Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation

EMBO Journal

Volumn 34, Issue 17, 2015, Pages 2255-2271

  El Daher, Marie Thérèse ^a,b   Hangen, Emilie ^a,b   Bruyère, Julie ^a,b,c,d   Poizat, Ghislaine ^a,b   Al Ramahi, Ismael ^e,f   Pardo, Raul ^a,b   Bourg, Nicolas ^g,h   Souquere, Sylvie ^i,j   Mayet, Céline ^g,h   Pierron, Gérard ^i,j   Lévêque Fort, Sandrine ^g,h   Botas, Juan ^e,f   Humbert, Sandrine ^a,b,c,d   Saudou, Frédéric ^a,b,c,d,k  

^a INSTITUT CURIE   (France)

^b INSERM U1005   (France)

^c GRENOBLE INSTITUT DES NEUROSCIENCES   (France)

^d UNIV GRENOBLE ALPES   (France)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f TEXAS CHILDREN S HOSPITAL   (United States)

^g INSTITUT DES SCIENCES MOLÉCULAIRES D ORSAY   (France)

^h UNIVERSITÉ PARIS SACLAY   (France)

ⁱ Institut Gustave Roussy   (France)

^j INSTITUT GUSTAVE ROUSSY   (France)

^k GRENOBLE UNIVERSITY HOSPITAL   (France)

more..

Author keywords

Drosophila; endoplasmic reticulum; ER dilation; Huntington's disease; TEV proteolysis

Indexed keywords

DYNAMIN I; HUNTINGTIN; POLYGLUTAMINE; HTT PROTEIN, HUMAN; HUNTINGTIN PROTEIN, DROSOPHILA; MICROTUBULE ASSOCIATED PROTEIN; NERVE PROTEIN; PEPTIDE; SEROTONIN TRANSPORTER; SLC6A4 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DIPTERA; ENDOPLASMIC RETICULUM MEMBRANE; ENDOPLASMIC RETICULUM STRESS; FEMALE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN SECRETION; ANIMAL; DROSOPHILA MELANOGASTER; ENDOPLASMIC RETICULUM; GENETICS; METABOLISM;

ANIMALS; DROSOPHILA MELANOGASTER; DYNAMIN I; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMANS; HUNTINGTON DISEASE; MICE; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; PEPTIDES; PROTEOLYSIS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84940640081     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201490808     Document Type: Article

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