-
1
-
-
0030941458
-
P53, the cellular gatekeeper for growth and division
-
Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88, 323 331.
-
(1997)
Cell
, vol.88
, pp. 323-331
-
-
Levine, A.J.1
-
2
-
-
34248194200
-
The regulation of AMPK beta1, TSC2, and PTEN expression by p53: Stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways
-
Feng Z, Hu W, de Stanchina E, Teresky AK, Jin S, Lowe S Levine AJ (2007) The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways. Cancer Res 67, 3043 3053.
-
(2007)
Cancer Res
, vol.67
, pp. 3043-3053
-
-
Feng, Z.1
Hu, W.2
De Stanchina, E.3
Teresky, A.K.4
Jin, S.5
Lowe, S.6
Levine, A.J.7
-
3
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
Feng Z, Zhang H, Levine AJ Jin S (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci USA 102, 8204 8209.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
Jin, S.4
-
4
-
-
32044435126
-
Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways
-
Levine AJ, Feng Z, Mak TW, You H Jin S (2006) Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways. Genes Dev 20, 267 275.
-
(2006)
Genes Dev
, vol.20
, pp. 267-275
-
-
Levine, A.J.1
Feng, Z.2
Mak, T.W.3
You, H.4
Jin, S.5
-
5
-
-
33745149291
-
P53 regulates mitochondrial respiration
-
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F Hwang PM (2006) p53 regulates mitochondrial respiration. Science 312, 1650 1653.
-
(2006)
Science
, vol.312
, pp. 1650-1653
-
-
Matoba, S.1
Kang, J.G.2
Patino, W.D.3
Wragg, A.4
Boehm, M.5
Gavrilova, O.6
Hurley, P.J.7
Bunz, F.8
Hwang, P.M.9
-
6
-
-
0027244682
-
Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species
-
Margulies L Sehgal PB (1993) Modulation of the human interleukin-6 promoter (IL-6) and transcription factor C/EBP beta (NF-IL6) activity by p53 species. J Biol Chem 268, 15096 15100.
-
(1993)
J Biol Chem
, vol.268
, pp. 15096-15100
-
-
Margulies, L.1
Sehgal, P.B.2
-
7
-
-
34247137556
-
A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein
-
Dijsselbloem N, Goriely S, Albarani V, Gerlo S, Francoz S, Marine JC, Goldman M, Haegeman G Vanden Berghe W (2007) A critical role for p53 in the control of NF-kappaB-dependent gene expression in TLR4-stimulated dendritic cells exposed to Genistein. J Immunol 178, 5048 5057.
-
(2007)
J Immunol
, vol.178
, pp. 5048-5057
-
-
Dijsselbloem, N.1
Goriely, S.2
Albarani, V.3
Gerlo, S.4
Francoz, S.5
Marine, J.C.6
Goldman, M.7
Haegeman, G.8
Vanden Berghe, W.9
-
8
-
-
38949092911
-
Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells
-
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio MG, Rustighi A, Del Sal G Zauli G (2008) Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood 111, 1287 1294.
-
(2008)
Blood
, vol.111
, pp. 1287-1294
-
-
Secchiero, P.1
Corallini, F.2
Rimondi, E.3
Chiaruttini, C.4
Di Iasio, M.G.5
Rustighi, A.6
Del Sal, G.7
Zauli, G.8
-
9
-
-
63049118190
-
Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology
-
doi:.
-
Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E Lowe SW (2009) Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harb Symp Quant Biol, doi :.
-
(2009)
Cold Spring Harb Symp Quant Biol
-
-
Krizhanovsky, V.1
Xue, W.2
Zender, L.3
Yon, M.4
Hernando, E.5
Lowe, S.W.6
-
10
-
-
49749145668
-
Senescence of activated stellate cells limits liver fibrosis
-
Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L Lowe SW (2008) Senescence of activated stellate cells limits liver fibrosis. Cell 134, 657 667.
-
(2008)
Cell
, vol.134
, pp. 657-667
-
-
Krizhanovsky, V.1
Yon, M.2
Dickins, R.A.3
Hearn, S.4
Simon, J.5
Miething, C.6
Yee, H.7
Zender, L.8
Lowe, S.W.9
-
11
-
-
33846937033
-
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
-
Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C Lowe SW (2007) Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature 445, 656 660.
-
(2007)
Nature
, vol.445
, pp. 656-660
-
-
Xue, W.1
Zender, L.2
Miething, C.3
Dickins, R.A.4
Hernando, E.5
Krizhanovsky, V.6
Cordon-Cardo, C.7
Lowe, S.W.8
-
12
-
-
33646416463
-
The regulation of exosome secretion: A novel function of the p53 protein
-
Yu X, Harris SL Levine AJ (2006) The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res 66, 4795 4801.
-
(2006)
Cancer Res
, vol.66
, pp. 4795-4801
-
-
Yu, X.1
Harris, S.L.2
Levine, A.J.3
-
13
-
-
0033767690
-
Exosome: From internal vesicle of the multivesicular body to intercellular signaling device
-
Denzer K, Kleijmeer MJ, Heijnen HF, Stoorvogel W Geuze HJ (2000) Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J Cell Sci 113, 3365 3374.
-
(2000)
J Cell Sci
, vol.113
, pp. 3365-3374
-
-
Denzer, K.1
Kleijmeer, M.J.2
Heijnen, H.F.3
Stoorvogel, W.4
Geuze, H.J.5
-
14
-
-
3142630225
-
Exosomes: Endosomal-derived vesicles shipping extracellular messages
-
Fevrier B Raposo G (2004) Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr Opin Cell Biol 16, 415 421.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 415-421
-
-
Fevrier, B.1
Raposo, G.2
-
15
-
-
8544232810
-
TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway
-
Amzallag N, Passer BJ, Allanic D, Segura E, Thery C, Goud B, Amson R Telerman A (2004) TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway. J Biol Chem 279, 46104 46112.
-
(2004)
J Biol Chem
, vol.279
, pp. 46104-46112
-
-
Amzallag, N.1
Passer, B.J.2
Allanic, D.3
Segura, E.4
Thery, C.5
Goud, B.6
Amson, R.7
Telerman, A.8
-
16
-
-
0037418216
-
The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase
-
Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L et al. (2003) The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. Proc Natl Acad Sci USA 100, 2284 2289.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2284-2289
-
-
Passer, B.J.1
Nancy-Portebois, V.2
Amzallag, N.3
Prieur, S.4
Cans, C.5
Roborel De Climens, A.6
Fiucci, G.7
Bouvard, V.8
Tuynder, M.9
Susini, L.10
-
17
-
-
54049088501
-
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice
-
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R Telerman A (2008) Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ 15, 1723 1733.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1723-1733
-
-
Lespagnol, A.1
Duflaut, D.2
Beekman, C.3
Blanc, L.4
Fiucci, G.5
Marine, J.C.6
Vidal, M.7
Amson, R.8
Telerman, A.9
-
18
-
-
44949136325
-
Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle
-
Sendamarai AK, Ohgami RS, Fleming MD Lawrence CM (2008) Structure of the membrane proximal oxidoreductase domain of human Steap3, the dominant ferrireductase of the erythroid transferrin cycle. Proc Natl Acad Sci USA 105, 7410 7415.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 7410-7415
-
-
Sendamarai, A.K.1
Ohgami, R.S.2
Fleming, M.D.3
Lawrence, C.M.4
-
19
-
-
27644455133
-
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
-
Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, Chen J, Sharp JJ, Fujiwara Y, Barker JE Fleming MD (2005) Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet 37, 1264 1269.
-
(2005)
Nat Genet
, vol.37
, pp. 1264-1269
-
-
Ohgami, R.S.1
Campagna, D.R.2
Greer, E.L.3
Antiochos, B.4
McDonald, A.5
Chen, J.6
Sharp, J.J.7
Fujiwara, Y.8
Barker, J.E.9
Fleming, M.D.10
-
20
-
-
59749089436
-
ESCRT proteins, endosome organization and mitogenic receptor down-regulation
-
Woodman P (2009) ESCRT proteins, endosome organization and mitogenic receptor down-regulation. Biochem Soc Trans 37, 146 150.
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 146-150
-
-
Woodman, P.1
-
25
-
-
13444263549
-
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling
-
Le Roy C Wrana JL (2005) Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling. Nat Rev Mol Cell Biol 6, 112 126.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 112-126
-
-
Le Roy, C.1
Wrana, J.L.2
-
26
-
-
33845338025
-
Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers
-
Sotgia F, Rui H, Bonuccelli G, Mercier I, Pestell RG Lisanti MP (2006) Caveolin-1, mammary stem cells, and estrogen-dependent breast cancers. Cancer Res 66, 10647 10651.
-
(2006)
Cancer Res
, vol.66
, pp. 10647-10651
-
-
Sotgia, F.1
Rui, H.2
Bonuccelli, G.3
Mercier, I.4
Pestell, R.G.5
Lisanti, M.P.6
-
27
-
-
19944366937
-
Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion
-
Williams TM, Medina F, Badano I, Hazan RB, Hutchinson J, Muller WJ, Chopra NG, Scherer PE, Pestell RG Lisanti MP (2004) Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem 279, 51630 51646.
-
(2004)
J Biol Chem
, vol.279
, pp. 51630-51646
-
-
Williams, T.M.1
Medina, F.2
Badano, I.3
Hazan, R.B.4
Hutchinson, J.5
Muller, W.J.6
Chopra, N.G.7
Scherer, P.E.8
Pestell, R.G.9
Lisanti, M.P.10
-
28
-
-
0035963942
-
Upregulation of caveolin in multidrug resistant cancer cells: Functional implications
-
Lavie Y, Fiucci G Liscovitch M (2001) Upregulation of caveolin in multidrug resistant cancer cells: functional implications. Adv Drug Deliv Rev 49, 317 323.
-
(2001)
Adv Drug Deliv Rev
, vol.49
, pp. 317-323
-
-
Lavie, Y.1
Fiucci, G.2
Liscovitch, M.3
-
29
-
-
34247589588
-
Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence
-
Karam JA, Lotan Y, Roehrborn CG, Ashfaq R, Karakiewicz PI Shariat SF (2007) Caveolin-1 overexpression is associated with aggressive prostate cancer recurrence. Prostate 67, 614 622.
-
(2007)
Prostate
, vol.67
, pp. 614-622
-
-
Karam, J.A.1
Lotan, Y.2
Roehrborn, C.G.3
Ashfaq, R.4
Karakiewicz, P.I.5
Shariat, S.F.6
-
30
-
-
36448959111
-
Caveolin-1 expression in benign and malignant lesions of the breast
-
Liedtke C, Kersting C, Burger H, Kiesel L Wulfing P (2007) Caveolin-1 expression in benign and malignant lesions of the breast. World J Surg Oncol 5, 110.
-
(2007)
World J Surg Oncol
, vol.5
, pp. 110
-
-
Liedtke, C.1
Kersting, C.2
Burger, H.3
Kiesel, L.4
Wulfing, P.5
-
31
-
-
33846288318
-
Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: A morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis
-
Savage K, Lambros MB, Robertson D, Jones RL, Jones C, Mackay A, James M, Hornick JL, Pereira EM, Milanezi F et al. (2007) Caveolin 1 is overexpressed and amplified in a subset of basal-like and metaplastic breast carcinomas: a morphologic, ultrastructural, immunohistochemical, and in situ hybridization analysis. Clin Cancer Res 13, 90 101.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 90-101
-
-
Savage, K.1
Lambros, M.B.2
Robertson, D.3
Jones, R.L.4
Jones, C.5
MacKay, A.6
James, M.7
Hornick, J.L.8
Pereira, E.M.9
Milanezi, F.10
-
32
-
-
14544295742
-
Endocytosis of membrane receptors: Two pathways are better than one
-
Aguilar RC Wendland B (2005) Endocytosis of membrane receptors: two pathways are better than one. Proc Natl Acad Sci USA 102, 2679 2680.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2679-2680
-
-
Aguilar, R.C.1
Wendland, B.2
-
33
-
-
0036733284
-
Caveolae: From cell biology to animal physiology
-
Razani B, Woodman SE Lisanti MP (2002) Caveolae: from cell biology to animal physiology. Pharmacol Rev 54, 431 467.
-
(2002)
Pharmacol Rev
, vol.54
, pp. 431-467
-
-
Razani, B.1
Woodman, S.E.2
Lisanti, M.P.3
-
34
-
-
0034728387
-
P53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism
-
Bist A, Fielding CJ Fielding PE (2000) p53 regulates caveolin gene transcription, cell cholesterol, and growth by a novel mechanism. Biochemistry 39, 1966 1972.
-
(2000)
Biochemistry
, vol.39
, pp. 1966-1972
-
-
Bist, A.1
Fielding, C.J.2
Fielding, P.E.3
-
35
-
-
0030982565
-
Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol
-
Bist A, Fielding PE Fielding CJ (1997) Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol. Proc Natl Acad Sci USA 94, 10693 10698.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10693-10698
-
-
Bist, A.1
Fielding, P.E.2
Fielding, C.J.3
-
36
-
-
0033453226
-
Identification and classification of p53-regulated genes
-
Yu J, Zhang L, Hwang PM, Rago C, Kinzler KW Vogelstein B (1999) Identification and classification of p53-regulated genes. Proc Natl Acad Sci USA 96, 14517 14522.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14517-14522
-
-
Yu, J.1
Zhang, L.2
Hwang, P.M.3
Rago, C.4
Kinzler, K.W.5
Vogelstein, B.6
-
37
-
-
0037173059
-
The p53MH algorithm and its application in detecting p53-responsive genes
-
Hoh J, Jin S, Parrado T, Edington J, Levine AJ Ott J (2002) The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci USA 99, 8467 8472.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8467-8472
-
-
Hoh, J.1
Jin, S.2
Parrado, T.3
Edington, J.4
Levine, A.J.5
Ott, J.6
-
38
-
-
4644280871
-
Interactions of EGFR and caveolin-1 in human glioblastoma cells: Evidence that tyrosine phosphorylation regulates EGFR association with caveolae
-
Abulrob A, Giuseppin S, Andrade MF, McDermid A, Moreno M Stanimirovic D (2004) Interactions of EGFR and caveolin-1 in human glioblastoma cells: evidence that tyrosine phosphorylation regulates EGFR association with caveolae. Oncogene 23, 6967 6979.
-
(2004)
Oncogene
, vol.23
, pp. 6967-6979
-
-
Abulrob, A.1
Giuseppin, S.2
Andrade, M.F.3
McDermid, A.4
Moreno, M.5
Stanimirovic, D.6
-
39
-
-
34848844374
-
Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma and down regulates EGFR-MAPKs signaling pathway
-
Gu D, Li H, Wang Z, Chen Q, Jiang J Zhu H (2007) Caveolin-1 inhibits the growth of human laryngeal squamous cell carcinoma and down regulates EGFR-MAPKs signaling pathway. Laryngoscope 117, 1782 1789.
-
(2007)
Laryngoscope
, vol.117
, pp. 1782-1789
-
-
Gu, D.1
Li, H.2
Wang, Z.3
Chen, Q.4
Jiang, J.5
Zhu, H.6
-
40
-
-
35448931927
-
Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside
-
Wang XQ, Yan Q, Sun P, Liu JW, Go L, McDaniel SM Paller AS (2007) Suppression of epidermal growth factor receptor signaling by protein kinase C-alpha activation requires CD82, caveolin-1, and ganglioside. Cancer Res 67, 9986 9995.
-
(2007)
Cancer Res
, vol.67
, pp. 9986-9995
-
-
Wang, X.Q.1
Yan, Q.2
Sun, P.3
Liu, J.W.4
Go, L.5
McDaniel, S.M.6
Paller, A.S.7
-
41
-
-
18344377030
-
The p53 pathway: Positive and negative feedback loops
-
Harris SL Levine AJ (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24, 2899 2908.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
42
-
-
0033591433
-
Activation of an MDM2-specific caspase by p53 in the absence of apoptosis
-
Pochampally R, Fodera B, Chen L, Lu W Chen J (1999) Activation of an MDM2-specific caspase by p53 in the absence of apoptosis. J Biol Chem 274, 15271 15277.
-
(1999)
J Biol Chem
, vol.274
, pp. 15271-15277
-
-
Pochampally, R.1
Fodera, B.2
Chen, L.3
Lu, W.4
Chen, J.5
-
43
-
-
0029802591
-
P53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen X, Ko LJ, Jayaraman L Prives C (1996) p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev 10, 2438 2451.
-
(1996)
Genes Dev
, vol.10
, pp. 2438-2451
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
44
-
-
0028303752
-
Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein
-
Lin J, Chen J, Elenbaas B Levine AJ (1994) Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein. Genes Dev 8, 1235 1246.
-
(1994)
Genes Dev
, vol.8
, pp. 1235-1246
-
-
Lin, J.1
Chen, J.2
Elenbaas, B.3
Levine, A.J.4
|