Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington’s Disease

PLoS Genetics

Volumn 11, Issue 8, 2015, Pages

  Budworth, Helen ^a   Harris, Faye R ^b   Williams, Paul ^a   Lee, Do Yup ^c   Holt, Amy ^a   Pahnke, Jens ^d,e   Szczesny, Bartosz ^f   Acevedo Torres, Karina ^g,h   Ayala Peña, Sylvette ^g,h   McMurray, Cynthia T ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c Kookmin University   (South Korea)

^d UNIVERSITY OF OSLO   (Norway)

^e UNIVERSITY OF LÜBECK   (Germany)

^f University of Texas Medical Branch School of Medicine   (United States)

^g UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^h UNIVERSITY OF PUERTO RICO SCHOOL OF MEDICINE   (Puerto Rico)

Author keywords

[No Author keywords available]

Indexed keywords

NEUROPROTECTIVE AGENT; UNCLASSIFIED DRUG; XJB 5 131; AMINE OXIDE; DNA GLYCOSYLTRANSFERASE; OGG1 PROTEIN, MOUSE; XJB-5-131;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAG REPEAT; CELL EXPANSION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; GENE DOSAGE; GENE FREQUENCY; GENETIC PARAMETERS; HUNTINGTON CHOREA; MOTOR PERFORMANCE; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; SOMATIC EXPANSION; SOMATIC MUTATION; ANIMAL; C57BL MOUSE; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; HUNTINGTON DISEASE; KNOCKOUT MOUSE; MALE; PATHOLOGY; TRINUCLEOTIDE REPEAT;

ANIMALS; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA GLYCOSYLASES; FEMALE; HUNTINGTON DISEASE; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 84940737138     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005267     Document Type: Article

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