메뉴 건너뛰기




Volumn 7, Issue 8, 2015, Pages 4461-4481

Structural and functional properties of the hepatitis C virus p7 viroporin

Author keywords

Antiviral target; Hepatitis C virus; Ion channel activity; Oligomeric structure; p7 protein; Pore like function; Small membrane protein; Viroporins; Virus assembly and release

Indexed keywords

ADAMANTANE; AMANTADINE; GLYCOPROTEIN E1; GLYCOPROTEIN E2; IMINOSUGAR; ION CHANNEL; N [5 (1 METHYL 1H PYRAZOL 4 YL) 2 NAPHTHOYL] GUANIDINE; P7 VIROPORIN; PROTEIN M2; RIBAVIRIN; RIMANTADINE; UNCLASSIFIED DRUG; VIRUS PROTEIN; P7 PROTEIN, HEPATITIS C VIRUS; VIRAL PROTEIN;

EID: 84941129656     PISSN: None     EISSN: 19994915     Source Type: Journal    
DOI: 10.3390/v7082826     Document Type: Review
Times cited : (37)

References (101)
  • 1
    • 84876572287 scopus 로고    scopus 로고
    • The origin of hepatitis C virus
    • [PubMed]
    • Simmonds, P. The origin of hepatitis C virus. Curr. Top. Microbiol. Immunol. 2013, 369, 1-15. [PubMed]
    • (2013) Curr. Top. Microbiol. Immunol , vol.369 , pp. 1-15
    • Simmonds, P.1
  • 2
    • 84876560298 scopus 로고    scopus 로고
    • Hepatitis C virus RNA translation
    • [PubMed]
    • Niepmann, M. Hepatitis C virus RNA translation. Curr. Top. Microbiol. Immunol. 2013, 369, 143-166. [PubMed]
    • (2013) Curr. Top. Microbiol. Immunol , vol.369 , pp. 143-166
    • Niepmann, M.1
  • 3
    • 84876520299 scopus 로고    scopus 로고
    • Hepatitis C virus proteins: From structure to function
    • [PubMed]
    • Moradpour, D.; Penin, F. Hepatitis C virus proteins: From structure to function. Curr. Top. Microbiol. Immunol. 2013, 369, 113-142. [PubMed]
    • (2013) Curr. Top. Microbiol. Immunol , vol.369 , pp. 113-142
    • Moradpour, D.1    Penin, F.2
  • 4
    • 84876556033 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication
    • [PubMed]
    • Lohmann, V. Hepatitis C virus RNA replication. Curr. Top. Microbiol. Immunol. 2013, 369, 167-198. [PubMed]
    • (2013) Curr. Top. Microbiol. Immunol , vol.369 , pp. 167-198
    • Lohmann, V.1
  • 5
    • 0028290389 scopus 로고
    • Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini
    • [PubMed]
    • Lin, C.; Lindenbach, B.D.; Pragai, B.M.; McCourt, D.W.; Rice, C.M. Processing in the hepatitis C virus E2-NS2 region: Identification of p7 and two distinct E2-specific products with different C termini. J. Virol. 1994, 68, 5063-5073. [PubMed]
    • (1994) J. Virol , vol.68 , pp. 5063-5073
    • Lin, C.1    Lindenbach, B.D.2    Pragai, B.M.3    McCourt, D.W.4    Rice, C.M.5
  • 6
    • 0027993526 scopus 로고
    • Two hepatitis C virus glycoprotein E2 products with different C termini
    • [PubMed]
    • Mizushima, H.; Hijikata, M.; Asabe, S.; Hirota, M.; Kimura, K.; Shimotohno, K. Two hepatitis C virus glycoprotein E2 products with different C termini. J. Virol. 1994, 68, 6215-6222. [PubMed]
    • (1994) J. Virol , vol.68 , pp. 6215-6222
    • Mizushima, H.1    Hijikata, M.2    Asabe, S.3    Hirota, M.4    Kimura, K.5    Shimotohno, K.6
  • 7
    • 4744376094 scopus 로고    scopus 로고
    • Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions
    • [CrossRef] [PubMed]
    • Carrere-Kremer, S.; Montpellier, C.; Lorenzo, L.; Brulin, B.; Cocquerel, L.; Belouzard, S.; Penin, F.; Dubuisson, J. Regulation of hepatitis C virus polyprotein processing by signal peptidase involves structural determinants at the p7 sequence junctions. J. Biol. Chem. 2004, 279, 41384-41392. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem , vol.279 , pp. 41384-41392
    • Carrere-Kremer, S.1    Montpellier, C.2    Lorenzo, L.3    Brulin, B.4    Cocquerel, L.5    Belouzard, S.6    Penin, F.7    Dubuisson, J.8
  • 8
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • [CrossRef] [PubMed]
    • Lohmann, V.; Korner, F.; Koch, J.; Herian, U.; Theilmann, L.; Bartenschlager, R. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 1999, 285, 110-113. [CrossRef] [PubMed]
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1    Korner, F.2    Koch, J.3    Herian, U.4    Theilmann, L.5    Bartenschlager, R.6
  • 9
    • 0036199092 scopus 로고    scopus 로고
    • Subcellular localization and topology of the p7 polypeptide of hepatitis C virus
    • [CrossRef] [PubMed]
    • Carrere-Kremer, S.; Montpellier-Pala, C.; Cocquerel, L.; Wychowski, C.; Penin, F.; Dubuisson, J. Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. J. Virol. 2002, 76, 3720-3730. [CrossRef] [PubMed]
    • (2002) J. Virol , vol.76 , pp. 3720-3730
    • Carrere-Kremer, S.1    Montpellier-Pala, C.2    Cocquerel, L.3    Wychowski, C.4    Penin, F.5    Dubuisson, J.6
  • 10
    • 0033819541 scopus 로고    scopus 로고
    • E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies
    • [CrossRef] [PubMed]
    • Harada, T.; Tautz, N.; Thiel, H.J. E2-p7 region of the bovine viral diarrhea virus polyprotein: Processing and functional studies. J. Virol. 2000, 74, 9498-9506. [CrossRef] [PubMed]
    • (2000) J. Virol , vol.74 , pp. 9498-9506
    • Harada, T.1    Tautz, N.2    Thiel, H.J.3
  • 12
    • 0037472806 scopus 로고    scopus 로고
    • The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine
    • [CrossRef]
    • Griffin, S.D.; Beales, L.P.; Clarke, D.S.; Worsfold, O.; Evans, S.D.; Jaeger, J.; Harris, M.P.; Rowlands, D.J. The p7 protein of hepatitis C virus forms an ion channel that is blocked by the antiviral drug, Amantadine. FEBS Lett. 2003, 535, 34-38. [CrossRef]
    • (2003) FEBS Lett , vol.535 , pp. 34-38
    • Griffin, S.D.1    Beales, L.P.2    Clarke, D.S.3    Worsfold, O.4    Evans, S.D.5    Jaeger, J.6    Harris, M.P.7    Rowlands, D.J.8
  • 13
    • 0038284830 scopus 로고    scopus 로고
    • The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives
    • [CrossRef] [PubMed]
    • Pavlovic, D.; Neville, D.C.; Argaud, O.; Blumberg, B.; Dwek, R.A.; Fischer, W.B.; Zitzmann, N. The hepatitis C virus p7 protein forms an ion channel that is inhibited by long-alkyl-chain iminosugar derivatives. Proc. Natl. Acad. Sci. USA 2003, 100, 6104-6108. [CrossRef] [PubMed]
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 6104-6108
    • Pavlovic, D.1    Neville, D.C.2    Argaud, O.3    Blumberg, B.4    Dwek, R.A.5    Fischer, W.B.6    Zitzmann, N.7
  • 14
    • 1642450632 scopus 로고    scopus 로고
    • Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride
    • [CrossRef]
    • Premkumar, A.; Wilson, L.; Ewart, G.D.; Gage, P.W. Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett. 2004, 557, 99-103. [CrossRef]
    • (2004) FEBS Lett , vol.557 , pp. 99-103
    • Premkumar, A.1    Wilson, L.2    Ewart, G.D.3    Gage, P.W.4
  • 15
    • 33846005485 scopus 로고    scopus 로고
    • Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro
    • [CrossRef] [PubMed]
    • Clarke, D.; Griffin, S.; Beales, L.; Gelais, C.S.; Burgess, S.; Harris, M.; Rowlands, D. Evidence for the formation of a heptameric ion channel complex by the hepatitis C virus p7 protein in vitro. J. Biol. Chem. 2006, 281, 37057-37068. [CrossRef] [PubMed]
    • (2006) J. Biol. Chem , vol.281 , pp. 37057-37068
    • Clarke, D.1    Griffin, S.2    Beales, L.3    Gelais, C.S.4    Burgess, S.5    Harris, M.6    Rowlands, D.7
  • 18
    • 0345223476 scopus 로고    scopus 로고
    • Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon
    • [CrossRef] [PubMed]
    • Kato, T.; Date, T.; Miyamoto, M.; Furusaka, A.; Tokushige, K.; Mizokami, M.; Wakita, T. Efficient replication of the genotype 2a hepatitis C virus subgenomic replicon. Gastroenterology 2003, 125, 1808-1817. [CrossRef] [PubMed]
    • (2003) Gastroenterology , vol.125 , pp. 1808-1817
    • Kato, T.1    Date, T.2    Miyamoto, M.3    Furusaka, A.4    Tokushige, K.5    Mizokami, M.6    Wakita, T.7
  • 20
    • 34547616693 scopus 로고    scopus 로고
    • Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
    • [CrossRef] [PubMed]
    • Steinmann, E.; Penin, F.; Kallis, S.; Patel, A.H.; Bartenschlager, R.; Pietschmann, T. Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog. 2007, 3, e103. [CrossRef] [PubMed]
    • (2007) PLoS Pathog , vol.3
    • Steinmann, E.1    Penin, F.2    Kallis, S.3    Patel, A.H.4    Bartenschlager, R.5    Pietschmann, T.6
  • 21
    • 34547734952 scopus 로고    scopus 로고
    • Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    • [CrossRef] [PubMed]
    • Jones, C.T.; Murray, C.L.; Eastman, D.K.; Tassello, J.; Rice, C.M. Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus. J. Virol. 2007, 81, 8374-8383. [CrossRef] [PubMed]
    • (2007) J. Virol , vol.81 , pp. 8374-8383
    • Jones, C.T.1    Murray, C.L.2    Eastman, D.K.3    Tassello, J.4    Rice, C.M.5
  • 22
    • 0141816748 scopus 로고    scopus 로고
    • The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences
    • [CrossRef] [PubMed]
    • Sakai, A.; Claire, M.S.; Faulk, K.; Govindarajan, S.; Emerson, S.U.; Purcell, R.H.; Bukh, J. The p7 polypeptide of hepatitis C virus is critical for infectivity and contains functionally important genotype-specific sequences. Proc. Natl. Acad. Sci. USA 2003, 100, 11646-11651. [CrossRef] [PubMed]
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 11646-11651
    • Sakai, A.1    Claire, M.S.2    Faulk, K.3    Govindarajan, S.4    Emerson, S.U.5    Purcell, R.H.6    Bukh, J.7
  • 23
    • 0037213932 scopus 로고    scopus 로고
    • Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes
    • [CrossRef] [PubMed]
    • Saunier, B.; Triyatni, M.; Ulianich, L.; Maruvada, P.; Yen, P.; Kohn, L.D. Role of the asialoglycoprotein receptor in binding and entry of hepatitis C virus structural proteins in cultured human hepatocytes. J. Virol. 2003, 77, 546-559. [CrossRef] [PubMed]
    • (2003) J. Virol , vol.77 , pp. 546-559
    • Saunier, B.1    Triyatni, M.2    Ulianich, L.3    Maruvada, P.4    Yen, P.5    Kohn, L.D.6
  • 24
    • 58149390243 scopus 로고    scopus 로고
    • Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel
    • [CrossRef] [PubMed]
    • Griffin, S.; Stgelais, C.; Owsianka, A.M.; Patel, A.H.; Rowlands, D.; Harris, M. Genotype-dependent sensitivity of hepatitis C virus to inhibitors of the p7 ion channel. Hepatology 2008, 48, 1779-1790. [CrossRef] [PubMed]
    • (2008) Hepatology , vol.48 , pp. 1779-1790
    • Griffin, S.1    Stgelais, C.2    Owsianka, A.M.3    Patel, A.H.4    Rowlands, D.5    Harris, M.6
  • 25
    • 84873032687 scopus 로고    scopus 로고
    • Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells
    • [CrossRef] [PubMed]
    • Vieyres, G.; Brohm, C.; Friesland, M.; Gentzsch, J.; Wolk, B.; Roingeard, P.; Steinmann, E.; Pietschmann, T. Subcellular localization and function of an epitope-tagged p7 viroporin in hepatitis C virus-producing cells. J. Virol. 2013, 87, 1664-1678. [CrossRef] [PubMed]
    • (2013) J. Virol , vol.87 , pp. 1664-1678
    • Vieyres, G.1    Brohm, C.2    Friesland, M.3    Gentzsch, J.4    Wolk, B.5    Roingeard, P.6    Steinmann, E.7    Pietschmann, T.8
  • 26
    • 84863981448 scopus 로고    scopus 로고
    • Viroporins: Structure and biological functions
    • [CrossRef] [PubMed]
    • Nieva, J.L.; Madan, V.; Carrasco, L. Viroporins: Structure and biological functions. Nat. Rev. Microbiol. 2012, 10, 563-574. [CrossRef] [PubMed]
    • (2012) Nat. Rev. Microbiol , vol.10 , pp. 563-574
    • Nieva, J.L.1    Madan, V.2    Carrasco, L.3
  • 28
    • 38049161643 scopus 로고    scopus 로고
    • Viroporins from RNA viruses induce caspase-dependent apoptosis
    • [CrossRef] [PubMed]
    • Madan, V.; Castello, A.; Carrasco, L. Viroporins from RNA viruses induce caspase-dependent apoptosis. Cell Microbiol. 2008, 10, 437-451. [CrossRef] [PubMed]
    • (2008) Cell Microbiol , vol.10 , pp. 437-451
    • Madan, V.1    Castello, A.2    Carrasco, L.3
  • 29
    • 0025139857 scopus 로고
    • The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release
    • [PubMed]
    • Klimkait, T.; Strebel, K.; Hoggan, M.D.; Martin, M.A.; Orenstein, J.M. The human immunodeficiency virus type 1-specific protein vpu is required for efficient virus maturation and release. J. Virol. 1990, 64, 621-629. [PubMed]
    • (1990) J. Virol , vol.64 , pp. 621-629
    • Klimkait, T.1    Strebel, K.2    Hoggan, M.D.3    Martin, M.A.4    Orenstein, J.M.5
  • 30
    • 0034904097 scopus 로고    scopus 로고
    • Sindbis virus variant with a deletion in the 6K gene shows defects in glycoprotein processing and trafficking: Lack of complementation by a wild-type 6K gene in trans
    • [CrossRef] [PubMed]
    • Sanz, M.A.; Carrasco, L. Sindbis virus variant with a deletion in the 6K gene shows defects in glycoprotein processing and trafficking: Lack of complementation by a wild-type 6K gene in trans. J. Virol. 2001, 75, 7778-7784. [CrossRef] [PubMed]
    • (2001) J. Virol , vol.75 , pp. 7778-7784
    • Sanz, M.A.1    Carrasco, L.2
  • 31
    • 39749196785 scopus 로고    scopus 로고
    • Novel approach to the development of effective H5N1 influenza A virus vaccines: Use of M2 cytoplasmic tail mutants
    • [CrossRef] [PubMed]
    • Watanabe, T.; Watanabe, S.; Kim, J.H.; Hatta, M.; Kawaoka, Y. Novel approach to the development of effective H5N1 influenza A virus vaccines: Use of M2 cytoplasmic tail mutants. J. Virol. 2008, 82, 2486-2492. [CrossRef] [PubMed]
    • (2008) J. Virol , vol.82 , pp. 2486-2492
    • Watanabe, T.1    Watanabe, S.2    Kim, J.H.3    Hatta, M.4    Kawaoka, Y.5
  • 33
    • 84881373909 scopus 로고    scopus 로고
    • Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production
    • [CrossRef] [PubMed]
    • Atoom, A.M.; Jones, D.M.; Russell, R.S. Evidence suggesting that HCV p7 protects E2 glycoprotein from premature degradation during virus production. Virus Res. 2013, 176, 199-210. [CrossRef] [PubMed]
    • (2013) Virus Res , vol.176 , pp. 199-210
    • Atoom, A.M.1    Jones, D.M.2    Russell, R.S.3
  • 34
    • 14744305633 scopus 로고    scopus 로고
    • Analysis of the processing and transmembrane topology of the E2p7 protein of hepatitis C virus
    • [CrossRef] [PubMed]
    • Isherwood, B.J.; Patel, A.H. Analysis of the processing and transmembrane topology of the E2p7 protein of hepatitis C virus. J. Gen. Virol. 2005, 86, 667-676. [CrossRef] [PubMed]
    • (2005) J. Gen. Virol , vol.86 , pp. 667-676
    • Isherwood, B.J.1    Patel, A.H.2
  • 35
    • 84879695534 scopus 로고    scopus 로고
    • Unusual architecture of the p7 channel from hepatitis C virus
    • [CrossRef] [PubMed]
    • OuYang, B.; Xie, S.; Berardi, M.J.; Zhao, X.; Dev, J.; Yu, W.; Sun, B.; Chou, J.J. Unusual architecture of the p7 channel from hepatitis C virus. Nature 2013, 498, 521-525. [CrossRef] [PubMed]
    • (2013) Nature , vol.498 , pp. 521-525
    • OuYang, B.1    Xie, S.2    Berardi, M.J.3    Zhao, X.4    Dev, J.5    Yu, W.6    Sun, B.7    Chou, J.J.8
  • 36
    • 31544478873 scopus 로고    scopus 로고
    • Protein-protein interactions: Modeling the hepatitis C virus ion channel p7
    • [CrossRef] [PubMed]
    • Patargias, G.; Zitzmann, N.; Dwek, R.; Fischer, W.B. Protein-protein interactions: Modeling the hepatitis C virus ion channel p7. J. Med. Chem. 2006, 49, 648-655. [CrossRef] [PubMed]
    • (2006) J. Med. Chem , vol.49 , pp. 648-655
    • Patargias, G.1    Zitzmann, N.2    Dwek, R.3    Fischer, W.B.4
  • 37
    • 84866943211 scopus 로고    scopus 로고
    • The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels
    • [CrossRef] [PubMed]
    • Chandler, D.E.; Penin, F.; Schulten, K.; Chipot, C. The p7 protein of hepatitis C virus forms structurally plastic, minimalist ion channels. PLoS. Comput. Biol. 2012, 8, e1002702. [CrossRef] [PubMed]
    • (2012) PLoS. Comput. Biol , vol.8
    • Chandler, D.E.1    Penin, F.2    Schulten, K.3    Chipot, C.4
  • 38
    • 84925430584 scopus 로고    scopus 로고
    • Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein
    • [CrossRef] [PubMed]
    • Kalita, M.M.; Griffin, S.; Chou, J.J.; Fischer, W.B. Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein. Biochim. Biophys. Acta 2015, 1848, 1383-1392. [CrossRef] [PubMed]
    • (2015) Biochim. Biophys. Acta , vol.1848 , pp. 1383-1392
    • Kalita, M.M.1    Griffin, S.2    Chou, J.J.3    Fischer, W.B.4
  • 40
    • 84881221576 scopus 로고    scopus 로고
    • Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance
    • [CrossRef] [PubMed]
    • Cook, G.A.; Dawson, L.A.; Tian, Y.; Opella, S.J. Three-dimensional structure and interaction studies of hepatitis C virus p7 in 1,2-dihexanoyl-sn-glycero-3-phosphocholine by solution nuclear magnetic resonance. Biochemistry 2013, 52, 5295-5303. [CrossRef] [PubMed]
    • (2013) Biochemistry , vol.52 , pp. 5295-5303
    • Cook, G.A.1    Dawson, L.A.2    Tian, Y.3    Opella, S.J.4
  • 41
    • 84915733478 scopus 로고    scopus 로고
    • NMR structures of membrane proteins in phospholipid bilayers
    • [CrossRef] [PubMed]
    • Radoicic, J.; Lu, G.J.; Opella, S.J. NMR structures of membrane proteins in phospholipid bilayers. Q. Rev. Biophys. 2014, 47, 249-283. [CrossRef] [PubMed]
    • (2014) Q. Rev. Biophys , vol.47 , pp. 249-283
    • Radoicic, J.1    Lu, G.J.2    Opella, S.J.3
  • 42
    • 1342289027 scopus 로고    scopus 로고
    • A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria
    • [CrossRef] [PubMed]
    • Griffin, S.D.; Harvey, R.; Clarke, D.S.; Barclay, W.S.; Harris, M.; Rowlands, D.J. A conserved basic loop in hepatitis C virus p7 protein is required for amantadine-sensitive ion channel activity in mammalian cells but is dispensable for localization to mitochondria. J. Gen. Virol. 2004, 85, 451-461. [CrossRef] [PubMed]
    • (2004) J. Gen. Virol , vol.85 , pp. 451-461
    • Griffin, S.D.1    Harvey, R.2    Clarke, D.S.3    Barclay, W.S.4    Harris, M.5    Rowlands, D.J.6
  • 43
    • 55749102288 scopus 로고    scopus 로고
    • Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex
    • [CrossRef] [PubMed]
    • Brass, V.; Berke, J.M.; Montserret, R.; Blum, H.E.; Penin, F.; Moradpour, D. Structural determinants for membrane association and dynamic organization of the hepatitis C virus NS3-4A complex. Proc. Natl. Acad. Sci. USA 2008, 105, 14545-14550. [CrossRef] [PubMed]
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14545-14550
    • Brass, V.1    Berke, J.M.2    Montserret, R.3    Blum, H.E.4    Penin, F.5    Moradpour, D.6
  • 44
    • 84896689575 scopus 로고    scopus 로고
    • Helical membrane protein conformations and their environment
    • [CrossRef] [PubMed]
    • Cross, T.A.; Murray, D.T.; Watts, A. Helical membrane protein conformations and their environment. Eur. Biophys. J. 2013, 42, 731-755. [CrossRef] [PubMed]
    • (2013) Eur. Biophys. J , vol.42 , pp. 731-755
    • Cross, T.A.1    Murray, D.T.2    Watts, A.3
  • 45
    • 0028221512 scopus 로고
    • Influenza virus M2 protein modifies membrane permeability in E
    • [CrossRef]
    • Guinea, R.; Carrasco, L. Influenza virus M2 protein modifies membrane permeability in E. coli cells. FEBS Lett. 1994, 343, 242-246. [CrossRef]
    • (1994) coli cells. FEBS Lett , vol.343 , pp. 242-246
    • Guinea, R.1    Carrasco, L.2
  • 46
    • 0028180193 scopus 로고
    • Semliki Forest virus 6K protein modifies membrane permeability after inducible expression in Escherichia coli cells
    • [PubMed]
    • Sanz, M.A.; Perez, L.; Carrasco, L. Semliki Forest virus 6K protein modifies membrane permeability after inducible expression in Escherichia coli cells. J. Biol. Chem. 1994, 269, 12106-12110. [PubMed]
    • (1994) J. Biol. Chem , vol.269 , pp. 12106-12110
    • Sanz, M.A.1    Perez, L.2    Carrasco, L.3
  • 47
    • 0343924538 scopus 로고    scopus 로고
    • Membrane permeability changes induced in Escherichia coli by the SH protein of human respiratory syncytial virus
    • [CrossRef] [PubMed]
    • Perez, M.; Garcia-Barreno, B.; Melero, J.A.; Carrasco, L.; Guinea, R. Membrane permeability changes induced in Escherichia coli by the SH protein of human respiratory syncytial virus. Virology 1997, 235, 342-351. [CrossRef] [PubMed]
    • (1997) Virology , vol.235 , pp. 342-351
    • Perez, M.1    Garcia-Barreno, B.2    Melero, J.A.3    Carrasco, L.4    Guinea, R.5
  • 48
    • 0029814801 scopus 로고    scopus 로고
    • Membrane permeabilization by poliovirus proteins 2B and 2BC
    • [PubMed]
    • Aldabe, R.; Barco, A.; Carrasco, L. Membrane permeabilization by poliovirus proteins 2B and 2BC. J. Biol. Chem. 1996, 271, 23134-23137. [PubMed]
    • (1996) J. Biol. Chem , vol.271 , pp. 23134-23137
    • Aldabe, R.1    Barco, A.2    Carrasco, L.3
  • 49
    • 0042072321 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability
    • [CrossRef] [PubMed]
    • Gonzalez, M.E.; Carrasco, L. The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability. Biochemistry 1998, 37, 13710-13719. [CrossRef] [PubMed]
    • (1998) Biochemistry , vol.37 , pp. 13710-13719
    • Gonzalez, M.E.1    Carrasco, L.2
  • 50
    • 0032768961 scopus 로고    scopus 로고
    • Membrane permeabilization by small hydrophobic nonstructural proteins of Japanese encephalitis virus
    • [PubMed]
    • Chang, Y.S.; Liao, C.L.; Tsao, C.H.; Chen, M.C.; Liu, C.I.; Chen, L.K.; Lin, Y.L. Membrane permeabilization by small hydrophobic nonstructural proteins of Japanese encephalitis virus. J. Virol. 1999, 73, 6257-6264. [PubMed]
    • (1999) J. Virol , vol.73 , pp. 6257-6264
    • Chang, Y.S.1    Liao, C.L.2    Tsao, C.H.3    Chen, M.C.4    Liu, C.I.5    Chen, L.K.6    Lin, Y.L.7
  • 52
    • 5644221347 scopus 로고    scopus 로고
    • The NS3 protein of bluetongue virus exhibits viroporin-like properties
    • [CrossRef] [PubMed]
    • Han, Z.; Harty, R.N. The NS3 protein of bluetongue virus exhibits viroporin-like properties. J. Biol. Chem. 2004, 279, 43092-43097. [CrossRef] [PubMed]
    • (2004) J. Biol. Chem , vol.279 , pp. 43092-43097
    • Han, Z.1    Harty, R.N.2
  • 53
    • 21244447668 scopus 로고    scopus 로고
    • Viroporin activity of murine hepatitis virus E protein
    • [CrossRef] [PubMed]
    • Madan, V.; Garcia, M.J.; Sanz, M.A.; Carrasco, L. Viroporin activity of murine hepatitis virus E protein. FEBS Lett. 2005, 579, 3607-3612. [CrossRef] [PubMed]
    • (2005) FEBS Lett , vol.579 , pp. 3607-3612
    • Madan, V.1    Garcia, M.J.2    Sanz, M.A.3    Carrasco, L.4
  • 57
    • 84861326301 scopus 로고    scopus 로고
    • High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors
    • [CrossRef] [PubMed]
    • Wetherill, L.F.; Holmes, K.K.; Verow, M.; Muller, M.; Howell, G.; Harris, M.; Fishwick, C.; Stonehouse, N.; Foster, R.; Blair, G.E.; et al. High-risk human papillomavirus E5 oncoprotein displays channel-forming activity sensitive to small-molecule inhibitors. J. Virol. 2012, 86, 5341-5351. [CrossRef] [PubMed]
    • (2012) J. Virol , vol.86 , pp. 5341-5351
    • Wetherill, L.F.1    Holmes, K.K.2    Verow, M.3    Muller, M.4    Howell, G.5    Harris, M.6    Fishwick, C.7    Stonehouse, N.8    Foster, R.9    Blair, G.E.10
  • 58
    • 78149341400 scopus 로고    scopus 로고
    • Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production
    • [CrossRef] [PubMed]
    • Wozniak, A.L.; Griffin, S.; Rowlands, D.; Harris, M.; Yi, M.; Lemon, S.M.; Weinman, S.A. Intracellular proton conductance of the hepatitis C virus p7 protein and its contribution to infectious virus production. PLoS Pathog. 2010, 6, e1001087. [CrossRef] [PubMed]
    • (2010) PLoS Pathog , vol.6
    • Wozniak, A.L.1    Griffin, S.2    Rowlands, D.3    Harris, M.4    Yi, M.5    Lemon, S.M.6    Weinman, S.A.7
  • 59
    • 34547418131 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system
    • [CrossRef] [PubMed]
    • Stgelais, C.; Tuthill, T.J.; Clarke, D.S.; Rowlands, D.J.; Harris, M.; Griffin, S. Inhibition of hepatitis C virus p7 membrane channels in a liposome-based assay system. Antivir. Res. 2007, 76, 48-58. [CrossRef] [PubMed]
    • (2007) Antivir. Res , vol.76 , pp. 48-58
    • Stgelais, C.1    Tuthill, T.J.2    Clarke, D.S.3    Rowlands, D.J.4    Harris, M.5    Griffin, S.6
  • 60
    • 79954611840 scopus 로고    scopus 로고
    • Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin
    • [CrossRef] [PubMed]
    • Gervais, C.; Do, F.; Cantin, A.; Kukolj, G.; White, P.W.; Gauthier, A.; Vaillancourt, F.H. Development and validation of a high-throughput screening assay for the hepatitis C virus p7 viroporin. J. Biomol. Screen. 2011, 16, 363-369. [CrossRef] [PubMed]
    • (2011) J. Biomol. Screen , vol.16 , pp. 363-369
    • Gervais, C.1    Do, F.2    Cantin, A.3    Kukolj, G.4    White, P.W.5    Gauthier, A.6    Vaillancourt, F.H.7
  • 61
    • 0026612385 scopus 로고
    • Influenza virus M2 protein has ion channel activity
    • [CrossRef]
    • Pinto, L.H.; Holsinger, L.J.; Lamb, R.A. Influenza virus M2 protein has ion channel activity. Cell 1992, 69, 517-528. [CrossRef]
    • (1992) Cell , vol.69 , pp. 517-528
    • Pinto, L.H.1    Holsinger, L.J.2    Lamb, R.A.3
  • 63
    • 84884179566 scopus 로고    scopus 로고
    • Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function
    • [CrossRef] [PubMed]
    • Bentham, M.J.; Foster, T.L.; McCormick, C.; Griffin, S. Mutations in hepatitis C virus p7 reduce both the egress and infectivity of assembled particles via impaired proton channel function. J. Gen. Virol. 2013, 94, 2236-2248. [CrossRef] [PubMed]
    • (2013) J. Gen. Virol , vol.94 , pp. 2236-2248
    • Bentham, M.J.1    Foster, T.L.2    McCormick, C.3    Griffin, S.4
  • 64
    • 84867681380 scopus 로고    scopus 로고
    • Structural basis for proton conduction and inhibition by the influenza M2 protein
    • [CrossRef] [PubMed]
    • Hong, M.; DeGrado, W.F. Structural basis for proton conduction and inhibition by the influenza M2 protein. Protein Sci. 2012, 21, 1620-1633. [CrossRef] [PubMed]
    • (2012) Protein Sci , vol.21 , pp. 1620-1633
    • Hong, M.1    DeGrado, W.F.2
  • 65
    • 58849123788 scopus 로고    scopus 로고
    • Determination of pore-lining residues in the hepatitis C virus p7 protein
    • [CrossRef] [PubMed]
    • Chew, C.F.; Vijayan, R.; Chang, J.; Zitzmann, N.; Biggin, P.C. Determination of pore-lining residues in the hepatitis C virus p7 protein. Biophys. J. 2009, 96, L10-L12. [CrossRef] [PubMed]
    • (2009) Biophys. J , vol.96 , pp. L10-L12
    • Chew, C.F.1    Vijayan, R.2    Chang, J.3    Zitzmann, N.4    Biggin, P.C.5
  • 66
    • 60349101435 scopus 로고    scopus 로고
    • Reverse genetic analysis of a putative, influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus
    • [CrossRef] [PubMed]
    • Meshkat, Z.; Audsley, M.; Beyer, C.; Gowans, E.J.; Haqshenas, G. Reverse genetic analysis of a putative, influenza virus M2 HXXXW-like motif in the p7 protein of hepatitis C virus. J. Viral Hepat. 2009, 16, 187-194. [CrossRef] [PubMed]
    • (2009) J. Viral Hepat , vol.16 , pp. 187-194
    • Meshkat, Z.1    Audsley, M.2    Beyer, C.3    Gowans, E.J.4    Haqshenas, G.5
  • 67
    • 70350266403 scopus 로고    scopus 로고
    • Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation
    • [CrossRef] [PubMed]
    • Brohm, C.; Steinmann, E.; Friesland, M.; Lorenz, I.C.; Patel, A.; Penin, F.; Bartenschlager, R.; Pietschmann, T. Characterization of determinants important for hepatitis C virus p7 function in morphogenesis by using trans-complementation. J. Virol. 2009, 83, 11682-11693. [CrossRef] [PubMed]
    • (2009) J. Virol , vol.83 , pp. 11682-11693
    • Brohm, C.1    Steinmann, E.2    Friesland, M.3    Lorenz, I.C.4    Patel, A.5    Penin, F.6    Bartenschlager, R.7    Pietschmann, T.8
  • 68
    • 67749139975 scopus 로고    scopus 로고
    • Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro
    • [CrossRef] [PubMed]
    • Stgelais, C.; Foster, T.L.; Verow, M.; Atkins, E.; Fishwick, C.W.; Rowlands, D.; Harris, M.; Griffin, S. Determinants of hepatitis C virus p7 ion channel function and drug sensitivity identified in vitro. J. Virol. 2009, 83, 7970-7981. [CrossRef] [PubMed]
    • (2009) J. Virol , vol.83 , pp. 7970-7981
    • Stgelais, C.1    Foster, T.L.2    Verow, M.3    Atkins, E.4    Fishwick, C.W.5    Rowlands, D.6    Harris, M.7    Griffin, S.8
  • 69
    • 84886240989 scopus 로고    scopus 로고
    • The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences
    • [CrossRef] [PubMed]
    • Atkins, E.; Tatineni, R.; Li, H.; Gretch, D.; Harris, M.; Griffin, S. The stability of secreted, acid-labile H77/JFH-1 hepatitis C virus (HCV) particles is altered by patient isolate genotype 1a p7 sequences. Virology 2014, 448, 117-124. [CrossRef] [PubMed]
    • (2014) Virology , vol.448 , pp. 117-124
    • Atkins, E.1    Tatineni, R.2    Li, H.3    Gretch, D.4    Harris, M.5    Griffin, S.6
  • 72
    • 79960631284 scopus 로고    scopus 로고
    • The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein
    • [CrossRef] [PubMed]
    • Whitfield, T.; Miles, A.J.; Scheinost, J.C.; Offer, J.; Wentworth, P., Jr.; Dwek, R.A.; Wallace, B.A.; Biggin, P.C.; Zitzmann, N. The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein. Mol. Membr. Biol. 2011, 28, 254-264. [CrossRef] [PubMed]
    • (2011) Mol. Membr. Biol , vol.28 , pp. 254-264
    • Whitfield, T.1    Miles, A.J.2    Scheinost, J.C.3    Offer, J.4    Wentworth, W.P.5    Dwek, R.A.6    Wallace, B.A.7    Biggin, P.C.8    Zitzmann, N.9
  • 73
    • 84896902534 scopus 로고    scopus 로고
    • Two different conformations in hepatitis C virus p7 protein account for proton transport and dye release
    • [CrossRef] [PubMed]
    • Gan, S.W.; Surya, W.; Vararattanavech, A.; Torres, J. Two different conformations in hepatitis C virus p7 protein account for proton transport and dye release. PLoS ONE 2014, 9, e78494. [CrossRef] [PubMed]
    • (2014) PLoS ONE , vol.9
    • Gan, S.W.1    Surya, W.2    Vararattanavech, A.3    Torres, J.4
  • 74
    • 43749124014 scopus 로고    scopus 로고
    • Identification of the membrane-active regions of hepatitis C virus p7 protein: Biophysical characterization of the loop region
    • [CrossRef] [PubMed]
    • Perez-Berna, A.J.; Guillen, J.; Moreno, M.R.; Bernabeu, A.; Pabst, G.; Laggner, P.; Villalain, J. Identification of the membrane-active regions of hepatitis C virus p7 protein: Biophysical characterization of the loop region. J. Biol. Chem. 2008, 283, 8089-8101. [CrossRef] [PubMed]
    • (2008) J. Biol. Chem , vol.283 , pp. 8089-8101
    • Perez-Berna, A.J.1    Guillen, J.2    Moreno, M.R.3    Bernabeu, A.4    Pabst, G.5    Laggner, P.6    Villalain, J.7
  • 75
    • 0029929748 scopus 로고    scopus 로고
    • The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus
    • [CrossRef] [PubMed]
    • Sakaguchi, T.; Leser, G.P.; Lamb, R.A. The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus. J. Cell Biol. 1996, 133, 733-747. [CrossRef] [PubMed]
    • (1996) J. Cell Biol , vol.133 , pp. 733-747
    • Sakaguchi, T.1    Leser, G.P.2    Lamb, R.A.3
  • 76
    • 78951472169 scopus 로고    scopus 로고
    • Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome
    • [CrossRef] [PubMed]
    • Merz, A.; Long, G.; Hiet, M.S.; Brugger, B.; Chlanda, P.; Andre, P.; Wieland, F.; Krijnse-Locker, J.; Bartenschlager, R. Biochemical and morphological properties of hepatitis C virus particles and determination of their lipidome. J. Biol. Chem. 2011, 286, 3018-3032. [CrossRef] [PubMed]
    • (2011) J. Biol. Chem , vol.286 , pp. 3018-3032
    • Merz, A.1    Long, G.2    Hiet, M.S.3    Brugger, B.4    Chlanda, P.5    Andre, P.6    Wieland, F.7    Krijnse-Locker, J.8    Bartenschlager, R.9
  • 78
    • 84908010481 scopus 로고    scopus 로고
    • Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins
    • [CrossRef] [PubMed]
    • Lee, J.Y.; Acosta, E.G.; Stoeck, I.K.; Long, G.; Hiet, M.S.; Mueller, B.; Fackler, O.T.; Kallis, S.; Bartenschlager, R. Apolipoprotein E likely contributes to a maturation step of infectious hepatitis C virus particles and interacts with viral envelope glycoproteins. J. Virol. 2014, 88, 12422-12437. [CrossRef] [PubMed]
    • (2014) J. Virol , vol.88 , pp. 12422-12437
    • Lee, J.Y.1    Acosta, E.G.2    Stoeck, I.K.3    Long, G.4    Hiet, M.S.5    Mueller, B.6    Fackler, O.T.7    Kallis, S.8    Bartenschlager, R.9
  • 79
    • 85047689072 scopus 로고    scopus 로고
    • The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles
    • [CrossRef] [PubMed]
    • Boyer, A.; Dumans, A.; Beaumont, E.; Etienne, L.; Roingeard, P.; Meunier, J.C. The association of hepatitis C virus glycoproteins with apolipoproteins E and B early in assembly is conserved in lipoviral particles. J. Biol. Chem. 2014, 289, 18904-18913. [CrossRef] [PubMed]
    • (2014) J. Biol. Chem , vol.289 , pp. 18904-18913
    • Boyer, A.1    Dumans, A.2    Beaumont, E.3    Etienne, L.4    Roingeard, P.5    Meunier, J.C.6
  • 81
    • 78651252353 scopus 로고    scopus 로고
    • Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly
    • [CrossRef] [PubMed]
    • Jirasko, V.; Montserret, R.; Lee, J.Y.; Gouttenoire, J.; Moradpour, D.; Penin, F.; Bartenschlager, R. Structural and functional studies of nonstructural protein 2 of the hepatitis C virus reveal its key role as organizer of virion assembly. PLoS Pathog. 2010, 6, e1001233. [CrossRef] [PubMed]
    • (2010) PLoS Pathog , vol.6
    • Jirasko, V.1    Montserret, R.2    Lee, J.Y.3    Gouttenoire, J.4    Moradpour, D.5    Penin, F.6    Bartenschlager, R.7
  • 82
    • 78650062692 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins
    • [CrossRef] [PubMed]
    • Ma, Y.; Anantpadma, M.; Timpe, J.M.; Shanmugam, S.; Singh, S.M.; Lemon, S.M.; Yi, M. Hepatitis C virus NS2 protein serves as a scaffold for virus assembly by interacting with both structural and nonstructural proteins. J. Virol. 2011, 85, 86-97. [CrossRef] [PubMed]
    • (2011) J. Virol , vol.85 , pp. 86-97
    • Ma, Y.1    Anantpadma, M.2    Timpe, J.M.3    Shanmugam, S.4    Singh, S.M.5    Lemon, S.M.6    Yi, M.7
  • 84
    • 78951472458 scopus 로고    scopus 로고
    • Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes
    • [CrossRef] [PubMed]
    • Stapleford, K.A.; Lindenbach, B.D. Hepatitis C virus NS2 coordinates virus particle assembly through physical interactions with the E1-E2 glycoprotein and NS3-NS4A enzyme complexes. J. Virol. 2011, 85, 1706-1717. [CrossRef] [PubMed]
    • (2011) J. Virol , vol.85 , pp. 1706-1717
    • Stapleford, K.A.1    Lindenbach, B.D.2
  • 85
    • 79955778897 scopus 로고    scopus 로고
    • The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein
    • [CrossRef] [PubMed]
    • Tedbury, P.; Welbourn, S.; Pause, A.; King, B.; Griffin, S.; Harris, M. The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein. J. Gen. Virol. 2011, 92, 819-830. [CrossRef] [PubMed]
    • (2011) J. Gen. Virol , vol.92 , pp. 819-830
    • Tedbury, P.1    Welbourn, S.2    Pause, A.3    King, B.4    Griffin, S.5    Harris, M.6
  • 86
    • 79960951066 scopus 로고    scopus 로고
    • A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly
    • [CrossRef] [PubMed]
    • Boson, B.; Granio, O.; Bartenschlager, R.; Cosset, F.L. A concerted action of hepatitis C virus p7 and nonstructural protein 2 regulates core localization at the endoplasmic reticulum and virus assembly. PLoS Pathog. 2011, 7, e1002144. [CrossRef] [PubMed]
    • (2011) PLoS Pathog , vol.7
    • Boson, B.1    Granio, O.2    Bartenschlager, R.3    Cosset, F.L.4
  • 87
    • 84904133963 scopus 로고    scopus 로고
    • The intraviral protein interaction network of hepatitis C virus
    • [CrossRef] [PubMed]
    • Hagen, N.; Bayer, K.; Rosch, K.; Schindler, M. The intraviral protein interaction network of hepatitis C virus. Mol. Cell Proteom. 2014, 13, 1676-1689. [CrossRef] [PubMed]
    • (2014) Mol. Cell Proteom , vol.13 , pp. 1676-1689
    • Hagen, N.1    Bayer, K.2    Rosch, K.3    Schindler, M.4
  • 88
    • 84863682657 scopus 로고    scopus 로고
    • Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems
    • [CrossRef] [PubMed]
    • Scheel, T.K.; Prentoe, J.; Carlsen, T.H.; Mikkelsen, L.S.; Gottwein, J.M.; Bukh, J. Analysis of functional differences between hepatitis C virus NS5A of genotypes 1-7 in infectious cell culture systems. PLoS Pathog. 2012, 8, e1002696. [CrossRef] [PubMed]
    • (2012) PLoS Pathog , vol.8
    • Scheel, T.K.1    Prentoe, J.2    Carlsen, T.H.3    Mikkelsen, L.S.4    Gottwein, J.M.5    Bukh, J.6
  • 89
    • 29744467205 scopus 로고    scopus 로고
    • Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes
    • [CrossRef] [PubMed]
    • Griffin, S.; Clarke, D.; McCormick, C.; Rowlands, D.; Harris, M. Signal peptide cleavage and internal targeting signals direct the hepatitis C virus p7 protein to distinct intracellular membranes. J. Virol. 2005, 79, 15525-15536. [CrossRef] [PubMed]
    • (2005) J. Virol , vol.79 , pp. 15525-15536
    • Griffin, S.1    Clarke, D.2    McCormick, C.3    Rowlands, D.4    Harris, M.5
  • 90
    • 33846139969 scopus 로고    scopus 로고
    • Hepatitis C virus p7 protein is localized in the endoplasmic reticulum when it is encoded by a replication-competent genome
    • [CrossRef] [PubMed]
    • Haqshenas, G.; Mackenzie, J.M.; Dong, X.; Gowans, E.J. Hepatitis C virus p7 protein is localized in the endoplasmic reticulum when it is encoded by a replication-competent genome. J. Gen. Virol. 2007, 88, 134-142. [CrossRef] [PubMed]
    • (2007) J. Gen. Virol , vol.88 , pp. 134-142
    • Haqshenas, G.1    Mackenzie, J.M.2    Dong, X.3    Gowans, E.J.4
  • 93
    • 84910629145 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication and assembly: Living on the fat of the land
    • [CrossRef] [PubMed]
    • Paul, D.; Madan, V.; Bartenschlager, R. Hepatitis C virus RNA replication and assembly: Living on the fat of the land. Cell Host Microbe 2014, 16, 569-579. [CrossRef] [PubMed]
    • (2014) Cell Host Microbe , vol.16 , pp. 569-579
    • Paul, D.1    Madan, V.2    Bartenschlager, R.3
  • 95
    • 80052283930 scopus 로고    scopus 로고
    • Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A
    • [CrossRef] [PubMed]
    • Gottwein, J.M.; Jensen, T.B.; Mathiesen, C.K.; Meuleman, P.; Serre, S.B.; Lademann, J.B.; Ghanem, L.; Scheel, T.K.; Leroux-Roels, G.; Bukh, J. Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A. J. Virol. 2011, 85, 8913-8928. [CrossRef] [PubMed]
    • (2011) J. Virol , vol.85 , pp. 8913-8928
    • Gottwein, J.M.1    Jensen, T.B.2    Mathiesen, C.K.3    Meuleman, P.4    Serre, S.B.5    Lademann, J.B.6    Ghanem, L.7    Scheel, T.K.8    Leroux-Roels, G.9    Bukh, J.10
  • 96
    • 84887139291 scopus 로고    scopus 로고
    • Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission
    • [CrossRef] [PubMed]
    • Meredith, L.W.; Zitzmann, N.; McKeating, J.A. Differential effect of p7 inhibitors on hepatitis C virus cell-to-cell transmission. Antivir. Res. 2013, 100, 636-639. [CrossRef] [PubMed]
    • (2013) Antivir. Res , vol.100 , pp. 636-639
    • Meredith, L.W.1    Zitzmann, N.2    McKeating, J.A.3
  • 98
    • 33845965324 scopus 로고    scopus 로고
    • Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine
    • [CrossRef] [PubMed]
    • Castelain, S.; Bonte, D.; Penin, F.; Francois, C.; Capron, D.; Dedeurwaerder, S.; Zawadzki, P.; Morel, V.; Wychowski, C.; Duverlie, G. Hepatitis C Virus p7 membrane protein quasispecies variability in chronically infected patients treated with interferon and ribavirin, with or without amantadine. J. Med. Virol. 2007, 79, 144-154. [CrossRef] [PubMed]
    • (2007) J. Med. Virol , vol.79 , pp. 144-154
    • Castelain, S.1    Bonte, D.2    Penin, F.3    Francois, C.4    Capron, D.5    Dedeurwaerder, S.6    Zawadzki, P.7    Morel, V.8    Wychowski, C.9    Duverlie, G.10
  • 99
    • 75749156935 scopus 로고    scopus 로고
    • Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages
    • [CrossRef] [PubMed]
    • Khoury, G.; Ewart, G.; Luscombe, C.; Miller, M.; Wilkinson, J. Antiviral efficacy of the novel compound BIT225 against HIV-1 release from human macrophages. Antimicrob. Agents Chemother. 2010, 54, 835-845. [CrossRef] [PubMed]
    • (2010) Antimicrob. Agents Chemother , vol.54 , pp. 835-845
    • Khoury, G.1    Ewart, G.2    Luscombe, C.3    Miller, M.4    Wilkinson, J.5
  • 100
    • 77951296857 scopus 로고    scopus 로고
    • A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues
    • [CrossRef] [PubMed]
    • Luscombe, C.A.; Huang, Z.; Murray, M.G.; Miller, M.; Wilkinson, J.; Ewart, G.D. A novel Hepatitis C virus p7 ion channel inhibitor, BIT225, inhibits bovine viral diarrhea virus in vitro and shows synergism with recombinant interferon-alpha-2b and nucleoside analogues. Antiviral Res. 2010, 86, 144-153. [CrossRef] [PubMed]
    • (2010) Antiviral Res , vol.86 , pp. 144-153
    • Luscombe, C.A.1    Huang, Z.2    Murray, M.G.3    Miller, M.4    Wilkinson, J.5    Ewart, G.D.6
  • 101
    • 84911923769 scopus 로고    scopus 로고
    • Docking assay of small molecule antivirals to p7 of HCV
    • [CrossRef] [PubMed]
    • Bichmann, L.; Wang, Y.T.; Fischer, W.B. Docking assay of small molecule antivirals to p7 of HCV. Comput. Biol. Chem. 2014, 53, 308-317. [CrossRef] [PubMed]
    • (2014) Comput. Biol. Chem , vol.53 , pp. 308-317
    • Bichmann, L.1    Wang, Y.T.2    Fischer, W.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.