Fabrication of stable and RNase-resistant RNA nanoparticles active in gearing the nanomotors for viral DNA packaging

ACS Nano

Volumn 5, Issue 1, 2011, Pages 237-246

  Liu, Jing ^a,c   Guo, Songchuan ^b   Cinier, Mathieu ^a   Shlyakhtenko, Luda S ^e   Shu, Yi ^a   Chen, Chaoping ^d   Shen, Guanxin ^c   Guo, Peixuan ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

^b Kylin Therapeutics Inc   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d Department of Environmental and Radiological Health Sciences   (United States)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

2' F modification; Bionanotechnology; Dimer formation; Nanobiotechnology; Phi29 DNA packaging nanomotor; PRNA; RNase resistant; Viral assembly; Viral DNA packaging

Indexed keywords

2'-F MODIFICATION; BIONANOTECHNOLOGY; DIMER FORMATION; DNA-PACKAGING; PRNA; RNASE RESISTANT; VIRAL ASSEMBLY; VIRAL DNA;

CATALYST ACTIVITY; DNA; MACHINERY; NANOPARTICLES; NANOTECHNOLOGY; PACKAGING; WHEELS;

RNA;

BACTERIOPHAGE T7 RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE; NANOPARTICLE; PYRIMIDINE; PYRIMIDINE DERIVATIVE; RIBONUCLEASE; RNA; VIRUS DNA; VIRUS PROTEIN;

ANIMAL; ARTICLE; BACILLUS PHAGE; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DIMERIZATION; DNA PACKAGING; GENETIC TRANSCRIPTION; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; METHODOLOGY; MUTATION; NANOTECHNOLOGY; NUCLEOTIDE SEQUENCE; PH; PHYSIOLOGY; RNA STABILITY; VIRION; VIRUS ASSEMBLY;

ANIMALS; BACILLUS PHAGES; BASE SEQUENCE; CATTLE; DIMERIZATION; DNA PACKAGING; DNA, VIRAL; DNA-DIRECTED RNA POLYMERASES; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; MUTATION; NANOPARTICLES; NANOTECHNOLOGY; NUCLEIC ACID CONFORMATION; PYRIMIDINES; RIBONUCLEASES; RNA; RNA STABILITY; TRANSCRIPTION, GENETIC; VIRAL PROTEINS; VIRION; VIRUS ASSEMBLY;

EID: 79955115072     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn1024658     Document Type: Article

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