Dual Mechanism of Bacterial Lethality for a Cationic Sequence-Random Copolymer that Mimics Host-Defense Antimicrobial Peptides

Journal of Molecular Biology

Volumn 379, Issue 1, 2008, Pages 38-50

  Epand, Raquel F ^a   Mowery, Brendan P ^b   Lee, Sarah E ^b   Stahl, Shannon S ^b   Lehrer, Robert I ^c   Gellman, Samuel H ^b   Epand, Richard M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

antimicrobial polymer; bacterial encapsulation; cell wall; lipopolysaccharide; membrane permeability

Indexed keywords

2 NITROPHENYL BETA GALACTOSIDE; AMPHOLYTE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; BETA LACTAM; COPOLYMER; HOST DEFENSE PEPTIDE DERIVATIVE; LIPOPOLYSACCHARIDE; LIPOTEICHOIC ACID; PYRANOSIDE;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CELL MEMBRANE; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; ISOTHERMAL TITRATION CALORIMETRY; LIPID ANALYSIS; LIPID COMPOSITION; LIPID VESICLE; MEMBRANE BINDING; MEMBRANE PERMEABILITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 42749091734     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2008.03.047     Document Type: Article

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