Trinucleotide expansion in haploid germ cells by gap repair

Nature Genetics

Volumn 27, Issue 4, 2001, Pages 407-411

  Kovtun, Irina V ^a   McMurray, Cynthia T ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BASE PAIRING; DNA REPAIR; DNA STRAND BREAKAGE; EXCISION REPAIR; GENE CONVERSION; GENETIC RECOMBINATION; GERM CELL; HAPLOIDY; MITOSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; SISTER CHROMATID; TRINUCLEOTIDE REPEAT;

ANIMALS; BASE SEQUENCE; DNA PRIMERS; FEMALE; FLOW CYTOMETRY; HUNTINGTON DISEASE; MALE; MICE; MICE, TRANSGENIC; PEDIGREE; TESTIS; TRINUCLEOTIDE REPEATS;

ANIMALIA; MAMMALIA; MUS MUSCULUS;

EID: 0035065524     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/86906     Document Type: Article

References (30)

1. Recent advances on the pathogenesis of Huntington's disease
2. Trinucleotide repeats that expand in human disease form hairpin structures in vitro
3. GAA instability in Friedriech's ataxia shares a common, DNA-directed and intraallelic mechanism with other trinucleotide diseases
4. DNA secondary structure: A common and causative factor for expansion in human disease
5. Different mechanisms underlie DNA instability in Huntington disease and colorectal cancer
6. Triplet repeats form secondary structures that escape DNA repair in yeast
7. Inhibition of FEN-1 processing by DNA secondary structure at trinucleotide repeats
8. Expansion and deletion of triplet repeat sequences in Escherichia coli occur on the leading strand of DNA replication
9. Expansion and deletion of CTG repeats from human disease genes are determined by the direction of replication
10. Stability of a CTG/CAG trinucleotide repeat in yeast is dependent on its orientation in the genome
11. Orientation-dependent and sequence-specific expansion of CTG/CAG trinucleotide repeats in Saccharomyces cerevisiae
12. Expansions of CAG repeat tracts are frequent in a yeast mutant defective in Okazaki fragment maturation
13. Insertion of expanded CAG trinucleotide repeat motifs into a yeast artificial chromosome containing the human Machado-Joseph disease gene
14. Genetic instabilities in (CTG CAG) repeats occur by recombination
15. Expansion and length-dependent fragility of CTG repeats in yeast
16. Recombination-induced CAG trinucleotide repeat expansions in yeast involve the MRE11/RAD50/XRS2 complex
17. CTG repeats show bimodal amplication
18. Abasic sites induce triplet-repeat expansion during DNA replication in vitro
19. Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice
20. Correlation between magnitude of CAG repeat length alterations and length of the paternal repeat in paternally inherited Huntington's disease
21. Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease
22. Trinucleotide repeat length instability and age of onset in Huntington's disease
23. Analysis of germline mutation spectra at the Huntington's disease locus supports a mitotic mutation mechanism
24. Gametic but not somatic instability of CAG repeat length in Huntington's disease
25. Instability of highly expanded CAG in mice transgenic for the Huntington's disease mutation
26. Gender of the embryo contributes to CAG instability in transgenic mice containing a Huntington's disease gene
27. MSH2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice
28. Nicking of rat spermatid and spermatozoa DNA: Possible involvement of DNA topoisomerase II
29. DNA nicks and increased sensitivity of DNA to fluorescence in situ end labeling during functional spermiogenesis
30. Preparation of spermatogonia, spermatocytes, and round spermatids for analysis of gene expression using fluorescence-activated cell sorting