Direct cytosolic delivery of cargoes in vivo by a chimera consisting of D- and L-arginine residues

Journal of Controlled Release

Volumn 162, Issue 2, 2012, Pages 286-294

  Ma, Yan ^a,b   Gong, Cheng ^a,b   Ma, Yilong ^a,b   Fan, Fengkai ^a,b   Luo, Meijie ^a,b   Yang, Fei ^a,b   Zhang, Yu Hui ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Cell penetrating peptide; Cytosolic delivery; Heterogeneous; Oligoarginine; Systemic toxicity

Indexed keywords

CELL-PENETRATING PEPTIDE; CELLULAR UPTAKE; CULTURED CELL; CYTOSOLIC; CYTOSOLS; DESIGN AND APPLICATION; HETEROGENEOUS; HYBRID PEPTIDES; IN-VIVO; INTRACELLULAR DISTRIBUTION; INTRAVENOUS INJECTIONS; L-ARGININE; LIVING CELL; LIVING TISSUES; MEMBRANE POTENTIALS; MEMBRANE TRANSLOCATION; OLIGOARGININE; PEPTIDE SEQUENCES; UPTAKE MECHANISM;

AMINO ACIDS; BIOCHEMISTRY; CELLS; CYTOLOGY; DRUG DELIVERY; EFFICIENCY; MOLECULAR BIOLOGY; PEPTIDES; POSITIVE IONS; TISSUE;

TOXICITY;

ARGININE; HYBRID PROTEIN;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CHIMERA; CONTROLLED STUDY; CYTOSOL; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION;

ANIMALS; ARGININE; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CELL SURVIVAL; CELL-PENETRATING PEPTIDES; CYTOSOL; DRUG CARRIERS; FLUORESCENT DYES; HEK293 CELLS; HELA CELLS; HUMANS; MICE; OLIGOPEPTIDES; RHODAMINES;

EID: 84865343913     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.07.022     Document Type: Article

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