Rab27A regulates exosome secretion from lung adenocarcinoma cells A549: Involvement of EPI64

APMIS

Volumn 122, Issue 11, 2014, Pages 1080-1087

  Li, Wenhai ^a   Hu, Yunsheng ^a   Jiang, Tao ^a   Han, Yong ^a   Han, Guoliang ^a   Chen, Jiakuan ^a   Li, Xiaofei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

A549cells; EPI64; Exosome secretion; GAP; Lung cancer; Rab27A

Indexed keywords

EPI64 PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RAB27A PROTEIN; UNCLASSIFIED DRUG; RAB PROTEIN; RAB27A PROTEIN, HUMAN; SMALL INTERFERING RNA; TBC1D10A PROTEIN, HUMAN;

A549 CELL LINE; ARTICLE; ASSAY; CELLULAR SECRETION; CONTROLLED STUDY; EXOSOME; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; ADENOCARCINOMA; LUNG TUMOR; METABOLISM; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; EXOSOMES; GTPASE-ACTIVATING PROTEINS; HUMANS; LUNG NEOPLASMS; RAB GTP-BINDING PROTEINS; RNA, SMALL INTERFERING;

EID: 84919597008     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/apm.12261     Document Type: Article

References (27)

1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin 2012;62:10-29.
2. Eissa NT. The exosome in lung diseases: message in a bottle. J Allergy Clin Immunol 2013;131:904-5.
3. Kharaziha P, Ceder S, Li Q, Panaretakis T. Tumor cell-derived exosomes: a message in a bottle. Biochim Biophys Acta 2012;1826:103-11.
4. Greene CM, Gaughan KP. microRNAs in asthma: potential therapeutic targets. Curr Opin in Pulm Med 2013;19:66-72.
5. Sandoval CO, Simmen T. Rab proteins of the endoplasmic reticulum: functions and interactors. Biochem Soc Trans 2012;40:1426-32.
6. Seabra MC, Mules EH, Hume AN. Rab GTPases, intracellular traffic and disease. Trends Mol Med 2002;8:23-30.
7. Diekmann Y, Seixas E, Gouw M, Tavares-Cadete F, Seabra MC, Pereira-Leal JB. Thousands of Rab GTPases for the cell biologist. PLoS Comput Biol 2011;7:e1002217.
8. Van Gele M, Dynoodt P, Lambert J. Griscelli syndrome: a model system to study vesicular trafficking. Pigment Cell Melanoma Res 2009;22:268-82.
9. Tolmachova T, Anders R, Stinchcombe J, Bossi G, Griffiths GM, Huxley C, et al. A general role for Rab27a in secretory cells. Mol Biol Cell 2004;15:332-44.
10. Bobrie A, Krumeich S, Reyal F, Recchi C, Moita LF, Seabra MC, et al. Rab27a supports exosome-dependent and-independent mechanisms that modify the tumor microenvironment and can promote tumor progression. Cancer Res 2012;72:4920-30.
11. Imai A, Yoshie S, Nashida T, Fukuda M, Shimomura H. Redistribution of small GTP-binding protein, Rab27B, in rat parotid acinar cells after stimulation with isoproterenol. Eur J Oral Sci 2009;117:224-30.
12. Bernards A. GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta 2003;1603:47-82.
13. Itoh T, Fukuda M. Identification of EPI64 as a GTPase-activating protein specific for Rab27A. J Biol Chem 2006;281:31823-31.
14. Imai A, Yoshie S, Ishibashi K, Haga-Tsujimura M, Nashida T, Shimomura H, et al. EPI64 protein functions as a physiological GTPase-activating protein for Rab27 protein and regulates amylase release in rat parotid acinar cells. J Biol Chem 2011;286:33854-62.
15. Tsuboi T, Fukuda M. The C2B domain of rabphilin directly interacts with SNAP-25 and regulates the docking step of dense core vesicle exocytosis in PC12 cells. J Biol Chem 2005;280:39253-9.
16. Reczek D, Bretscher A. Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP. J Cell Biol 2001;153:191-206.
17. Xie X, Wu X, Cui J, Li H, Yan X. Increase ICAM-1 and LFA-1 expression by cerebrospinal fluid of subarachnoid hemorrhage patients: involvement of TNF-α. Brain Res 2013;1512:89-96.
18. Scheich C, Sievert V, Büssow K. An automated method for high-throughput protein purification applied to a comparison of His-tag and GST-tag affinity chromatography. BMC Biotechnol 2003;3:12.
19. Sosa MS, Lewin NE, Choi S-H, Blumberg PM, Kazanietz MG. Biochemical characterization of hyperactive β2-chimaerin mutants revealed an enhanced exposure of C1 and Rac-GAP domains. Biochemistry 2009;48:8171-8.
20. Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, et al. TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 Trafficking in Adipocytes. Traffic 2012;13:1429-41.
21. Du J, Zhao W, Wang Y, Cai Y. Lentivirus vector-mediated knockdown of erythropoietin-producing Hepatocellular Carcinoma Receptors B4 inhibits laser-induced choroidal neovascularization. J Ocul Pharmacol Ther 2013;29:14-22.
22. Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, et al. Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 2009;12:19-30.
23. Subramanian J, Govindan R. Lung cancer in never smokers: a review. J Clin Oncol 2007;25:561-70.
24. Cersosimo RJ. Lung cancer: a review. Am J Health Syst Pharm 2002;59:611-42.
25. Bach PB, Jett JR, Pastorino U, Tockman MS, Swensen SJ, Begg CB. Computed tomography screening and lung cancer outcomes. JAMA 2007;297:953-61.
26. Manser R, Irving L, Stone C, Byrnes G, Abramson M, Campbell D. Screening for lung cancer. Cochrane Libr 1999; doi: 10.1002/14651858.CD001991.
27. Rabinowits G, Gerçel-Taylor C, Day JM, Taylor DD, Kloecker GH. Exosomal microRNA: a diagnostic marker for lung cancer. Clin Lung Cancer 2009;10:42-6.