Antibacterial Activity of Enrofloxacin and Ciprofloxacin Derivatives of β-Octaarginine

Chemistry and Biodiversity

Volumn 12, Issue 2, 2015, Pages 179-193

  Purkayastha, Nirupam ^a,c   Capone, Stefania ^a,d   Beck, Albert K ^a   Seebach, Dieter ^a   Leeds, Jennifer ^b   Thompson, Katherine ^b   Moser, Heinz E ^b  

^a ETH ZURICH   (Switzerland)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c CLARIANT PRODUKTE DEUTSCHLAND GMBH   (Germany)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Antibacterial activity; Ciprofloxacin derivatives; Enrofloxacin derivatives; 3 Octaarginine derivatives

Indexed keywords

1 CYCLOPROPYL 7 (4 ETHYLPIPERAZIN 1 YL) 6 FLUORO 1,4 DIHYDRO 4 OXO N ( PROPAN 2 YL)QUINOLINE 3 CARBOXAMIDE; 7 (4 ACETYLPIPERAZIN 1 YL) 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; 7 [4 (CHLOROACETYL)PIPERAZIN 1 YL] 1 CYCLOPROPYL 6 FLUORO 1,4 DIHYDRO 4 OXOQUINOLINE 3 CARBOXYLIC ACID; AMIDE; ANTIBIOTIC AGENT; CELL PENETRATING PEPTIDE; CIPROFLOXACIN; CIRCULAR DNA; ENROFLOXACIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); OCTAARGININE; OLIGOPEPTIDE; QUINOLONE DERIVATIVE;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BINDING SITE; CHEMICAL MODIFICATION; COMPARATIVE STUDY; DRUG ACTIVITY; DRUG SENSITIVITY; DRUG SYNTHESIS; ENZYME STRUCTURE; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KLEBSIELLA PNEUMONIAE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; ULTRAVIOLET RADIATION; CHEMISTRY; DRUG EFFECTS; GRAM POSITIVE BACTERIUM; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DOCKING; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; BINDING SITES; CELL-PENETRATING PEPTIDES; CIPROFLOXACIN; DNA GYRASE; FLUOROQUINOLONES; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MOLECULAR DOCKING SIMULATION; OLIGOPEPTIDES; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941109648     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201400456     Document Type: Article

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