메뉴 건너뛰기




Volumn 85, Issue 1, 2013, Pages 5-11

Is there a future for cell-penetrating peptides in oligonucleotide delivery?

Author keywords

Cell penetrating peptide; Delivery; Endocytosis; Oligonucleotide; siRNA

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BEE VENOM; CELL PENETRATING PEPTIDE; GALANIN; GLYCOPROTEIN GP 41; LIPOSOME; LUCIFERASE; MASTOPARAN; POLYMER; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; VIRUS LARGE T ANTIGEN;

EID: 84882985069     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2013.03.021     Document Type: Review
Times cited : (72)

References (98)
  • 1
    • 84856431819 scopus 로고    scopus 로고
    • RNA therapeutics: Beyond RNA interference and antisense oligonucleotides
    • R. Kole, A.R. Krainer, and S. Altman RNA therapeutics: beyond RNA interference and antisense oligonucleotides Nat. Rev. Drug Discov. 11 2012 125 140
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 125-140
    • Kole, R.1    Krainer, A.R.2    Altman, S.3
  • 2
    • 84866899464 scopus 로고    scopus 로고
    • Endgame: Glybera finally recommended for approval as the first gene therapy drug in the European union
    • S. Yla-Herttuala Endgame: glybera finally recommended for approval as the first gene therapy drug in the European union Mol. Ther. 20 2012 1831 1832
    • (2012) Mol. Ther. , vol.20 , pp. 1831-1832
    • Yla-Herttuala, S.1
  • 3
    • 68549087056 scopus 로고    scopus 로고
    • Viral vectors: From virology to transgene expression
    • D. Bouard, N. Alazard-Dany, and F.L. Cosset Viral vectors: from virology to transgene expression Br. J. Pharmacol. 157 2009 153 165
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 153-165
    • Bouard, D.1    Alazard-Dany, N.2    Cosset, F.L.3
  • 4
    • 84863485635 scopus 로고    scopus 로고
    • In vivo gene delivery by nonviral vectors: Overcoming hurdles?
    • Y. Zhang, A. Satterlee, and L. Huang In vivo gene delivery by nonviral vectors: overcoming hurdles? Mol. Ther. 20 2012 1298 1304
    • (2012) Mol. Ther. , vol.20 , pp. 1298-1304
    • Zhang, Y.1    Satterlee, A.2    Huang, L.3
  • 6
    • 84862211680 scopus 로고    scopus 로고
    • The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity
    • A.E. Felber, N. Bayo-Puxan, G.F. Deleavey, B. Castagner, M.J. Damha, and J.C. Leroux The interactions of amphiphilic antisense oligonucleotides with serum proteins and their effects on in vitro silencing activity Biomaterials 33 2012 5955 5965
    • (2012) Biomaterials , vol.33 , pp. 5955-5965
    • Felber, A.E.1    Bayo-Puxan, N.2    Deleavey, G.F.3    Castagner, B.4    Damha, M.J.5    Leroux, J.C.6
  • 7
    • 0027473513 scopus 로고
    • Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy
    • A.M. Krieg, J. Tonkinson, S. Matson, Q. Zhao, M. Saxon, L.M. Zhang, U. Bhanja, L. Yakubov, and C.A. Stein Modification of antisense phosphodiester oligodeoxynucleotides by a 5' cholesteryl moiety increases cellular association and improves efficacy Proc. Natl. Acad. Sci. USA 90 1993 1048 1052
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1048-1052
    • Krieg, A.M.1    Tonkinson, J.2    Matson, S.3    Zhao, Q.4    Saxon, M.5    Zhang, L.M.6    Bhanja, U.7    Yakubov, L.8    Stein, C.A.9
  • 9
    • 38949095271 scopus 로고    scopus 로고
    • Protein and peptide transduction, 20 years later a happy birthday
    • A. Prochiantz Protein and peptide transduction, 20 years later a happy birthday Adv. Drug Deliv. Rev. 60 2008 448 451
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , pp. 448-451
    • Prochiantz, A.1
  • 10
    • 0031471203 scopus 로고    scopus 로고
    • Intercellular trafficking and protein delivery by a herpesvirus structural protein
    • G. Elliott, and P. O'Hare Intercellular trafficking and protein delivery by a herpesvirus structural protein Cell 88 1997 223 233
    • (1997) Cell , vol.88 , pp. 223-233
    • Elliott, G.1    O'Hare, P.2
  • 11
    • 0024262589 scopus 로고
    • Cellular uptake of the tat protein from human immunodeficiency virus
    • A.D. Frankel, and C.O. Pabo Cellular uptake of the tat protein from human immunodeficiency virus Cell 55 1988 1189 1193
    • (1988) Cell , vol.55 , pp. 1189-1193
    • Frankel, A.D.1    Pabo, C.O.2
  • 12
    • 0028239908 scopus 로고
    • The third helix of the Antennapedia homeodomain translocates through biological membranes
    • D. Derossi, A.H. Joliot, G. Chassaing, and A. Prochiantz The third helix of the Antennapedia homeodomain translocates through biological membranes J. Biol. Chem. 269 1994 10444 10450
    • (1994) J. Biol. Chem. , vol.269 , pp. 10444-10450
    • Derossi, D.1    Joliot, A.H.2    Chassaing, G.3    Prochiantz, A.4
  • 13
    • 68549110328 scopus 로고    scopus 로고
    • Twenty years of cell-penetrating peptides: From molecular mechanisms to therapeutics
    • F. Heitz, M.C. Morris, and G. Divita Twenty years of cell-penetrating peptides: from molecular mechanisms to therapeutics Br. J. Pharmacol. 157 2009 195 206
    • (2009) Br. J. Pharmacol. , vol.157 , pp. 195-206
    • Heitz, F.1    Morris, M.C.2    Divita, G.3
  • 14
    • 0030904245 scopus 로고    scopus 로고
    • A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
    • E. Vivès, P. Brodin, and B. Lebleu A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus J. Biol. Chem. 272 1997 16010 16017
    • (1997) J. Biol. Chem. , vol.272 , pp. 16010-16017
    • Vivès, E.1    Brodin, P.2    Lebleu, B.3
  • 15
    • 0030804766 scopus 로고    scopus 로고
    • A new peptide vector for efficient delivery of oligonucleotides into mammalian cells
    • M.C. Morris, P. Vidal, L. Chaloin, F. Heitz, and G. Divita A new peptide vector for efficient delivery of oligonucleotides into mammalian cells Nucl. Acids Res. 25 1997 2730 2736
    • (1997) Nucl. Acids Res. , vol.25 , pp. 2730-2736
    • Morris, M.C.1    Vidal, P.2    Chaloin, L.3    Heitz, F.4    Divita, G.5
  • 17
    • 0033520487 scopus 로고    scopus 로고
    • In vivo protein transduction: Delivery of a biologically active protein into the mouse
    • S.R. Schwarze, A. Ho, A. Vocero-Akbani, and S.F. Dowdy In vivo protein transduction: delivery of a biologically active protein into the mouse Science 285 1999 1569 1572
    • (1999) Science , vol.285 , pp. 1569-1572
    • Schwarze, S.R.1    Ho, A.2    Vocero-Akbani, A.3    Dowdy, S.F.4
  • 18
    • 0034700141 scopus 로고    scopus 로고
    • The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
    • P.A. Wender, D.J. Mitchell, K. Pattabiraman, E.T. Pelkey, L. Steinman, and J.B. Rothbard The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: peptoid molecular transporters Proc. Natl. Acad. Sci. USA 97 2000 13003 13008
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13003-13008
    • Wender, P.A.1    Mitchell, D.J.2    Pattabiraman, K.3    Pelkey, E.T.4    Steinman, L.5    Rothbard, J.B.6
  • 19
    • 0035937124 scopus 로고    scopus 로고
    • Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery
    • S. Futaki, T. Suzuki, W. Ohashi, T. Yagami, S. Tanaka, K. Ueda, and Y. Sugiura Arginine-rich peptides. An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery J. Biol. Chem. 276 2001 5836 5840
    • (2001) J. Biol. Chem. , vol.276 , pp. 5836-5840
    • Futaki, S.1    Suzuki, T.2    Ohashi, W.3    Yagami, T.4    Tanaka, S.5    Ueda, K.6    Sugiura, Y.7
  • 21
    • 2342595835 scopus 로고    scopus 로고
    • Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
    • J.S. Wadia, R.V. Stan, and S.F. Dowdy Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis Nat. Med. 10 2004 310 315
    • (2004) Nat. Med. , vol.10 , pp. 310-315
    • Wadia, J.S.1    Stan, R.V.2    Dowdy, S.F.3
  • 24
    • 76649130213 scopus 로고    scopus 로고
    • Delivery of macromolecules into live cells by simple co-incubation with a peptide
    • Y.J. Lee, A. Erazo-Oliveras, and J.P. Pellois Delivery of macromolecules into live cells by simple co-incubation with a peptide Chembiochem 11 2010 325 330
    • (2010) Chembiochem , vol.11 , pp. 325-330
    • Lee, Y.J.1    Erazo-Oliveras, A.2    Pellois, J.P.3
  • 25
    • 84859720244 scopus 로고    scopus 로고
    • Oral biodrug delivery using cell-penetrating peptide
    • E.-S. Khafagy, and M. Morishita Oral biodrug delivery using cell-penetrating peptide Adv. Drug Deliv. Rev. 64 2012 531 539
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 531-539
    • Khafagy, E.-S.1    Morishita, M.2
  • 26
    • 34248680739 scopus 로고    scopus 로고
    • Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides
    • B.R. Meade, and S.F. Dowdy Exogenous siRNA delivery using peptide transduction domains/cell penetrating peptides Adv. Drug Deliv. Rev. 59 2007 134 140
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , pp. 134-140
    • Meade, B.R.1    Dowdy, S.F.2
  • 28
    • 80051727049 scopus 로고    scopus 로고
    • The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides
    • L. Fei, L. Ren, J.L. Zaro, and W.C. Shen The influence of net charge and charge distribution on cellular uptake and cytosolic localization of arginine-rich peptides J. Drug Target. 19 2011 675 680
    • (2011) J. Drug Target. , vol.19 , pp. 675-680
    • Fei, L.1    Ren, L.2    Zaro, J.L.3    Shen, W.C.4
  • 29
    • 67249151969 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate
    • M. Meyer, C. Dohmen, A. Philipp, D. Kiener, G. Maiwald, C. Scheu, M. Ogris, and E. Wagner Synthesis and biological evaluation of a bioresponsive and endosomolytic siRNA-polymer conjugate Mol. Pharm. 6 2009 752 762
    • (2009) Mol. Pharm. , vol.6 , pp. 752-762
    • Meyer, M.1    Dohmen, C.2    Philipp, A.3    Kiener, D.4    Maiwald, G.5    Scheu, C.6    Ogris, M.7    Wagner, E.8
  • 30
    • 0037071859 scopus 로고    scopus 로고
    • T-box gene tbx5 is essential for formation of the pectoral limb bud
    • D.G. Ahn, M.J. Kourakis, L.A. Rohde, L.M. Silver, and R.K. Ho T-box gene tbx5 is essential for formation of the pectoral limb bud Nature 417 2002 754 758
    • (2002) Nature , vol.417 , pp. 754-758
    • Ahn, D.G.1    Kourakis, M.J.2    Rohde, L.A.3    Silver, L.M.4    Ho, R.K.5
  • 33
    • 0037592877 scopus 로고    scopus 로고
    • Insight into the mechanism of the peptide-based gene delivery system MPG: Implications for delivery of siRNA into mammalian cells
    • F. Simeoni, M.C. Morris, F. Heitz, and G. Divita Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells Nucl. Acids Res. 31 2003 2717 2724
    • (2003) Nucl. Acids Res. , vol.31 , pp. 2717-2724
    • Simeoni, F.1    Morris, M.C.2    Heitz, F.3    Divita, G.4
  • 34
    • 35048856889 scopus 로고    scopus 로고
    • Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: A comparative study
    • S. El-Andaloussi, P. Jarver, H.J. Johansson, and U. Langel Cargo-dependent cytotoxicity and delivery efficacy of cell-penetrating peptides: a comparative study Biochem. J. 407 2007 285 292
    • (2007) Biochem. J. , vol.407 , pp. 285-292
    • El-Andaloussi, S.1    Jarver, P.2    Johansson, H.J.3    Langel, U.4
  • 35
    • 27644481173 scopus 로고    scopus 로고
    • C-versus N-terminally linked melittin-polyethylenimine conjugates: The site of linkage strongly influences activity of DNA polyplexes
    • S. Boeckle, E. Wagner, and M. Ogris C-versus N-terminally linked melittin-polyethylenimine conjugates: the site of linkage strongly influences activity of DNA polyplexes J. Gene Med. 7 2005 1335 1347
    • (2005) J. Gene Med. , vol.7 , pp. 1335-1347
    • Boeckle, S.1    Wagner, E.2    Ogris, M.3
  • 37
    • 77958152873 scopus 로고    scopus 로고
    • Morpholinos and their peptide conjugates: Therapeutic promise and challenge for Duchenne muscular dystrophy
    • H.M. Moulton, and J.D. Moulton Morpholinos and their peptide conjugates: therapeutic promise and challenge for Duchenne muscular dystrophy Biochim. Biophys. Acta 1798 2010 2296 2303
    • (2010) Biochim. Biophys. Acta , vol.1798 , pp. 2296-2303
    • Moulton, H.M.1    Moulton, J.D.2
  • 39
    • 84856964238 scopus 로고    scopus 로고
    • Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate
    • F.A. Rogers, S.S. Lin, D.C. Hegan, D.S. Krause, and P.M. Glazer Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate Mol. Ther. 20 2012 109 118
    • (2012) Mol. Ther. , vol.20 , pp. 109-118
    • Rogers, F.A.1    Lin, S.S.2    Hegan, D.C.3    Krause, D.S.4    Glazer, P.M.5
  • 44
    • 51849096484 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element
    • S. Ganguly, B. Chaubey, S. Tripathi, A. Upadhyay, P.V. Neti, R.W. Howell, and V.N. Pandey Pharmacokinetic analysis of polyamide nucleic-acid-cell penetrating peptide conjugates targeted against HIV-1 transactivation response element Oligonucleotides 18 2008 277 286
    • (2008) Oligonucleotides , vol.18 , pp. 277-286
    • Ganguly, S.1    Chaubey, B.2    Tripathi, S.3    Upadhyay, A.4    Neti, P.V.5    Howell, R.W.6    Pandey, V.N.7
  • 45
  • 46
    • 41149156893 scopus 로고    scopus 로고
    • Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans
    • M. Kosuge, T. Takeuchi, I. Nakase, A.T. Jones, and S. Futaki Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans Bioconjug. Chem. 19 2008 656 664
    • (2008) Bioconjug. Chem. , vol.19 , pp. 656-664
    • Kosuge, M.1    Takeuchi, T.2    Nakase, I.3    Jones, A.T.4    Futaki, S.5
  • 50
    • 67149093390 scopus 로고    scopus 로고
    • Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein
    • A. Eguchi, B.R. Meade, Y.C. Chang, C.T. Fredrickson, K. Willert, N. Puri, and S.F. Dowdy Efficient siRNA delivery into primary cells by a peptide transduction domain-dsRNA binding domain fusion protein Nat. Biotechnol. 27 2009 567 571
    • (2009) Nat. Biotechnol. , vol.27 , pp. 567-571
    • Eguchi, A.1    Meade, B.R.2    Chang, Y.C.3    Fredrickson, C.T.4    Willert, K.5    Puri, N.6    Dowdy, S.F.7
  • 56
    • 70349481725 scopus 로고    scopus 로고
    • Intracellular small interfering RNA delivery using genetically engineered double-stranded RNA binding protein domain
    • J. Kim, S.H. Lee, J. Choe, and T.G. Park Intracellular small interfering RNA delivery using genetically engineered double-stranded RNA binding protein domain J. Gene Med. 11 2009 804 812
    • (2009) J. Gene Med. , vol.11 , pp. 804-812
    • Kim, J.1    Lee, S.H.2    Choe, J.3    Park, T.G.4
  • 57
    • 84856917252 scopus 로고    scopus 로고
    • Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy
    • R.H. Mo, J.L. Zaro, and W.-C. Shen Comparison of cationic and amphipathic cell penetrating peptides for siRNA delivery and efficacy Mol. Pharm. 9 2012 299 309
    • (2012) Mol. Pharm. , vol.9 , pp. 299-309
    • Mo, R.H.1    Zaro, J.L.2    Shen, W.-C.3
  • 58
    • 28444435477 scopus 로고    scopus 로고
    • Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI
    • E. Kleemann, M. Neu, N. Jekel, L. Fink, T. Schmehl, T. Gessler, W. Seeger, and T. Kissel Nano-carriers for DNA delivery to the lung based upon a TAT-derived peptide covalently coupled to PEG-PEI J. Control. Release 109 2005 299 316
    • (2005) J. Control. Release , vol.109 , pp. 299-316
    • Kleemann, E.1    Neu, M.2    Jekel, N.3    Fink, L.4    Schmehl, T.5    Gessler, T.6    Seeger, W.7    Kissel, T.8
  • 59
    • 33745226168 scopus 로고    scopus 로고
    • Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles
    • J.S. Suk, J. Suh, K. Choy, S.K. Lai, J. Fu, and J. Hanes Gene delivery to differentiated neurotypic cells with RGD and HIV Tat peptide functionalized polymeric nanoparticles Biomaterials 27 2006 5143 5150
    • (2006) Biomaterials , vol.27 , pp. 5143-5150
    • Suk, J.S.1    Suh, J.2    Choy, K.3    Lai, S.K.4    Fu, J.5    Hanes, J.6
  • 60
    • 33646144003 scopus 로고    scopus 로고
    • SiRNA-containing liposomes modified with polyarginine effectively silence the targeted gene
    • C. Zhang, N. Tang, X. Liu, W. Liang, W. Xu, and V.P. Torchilin SiRNA-containing liposomes modified with polyarginine effectively silence the targeted gene J. Control. Release 112 2006 229 239
    • (2006) J. Control. Release , vol.112 , pp. 229-239
    • Zhang, C.1    Tang, N.2    Liu, X.3    Liang, W.4    Xu, W.5    Torchilin, V.P.6
  • 61
    • 33746015970 scopus 로고    scopus 로고
    • Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice
    • D. Mudhakir, H. Akita, I.A. Khalil, S. Futaki, and H. Harashima Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice Drug Metab. Pharmacokinet. 20 2005 275 281
    • (2005) Drug Metab. Pharmacokinet. , vol.20 , pp. 275-281
    • Mudhakir, D.1    Akita, H.2    Khalil, I.A.3    Futaki, S.4    Harashima, H.5
  • 62
    • 34548178892 scopus 로고    scopus 로고
    • Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption
    • T. Shiraishi, and P.E. Nielsen Enhanced delivery of cell-penetrating peptide-peptide nucleic acid conjugates by endosomal disruption Nat. Protoc. 1 2006 633 636
    • (2006) Nat. Protoc. , vol.1 , pp. 633-636
    • Shiraishi, T.1    Nielsen, P.E.2
  • 63
    • 0030890748 scopus 로고    scopus 로고
    • Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers
    • T.B. Wyman, F. Nicol, O. Zelphati, P.V. Scaria, C. Plank, and F.C. Szoka Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers Biochemistry 36 1997 3008 3017
    • (1997) Biochemistry , vol.36 , pp. 3008-3017
    • Wyman, T.B.1    Nicol, F.2    Zelphati, O.3    Scaria, P.V.4    Plank, C.5    Szoka, F.C.6
  • 64
    • 34247153120 scopus 로고    scopus 로고
    • Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide
    • S.H. Lee, S.H. Kim, and T.G. Park Intracellular siRNA delivery system using polyelectrolyte complex micelles prepared from VEGF siRNA-PEG conjugate and cationic fusogenic peptide Biochem. Biophys. Res. Commun. 357 2007 511 516
    • (2007) Biochem. Biophys. Res. Commun. , vol.357 , pp. 511-516
    • Lee, S.H.1    Kim, S.H.2    Park, T.G.3
  • 65
    • 34548484580 scopus 로고    scopus 로고
    • Delivery of short interfering RNA using endosomolytic cell-penetrating peptides
    • P. Lundberg, S. El-Andaloussi, T. Sutlu, H. Johansson, and U. Langel Delivery of short interfering RNA using endosomolytic cell-penetrating peptides FASEB J. 21 2007 2664 2671
    • (2007) FASEB J. , vol.21 , pp. 2664-2671
    • Lundberg, P.1    El-Andaloussi, S.2    Sutlu, T.3    Johansson, H.4    Langel, U.5
  • 66
    • 84867795473 scopus 로고    scopus 로고
    • Identification and characterization of receptor-specific peptides for siRNA delivery
    • Y. Ren, S. Hauert, J.H. Lo, and S.N. Bhatia Identification and characterization of receptor-specific peptides for siRNA delivery ACS Nano 6 2012 8620 8631
    • (2012) ACS Nano , vol.6 , pp. 8620-8631
    • Ren, Y.1    Hauert, S.2    Lo, J.H.3    Bhatia, S.N.4
  • 69
    • 84859387896 scopus 로고    scopus 로고
    • Do cell-penetrating peptides actually "penetrate" cellular membranes?
    • C. Palm-Apergi, P. Lonn, and S.F. Dowdy Do cell-penetrating peptides actually "penetrate" cellular membranes? Mol. Ther. 20 2012 695 697
    • (2012) Mol. Ther. , vol.20 , pp. 695-697
    • Palm-Apergi, C.1    Lonn, P.2    Dowdy, S.F.3
  • 71
    • 58249095956 scopus 로고    scopus 로고
    • The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake
    • C. Palm-Apergi, A. Lorents, K. Padari, M. Pooga, and M. Hallbrink The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake FASEB J. 23 2009 214 223
    • (2009) FASEB J. , vol.23 , pp. 214-223
    • Palm-Apergi, C.1    Lorents, A.2    Padari, K.3    Pooga, M.4    Hallbrink, M.5
  • 72
    • 84860850876 scopus 로고    scopus 로고
    • Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration
    • A. Lorents, P.K. Kodavali, N. Oskolkov, Ü. Langel, M. Hällbrink, and M. Pooga Cell-penetrating peptides split into two groups based on modulation of intracellular calcium concentration J. Biol. Chem. 287 2012 16880 16889
    • (2012) J. Biol. Chem. , vol.287 , pp. 16880-16889
    • Lorents, A.1    Kodavali, P.K.2    Oskolkov, N.3    Langel, Ü.4    Hällbrink, M.5    Pooga, M.6
  • 73
    • 80855144226 scopus 로고    scopus 로고
    • Macropinocytosis: An endocytic pathway for internalising large gulps
    • J.P. Lim, and P.A. Gleeson Macropinocytosis: an endocytic pathway for internalising large gulps Immunol. Cell Biol. 89 2011 836 843
    • (2011) Immunol. Cell Biol. , vol.89 , pp. 836-843
    • Lim, J.P.1    Gleeson, P.A.2
  • 77
    • 70349482671 scopus 로고    scopus 로고
    • C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration
    • T. Teesalu, K.N. Sugahara, V.R. Kotamraju, and E. Ruoslahti C-end rule peptides mediate neuropilin-1-dependent cell, vascular, and tissue penetration Proc. Natl. Acad. Sci. USA 106 2009 16157 16162
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 16157-16162
    • Teesalu, T.1    Sugahara, K.N.2    Kotamraju, V.R.3    Ruoslahti, E.4
  • 80
    • 34547657290 scopus 로고    scopus 로고
    • Enhanced transfection of tumor cells in vivo using "smart" pH-sensitive TAT-modified pegylated liposomes
    • A.A. Kale, and V.P. Torchilin Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes J. Drug Target. 15 2007 538 545
    • (2007) J. Drug Target. , vol.15 , pp. 538-545
    • Kale, A.A.1    Torchilin, V.P.2
  • 81
    • 61549102484 scopus 로고    scopus 로고
    • PEGylated and MMP-2 specifically dePEGylated quantum dots: Comparative evaluation of cellular uptake
    • H. Mok, K.H. Bae, C.H. Ahn, and T.G. Park PEGylated and MMP-2 specifically dePEGylated quantum dots: comparative evaluation of cellular uptake Langmuir 25 2009 1645 1650
    • (2009) Langmuir , vol.25 , pp. 1645-1650
    • Mok, H.1    Bae, K.H.2    Ahn, C.H.3    Park, T.G.4
  • 82
    • 84865849224 scopus 로고    scopus 로고
    • Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds
    • J.P.M. Motion, J. Nguyen, and F.C. Szoka Phosphatase-triggered fusogenic liposomes for cytoplasmic delivery of cell-impermeable compounds Angew. Chem. Int. Ed. Engl. 51 2012 9047 9051
    • (2012) Angew. Chem. Int. Ed. Engl. , vol.51 , pp. 9047-9051
    • Motion, J.P.M.1    Nguyen, J.2    Szoka, F.C.3
  • 83
    • 84868546970 scopus 로고    scopus 로고
    • Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes
    • M.B. Hansen, E. van Gaal, I. Minten, G. Storm, J.C. van Hest, and D.W. Lowik Constrained and UV-activatable cell-penetrating peptides for intracellular delivery of liposomes J. Control. Release 164 2012 87 94
    • (2012) J. Control. Release , vol.164 , pp. 87-94
    • Hansen, M.B.1    Van Gaal, E.2    Minten, I.3    Storm, G.4    Van Hest, J.C.5    Lowik, D.W.6
  • 84
    • 9244261790 scopus 로고    scopus 로고
    • Quantitative assessment of the cell penetrating properties of RI-Tat-9: Evidence for a cell type-specific barrier at the plasma membrane of epithelial cells
    • X. Zhang, L. Wan, S. Pooyan, Y. Su, C.R. Gardner, M.J. Leibowitz, S. Stein, and P.J. Sinko Quantitative assessment of the cell penetrating properties of RI-Tat-9: evidence for a cell type-specific barrier at the plasma membrane of epithelial cells Mol. Pharm. 1 2004 145 155
    • (2004) Mol. Pharm. , vol.1 , pp. 145-155
    • Zhang, X.1    Wan, L.2    Pooyan, S.3    Su, Y.4    Gardner, C.R.5    Leibowitz, M.J.6    Stein, S.7    Sinko, P.J.8
  • 85
    • 33947097525 scopus 로고    scopus 로고
    • Differentiation restricted endocytosis of cell penetrating peptides in MDCK cells corresponds with activities of Rho-GTPases
    • C. Foerg, U. Ziegler, J. Fernandez-Carneado, E. Giralt, and H.P. Merkle Differentiation restricted endocytosis of cell penetrating peptides in MDCK cells corresponds with activities of Rho-GTPases Pharm. Res. 24 2007 628 642
    • (2007) Pharm. Res. , vol.24 , pp. 628-642
    • Foerg, C.1    Ziegler, U.2    Fernandez-Carneado, J.3    Giralt, E.4    Merkle, H.P.5
  • 86
    • 1642457360 scopus 로고    scopus 로고
    • Cellular internalization of human calcitonin derived peptides in MDCK monolayers: A comparative study with Tat(47-57) and penetratin(43-58)
    • R. Trehin, U. Krauss, R. Muff, M. Meinecke, A.G. Beck-Sickinger, and H.P. Merkle Cellular internalization of human calcitonin derived peptides in MDCK monolayers: a comparative study with Tat(47-57) and penetratin(43-58) Pharm. Res. 21 2004 33 42
    • (2004) Pharm. Res. , vol.21 , pp. 33-42
    • Trehin, R.1    Krauss, U.2    Muff, R.3    Meinecke, M.4    Beck-Sickinger, A.G.5    Merkle, H.P.6
  • 87
    • 38349174536 scopus 로고    scopus 로고
    • On the biomedical promise of cell penetrating peptides: Limits versus prospects
    • C. Foerg, and H.P. Merkle On the biomedical promise of cell penetrating peptides: limits versus prospects J. Pharm. Sci. 97 2008 144 162
    • (2008) J. Pharm. Sci. , vol.97 , pp. 144-162
    • Foerg, C.1    Merkle, H.P.2
  • 90
    • 34248570504 scopus 로고    scopus 로고
    • Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo
    • E. Bárány-Wallje, J. Gaur, P. Lundberg, Ü. Langel, and A. Gräslund Differential membrane perturbation caused by the cell penetrating peptide Tp10 depending on attached cargo FEBS Lett. 581 2007 2389 2393
    • (2007) FEBS Lett. , vol.581 , pp. 2389-2393
    • Bárány-Wallje, E.1    Gaur, J.2    Lundberg, P.3    Langel, Ü.4    Gräslund, A.5
  • 98
    • 77749335904 scopus 로고    scopus 로고
    • Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides
    • T.A. Aguilera, E.S. Olson, M.M. Timmers, T. Jiang, and R.Y. Tsien Systemic in vivo distribution of activatable cell penetrating peptides is superior to that of cell penetrating peptides Integr. Biol. (Camb) 1 2009 371 381
    • (2009) Integr. Biol. (Camb) , vol.1 , pp. 371-381
    • Aguilera, T.A.1    Olson, E.S.2    Timmers, M.M.3    Jiang, T.4    Tsien, R.Y.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.