Structure-guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release

Hepatology

Volumn 59, Issue 2, 2014, Pages 408-422

  Foster, Toshana L ^a,b,c   Thompson, Gary S ^b   Kalverda, Arnout P ^b   Kankanala, Jayakanth ^b   Bentham, Matthew ^a   Wetherill, Laura F ^a   Thompson, Joseph ^b,c   Barker, Amy M ^b   Clarke, Dean ^b   Noerenberg, Marko ^b,d   Pearson, Arwen R ^b   Rowlands, David J ^b   Homans, Steven W ^b,e   Harris, Mark ^b   Foster, Richard ^b   Griffin, Stephen ^a,b  

^a ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; HEPATITIS C VIRUS P7 INHIBITOR; ION CHANNEL; UNCLASSIFIED DRUG; VIROPORIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPUTER MODEL; CONTROLLED STUDY; DRUG CONFORMATION; DRUG DESIGN; DRUG SPECIFICITY; DRUG STRUCTURE; GENOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; VIRION; VIRUS INHIBITION; VIRUS RELEASE;

ALLOSTERIC SITE; ANTIVIRAL AGENTS; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MODELS, STRUCTURAL; PROTEIN CONFORMATION; VIRAL PROTEINS; VIRION; VIRUS REPLICATION;

EID: 84893704261     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.26685     Document Type: Article

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