietz, H. and Bathe, M. Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures. Nucleic Acids Res. 40, 2862-2868 (2012)
    • (2012) Nucleic Acids Res. , vol.40 , pp. 2862-2868
    • Kim, D.-N.1    Kilchherr, F.2    Dietz, H.3    Bathe, M.4
  • 100
    • 84922729623 scopus 로고    scopus 로고
    • Lattice-free prediction of three-dimensional structure of programmed DNA assemblies
    • Pan, K. et al. Lattice-free prediction of three-dimensional structure of programmed DNA assemblies. Nature Commun. 5, 5578 (2014)
    • (2014) Nature Commun. , vol.5 , pp. 5578
    • Pan, K.1
  • 101
    • 40749140401 scopus 로고    scopus 로고
    • Hierarchical self-assembly of DNA into symmetrical supramolecular polyhedra
    • He, Y. et al. Hierarchical self-assembly of DNA into symmetrical supramolecular polyhedra. Nature 452, 198-201 (2013)
    • (2013) Nature , vol.452 , pp. 198-201
    • He, Y.1
  • 102
    • 28844463033 scopus 로고    scopus 로고
    • Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication
    • Goodman, R. P. et al. Rapid chiral assembly of rigid DNA building blocks for molecular nanofabrication. Science 310, 1661-1665 (2005)
    • (2005) Science , vol.310 , pp. 1661-1665
    • Goodman, R.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.