메뉴 건너뛰기




Volumn 21, Issue 9, 2015, Pages 533-542

Extracellular vesicles in lung microenvironment and pathogenesis

Author keywords

COPD; Exosome; Extracellular vesicle; Lung cancer; Mesenchymal stem cell; MicroRNA

Indexed keywords

MICRORNA; PROTEIN;

EID: 84940580351     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2015.07.004     Document Type: Review
Times cited : (159)

References (98)
  • 1
    • 79951576785 scopus 로고    scopus 로고
    • Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo
    • Shaykhiev R., et al. Cigarette smoking reprograms apical junctional complex molecular architecture in the human airway epithelium in vivo. Cell. Mol. Life Sci. 2011, 68:877-892.
    • (2011) Cell. Mol. Life Sci. , vol.68 , pp. 877-892
    • Shaykhiev, R.1
  • 2
    • 0033258479 scopus 로고    scopus 로고
    • The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit
    • Evans M.J., et al. The attenuated fibroblast sheath of the respiratory tract epithelial-mesenchymal trophic unit. Am. J. Respir. Cell Mol. Biol. 1999, 21:655-657.
    • (1999) Am. J. Respir. Cell Mol. Biol. , vol.21 , pp. 655-657
    • Evans, M.J.1
  • 3
    • 33746602210 scopus 로고    scopus 로고
    • Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit
    • Araya J., et al. Integrin-mediated transforming growth factor-beta activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am. J. Pathol. 2006, 169:405-415.
    • (2006) Am. J. Pathol. , vol.169 , pp. 405-415
    • Araya, J.1
  • 4
    • 0031904040 scopus 로고    scopus 로고
    • Mesenchyme specifies epithelial differentiation in reciprocal recombinants of embryonic lung and trachea
    • Shannon J.M., et al. Mesenchyme specifies epithelial differentiation in reciprocal recombinants of embryonic lung and trachea. Dev. Dyn. 1998, 212:482-494.
    • (1998) Dev. Dyn. , vol.212 , pp. 482-494
    • Shannon, J.M.1
  • 5
    • 0036724075 scopus 로고    scopus 로고
    • Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?
    • Demayo F., et al. Mesenchymal-epithelial interactions in lung development and repair: are modeling and remodeling the same process?. Am. J. Physiol. Lung Cell. Mol. Physiol. 2002, 283:L510-L517.
    • (2002) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.283 , pp. L510-L517
    • Demayo, F.1
  • 6
    • 38149077303 scopus 로고    scopus 로고
    • The endothelium in acute lung injury/acute respiratory distress syndrome
    • Maniatis N.A., Orfanos S.E. The endothelium in acute lung injury/acute respiratory distress syndrome. Curr. Opin. Crit. Care 2008, 14:22-30.
    • (2008) Curr. Opin. Crit. Care , vol.14 , pp. 22-30
    • Maniatis, N.A.1    Orfanos, S.E.2
  • 7
    • 0034080463 scopus 로고    scopus 로고
    • Epithelial damage and response
    • Holgate S.T. Epithelial damage and response. Clin. Exp. Allergy 2000, 30(Suppl. 1):37-41.
    • (2000) Clin. Exp. Allergy , vol.30 , pp. 37-41
    • Holgate, S.T.1
  • 8
    • 36048937539 scopus 로고    scopus 로고
    • Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients
    • Araya J., et al. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J. Clin. Invest. 2007, 117:3551-3562.
    • (2007) J. Clin. Invest. , vol.117 , pp. 3551-3562
    • Araya, J.1
  • 9
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo G., Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 2013, 200:373-383.
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 10
    • 84875712878 scopus 로고    scopus 로고
    • Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation
    • Kulshreshtha A., et al. Proinflammatory role of epithelial cell-derived exosomes in allergic airway inflammation. J. Allergy Clin. Immunol. 2013, 131:1194-1203.
    • (2013) J. Allergy Clin. Immunol. , vol.131 , pp. 1194-1203
    • Kulshreshtha, A.1
  • 11
    • 84902831135 scopus 로고    scopus 로고
    • Intercellular communication by extracellular vesicles and their microRNAs in asthma
    • Fujita Y., et al. Intercellular communication by extracellular vesicles and their microRNAs in asthma. Clin. Ther. 2014, 36:873-881.
    • (2014) Clin. Ther. , vol.36 , pp. 873-881
    • Fujita, Y.1
  • 12
    • 0141962590 scopus 로고    scopus 로고
    • Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid
    • Admyre C., et al. Exosomes with major histocompatibility complex class II and co-stimulatory molecules are present in human BAL fluid. Eur. Respir. J. 2003, 22:578-583.
    • (2003) Eur. Respir. J. , vol.22 , pp. 578-583
    • Admyre, C.1
  • 13
    • 84924846435 scopus 로고    scopus 로고
    • Functional analysis of exosomal microRNA in cell-cell communication research
    • Kosaka N., et al. Functional analysis of exosomal microRNA in cell-cell communication research. Methods Mol. Biol. 2013, 1024:1-10.
    • (2013) Methods Mol. Biol. , vol.1024 , pp. 1-10
    • Kosaka, N.1
  • 14
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • Pan B.T., Johnstone R.M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 1983, 33:967-978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 15
    • 55749112807 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes: current perspectives
    • Simpson R.J., et al. Proteomic profiling of exosomes: current perspectives. Proteomics 2008, 8:4083-4099.
    • (2008) Proteomics , vol.8 , pp. 4083-4099
    • Simpson, R.J.1
  • 16
    • 84877585949 scopus 로고    scopus 로고
    • Extracellular vesicles: biology and emerging therapeutic opportunities
    • El Andaloussi S., et al. Extracellular vesicles: biology and emerging therapeutic opportunities. Nat. Rev. Drug Discov. 2013, 12:347-357.
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 347-357
    • El Andaloussi, S.1
  • 17
    • 0032493658 scopus 로고    scopus 로고
    • Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes
    • Escola J.M., et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 1998, 273:20121-20127.
    • (1998) J. Biol. Chem. , vol.273 , pp. 20121-20127
    • Escola, J.M.1
  • 18
    • 85017356000 scopus 로고    scopus 로고
    • Comparative marker analysis of extracellular vesicles in different human cancer types
    • Yoshioka Y., et al. Comparative marker analysis of extracellular vesicles in different human cancer types. J. Extracell. Vesicles 2013, 2:20424.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20424
    • Yoshioka, Y.1
  • 19
    • 59149083102 scopus 로고    scopus 로고
    • Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis
    • Castellana D., et al. Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res. 2009, 69:785-793.
    • (2009) Cancer Res. , vol.69 , pp. 785-793
    • Castellana, D.1
  • 20
    • 75149125508 scopus 로고    scopus 로고
    • The role of microparticles in the pathogenesis of rheumatic diseases
    • Beyer C., Pisetsky D.S. The role of microparticles in the pathogenesis of rheumatic diseases. Nat. Rev. Rheumatol. 2010, 6:21-29.
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 21-29
    • Beyer, C.1    Pisetsky, D.S.2
  • 21
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • Witwer K.W., et al. Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell. Vesicles 2013, 2:20360.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20360
    • Witwer, K.W.1
  • 22
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould S.J., Raposo G. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J. Extracell. Vesicles 2013, 2:20389.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20389
    • Gould, S.J.1    Raposo, G.2
  • 23
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi H., et al. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9:654-659.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1
  • 24
    • 77956705683 scopus 로고    scopus 로고
    • Isolation and characterization of microparticles in sputum from cystic fibrosis patients
    • Porro C., et al. Isolation and characterization of microparticles in sputum from cystic fibrosis patients. Respir. Res. 2010, 11:94.
    • (2010) Respir. Res. , vol.11 , pp. 94
    • Porro, C.1
  • 25
    • 71949114684 scopus 로고    scopus 로고
    • Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome
    • Bastarache J.A., et al. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome. Am. J. Physiol. Lung Cell. Mol. Physiol. 2009, 297:L1035-L1041.
    • (2009) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.297 , pp. L1035-L1041
    • Bastarache, J.A.1
  • 26
    • 84940590544 scopus 로고    scopus 로고
    • Physical characterization and profiling of airway epithelial derived exosomes using light scattering
    • Published online March 27, 2015
    • Kesimer M., Gupta R. Physical characterization and profiling of airway epithelial derived exosomes using light scattering. Methods 2015, Published online March 27, 2015. 10.1016/j.ymeth.2015.03.013.
    • (2015) Methods
    • Kesimer, M.1    Gupta, R.2
  • 27
    • 33644620356 scopus 로고    scopus 로고
    • Respiratory tract mucin genes and mucin glycoproteins in health and disease
    • Rose M.C., Voynow J.A. Respiratory tract mucin genes and mucin glycoproteins in health and disease. Physiol. Rev. 2006, 86:245-278.
    • (2006) Physiol. Rev. , vol.86 , pp. 245-278
    • Rose, M.C.1    Voynow, J.A.2
  • 28
    • 67649365976 scopus 로고    scopus 로고
    • Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense
    • Kesimer M., et al. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. FASEB J. 2009, 23:1858-1868.
    • (2009) FASEB J. , vol.23 , pp. 1858-1868
    • Kesimer, M.1
  • 29
    • 84873596150 scopus 로고    scopus 로고
    • Macrophage microvesicles induce macrophage differentiation and miR-223 transfer
    • Ismail N., et al. Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood 2013, 121:984-995.
    • (2013) Blood , vol.121 , pp. 984-995
    • Ismail, N.1
  • 30
    • 84940600988 scopus 로고    scopus 로고
    • Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling
    • Bourdonnay E., et al. Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling. J. Exp. Med. 2015, 212:729-742.
    • (2015) J. Exp. Med. , vol.212 , pp. 729-742
    • Bourdonnay, E.1
  • 31
    • 84903397339 scopus 로고    scopus 로고
    • Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD
    • Eltom S., et al. Respiratory infections cause the release of extracellular vesicles: implications in exacerbation of asthma/COPD. PLoS ONE 2014, 9:e101087.
    • (2014) PLoS ONE , vol.9 , pp. e101087
    • Eltom, S.1
  • 32
    • 84922747164 scopus 로고    scopus 로고
    • Exosomes: an emerging factor in stress-induced immunomodulation
    • Beninson L.A., Fleshner M. Exosomes: an emerging factor in stress-induced immunomodulation. Seminars in immunology 2014, 26:394-401.
    • (2014) Seminars in immunology , vol.26 , pp. 394-401
    • Beninson, L.A.1    Fleshner, M.2
  • 33
    • 84919465425 scopus 로고    scopus 로고
    • Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness
    • Baixauli F., et al. Exosomes and autophagy: coordinated mechanisms for the maintenance of cellular fitness. Front. Immunol. 2014, 5:403.
    • (2014) Front. Immunol. , vol.5 , pp. 403
    • Baixauli, F.1
  • 34
    • 77956314712 scopus 로고    scopus 로고
    • Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria
    • Anand P.K., et al. Exosomal Hsp70 induces a pro-inflammatory response to foreign particles including mycobacteria. PLoS ONE 2010, 5:e10136.
    • (2010) PLoS ONE , vol.5 , pp. e10136
    • Anand, P.K.1
  • 35
    • 84902688869 scopus 로고    scopus 로고
    • 2+ mobilization
    • 2+ mobilization. Inflamm. Res. 2014, 63:539-547.
    • (2014) Inflamm. Res. , vol.63 , pp. 539-547
    • Cordazzo, C.1
  • 36
    • 79958186405 scopus 로고    scopus 로고
    • Integrating miRNA and mRNA expression profiles in response to heat stress-induced injury in rat small intestine
    • Yu J., et al. Integrating miRNA and mRNA expression profiles in response to heat stress-induced injury in rat small intestine. Funct. Integr. Genomics 2011, 11:203-213.
    • (2011) Funct. Integr. Genomics , vol.11 , pp. 203-213
    • Yu, J.1
  • 37
    • 84863484916 scopus 로고    scopus 로고
    • Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy
    • Sharma S., et al. Repression of miR-142 by p300 and MAPK is required for survival signalling via gp130 during adaptive hypertrophy. EMBO Mol. Med. 2012, 4:617-632.
    • (2012) EMBO Mol. Med. , vol.4 , pp. 617-632
    • Sharma, S.1
  • 38
    • 84907908424 scopus 로고    scopus 로고
    • Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203)
    • Beninson L.A., et al. Acute stressor exposure modifies plasma exosome-associated heat shock protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203). PLoS ONE 2014, 9:e108748.
    • (2014) PLoS ONE , vol.9 , pp. e108748
    • Beninson, L.A.1
  • 39
    • 84862908547 scopus 로고    scopus 로고
    • Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes
    • Montecalvo A., et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 2012, 119:756-766.
    • (2012) Blood , vol.119 , pp. 756-766
    • Montecalvo, A.1
  • 40
    • 80051565223 scopus 로고    scopus 로고
    • Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers
    • Gordon C., et al. Circulating endothelial microparticles as a measure of early lung destruction in cigarette smokers. Am. J. Respir. Crit. Care Med. 2011, 184:224-232.
    • (2011) Am. J. Respir. Crit. Care Med. , vol.184 , pp. 224-232
    • Gordon, C.1
  • 41
    • 84922247168 scopus 로고    scopus 로고
    • Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding
    • Letsiou E., et al. Pathologic mechanical stress and endotoxin exposure increases lung endothelial microparticle shedding. Am. J. Respir. Cell Mol. Biol. 2015, 52:193-204.
    • (2015) Am. J. Respir. Cell Mol. Biol. , vol.52 , pp. 193-204
    • Letsiou, E.1
  • 42
    • 84904870078 scopus 로고    scopus 로고
    • Circulating endothelial microparticles involved in lung function decline in a rat exposed in cigarette smoke maybe from apoptotic pulmonary capillary endothelial cells
    • Liu H., et al. Circulating endothelial microparticles involved in lung function decline in a rat exposed in cigarette smoke maybe from apoptotic pulmonary capillary endothelial cells. J. Thorac. Dis. 2014, 6:649-655.
    • (2014) J. Thorac. Dis. , vol.6 , pp. 649-655
    • Liu, H.1
  • 43
    • 77955982297 scopus 로고    scopus 로고
    • Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages
    • Li M., et al. Tobacco smoke induces the generation of procoagulant microvesicles from human monocytes/macrophages. Arterioscler. Thromb. Vasc. Biol. 2010, 30:1818-1824.
    • (2010) Arterioscler. Thromb. Vasc. Biol. , vol.30 , pp. 1818-1824
    • Li, M.1
  • 44
    • 84876518109 scopus 로고    scopus 로고
    • Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke
    • Li C.J., et al. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. Am. J. Pathol. 2013, 182:1552-1562.
    • (2013) Am. J. Pathol. , vol.182 , pp. 1552-1562
    • Li, C.J.1
  • 45
    • 84906098407 scopus 로고    scopus 로고
    • CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke
    • Moon H.G., et al. CCN1 secretion and cleavage regulate the lung epithelial cell functions after cigarette smoke. Am. J. Physiol. Lung Cell. Mol. Physiol. 2014, 307:L326-L337.
    • (2014) Am. J. Physiol. Lung Cell. Mol. Physiol. , vol.307 , pp. L326-L337
    • Moon, H.G.1
  • 46
    • 84899738700 scopus 로고    scopus 로고
    • Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: an observational study
    • Novelli F., et al. Procoagulant, tissue factor-bearing microparticles in bronchoalveolar lavage of interstitial lung disease patients: an observational study. PLoS ONE 2014, 9:e95013.
    • (2014) PLoS ONE , vol.9 , pp. e95013
    • Novelli, F.1
  • 47
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka N., et al. Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 2010, 285:17442-17452.
    • (2010) J. Biol. Chem. , vol.285 , pp. 17442-17452
    • Kosaka, N.1
  • 48
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • Ostrowski M., et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 2010, 12:19-30.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 19-30
    • Ostrowski, M.1
  • 49
    • 77951183654 scopus 로고    scopus 로고
    • Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
    • Hsu C., et al. Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J. Cell Biol. 2010, 189:223-232.
    • (2010) J. Cell Biol. , vol.189 , pp. 223-232
    • Hsu, C.1
  • 50
    • 63649086486 scopus 로고    scopus 로고
    • The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    • Raiborg C., Stenmark H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 2009, 458:445-452.
    • (2009) Nature , vol.458 , pp. 445-452
    • Raiborg, C.1    Stenmark, H.2
  • 51
    • 0037490207 scopus 로고    scopus 로고
    • Exosome release is regulated by a calcium-dependent mechanism in K562 cells
    • Savina A., et al. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J. Biol. Chem. 2003, 278:20083-20090.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20083-20090
    • Savina, A.1
  • 52
    • 33646416463 scopus 로고    scopus 로고
    • The regulation of exosome secretion: a novel function of the p53 protein
    • Yu X., et al. The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res. 2006, 66:4795-4801.
    • (2006) Cancer Res. , vol.66 , pp. 4795-4801
    • Yu, X.1
  • 53
    • 63049113332 scopus 로고    scopus 로고
    • The regulation of the endosomal compartment by p53 the tumor suppressor gene
    • Yu X., et al. The regulation of the endosomal compartment by p53 the tumor suppressor gene. FEBS J. 2009, 276:2201-2212.
    • (2009) FEBS J. , vol.276 , pp. 2201-2212
    • Yu, X.1
  • 54
    • 60749124122 scopus 로고    scopus 로고
    • The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules
    • Hao S., Baltimore D. The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 2009, 10:281-288.
    • (2009) Nat. Immunol. , vol.10 , pp. 281-288
    • Hao, S.1    Baltimore, D.2
  • 55
    • 78149360255 scopus 로고    scopus 로고
    • Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis
    • Qazi K.R., et al. Proinflammatory exosomes in bronchoalveolar lavage fluid of patients with sarcoidosis. Thorax 2010, 65:1016-1024.
    • (2010) Thorax , vol.65 , pp. 1016-1024
    • Qazi, K.R.1
  • 56
    • 66149093072 scopus 로고    scopus 로고
    • The pathology of chronic obstructive pulmonary disease
    • Hogg J.C., Timens W. The pathology of chronic obstructive pulmonary disease. Annu. Rev. Pathol. 2009, 4:435-459.
    • (2009) Annu. Rev. Pathol. , vol.4 , pp. 435-459
    • Hogg, J.C.1    Timens, W.2
  • 57
    • 84860691114 scopus 로고    scopus 로고
    • The airway epithelium in asthma
    • Lambrecht B.N., Hammad H. The airway epithelium in asthma. Nat. Med. 2012, 18:684-692.
    • (2012) Nat. Med. , vol.18 , pp. 684-692
    • Lambrecht, B.N.1    Hammad, H.2
  • 58
    • 2942720573 scopus 로고    scopus 로고
    • The nature of small-airway obstruction in chronic obstructive pulmonary disease
    • Hogg J.C., et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. New Engl. J. Med. 2004, 350:2645-2653.
    • (2004) New Engl. J. Med. , vol.350 , pp. 2645-2653
    • Hogg, J.C.1
  • 59
    • 40049104892 scopus 로고    scopus 로고
    • Immunology of asthma and chronic obstructive pulmonary disease
    • Barnes P.J. Immunology of asthma and chronic obstructive pulmonary disease. Nat. Rev. Immunol. 2008, 8:183-192.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 183-192
    • Barnes, P.J.1
  • 60
    • 0032416948 scopus 로고    scopus 로고
    • Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease
    • de Boer W.I., et al. Transforming growth factor beta1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998, 158:1951-1957.
    • (1998) Am. J. Respir. Crit. Care Med. , vol.158 , pp. 1951-1957
    • de Boer, W.I.1
  • 61
    • 17044453955 scopus 로고    scopus 로고
    • Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    • Takizawa H., et al. Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am. J. Respir. Crit. Care Med. 2001, 163:1476-1483.
    • (2001) Am. J. Respir. Crit. Care Med. , vol.163 , pp. 1476-1483
    • Takizawa, H.1
  • 62
    • 84871916713 scopus 로고    scopus 로고
    • Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
    • Fujii S., et al. Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease. Oncoimmunology 2012, 1:630-641.
    • (2012) Oncoimmunology , vol.1 , pp. 630-641
    • Fujii, S.1
  • 63
    • 0034966686 scopus 로고    scopus 로고
    • 5' flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus
    • Schutze N., et al. 5' flanking sequence of the human immediate early responsive gene ccn1 (cyr61) and mapping of polymorphic CA repeat sequence motifs in the human ccn1 (cyr61) locus. Mol. Pathol. 2001, 54:170-175.
    • (2001) Mol. Pathol. , vol.54 , pp. 170-175
    • Schutze, N.1
  • 64
    • 84879915160 scopus 로고    scopus 로고
    • CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells
    • Moon H.G., et al. CCN1 secretion induced by cigarette smoking extracts augments IL-8 release from bronchial epithelial cells. PLoS ONE 2013, 8:e68199.
    • (2013) PLoS ONE , vol.8 , pp. e68199
    • Moon, H.G.1
  • 65
    • 84899719111 scopus 로고    scopus 로고
    • Active trafficking of alpha 1 antitrypsin across the lung endothelium
    • Lockett A.D., et al. Active trafficking of alpha 1 antitrypsin across the lung endothelium. PLoS ONE 2014, 9:e93979.
    • (2014) PLoS ONE , vol.9 , pp. e93979
    • Lockett, A.D.1
  • 66
    • 84897548878 scopus 로고    scopus 로고
    • The role of microparticles in chronic obstructive pulmonary disease
    • Takahashi T., Kubo H. The role of microparticles in chronic obstructive pulmonary disease. Int. J. Chronic Obstructive Pulmonary Dis. 2014, 9:303-314.
    • (2014) Int. J. Chronic Obstructive Pulmonary Dis. , vol.9 , pp. 303-314
    • Takahashi, T.1    Kubo, H.2
  • 67
    • 79251490374 scopus 로고    scopus 로고
    • New driver mutations in non-small-cell lung cancer
    • Pao W., Girard N. New driver mutations in non-small-cell lung cancer. Lancet Oncol. 2011, 12:175-180.
    • (2011) Lancet Oncol. , vol.12 , pp. 175-180
    • Pao, W.1    Girard, N.2
  • 68
    • 84917693100 scopus 로고    scopus 로고
    • The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research
    • Fujita Y., et al. The impact of extracellular vesicle-encapsulated circulating microRNAs in lung cancer research. BioMed Res. Int. 2014, 2014:486413.
    • (2014) BioMed Res. Int. , vol.2014 , pp. 486413
    • Fujita, Y.1
  • 69
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin G.A., Croce C.M. MicroRNA signatures in human cancers. Nat. Rev. Cancer 2006, 6:857-866.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 70
    • 84873655073 scopus 로고    scopus 로고
    • RNAi therapeutic platforms for lung diseases
    • Fujita Y., et al. RNAi therapeutic platforms for lung diseases. Pharmaceuticals 2013, 6:223-250.
    • (2013) Pharmaceuticals , vol.6 , pp. 223-250
    • Fujita, Y.1
  • 71
    • 84925881823 scopus 로고    scopus 로고
    • Development of small RNA delivery systems for lung cancer therapy
    • Fujita Y., et al. Development of small RNA delivery systems for lung cancer therapy. Int. J. Mol. Sci. 2015, 16:5254-5270.
    • (2015) Int. J. Mol. Sci. , vol.16 , pp. 5254-5270
    • Fujita, Y.1
  • 72
    • 62549125455 scopus 로고    scopus 로고
    • Exosomal microRNA: a diagnostic marker for lung cancer
    • Rabinowits G., et al. Exosomal microRNA: a diagnostic marker for lung cancer. Clin. Lung Cancer 2009, 10:42-46.
    • (2009) Clin. Lung Cancer , vol.10 , pp. 42-46
    • Rabinowits, G.1
  • 73
    • 84883373154 scopus 로고    scopus 로고
    • MicroRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer
    • Cazzoli R., et al. microRNAs derived from circulating exosomes as noninvasive biomarkers for screening and diagnosing lung cancer. J. Thorac. Oncol. 2013, 8:1156-1162.
    • (2013) J. Thorac. Oncol. , vol.8 , pp. 1156-1162
    • Cazzoli, R.1
  • 74
    • 84940577028 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes
    • Cui H., et al. Tissue inhibitor of metalloproteinases-1 induces a pro-tumourigenic increase of miR-210 in lung adenocarcinoma cells and their exosomes. Oncogene 2015, 34:3640-3650.
    • (2015) Oncogene , vol.34 , pp. 3640-3650
    • Cui, H.1
  • 75
    • 84874637012 scopus 로고    scopus 로고
    • Exosomal tumor microRNA modulates premetastatic organ cells
    • Rana S., et al. Exosomal tumor microRNA modulates premetastatic organ cells. Neoplasia 2013, 15:281-295.
    • (2013) Neoplasia , vol.15 , pp. 281-295
    • Rana, S.1
  • 76
    • 84864503916 scopus 로고    scopus 로고
    • MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
    • Fabbri M., et al. microRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:E2110-E2116.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. E2110-E2116
    • Fabbri, M.1
  • 77
    • 84878653585 scopus 로고    scopus 로고
    • Contribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: state of the art and new perspectives
    • Fontana S., et al. Contribution of proteomics to understanding the role of tumor-derived exosomes in cancer progression: state of the art and new perspectives. Proteomics 2013, 13:1581-1594.
    • (2013) Proteomics , vol.13 , pp. 1581-1594
    • Fontana, S.1
  • 78
    • 84880630042 scopus 로고    scopus 로고
    • Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions
    • Park J.O., et al. Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. Proteomics 2013, 13:2125-2134.
    • (2013) Proteomics , vol.13 , pp. 2125-2134
    • Park, J.O.1
  • 79
    • 79960728743 scopus 로고    scopus 로고
    • Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC
    • Li Y., et al. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC. Electrophoresis 2011, 32:1976-1983.
    • (2011) Electrophoresis , vol.32 , pp. 1976-1983
    • Li, Y.1
  • 80
    • 84892702249 scopus 로고    scopus 로고
    • Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis
    • Yamashita T., et al. Epidermal growth factor receptor localized to exosome membranes as a possible biomarker for lung cancer diagnosis. Die Pharmazie 2013, 68:969-973.
    • (2013) Die Pharmazie , vol.68 , pp. 969-973
    • Yamashita, T.1
  • 81
    • 84877947179 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells
    • Huang S.H., et al. Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells. Cancer Invest. 2013, 31:330-335.
    • (2013) Cancer Invest. , vol.31 , pp. 330-335
    • Huang, S.H.1
  • 82
    • 84906818368 scopus 로고    scopus 로고
    • Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes
    • Ueda K., et al. Antibody-coupled monolithic silica microtips for highthroughput molecular profiling of circulating exosomes. Sci. Rep. 2014, 4:6232.
    • (2014) Sci. Rep. , vol.4 , pp. 6232
    • Ueda, K.1
  • 83
    • 85016462671 scopus 로고    scopus 로고
    • Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma
    • Jakobsen K.R., et al. Exosomal proteins as potential diagnostic markers in advanced non-small cell lung carcinoma. J. Extracell. Vesicles 2015, 4:26659.
    • (2015) J. Extracell. Vesicles , vol.4 , pp. 26659
    • Jakobsen, K.R.1
  • 84
    • 84905705777 scopus 로고    scopus 로고
    • Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment
    • Choi D.Y., et al. Extracellular vesicles shed from gefitinib-resistant nonsmall cell lung cancer regulate the tumor microenvironment. Proteomics 2014, 14:1845-1856.
    • (2014) Proteomics , vol.14 , pp. 1845-1856
    • Choi, D.Y.1
  • 85
    • 84940583132 scopus 로고    scopus 로고
    • Phospholipids of tumor extracellular vesicles stratify gefitinib-resistant nonsmall cell lung cancer cells from gefitinib-sensitive cells
    • Jung J.H., et al. Phospholipids of tumor extracellular vesicles stratify gefitinib-resistant nonsmall cell lung cancer cells from gefitinib-sensitive cells. Proteomics 2015, 15:824-835.
    • (2015) Proteomics , vol.15 , pp. 824-835
    • Jung, J.H.1
  • 86
    • 84896760337 scopus 로고    scopus 로고
    • Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin
    • Xiao X., et al. Exosomes: decreased sensitivity of lung cancer A549 cells to cisplatin. PLoS ONE 2014, 9:e89534.
    • (2014) PLoS ONE , vol.9 , pp. e89534
    • Xiao, X.1
  • 87
    • 84874967621 scopus 로고    scopus 로고
    • Exosomal tumor-suppressive microRNAs as novel cancer therapy: 'exocure' is another choice for cancer treatment
    • Kosaka N., et al. Exosomal tumor-suppressive microRNAs as novel cancer therapy: 'exocure' is another choice for cancer treatment. Adv. Drug Deliv. Rev. 2013, 65:376-382.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 376-382
    • Kosaka, N.1
  • 88
    • 84876248584 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis
    • Kosaka N., et al. Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J. Biol. Chem. 2013, 288:10849-10859.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10849-10859
    • Kosaka, N.1
  • 89
    • 84919597008 scopus 로고    scopus 로고
    • Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64
    • Li W., et al. Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: involvement of EPI64. Acta Pathol. Microbiol. Immunol. Scand. 2014, 122:1080-1087.
    • (2014) Acta Pathol. Microbiol. Immunol. Scand. , vol.122 , pp. 1080-1087
    • Li, W.1
  • 90
    • 84908897430 scopus 로고    scopus 로고
    • β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome
    • Li J., et al. β-Elemene against human lung cancer via up-regulation of P53 protein expression to promote the release of exosome. Lung Cancer 2014, 86:144-150.
    • (2014) Lung Cancer , vol.86 , pp. 144-150
    • Li, J.1
  • 91
    • 84862734041 scopus 로고    scopus 로고
    • Exosome removal as a therapeutic adjuvant in cancer
    • Marleau A.M., et al. Exosome removal as a therapeutic adjuvant in cancer. J. Transl. Med. 2012, 10:134.
    • (2012) J. Transl. Med. , vol.10 , pp. 134
    • Marleau, A.M.1
  • 92
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger M.F., et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1
  • 93
    • 84872139846 scopus 로고    scopus 로고
    • Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?
    • Griffin M.D., et al. Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?. Immunol. Cell Biol. 2013, 91:40-51.
    • (2013) Immunol. Cell Biol. , vol.91 , pp. 40-51
    • Griffin, M.D.1
  • 94
    • 84928748370 scopus 로고    scopus 로고
    • Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome
    • Matthay M.A. Therapeutic potential of mesenchymal stromal cells for acute respiratory distress syndrome. Ann. Am. Thorac. Soc. 2015, 12(Suppl. 1):S54-S57.
    • (2015) Ann. Am. Thorac. Soc. , vol.12 , pp. S54-S57
    • Matthay, M.A.1
  • 95
    • 84929050359 scopus 로고    scopus 로고
    • Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications
    • Rani S., et al. Mesenchymal stem cell-derived extracellular vesicles: toward cell-free therapeutic applications. Mol. Ther. 2015, 23:812-823.
    • (2015) Mol. Ther. , vol.23 , pp. 812-823
    • Rani, S.1
  • 96
    • 79957619269 scopus 로고    scopus 로고
    • Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors
    • Lee J.W., et al. Concise review: mesenchymal stem cells for acute lung injury: role of paracrine soluble factors. Stem Cells 2011, 29:913-919.
    • (2011) Stem Cells , vol.29 , pp. 913-919
    • Lee, J.W.1
  • 97
    • 84891819825 scopus 로고    scopus 로고
    • Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice
    • Zhu Y.G., et al. Human mesenchymal stem cell microvesicles for treatment of Escherichia coli endotoxin-induced acute lung injury in mice. Stem Cells 2014, 32:116-125.
    • (2014) Stem Cells , vol.32 , pp. 116-125
    • Zhu, Y.G.1
  • 98
    • 84870239895 scopus 로고    scopus 로고
    • Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension
    • Lee C., et al. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation 2012, 126:2601-2611.
    • (2012) Circulation , vol.126 , pp. 2601-2611
    • Lee, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.