Structural basis for proton conduction and inhibition by the influenza M2 protein

Protein Science

Volumn 21, Issue 11, 2012, Pages 1620-1633

  Hong, Mei ^a   DeGrado, William F ^b  

^a IOWA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Drug inhibition; Magic angle spinning; Membrane protein structure determination; Protein dynamics; Solid state NMR

Indexed keywords

AMANTADINE; HISTIDINE; IMIDAZOLE; INFLUENZA M2 PROTEIN; PROTEIN M2; PROTON; RIMANTADINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SEQUENCE; BINDING AFFINITY; CHANNEL GATING; CONFORMATIONAL TRANSITION; DRUG BINDING SITE; DRUG INHIBITION; ELECTROPHYSIOLOGY; HYDROGEN BOND; HYDROPHOBICITY; INFLUENZA VIRUS; MATHEMATICAL MODEL; MEMBRANE STABILIZATION; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON TRANSPORT; REVIEW; SIMULATION; SOLID STATE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VIROGENESIS; VIRUS ENVELOPE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, VIRAL; HUMANS; HYDROGEN-ION CONCENTRATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTONS; VIRAL MATRIX PROTEINS;

EID: 84867681380     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2158     Document Type: Review

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