메뉴 건너뛰기




Volumn 3, Issue , 2002, Pages

The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor

Author keywords

[No Author keywords available]

Indexed keywords

CELL EXTRACT; HUNTINGTIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; NUCLEOPORIN; PROTEIN P105; PROTEIN P50; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DORSAL; TRANSCRIPTION FACTOR REL; UNCLASSIFIED DRUG;

EID: 0141742228     PISSN: 14712202     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2202-3-15     Document Type: Article
Times cited : (125)

References (49)
  • 1
    • 0022876328 scopus 로고
    • Huntington's disease. Pathogenesis and management
    • Martin JB, Gusella JF: Huntington's disease. Pathogenesis and management. N Engl J Med 1986, 315:1267-1276
    • (1986) N. Engl. J. Med. , vol.315 , pp. 1267-1276
    • Martin, J.B.1    Gusella, J.F.2
  • 2
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983
    • (1993) Cell , vol.72 , pp. 971-983
  • 3
    • 0034329159 scopus 로고    scopus 로고
    • Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease
    • Gusella JF, MacDonald ME: Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease. Nat Rev Neurosci 2000, 1:109-115
    • (2000) Nat. Rev. Neurosci. , vol.1 , pp. 109-115
    • Gusella, J.F.1    MacDonald, M.E.2
  • 6
    • 0031867231 scopus 로고    scopus 로고
    • Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways
    • Velier J, Kim M, Schwarz C, Kim TW, Sapp E, Chase K, Aronin N, Di-Figlia M: Wild-type and mutant huntingtins function in vesicle trafficking in the secretory and endocytic pathways. Exp Neurol 1998, 152:34-40
    • (1998) Exp. Neurol. , vol.152 , pp. 34-40
    • Velier, J.1    Kim, M.2    Schwarz, C.3    Kim, T.W.4    Sapp, E.5    Chase, K.6    Aronin, N.7    Di-Figlia, M.8
  • 9
    • 0033757718 scopus 로고    scopus 로고
    • Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice
    • Dragatsis I, Levine MS, Zeitlin S: Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nat Genet 2000, 26:300-306
    • (2000) Nat. Genet. , vol.26 , pp. 300-306
    • Dragatsis, I.1    Levine, M.S.2    Zeitlin, S.3
  • 10
    • 0029392854 scopus 로고
    • HEAT repeats in the Huntington's disease protein
    • Andrade MA, Bork P: HEAT repeats in the Huntington's disease protein. Nat Genet 1995, 11:115-116
    • (1995) Nat. Genet. , vol.11 , pp. 115-116
    • Andrade, M.A.1    Bork, P.2
  • 11
    • 0033612390 scopus 로고    scopus 로고
    • Structural view of the Ran-Importin beta interaction at 2.3 A resolution
    • Vetter IR, Arndt A, Kutay U, Gorlich D, Wittinghofer A: Structural view of the Ran-Importin beta interaction at 2.3 A resolution. Cell 1999, 97:635-646
    • (1999) Cell , vol.97 , pp. 635-646
    • Vetter, I.R.1    Arndt, A.2    Kutay, U.3    Gorlich, D.4    Wittinghofer, A.5
  • 12
    • 0034634450 scopus 로고    scopus 로고
    • Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association
    • Cingolani G, Lashuel HA, Gerace L, Muller CW: Nuclear import factors importin alpha and importin beta undergo mutually induced conformational changes upon association. FEBS Lett 2000, 484:291-298
    • (2000) FEBS Lett. , vol.484 , pp. 291-298
    • Cingolani, G.1    Lashuel, H.A.2    Gerace, L.3    Muller, C.W.4
  • 13
    • 0033587167 scopus 로고    scopus 로고
    • Structure of importin-beta bound to the IBB domain of importin-alpha
    • Cingolani G, Petosa C, Weis K, Muller CW: Structure of importin-beta bound to the IBB domain of importin-alpha. Nature 1999, 399:221-229
    • (1999) Nature , vol.399 , pp. 221-229
    • Cingolani, G.1    Petosa, C.2    Weis, K.3    Muller, C.W.4
  • 14
    • 0033534405 scopus 로고    scopus 로고
    • The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
    • Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D: The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell 1999, 96:99-110
    • (1999) Cell , vol.96 , pp. 99-110
    • Groves, M.R.1    Hanlon, N.2    Turowski, P.3    Hemmings, B.A.4    Barford, D.5
  • 15
    • 0033150672 scopus 로고    scopus 로고
    • Topological characteristics of helical repeat proteins
    • Groves MR, Barford D: Topological characteristics of helical repeat proteins. Curr Opin Struct Biol 1999, 9:383-389
    • (1999) Curr. Opin. Struct. Biol. , vol.9 , pp. 383-389
    • Groves, M.R.1    Barford, D.2
  • 16
    • 0001506297 scopus 로고    scopus 로고
    • Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp
    • Chook YM, Blobel G: Structure of the nuclear transport complex karyopherin-beta2-Ran x GppNHp. Nature 1999, 399:230-237
    • (1999) Nature , vol.39 , pp. 230-237
    • Chook, Y.M.1    Blobel, G.2
  • 17
    • 0027480960 scopus 로고
    • A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
    • Huntington's Disease Collaborative Research Group
    • Huntington's Disease Collaborative Research Group: A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell 1993, 72:971-983
    • (1993) Cell , vol.72 , pp. 971-983
  • 18
    • 0033914771 scopus 로고    scopus 로고
    • Huntingtin-interacting proteins an their relevance to Huntington's disease etiology
    • Jones L: Huntingtin-interacting proteins an their relevance to Huntington's disease etiology. Neuroscience News 2000, 3:55-63
    • (2000) Neuroscience News , vol.3 , pp. 55-63
    • Jones, L.1
  • 22
    • 0033141406 scopus 로고    scopus 로고
    • NF-kappaB to the rescue: RELs, apoptosis and cellular transformation
    • Foo SY, Nolan GP: NF-kappaB to the rescue: RELs, apoptosis and cellular transformation. Trends Genet 1999, 15:229-235
    • (1999) Trends Genet. , vol.15 , pp. 229-235
    • Foo, S.Y.1    Nolan, G.P.2
  • 23
    • 0033624450 scopus 로고    scopus 로고
    • NF-kappaB transcription factors: Critical regulators of hematopoiesis and neuronal survival
    • Denk A, Wirth T, Baumann B: NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival. Cytokine Growth Factor Rev 2000, 11:303-320
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 303-320
    • Denk, A.1    Wirth, T.2    Baumann, B.3
  • 24
    • 0031748547 scopus 로고    scopus 로고
    • A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis
    • Qiu P, Pan PC, Govind S: A role for the Drosophila Toll/Cactus pathway in larval hematopoiesis. Development 1998, 125:1909-1920
    • (1998) Development , vol.125 , pp. 1909-1920
    • Qiu, P.1    Pan, P.C.2    Govind, S.3
  • 26
    • 0034635361 scopus 로고    scopus 로고
    • A functional interaction between dorsal and components of the Smt3 conjugation machinery
    • Bhaskar V, Valentine SA, Courey AJ: A functional interaction between dorsal and components of the Smt3 conjugation machinery. J Biol Chem 2000, 275:4033-4040
    • (2000) J. Biol. Chem. , vol.275 , pp. 4033-4040
    • Bhaskar, V.1    Valentine, S.A.2    Courey, A.J.3
  • 27
    • 0032485392 scopus 로고    scopus 로고
    • Regulated nuclear import of Rel proteins in the Drosophila immune response
    • Wu LP, Anderson KV: Regulated nuclear import of Rel proteins in the Drosophila immune response. Nature 1998, 392:93-97
    • (1998) Nature , vol.392 , pp. 93-97
    • Wu, L.P.1    Anderson, K.V.2
  • 28
    • 0027368433 scopus 로고
    • Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila
    • Reichhart JM, Georgel P, Meister M, Lemaitre B, Kappler C, Hoffmann JA: Expression and nuclear translocation of the rel/NF-kappa B-related morphogen dorsal during the immune response of Drosophila. C R Acad Sci III 1993, 316:1218-1224
    • (1993) C. R. Acad. Sci. III , vol.316 , pp. 1218-1224
    • Reichhart, J.M.1    Georgel, P.2    Meister, M.3    Lemaitre, B.4    Kappler, C.5    Hoffmann, J.A.6
  • 29
    • 0034581528 scopus 로고    scopus 로고
    • Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences
    • Reuther GW, Buss JE, Quilliam LA, Clark GJ, Der CJ: Analysis of function and regulation of proteins that mediate signal transduction by use of lipid-modified plasma membrane-targeting sequences. Methods Enzymol 2000, 327:331-350
    • (2000) Methods Enzymol. , vol.327 , pp. 331-350
    • Reuther, G.W.1    Buss, J.E.2    Quilliam, L.A.3    Clark, G.J.4    Der, C.J.5
  • 30
    • 0033900370 scopus 로고    scopus 로고
    • Members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation
    • Uv AE, Roth P, Xylourgidis N, Wickberg A, Cantera R, Samakovlis C: members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Genes Dev 2000, 14:1945-1957
    • (2000) Genes Dev. , vol.14 , pp. 1945-1957
    • Uv, A.E.1    Roth, P.2    Xylourgidis, N.3    Wickberg, A.4    Cantera, R.5    Samakovlis, C.6
  • 31
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand AH, Perrimon N: Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 1993, 118:401-415
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 32
    • 0033520466 scopus 로고    scopus 로고
    • Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled
    • Usui T, Shima Y, Shimada Y, Hirano S, Burgess RW, Schwarz TL, Takeichi M, Uemura T: Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell 1999, 98:585-595
    • (1999) Cell , vol.98 , pp. 585-595
    • Usui, T.1    Shima, Y.2    Shimada, Y.3    Hirano, S.4    Burgess, R.W.5    Schwarz, T.L.6    Takeichi, M.7    Uemura, T.8
  • 35
    • 0031877016 scopus 로고    scopus 로고
    • Combining evidence using p-values: Application to sequence homology searches
    • Bailey TL, Gribskov M: Combining evidence using p-values: application to sequence homology searches. Bioinformatics 1998, 14:48-54
    • (1998) Bioinformatics , vol.14 , pp. 48-54
    • Bailey, T.L.1    Gribskov, M.2
  • 37
    • 0034607552 scopus 로고    scopus 로고
    • Homology-based method for identification of protein repeats using statistical significance estimates
    • Andrade MA, Ponting CP, Gibson TJ, Bork P: Homology-based method for identification of protein repeats using statistical significance estimates. J Mol Biol 2000, 298:521-537
    • (2000) J. Mol. Biol. , vol.298 , pp. 521-537
    • Andrade, M.A.1    Ponting, C.P.2    Gibson, T.J.3    Bork, P.4
  • 40
    • 0030043628 scopus 로고    scopus 로고
    • Regulated nuclear import of the Drosophila rel protein dorsal: Structure-function analysis
    • Govind S, Drier E, Huang LH, Steward R: Regulated nuclear import of the Drosophila rel protein dorsal: structure-function analysis. Mol Cell Biol 1996, 16:1103-1114
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1103-1114
    • Govind, S.1    Drier, E.2    Huang, L.H.3    Steward, R.4
  • 41
    • 0031126767 scopus 로고    scopus 로고
    • The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila
    • Drier EA, Steward R: The dorsoventral signal transduction pathway and the Rel-like transcription factors in Drosophila. Semin Cancer Biol 1997, 8:83-92
    • (1997) Semin. Cancer Biol. , vol.8 , pp. 83-92
    • Drier, E.A.1    Steward, R.2
  • 42
    • 0033105577 scopus 로고    scopus 로고
    • Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation
    • Drier EA, Huang LH, Steward R: Nuclear import of the Drosophila Rel protein Dorsal is regulated by phosphorylation. Genes Dev 1999, 13:556-568
    • (1999) Genes. Dev. , vol.13 , pp. 556-568
    • Drier, E.A.1    Huang, L.H.2    Steward, R.3
  • 43
    • 0033976430 scopus 로고    scopus 로고
    • Cactus-independent regulation of Dorsal nuclear import by the ventral signal
    • Drier EA, Govind S, Steward R: Cactus-independent regulation of Dorsal nuclear import by the ventral signal. Curr Biol 2000, 10:23-26
    • (2000) Curr. Biol. , vol.10 , pp. 23-26
    • Drier, E.A.1    Govind, S.2    Steward, R.3
  • 46
    • 0035940412 scopus 로고    scopus 로고
    • Caspase 3-cleaved N-terminal fragments of wildtype and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis
    • Kim YJ, Yi Y, Sapp E, Wang Y, Cuiffo B, Kegel KB, Qin ZH, Aronin N, DiFiglia M: Caspase 3-cleaved N-terminal fragments of wildtype and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis. Proc Natl Acad Sci U S A 2001, 98:12784-9
    • (2001) Proc. Natl. Acad. Sci. U S A , vol.98 , pp. 12784-12789
    • Kim, Y.J.1    Yi, Y.2    Sapp, E.3    Wang, Y.4    Cuiffo, B.5    Kegel, K.B.6    Qin, Z.H.7    Aronin, N.8    DiFiglia, M.9
  • 49
    • 0030028059 scopus 로고    scopus 로고
    • A nuclear GFP/beta-galactosidase fusion protein as a marker for morphogenesis in living Drosophila
    • Shiga Y, Tanaka-Makatsu M, Hayashi S: A nuclear GFP/beta-galactosidase fusion protein as a marker for morphogenesis in living Drosophila. Dev Growth Diff 1996, 38:99-106
    • (1996) Dev. Growth Diff. , vol.38 , pp. 99-106
    • Shiga, Y.1    Tanaka-Makatsu, M.2    Hayashi, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.