메뉴 건너뛰기




Volumn 1, Issue 1, 2015, Pages 3-17

The molecular background of mucinous carcinoma beyond MUC2

Author keywords

colorectal carcinoma; genotype; molecular pathology; mucinous carcinoma; phenotype

Indexed keywords

B RAF KINASE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MUCIN 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; RAF PROTEIN; RAS PROTEIN;

EID: 84940450185     PISSN: None     EISSN: 20564538     Source Type: Journal    
DOI: 10.1002/cjp2.1     Document Type: Review
Times cited : (69)

References (171)
  • 1
    • 78049485263 scopus 로고    scopus 로고
    • Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
    • Ferlay J, Shin HR, Bray F, et al. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127: 2893–2917.
    • (2010) Int J Cancer , vol.127 , pp. 2893-2917
    • Ferlay, J.1    Shin, H.R.2    Bray, F.3
  • 2
    • 77955179596 scopus 로고    scopus 로고
    • 4th edn, International Agency for Research on Cancer, Lyon
    • Bosman FT, World Health Organization, International Agency for Research on Cancer. WHO Classification of Tumours of the Digestive System (4th edn). International Agency for Research on Cancer: Lyon, 2010.
    • (2010) WHO Classification of Tumours of the Digestive System
    • Bosman, F.T.1
  • 3
    • 84867398441 scopus 로고    scopus 로고
    • Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base
    • Hyngstrom JR, Hu CY, Xing Y, et al. Clinicopathology and outcomes for mucinous and signet ring colorectal adenocarcinoma: analysis from the National Cancer Data Base. Ann Surg Oncol 2012; 19: 2814–2821.
    • (2012) Ann Surg Oncol , vol.19 , pp. 2814-2821
    • Hyngstrom, J.R.1    Hu, C.Y.2    Xing, Y.3
  • 4
    • 84887027951 scopus 로고    scopus 로고
    • Prognosis and value of adjuvant chemotherapy in stage III mucinous colorectal carcinoma
    • Hugen N, Verhoeven RH, Radema SA, et al. Prognosis and value of adjuvant chemotherapy in stage III mucinous colorectal carcinoma. Ann Oncol 2013; 24: 2819–2824.
    • (2013) Ann Oncol , vol.24 , pp. 2819-2824
    • Hugen, N.1    Verhoeven, R.H.2    Radema, S.A.3
  • 5
    • 23844521660 scopus 로고    scopus 로고
    • Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer
    • Negri FV, Wotherspoon A, Cunningham D, et al. Mucinous histology predicts for reduced fluorouracil responsiveness and survival in advanced colorectal cancer. Ann Oncol 2005; 16: 1305–1310.
    • (2005) Ann Oncol , vol.16 , pp. 1305-1310
    • Negri, F.V.1    Wotherspoon, A.2    Cunningham, D.3
  • 6
    • 84857051602 scopus 로고    scopus 로고
    • Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer
    • Mekenkamp LJ, Heesterbeek KJ, Koopman M, et al. Mucinous adenocarcinomas: poor prognosis in metastatic colorectal cancer. Eur J Cancer 2012; 48: 501–509.
    • (2012) Eur J Cancer , vol.48 , pp. 501-509
    • Mekenkamp, L.J.1    Heesterbeek, K.J.2    Koopman, M.3
  • 7
    • 62549089251 scopus 로고    scopus 로고
    • Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy
    • Catalano V, Loupakis F, Graziano F, et al. Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy. Br J Cancer 2009; 100: 881–887.
    • (2009) Br J Cancer , vol.100 , pp. 881-887
    • Catalano, V.1    Loupakis, F.2    Graziano, F.3
  • 8
    • 84896855951 scopus 로고    scopus 로고
    • Metastatic pattern in colorectal cancer is strongly influenced by histological subtype
    • Hugen N, van de Velde CJ, de Wilt JH, et al. Metastatic pattern in colorectal cancer is strongly influenced by histological subtype. Ann Oncol 2014; 25: 651–657.
    • (2014) Ann Oncol , vol.25 , pp. 651-657
    • Hugen, N.1    van de Velde, C.J.2    de Wilt, J.H.3
  • 9
    • 0030799951 scopus 로고    scopus 로고
    • Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary
    • Hanski C, Hofmeier M, Schmitt-Graff A, et al. Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary. J Pathol 1997; 182: 385–391.
    • (1997) J Pathol , vol.182 , pp. 385-391
    • Hanski, C.1    Hofmeier, M.2    Schmitt-Graff, A.3
  • 10
    • 84863922124 scopus 로고    scopus 로고
    • Comprehensive molecular characterization of human colon and rectal cancer
    • Cancer Genome Atlas N. Comprehensive molecular characterization of human colon and rectal cancer. Nature 2012; 487: 330–337.
    • (2012) Nature , vol.487 , pp. 330-337
  • 11
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646–674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 12
    • 1242337458 scopus 로고    scopus 로고
    • Mucins and mucin binding proteins in colorectal cancer
    • Byrd JC, Bresalier RS. Mucins and mucin binding proteins in colorectal cancer. Cancer Metastasis Rev 2004; 23: 77–99.
    • (2004) Cancer Metastasis Rev , vol.23 , pp. 77-99
    • Byrd, J.C.1    Bresalier, R.S.2
  • 13
    • 0029840759 scopus 로고    scopus 로고
    • Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues
    • Weiss AA, Babyatsky MW, Ogata S, et al. Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues. J Histochem Cytochem 1996; 44: 1161–1166.
    • (1996) J Histochem Cytochem , vol.44 , pp. 1161-1166
    • Weiss, A.A.1    Babyatsky, M.W.2    Ogata, S.3
  • 14
    • 33745591883 scopus 로고    scopus 로고
    • Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to location
    • Park SY, Lee HS, Choe G, et al. Clinicopathological characteristics, microsatellite instability, and expression of mucin core proteins and p53 in colorectal mucinous adenocarcinomas in relation to location. Virchows Arch 2006; 449: 40–47.
    • (2006) Virchows Arch , vol.449 , pp. 40-47
    • Park, S.Y.1    Lee, H.S.2    Choe, G.3
  • 15
    • 33947510310 scopus 로고    scopus 로고
    • Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients
    • You JF, Hsieh LL, Changchien CR, et al. Inverse effects of mucin on survival of matched hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer patients. Clin Cancer Res 2006; 12: 4244–4250.
    • (2006) Clin Cancer Res , vol.12 , pp. 4244-4250
    • You, J.F.1    Hsieh, L.L.2    Changchien, C.R.3
  • 16
    • 34547595713 scopus 로고    scopus 로고
    • Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity?
    • Tozawa E, Ajioka Y, Watanabe H, et al. Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: is mucinous carcinoma a distinct histological entity? Pathol Res Pract 2007; 203: 567–574.
    • (2007) Pathol Res Pract , vol.203 , pp. 567-574
    • Tozawa, E.1    Ajioka, Y.2    Watanabe, H.3
  • 17
    • 84865174115 scopus 로고    scopus 로고
    • Clinicopathological significance of mucin 2 immuno-histochemical expression in colorectal cancer: a meta-analysis
    • Li L, Huang PL, Yu XJ, et al. Clinicopathological significance of mucin 2 immuno-histochemical expression in colorectal cancer: a meta-analysis. Chin J Cancer Res 2012; 24: 190–195.
    • (2012) Chin J Cancer Res , vol.24 , pp. 190-195
    • Li, L.1    Huang, P.L.2    Yu, X.J.3
  • 18
    • 77749333040 scopus 로고    scopus 로고
    • MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues
    • Okudaira K, Kakar S, Cun L, et al. MUC2 gene promoter methylation in mucinous and non-mucinous colorectal cancer tissues. Int J Oncol 2010; 36: 765–775.
    • (2010) Int J Oncol , vol.36 , pp. 765-775
    • Okudaira, K.1    Kakar, S.2    Cun, L.3
  • 19
    • 84906251530 scopus 로고    scopus 로고
    • Insight into mucinous colorectal carcinoma: clues from etiology
    • epub ahead of print (PMID 24728741)
    • Hugen N, van Beek JJ, de Wilt JH, et al. Insight into mucinous colorectal carcinoma: clues from etiology. Ann Surg Oncol 2014; epub ahead of print (PMID 24728741).
    • (2014) Ann Surg Oncol
    • Hugen, N.1    van Beek, J.J.2    de Wilt, J.H.3
  • 20
    • 77449130761 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer
    • e2073
    • Boland CR, Goel A. Microsatellite instability in colorectal cancer. Gastroenterology 2010; 138: 2073–2087, e2073.
    • (2010) Gastroenterology , vol.138 , pp. 2073-2087
    • Boland, C.R.1    Goel, A.2
  • 21
    • 0028276666 scopus 로고
    • Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
    • Kim H, Jen J, Vogelstein B, et al. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences. Am J Pathol 1994; 145: 148–156.
    • (1994) Am J Pathol , vol.145 , pp. 148-156
    • Kim, H.1    Jen, J.2    Vogelstein, B.3
  • 22
    • 0029895818 scopus 로고    scopus 로고
    • Genomic instability in colorectal carcinomas: comparison of different evaluation methods and their biological significance
    • Bocker T, Schlegel J, Kullmann F, et al. Genomic instability in colorectal carcinomas: comparison of different evaluation methods and their biological significance. J Pathol 1996; 179: 15–19.
    • (1996) J Pathol , vol.179 , pp. 15-19
    • Bocker, T.1    Schlegel, J.2    Kullmann, F.3
  • 23
    • 0034669608 scopus 로고    scopus 로고
    • Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability
    • Gafa R, Maestri I, Matteuzzi M, et al. Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability. Cancer 2000; 89: 2025–2037.
    • (2000) Cancer , vol.89 , pp. 2025-2037
    • Gafa, R.1    Maestri, I.2    Matteuzzi, M.3
  • 24
    • 0035185894 scopus 로고    scopus 로고
    • Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis
    • Young J, Simms LA, Biden KG, et al. Features of colorectal cancers with high-level microsatellite instability occurring in familial and sporadic settings: parallel pathways of tumorigenesis. Am J Pathol 2001; 159: 2107–2116.
    • (2001) Am J Pathol , vol.159 , pp. 2107-2116
    • Young, J.1    Simms, L.A.2    Biden, K.G.3
  • 25
    • 0036242782 scopus 로고    scopus 로고
    • CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability
    • Hawkins N, Norrie M, Cheong K, et al. CpG island methylation in sporadic colorectal cancers and its relationship to microsatellite instability. Gastroenterology 2002; 122: 1376–1387.
    • (2002) Gastroenterology , vol.122 , pp. 1376-1387
    • Hawkins, N.1    Norrie, M.2    Cheong, K.3
  • 26
    • 0142232032 scopus 로고    scopus 로고
    • Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer
    • Shia J, Ellis NA, Paty PB, et al. Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer. Am J Surg Pathol 2003; 27: 1407–1417.
    • (2003) Am J Surg Pathol , vol.27 , pp. 1407-1417
    • Shia, J.1    Ellis, N.A.2    Paty, P.B.3
  • 27
    • 2942514604 scopus 로고    scopus 로고
    • Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer
    • Sarli L, Bottarelli L, Azzoni C, et al. Abnormal Fhit protein expression and high frequency of microsatellite instability in sporadic colorectal cancer. Eur J Cancer 2004; 40: 1581–1588.
    • (2004) Eur J Cancer , vol.40 , pp. 1581-1588
    • Sarli, L.1    Bottarelli, L.2    Azzoni, C.3
  • 28
    • 4644286993 scopus 로고    scopus 로고
    • Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis
    • Mori S, Ogata Y, Shirouzu K. Biological features of sporadic colorectal carcinoma with high-frequency microsatellite instability: special reference to tumor proliferation and apoptosis. Int J Clin Oncol 2004; 9: 322–329.
    • (2004) Int J Clin Oncol , vol.9 , pp. 322-329
    • Mori, S.1    Ogata, Y.2    Shirouzu, K.3
  • 29
    • 33644851485 scopus 로고    scopus 로고
    • Relationship between genetic alterations and prognosis in sporadic colorectal cancer
    • Chang SC, Lin JK, Yang SH, et al. Relationship between genetic alterations and prognosis in sporadic colorectal cancer. Int J Cancer 2006; 118: 1721–1727.
    • (2006) Int J Cancer , vol.118 , pp. 1721-1727
    • Chang, S.C.1    Lin, J.K.2    Yang, S.H.3
  • 30
    • 37049036566 scopus 로고    scopus 로고
    • Microsatellite instability did not predict individual survival in sporadic stage II and III rectal cancer patients
    • Meng WJ, Sun XF, Tian C, et al. Microsatellite instability did not predict individual survival in sporadic stage II and III rectal cancer patients. Oncology 2007; 72: 82–88.
    • (2007) Oncology , vol.72 , pp. 82-88
    • Meng, W.J.1    Sun, X.F.2    Tian, C.3
  • 31
    • 50949106092 scopus 로고    scopus 로고
    • Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects
    • Ashktorab H, Brim H, Al-Riyami M, et al. Sporadic colon cancer: mismatch repair immunohistochemistry and microsatellite instability in Omani subjects. Dig Dis Sci 2008; 53: 2723–2731.
    • (2008) Dig Dis Sci , vol.53 , pp. 2723-2731
    • Ashktorab, H.1    Brim, H.2    Al-Riyami, M.3
  • 32
    • 77952091604 scopus 로고    scopus 로고
    • Difference between proximal and distal microsatellite-unstable sporadic colorectal cancers: analysis of clinicopathological and molecular features and prognoses
    • Kim YH, Min BH, Kim SJ, et al. Difference between proximal and distal microsatellite-unstable sporadic colorectal cancers: analysis of clinicopathological and molecular features and prognoses. Ann Surg Oncol 2010; 17: 1435–1441.
    • (2010) Ann Surg Oncol , vol.17 , pp. 1435-1441
    • Kim, Y.H.1    Min, B.H.2    Kim, S.J.3
  • 33
    • 84863498717 scopus 로고    scopus 로고
    • Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma
    • Kakar S, Deng G, Smyrk TC, et al. Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma. Mod Pathol 2012; 25: 1040–1047.
    • (2012) Mod Pathol , vol.25 , pp. 1040-1047
    • Kakar, S.1    Deng, G.2    Smyrk, T.C.3
  • 34
    • 84879471604 scopus 로고    scopus 로고
    • PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer
    • Day FL, Jorissen RN, Lipton L, et al. PIK3CA and PTEN gene and exon mutation-specific clinicopathologic and molecular associations in colorectal cancer. Clin Cancer Res 2013; 19: 3285–3296.
    • (2013) Clin Cancer Res , vol.19 , pp. 3285-3296
    • Day, F.L.1    Jorissen, R.N.2    Lipton, L.3
  • 35
    • 16544364390 scopus 로고    scopus 로고
    • HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences
    • Jass JR. HNPCC and sporadic MSI-H colorectal cancer: a review of the morphological similarities and differences. Familial Cancer 2004; 3: 93–100.
    • (2004) Familial Cancer , vol.3 , pp. 93-100
    • Jass, J.R.1
  • 36
    • 41649107445 scopus 로고    scopus 로고
    • Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features
    • Leopoldo S, Lorena B, Cinzia A, et al. Two subtypes of mucinous adenocarcinoma of the colorectum: clinicopathological and genetic features. Ann Surg Oncol 2008; 15: 1429–1439.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1429-1439
    • Leopoldo, S.1    Lorena, B.2    Cinzia, A.3
  • 37
    • 0033036918 scopus 로고    scopus 로고
    • Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers
    • Messerini L, Ciantelli M, Baglioni S, et al. Prognostic significance of microsatellite instability in sporadic mucinous colorectal cancers. Hum Pathol 1999; 30: 629–634.
    • (1999) Hum Pathol , vol.30 , pp. 629-634
    • Messerini, L.1    Ciantelli, M.2    Baglioni, S.3
  • 38
    • 2642535288 scopus 로고    scopus 로고
    • Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival
    • Kakar S, Aksoy S, Burgart LJ, et al. Mucinous carcinoma of the colon: correlation of loss of mismatch repair enzymes with clinicopathologic features and survival. Mod Pathol 2004; 17: 696–700.
    • (2004) Mod Pathol , vol.17 , pp. 696-700
    • Kakar, S.1    Aksoy, S.2    Burgart, L.J.3
  • 39
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa JP. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988–993.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 40
    • 33646372471 scopus 로고    scopus 로고
    • BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer
    • Tanaka H, Deng G, Matsuzaki K, et al. BRAF mutation, CpG island methylator phenotype and microsatellite instability occur more frequently and concordantly in mucinous than non-mucinous colorectal cancer. Int J Cancer 2006; 118: 2765–2771.
    • (2006) Int J Cancer , vol.118 , pp. 2765-2771
    • Tanaka, H.1    Deng, G.2    Matsuzaki, K.3
  • 41
    • 0033587747 scopus 로고    scopus 로고
    • CpG island methylator phenotype in colorectal cancer
    • Toyota M, Ahuja N, Ohe-Toyota M, et al. CpG island methylator phenotype in colorectal cancer. Proc Natl Acad Sci U S A 1999; 96: 8681−8686.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 8681-−8686
    • Toyota, M.1    Ahuja, N.2    Ohe-Toyota, M.3
  • 42
    • 24144449572 scopus 로고    scopus 로고
    • Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer
    • Samowitz WS, Albertsen H, Herrick J, et al. Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer. Gastroenterology 2005; 129: 837–845.
    • (2005) Gastroenterology , vol.129 , pp. 837-845
    • Samowitz, W.S.1    Albertsen, H.2    Herrick, J.3
  • 43
    • 56649084987 scopus 로고    scopus 로고
    • Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample
    • Nosho K, Irahara N, Shima K, et al. Comprehensive biostatistical analysis of CpG island methylator phenotype in colorectal cancer using a large population-based sample. PloS One 2008; 3: e3698.
    • (2008) PloS One , vol.3
    • Nosho, K.1    Irahara, N.2    Shima, K.3
  • 44
    • 79961137937 scopus 로고    scopus 로고
    • The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy
    • Min BH, Bae JM, Lee EJ, et al. The CpG island methylator phenotype may confer a survival benefit in patients with stage II or III colorectal carcinomas receiving fluoropyrimidine-based adjuvant chemotherapy. BMC Cancer 2011; 11: 344.
    • (2011) BMC Cancer , vol.11 , pp. 344
    • Min, B.H.1    Bae, J.M.2    Lee, E.J.3
  • 45
    • 0023256456 scopus 로고
    • Prevalence of ras gene mutations in human colorectal cancers
    • Bos JL, Fearon ER, Hamilton SR, et al. Prevalence of ras gene mutations in human colorectal cancers. Nature 1987; 327: 293–297.
    • (1987) Nature , vol.327 , pp. 293-297
    • Bos, J.L.1    Fearon, E.R.2    Hamilton, S.R.3
  • 46
    • 0023748414 scopus 로고
    • Genetic alterations during colorectal-tumor development
    • Vogelstein B, Fearon ER, Hamilton SR, et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988; 319: 525–532.
    • (1988) N Engl J Med , vol.319 , pp. 525-532
    • Vogelstein, B.1    Fearon, E.R.2    Hamilton, S.R.3
  • 47
    • 84857913195 scopus 로고    scopus 로고
    • Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia
    • Sammoud S, Khiari M, Semeh A, et al. Relationship between expression of ras p21 oncoprotein and mutation status of the K-ras gene in sporadic colorectal cancer patients in Tunisia. Appl Immunohistochem Mol Morphol 2012; 20: 146–152.
    • (2012) Appl Immunohistochem Mol Morphol , vol.20 , pp. 146-152
    • Sammoud, S.1    Khiari, M.2    Semeh, A.3
  • 48
    • 84859885193 scopus 로고    scopus 로고
    • BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features
    • Pai RK, Jayachandran P, Koong AC, et al. BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Am J Surg Pathol 2012; 36: 744–752.
    • (2012) Am J Surg Pathol , vol.36 , pp. 744-752
    • Pai, R.K.1    Jayachandran, P.2    Koong, A.C.3
  • 49
    • 24944525406 scopus 로고    scopus 로고
    • Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
    • Westra JL, Schaapveld M, Hollema H, et al. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol 2005; 23: 5635–5643.
    • (2005) J Clin Oncol , vol.23 , pp. 5635-5643
    • Westra, J.L.1    Schaapveld, M.2    Hollema, H.3
  • 50
    • 32844456752 scopus 로고    scopus 로고
    • Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component
    • Ogino S, Brahmandam M, Cantor M, et al. Distinct molecular features of colorectal carcinoma with signet ring cell component and colorectal carcinoma with mucinous component. Mod Pathol 2006; 19: 59–68.
    • (2006) Mod Pathol , vol.19 , pp. 59-68
    • Ogino, S.1    Brahmandam, M.2    Cantor, M.3
  • 51
    • 84861704697 scopus 로고    scopus 로고
    • KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors
    • Garrido-Laguna I, Hong DS, Janku F, et al. KRASness and PIK3CAness in patients with advanced colorectal cancer: outcome after treatment with early-phase trials with targeted pathway inhibitors. PloS One 2012; 7: e38033.
    • (2012) PloS One , vol.7
    • Garrido-Laguna, I.1    Hong, D.S.2    Janku, F.3
  • 52
    • 84879880574 scopus 로고    scopus 로고
    • KRAS mutations are associated with specific morphologic features in colon cancer
    • Gunal A, Hui P, Kilic S, et al. KRAS mutations are associated with specific morphologic features in colon cancer. J Clin Gastroenterol 2013; 47: 509–514.
    • (2013) J Clin Gastroenterol , vol.47 , pp. 509-514
    • Gunal, A.1    Hui, P.2    Kilic, S.3
  • 53
    • 84881475403 scopus 로고    scopus 로고
    • Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer?
    • Selcukbiricik F, Bilici A, Tural D, et al. Are high initial CEA and CA 19-9 levels associated with the presence of K-ras mutation in patients with metastatic colorectal cancer? Tumour Biol 2013; 34: 2233–2239.
    • (2013) Tumour Biol , vol.34 , pp. 2233-2239
    • Selcukbiricik, F.1    Bilici, A.2    Tural, D.3
  • 54
    • 0036739336 scopus 로고    scopus 로고
    • Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype
    • Bazan V, Migliavacca M, Zanna I, et al. Specific codon 13 K-ras mutations are predictive of clinical outcome in colorectal cancer patients, whereas codon 12 K-ras mutations are associated with mucinous histotype. Ann Oncol 2002; 13: 1438–1446.
    • (2002) Ann Oncol , vol.13 , pp. 1438-1446
    • Bazan, V.1    Migliavacca, M.2    Zanna, I.3
  • 55
    • 72249091662 scopus 로고    scopus 로고
    • Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma
    • Abubaker J, Bavi P, Al-Haqawi W, et al. Prognostic significance of alterations in KRAS isoforms KRAS-4A/4B and KRAS mutations in colorectal carcinoma. J Pathol 2009; 219: 435–445.
    • (2009) J Pathol , vol.219 , pp. 435-445
    • Abubaker, J.1    Bavi, P.2    Al-Haqawi, W.3
  • 56
    • 77953688634 scopus 로고    scopus 로고
    • Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis
    • Zlobec I, Bihl MP, Schwarb H, et al. Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer 2010; 127: 367–380.
    • (2010) Int J Cancer , vol.127 , pp. 367-380
    • Zlobec, I.1    Bihl, M.P.2    Schwarb, H.3
  • 57
    • 84878549248 scopus 로고    scopus 로고
    • Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features
    • Rosty C, Young JP, Walsh MD, et al. Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features. Modern Pathol 2013; 26: 825–834.
    • (2013) Modern Pathol , vol.26 , pp. 825-834
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3
  • 58
    • 84860617477 scopus 로고    scopus 로고
    • KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer
    • Mao C, Zhou J, Yang Z, et al. KRAS, BRAF and PIK3CA mutations and the loss of PTEN expression in Chinese patients with colorectal cancer. PloS One 2012; 7: e36653.
    • (2012) PloS One , vol.7
    • Mao, C.1    Zhou, J.2    Yang, Z.3
  • 59
    • 79954490871 scopus 로고    scopus 로고
    • KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer
    • Li HT, Lu YY, An YX, et al. KRAS, BRAF and PIK3CA mutations in human colorectal cancer: relationship with metastatic colorectal cancer. Oncol Rep 2011; 25: 1691–1697.
    • (2011) Oncol Rep , vol.25 , pp. 1691-1697
    • Li, H.T.1    Lu, Y.Y.2    An, Y.X.3
  • 60
    • 0025879277 scopus 로고
    • Association of Ki-ras mutation with differentiation and tumor-formation pathways in colorectal carcinoma
    • Laurent-Puig P, Olschwang S, Delattre O, et al. Association of Ki-ras mutation with differentiation and tumor-formation pathways in colorectal carcinoma. Int J Cancer 1991; 49: 220–223.
    • (1991) Int J Cancer , vol.49 , pp. 220-223
    • Laurent-Puig, P.1    Olschwang, S.2    Delattre, O.3
  • 61
    • 0032401026 scopus 로고    scopus 로고
    • K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa
    • Zhang H, Nordenskjold B, Dufmats M, et al. K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa. Eur J Cancer 1998; 34: 2053–2057.
    • (1998) Eur J Cancer , vol.34 , pp. 2053-2057
    • Zhang, H.1    Nordenskjold, B.2    Dufmats, M.3
  • 62
    • 43549088302 scopus 로고    scopus 로고
    • Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients
    • Akkiprik M, Celikel CA, Dusunceli F, et al. Relationship between overexpression of ras p21 oncoprotein and K-ras codon 12 and 13 mutations in Turkish colorectal cancer patients. Turk J Gastroenterol 2008; 19: 22–27.
    • (2008) Turk J Gastroenterol , vol.19 , pp. 22-27
    • Akkiprik, M.1    Celikel, C.A.2    Dusunceli, F.3
  • 63
    • 32044455746 scopus 로고    scopus 로고
    • BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status
    • Li WQ, Kawakami K, Ruszkiewicz A, et al. BRAF mutations are associated with distinctive clinical, pathological and molecular features of colorectal cancer independently of microsatellite instability status. Mol Cancer 2006; 5: 2.
    • (2006) Mol Cancer , vol.5 , pp. 2
    • Li, W.Q.1    Kawakami, K.2    Ruszkiewicz, A.3
  • 64
    • 67649652208 scopus 로고    scopus 로고
    • BRAF mutation in metastatic colorectal cancer
    • Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009; 361: 98–99.
    • (2009) N Engl J Med , vol.361 , pp. 98-99
    • Tol, J.1    Nagtegaal, I.D.2    Punt, C.J.3
  • 65
    • 18444374405 scopus 로고    scopus 로고
    • Mutations of the BRAF gene in human cancer
    • Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417: 949–954.
    • (2002) Nature , vol.417 , pp. 949-954
    • Davies, H.1    Bignell, G.R.2    Cox, C.3
  • 66
    • 16544363110 scopus 로고    scopus 로고
    • Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation
    • Nagasaka T, Sasamoto H, Notohara K, et al. Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. J Clin Oncol 2004; 22: 4584–4594.
    • (2004) J Clin Oncol , vol.22 , pp. 4584-4594
    • Nagasaka, T.1    Sasamoto, H.2    Notohara, K.3
  • 67
    • 38649135425 scopus 로고    scopus 로고
    • WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Kawasaki T, Ohnishi M, Suemoto Y, et al. WRN promoter methylation possibly connects mucinous differentiation, microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 2008; 21: 150–158.
    • (2008) Mod Pathol , vol.21 , pp. 150-158
    • Kawasaki, T.1    Ohnishi, M.2    Suemoto, Y.3
  • 68
    • 1642535480 scopus 로고    scopus 로고
    • BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer
    • Deng G, Bell I, Crawley S, et al. BRAF mutation is frequently present in sporadic colorectal cancer with methylated hMLH1, but not in hereditary nonpolyposis colorectal cancer. Clin Cancer Res 2004; 10: 191–195.
    • (2004) Clin Cancer Res , vol.10 , pp. 191-195
    • Deng, G.1    Bell, I.2    Crawley, S.3
  • 69
    • 0141593677 scopus 로고    scopus 로고
    • BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair
    • Wang L, Cunningham JM, Winters JL, et al. BRAF mutations in colon cancer are not likely attributable to defective DNA mismatch repair. Cancer Res 2003; 63: 5209–5212.
    • (2003) Cancer Res , vol.63 , pp. 5209-5212
    • Wang, L.1    Cunningham, J.M.2    Winters, J.L.3
  • 70
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2002; 2: 489–501.
    • (2002) Nat Rev Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 71
    • 44449124376 scopus 로고    scopus 로고
    • Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population
    • Abubaker J, Bavi P, Al-Harbi S, et al. Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population. Oncogene 2008; 27: 3539–3545.
    • (2008) Oncogene , vol.27 , pp. 3539-3545
    • Abubaker, J.1    Bavi, P.2    Al-Harbi, S.3
  • 72
    • 44449133319 scopus 로고    scopus 로고
    • PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations
    • Nosho K, Kawasaki T, Ohnishi M, et al. PIK3CA mutation in colorectal cancer: relationship with genetic and epigenetic alterations. Neoplasia 2008; 10: 534–541.
    • (2008) Neoplasia , vol.10 , pp. 534-541
    • Nosho, K.1    Kawasaki, T.2    Ohnishi, M.3
  • 73
    • 84879001702 scopus 로고    scopus 로고
    • PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival
    • Rosty C, Young JP, Walsh MD, et al. PIK3CA activating mutation in colorectal carcinoma: associations with molecular features and survival. PloS One 2013; 8: e65479.
    • (2013) PloS One , vol.8
    • Rosty, C.1    Young, J.P.2    Walsh, M.D.3
  • 74
    • 84873414664 scopus 로고    scopus 로고
    • Combined analysis of KRAS and PIK3CA mutations, MET and PTEN expression in primary tumors and corresponding metastases in colorectal cancer
    • Voutsina A, Tzardi M, Kalikaki A, et al. Combined analysis of KRAS and PIK3CA mutations, MET and PTEN expression in primary tumors and corresponding metastases in colorectal cancer. Mod Pathol 2013; 26: 302–313.
    • (2013) Mod Pathol , vol.26 , pp. 302-313
    • Voutsina, A.1    Tzardi, M.2    Kalikaki, A.3
  • 75
    • 84878558999 scopus 로고    scopus 로고
    • The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
    • Eklof V, Wikberg ML, Edin S, et al. The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer. Br J Cancer 2013; 108: 2153–2163.
    • (2013) Br J Cancer , vol.108 , pp. 2153-2163
    • Eklof, V.1    Wikberg, M.L.2    Edin, S.3
  • 76
    • 33947658915 scopus 로고    scopus 로고
    • The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T
    • Hatayama H, Iwashita J, Kuwajima A, et al. The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T. Biochem Biophys Res Commun 2007; 356: 599–603.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 599-603
    • Hatayama, H.1    Iwashita, J.2    Kuwajima, A.3
  • 77
    • 77749342704 scopus 로고    scopus 로고
    • Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway
    • Lee HY, Crawley S, Hokari R, et al. Bile acid regulates MUC2 transcription in colon cancer cells via positive EGFR/PKC/Ras/ERK/CREB, PI3K/Akt/IkappaB/NF-kappaB and p38/MSK1/CREB pathways and negative JNK/c-Jun/AP-1 pathway. Int J Oncol 2010; 36: 941–953.
    • (2010) Int J Oncol , vol.36 , pp. 941-953
    • Lee, H.Y.1    Crawley, S.2    Hokari, R.3
  • 78
    • 12444252936 scopus 로고    scopus 로고
    • TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation
    • Ahn DH, Crawley SC, Hokari R, et al. TNF-alpha activates MUC2 transcription via NF-kappaB but inhibits via JNK activation. Cell Physiol Biochem 2005; 15: 29–40.
    • (2005) Cell Physiol Biochem , vol.15 , pp. 29-40
    • Ahn, D.H.1    Crawley, S.C.2    Hokari, R.3
  • 79
    • 0042848801 scopus 로고    scopus 로고
    • mRNA of MUC2 is stimulated by IL-4, IL-13 or TNF-alpha through a mitogen-activated protein kinase pathway in human colon cancer cells
    • Iwashita J, Sato Y, Sugaya H, et al. mRNA of MUC2 is stimulated by IL-4, IL-13 or TNF-alpha through a mitogen-activated protein kinase pathway in human colon cancer cells. Immunol Cell Biol 2003; 81: 275–282.
    • (2003) Immunol Cell Biol , vol.81 , pp. 275-282
    • Iwashita, J.1    Sato, Y.2    Sugaya, H.3
  • 80
    • 16844365210 scopus 로고    scopus 로고
    • Bile acids induce MUC2 overexpression in human colon carcinoma cells
    • Song S, Byrd JC, Koo JS, et al. Bile acids induce MUC2 overexpression in human colon carcinoma cells. Cancer 2005; 103: 1606–1614.
    • (2005) Cancer , vol.103 , pp. 1606-1614
    • Song, S.1    Byrd, J.C.2    Koo, J.S.3
  • 81
    • 84889098679 scopus 로고    scopus 로고
    • Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype
    • Walsh MD, Clendenning M, Williamson E, et al. Expression of MUC2, MUC5AC, MUC5B, and MUC6 mucins in colorectal cancers and their association with the CpG island methylator phenotype. Mod Pathol 2013; 26: 1642–1656.
    • (2013) Mod Pathol , vol.26 , pp. 1642-1656
    • Walsh, M.D.1    Clendenning, M.2    Williamson, E.3
  • 82
    • 0026547020 scopus 로고
    • A clinicopathologic study of mucinous gastric carcinoma
    • Adachi Y, Mori M, Kido A, et al. A clinicopathologic study of mucinous gastric carcinoma. Cancer 1992; 69: 866–871.
    • (1992) Cancer , vol.69 , pp. 866-871
    • Adachi, Y.1    Mori, M.2    Kido, A.3
  • 83
    • 33646596947 scopus 로고    scopus 로고
    • Clinicopathologic characteristics and surgical outcomes of mucinous gastric carcinoma
    • Kunisaki C, Akiyama H, Nomura M, et al. Clinicopathologic characteristics and surgical outcomes of mucinous gastric carcinoma. Ann Surg Oncol 2006; 13: 836–842.
    • (2006) Ann Surg Oncol , vol.13 , pp. 836-842
    • Kunisaki, C.1    Akiyama, H.2    Nomura, M.3
  • 84
    • 79952932872 scopus 로고    scopus 로고
    • Clinicopathological characteristics and computed tomography features of mucinous gastric carcinoma
    • Yan C, Zhu ZG, Yan M, et al. Clinicopathological characteristics and computed tomography features of mucinous gastric carcinoma. J Int Med Res 2011; 39: 291–301.
    • (2011) J Int Med Res , vol.39 , pp. 291-301
    • Yan, C.1    Zhu, Z.G.2    Yan, M.3
  • 85
    • 0035040424 scopus 로고    scopus 로고
    • Pathology and prognosis of mucinous gastric carcinoma
    • Yasuda K, Adachi Y, Shiraishi N, et al. Pathology and prognosis of mucinous gastric carcinoma. J Surg Oncol 2001; 76: 272–277.
    • (2001) J Surg Oncol , vol.76 , pp. 272-277
    • Yasuda, K.1    Adachi, Y.2    Shiraishi, N.3
  • 86
    • 68149161646 scopus 로고    scopus 로고
    • Mucinous gastric carcinomas: clinicopathologic and molecular analyses
    • Choi JS, Kim MA, Lee HE, et al. Mucinous gastric carcinomas: clinicopathologic and molecular analyses. Cancer 2009; 115: 3581–3590.
    • (2009) Cancer , vol.115 , pp. 3581-3590
    • Choi, J.S.1    Kim, M.A.2    Lee, H.E.3
  • 87
    • 3242758353 scopus 로고    scopus 로고
    • Molecular pathological analysis of mucinous adenocarcinomas of the stomach
    • Wu M, Semba S, Li D, et al. Molecular pathological analysis of mucinous adenocarcinomas of the stomach. Pathobiology 2004; 71: 201–210.
    • (2004) Pathobiology , vol.71 , pp. 201-210
    • Wu, M.1    Semba, S.2    Li, D.3
  • 88
    • 0031746725 scopus 로고    scopus 로고
    • Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer
    • Wirtz HC, Muller W, Noguchi T, et al. Prognostic value and clinicopathological profile of microsatellite instability in gastric cancer. Clin Cancer Res 1998; 4: 1749–1754.
    • (1998) Clin Cancer Res , vol.4 , pp. 1749-1754
    • Wirtz, H.C.1    Muller, W.2    Noguchi, T.3
  • 89
    • 70349289082 scopus 로고    scopus 로고
    • A combined histologic and molecular approach identifies three groups of gastric cancer with different prognosis
    • Solcia E, Klersy C, Mastracci L, et al. A combined histologic and molecular approach identifies three groups of gastric cancer with different prognosis. Virchows Arch 2009; 455: 197–211.
    • (2009) Virchows Arch , vol.455 , pp. 197-211
    • Solcia, E.1    Klersy, C.2    Mastracci, L.3
  • 90
    • 61449224723 scopus 로고    scopus 로고
    • Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype
    • Seo HM, Chang YS, Joo SH, et al. Clinicopathologic characteristics and outcomes of gastric cancers with the MSI-H phenotype. J Surg Oncol 2009; 99: 143–147.
    • (2009) J Surg Oncol , vol.99 , pp. 143-147
    • Seo, H.M.1    Chang, Y.S.2    Joo, S.H.3
  • 91
    • 44649157590 scopus 로고    scopus 로고
    • Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival
    • Falchetti M, Saieva C, Lupi R, et al. Gastric cancer with high-level microsatellite instability: target gene mutations, clinicopathologic features, and long-term survival. Hum Pathol 2008; 39: 925–932.
    • (2008) Hum Pathol , vol.39 , pp. 925-932
    • Falchetti, M.1    Saieva, C.2    Lupi, R.3
  • 92
    • 79951593439 scopus 로고    scopus 로고
    • High microsatellite instability predicts good prognosis in intestinal-type gastric cancers
    • Kim H, An JY, Noh SH, et al. High microsatellite instability predicts good prognosis in intestinal-type gastric cancers. J Gastroenterol Hepatol 2011; 26: 585–592.
    • (2011) J Gastroenterol Hepatol , vol.26 , pp. 585-592
    • Kim, H.1    An, J.Y.2    Noh, S.H.3
  • 93
    • 0033802550 scopus 로고    scopus 로고
    • Microsatellite instability, prognosis and metastasis in gastric cancers from a low-risk population
    • Schneider BG, Bravo JC, Roa JC, et al. Microsatellite instability, prognosis and metastasis in gastric cancers from a low-risk population. Int J Cancer 2000; 89: 444–452.
    • (2000) Int J Cancer , vol.89 , pp. 444-452
    • Schneider, B.G.1    Bravo, J.C.2    Roa, J.C.3
  • 94
    • 84867843578 scopus 로고    scopus 로고
    • Tumor size predicts survival in mucinous gastric carcinoma
    • Sung CO, Lee SM, Choi JS, et al. Tumor size predicts survival in mucinous gastric carcinoma. J Surg Oncol 2012; 106: 757–764.
    • (2012) J Surg Oncol , vol.106 , pp. 757-764
    • Sung, C.O.1    Lee, S.M.2    Choi, J.S.3
  • 95
    • 0036127525 scopus 로고    scopus 로고
    • Promoter methylation and silencing of PTEN in gastric carcinoma
    • Kang YH, Lee HS, Kim WH. Promoter methylation and silencing of PTEN in gastric carcinoma. Lab Invest 2002; 82: 285–291.
    • (2002) Lab Invest , vol.82 , pp. 285-291
    • Kang, Y.H.1    Lee, H.S.2    Kim, W.H.3
  • 96
    • 42649133793 scopus 로고    scopus 로고
    • EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number
    • Kim MA, Lee HS, Lee HE, et al. EGFR in gastric carcinomas: prognostic significance of protein overexpression and high gene copy number. Histopathology 2008; 52: 738–746.
    • (2008) Histopathology , vol.52 , pp. 738-746
    • Kim, M.A.1    Lee, H.S.2    Lee, H.E.3
  • 97
    • 79960682968 scopus 로고    scopus 로고
    • Epidermal growth factor receptor mutation in gastric cancer
    • Liu Z, Liu L, Li M, et al. Epidermal growth factor receptor mutation in gastric cancer. Pathology 2011; 43: 234–238.
    • (2011) Pathology , vol.43 , pp. 234-238
    • Liu, Z.1    Liu, L.2    Li, M.3
  • 98
    • 0037407686 scopus 로고    scopus 로고
    • Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas
    • Adsay NV, Merati K, Nassar H, et al. Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloid carcinoma in the breast and pancreas. Am J Surg Pathol 2003; 27: 571–578.
    • (2003) Am J Surg Pathol , vol.27 , pp. 571-578
    • Adsay, N.V.1    Merati, K.2    Nassar, H.3
  • 99
    • 0035192708 scopus 로고    scopus 로고
    • Colloid (mucinous noncystic) carcinoma of the pancreas
    • Adsay NV, Pierson C, Sarkar F, et al. Colloid (mucinous noncystic) carcinoma of the pancreas. Am J Surg Pathol 2001; 25: 26–42.
    • (2001) Am J Surg Pathol , vol.25 , pp. 26-42
    • Adsay, N.V.1    Pierson, C.2    Sarkar, F.3
  • 100
    • 0036056752 scopus 로고    scopus 로고
    • Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions
    • Terris B, Dubois S, Buisine MP, et al. Mucin gene expression in intraductal papillary-mucinous pancreatic tumours and related lesions. J Pathol 2002; 197: 632–637.
    • (2002) J Pathol , vol.197 , pp. 632-637
    • Terris, B.1    Dubois, S.2    Buisine, M.P.3
  • 101
    • 0038795408 scopus 로고    scopus 로고
    • Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable
    • Luttges J, Beyser K, Pust S, et al. Pancreatic mucinous noncystic (colloid) carcinomas and intraductal papillary mucinous carcinomas are usually microsatellite stable. Mod Pathol 2003; 16: 537–542.
    • (2003) Mod Pathol , vol.16 , pp. 537-542
    • Luttges, J.1    Beyser, K.2    Pust, S.3
  • 102
    • 0036793788 scopus 로고    scopus 로고
    • K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China
    • Rashid A, Ueki T, Gao YT, et al. K-ras mutation, p53 overexpression, and microsatellite instability in biliary tract cancers: a population-based study in China. Clin Cancer Res 2002; 8: 3156–3163.
    • (2002) Clin Cancer Res , vol.8 , pp. 3156-3163
    • Rashid, A.1    Ueki, T.2    Gao, Y.T.3
  • 103
    • 84870864811 scopus 로고    scopus 로고
    • Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas
    • Dursun N, Escalona OT, Roa JC, et al. Mucinous carcinomas of the gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas. Arch Pathol Lab Med 2012; 136: 1347–1358.
    • (2012) Arch Pathol Lab Med , vol.136 , pp. 1347-1358
    • Dursun, N.1    Escalona, O.T.2    Roa, J.C.3
  • 104
    • 18144395073 scopus 로고    scopus 로고
    • Ovarian cancer incidence in the United States, 1992–1999
    • Quirk JT, Natarajan N. Ovarian cancer incidence in the United States, 1992–1999. Gynecol Oncol 2005; 97: 519–523.
    • (2005) Gynecol Oncol , vol.97 , pp. 519-523
    • Quirk, J.T.1    Natarajan, N.2
  • 105
    • 77957749527 scopus 로고    scopus 로고
    • Symptom presentation in invasive ovarian carcinoma by tumor histological type and grade in a multiethnic population: a case analysis
    • Lurie G, Wilkens LR, Thompson PJ, et al. Symptom presentation in invasive ovarian carcinoma by tumor histological type and grade in a multiethnic population: a case analysis. Gynecol Oncol 2010; 119: 278–284.
    • (2010) Gynecol Oncol , vol.119 , pp. 278-284
    • Lurie, G.1    Wilkens, L.R.2    Thompson, P.J.3
  • 106
    • 84871011770 scopus 로고    scopus 로고
    • Survival of ovarian cancer patients in Germany in the early 21st century: a period analysis by age, histology, laterality, and stage
    • Chen T, Jansen L, Gondos A, et al. Survival of ovarian cancer patients in Germany in the early 21st century: a period analysis by age, histology, laterality, and stage. Eur J Cancer Prev 2013; 22: 59–67.
    • (2013) Eur J Cancer Prev , vol.22 , pp. 59-67
    • Chen, T.1    Jansen, L.2    Gondos, A.3
  • 107
    • 80255127418 scopus 로고    scopus 로고
    • Natural history and outcome of mucinous carcinoma of the ovary
    • Schiavone MB, Herzog TJ, Lewin SN, et al. Natural history and outcome of mucinous carcinoma of the ovary. Am J Obstet Gynecol 2011; 205: 480 e481–488.
    • (2011) Am J Obstet Gynecol , vol.205 , pp. 480 e481-488
    • Schiavone, M.B.1    Herzog, T.J.2    Lewin, S.N.3
  • 108
    • 51149108542 scopus 로고    scopus 로고
    • Survival in ovarian cancer patients by histology and family history
    • Ji J, Forsti A, Sundquist J, et al. Survival in ovarian cancer patients by histology and family history. Acta Oncol 2008; 47: 1133–1139.
    • (2008) Acta Oncol , vol.47 , pp. 1133-1139
    • Ji, J.1    Forsti, A.2    Sundquist, J.3
  • 110
    • 0033061887 scopus 로고    scopus 로고
    • Detection and clinical correlations of ras gene mutations in human ovarian tumors
    • Varras MN, Sourvinos G, Diakomanolis E, et al. Detection and clinical correlations of ras gene mutations in human ovarian tumors. Oncology 1999; 56: 89–96.
    • (1999) Oncology , vol.56 , pp. 89-96
    • Varras, M.N.1    Sourvinos, G.2    Diakomanolis, E.3
  • 111
    • 0344406947 scopus 로고    scopus 로고
    • K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study
    • Hogdall EV, Hogdall CK, Blaakaer J, et al. K-ras alterations in Danish ovarian tumour patients. From the Danish "Malova" Ovarian Cancer study. Gynecol Oncol 2003; 89: 31–36.
    • (2003) Gynecol Oncol , vol.89 , pp. 31-36
    • Hogdall, E.V.1    Hogdall, C.K.2    Blaakaer, J.3
  • 112
    • 33751435867 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants
    • Mayr D, Hirschmann A, Lohrs U, et al. KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants. Gynecol Oncol 2006; 103: 883–887.
    • (2006) Gynecol Oncol , vol.103 , pp. 883-887
    • Mayr, D.1    Hirschmann, A.2    Lohrs, U.3
  • 113
    • 0025944479 scopus 로고
    • K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary
    • Enomoto T, Weghorst CM, Inoue M, et al. K-ras activation occurs frequently in mucinous adenocarcinomas and rarely in other common epithelial tumors of the human ovary. Am J Pathol 1991; 139: 777–785.
    • (1991) Am J Pathol , vol.139 , pp. 777-785
    • Enomoto, T.1    Weghorst, C.M.2    Inoue, M.3
  • 114
    • 65449169621 scopus 로고    scopus 로고
    • KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay
    • Auner V, Kriegshauser G, Tong D, et al. KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay. BMC Cancer 2009; 9: 111.
    • (2009) BMC Cancer , vol.9 , pp. 111
    • Auner, V.1    Kriegshauser, G.2    Tong, D.3
  • 115
    • 0031964463 scopus 로고    scopus 로고
    • Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology
    • Mandai M, Konishi I, Kuroda H, et al. Heterogeneous distribution of K-ras-mutated epithelia in mucinous ovarian tumors with special reference to histopathology. Hum Pathol 1998; 29: 34–40.
    • (1998) Hum Pathol , vol.29 , pp. 34-40
    • Mandai, M.1    Konishi, I.2    Kuroda, H.3
  • 116
    • 0035863092 scopus 로고    scopus 로고
    • Are DNA mismatch repair deficiencies responsible for accumulation of genetic alterations in epithelial ovarian cancers?
    • Suzuki M, Ohwada M, Saga Y, et al. Are DNA mismatch repair deficiencies responsible for accumulation of genetic alterations in epithelial ovarian cancers? Cancer Genet Cytogenet 2001; 124: 152–158.
    • (2001) Cancer Genet Cytogenet , vol.124 , pp. 152-158
    • Suzuki, M.1    Ohwada, M.2    Saga, Y.3
  • 117
    • 12144287841 scopus 로고    scopus 로고
    • In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours
    • Sieben NL, Macropoulos P, Roemen GM, et al. In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 2004; 202: 336–340.
    • (2004) J Pathol , vol.202 , pp. 336-340
    • Sieben, N.L.1    Macropoulos, P.2    Roemen, G.M.3
  • 118
    • 84884326080 scopus 로고    scopus 로고
    • TP53 mutations are common in all subtypes of epithelial ovarian cancer and occur concomitantly with KRAS mutations in the mucinous type
    • Rechsteiner M, Zimmermann AK, Wild PJ, et al. TP53 mutations are common in all subtypes of epithelial ovarian cancer and occur concomitantly with KRAS mutations in the mucinous type. Exp Mol Pathol 2013; 95: 235–241.
    • (2013) Exp Mol Pathol , vol.95 , pp. 235-241
    • Rechsteiner, M.1    Zimmermann, A.K.2    Wild, P.J.3
  • 119
    • 0042624835 scopus 로고    scopus 로고
    • Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma
    • Gemignani ML, Schlaerth AC, Bogomolniy F, et al. Role of KRAS and BRAF gene mutations in mucinous ovarian carcinoma. Gynecol Oncol 2003; 90: 378–381.
    • (2003) Gynecol Oncol , vol.90 , pp. 378-381
    • Gemignani, M.L.1    Schlaerth, A.C.2    Bogomolniy, F.3
  • 120
    • 40249118879 scopus 로고    scopus 로고
    • Genetic classification of ovarian carcinoma based on microsatellite analysis: relationship to clinicopathological features and patient survival
    • Huan Z, Nakayama K, Nakayama N, et al. Genetic classification of ovarian carcinoma based on microsatellite analysis: relationship to clinicopathological features and patient survival. Oncol Rep 2008; 19: 775–781.
    • (2008) Oncol Rep , vol.19 , pp. 775-781
    • Huan, Z.1    Nakayama, K.2    Nakayama, N.3
  • 121
    • 0141962933 scopus 로고    scopus 로고
    • Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma
    • Geisler JP, Goodheart MJ, Sood AK, et al. Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma. Cancer 2003; 98: 2199–2206.
    • (2003) Cancer , vol.98 , pp. 2199-2206
    • Geisler, J.P.1    Goodheart, M.J.2    Sood, A.K.3
  • 122
    • 1442277058 scopus 로고    scopus 로고
    • Molecular and clinicopathological analysis of ovarian carcinomas with and without microsatellite instability
    • Dellas A, Puhl A, Schraml P, et al. Molecular and clinicopathological analysis of ovarian carcinomas with and without microsatellite instability. Anticancer Res 2004; 24: 361–369.
    • (2004) Anticancer Res , vol.24 , pp. 361-369
    • Dellas, A.1    Puhl, A.2    Schraml, P.3
  • 123
    • 80052699883 scopus 로고    scopus 로고
    • Inactivation of O(6)-methyguanine-DNA methyltransferase by promoter hypermethylation: association of epithelial ovarian carcinogenesis in specific histological types
    • Roh HJ, Suh DS, Choi KU, et al. Inactivation of O(6)-methyguanine-DNA methyltransferase by promoter hypermethylation: association of epithelial ovarian carcinogenesis in specific histological types. J Obstet Gynaecol Res 2011; 37: 851–860.
    • (2011) J Obstet Gynaecol Res , vol.37 , pp. 851-860
    • Roh, H.J.1    Suh, D.S.2    Choi, K.U.3
  • 124
    • 84867398634 scopus 로고    scopus 로고
    • Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors
    • Lu FI, Gilks CB, Mulligan AM, et al. Prevalence of loss of expression of DNA mismatch repair proteins in primary epithelial ovarian tumors. Int J Gynecol Pathol 2012; 31: 524–531.
    • (2012) Int J Gynecol Pathol , vol.31 , pp. 524-531
    • Lu, F.I.1    Gilks, C.B.2    Mulligan, A.M.3
  • 125
    • 7444250290 scopus 로고    scopus 로고
    • Mutation of the PIK3CA gene in ovarian and breast cancer
    • Campbell IG, Russell SE, Choong DY, et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res 2004; 64: 7678–7681.
    • (2004) Cancer Res , vol.64 , pp. 7678-7681
    • Campbell, I.G.1    Russell, S.E.2    Choong, D.Y.3
  • 126
    • 0032523808 scopus 로고    scopus 로고
    • Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
    • Obata K, Morland SJ, Watson RH, et al. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Res 1998; 58: 2095–2097.
    • (1998) Cancer Res , vol.58 , pp. 2095-2097
    • Obata, K.1    Morland, S.J.2    Watson, R.H.3
  • 127
    • 33750185399 scopus 로고    scopus 로고
    • PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations
    • Kolasa IK, Rembiszewska A, Janiec-Jankowska A, et al. PTEN mutation, expression and LOH at its locus in ovarian carcinomas. Relation to TP53, K-RAS and BRCA1 mutations. Gynecol Oncol 2006; 103: 692–697.
    • (2006) Gynecol Oncol , vol.103 , pp. 692-697
    • Kolasa, I.K.1    Rembiszewska, A.2    Janiec-Jankowska, A.3
  • 128
    • 79651474755 scopus 로고    scopus 로고
    • Metastatic neoplasms of the ovaries: a clinicopathological study of 97 cases
    • Kondi-Pafiti A, Kairi-Vasilatou E, Iavazzo C, et al. Metastatic neoplasms of the ovaries: a clinicopathological study of 97 cases. Arch Gynecol Obstet 2011; 284: 1283–1288.
    • (2011) Arch Gynecol Obstet , vol.284 , pp. 1283-1288
    • Kondi-Pafiti, A.1    Kairi-Vasilatou, E.2    Iavazzo, C.3
  • 129
    • 73449102579 scopus 로고    scopus 로고
    • Secondary ovarian malignancies: frequency, origin, and characteristics
    • de Waal YR, Thomas CM, Oei AL, et al. Secondary ovarian malignancies: frequency, origin, and characteristics. Int J Gynecol Cancer 2009; 19: 1160–1165.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 1160-1165
    • de Waal, Y.R.1    Thomas, C.M.2    Oei, A.L.3
  • 130
    • 37549036313 scopus 로고    scopus 로고
    • Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification
    • Yemelyanova AV, Vang R, Judson K, et al. Distinction of primary and metastatic mucinous tumors involving the ovary: analysis of size and laterality data by primary site with reevaluation of an algorithm for tumor classification. Am J Surg Pathol 2008; 32: 128–138.
    • (2008) Am J Surg Pathol , vol.32 , pp. 128-138
    • Yemelyanova, A.V.1    Vang, R.2    Judson, K.3
  • 131
    • 1842477909 scopus 로고    scopus 로고
    • Incidence of metastasis to the ovaries from nongenital tract primary tumors
    • Moore RG, Chung M, Granai CO, et al. Incidence of metastasis to the ovaries from nongenital tract primary tumors. Gynecol Oncol 2004; 93: 87–91.
    • (2004) Gynecol Oncol , vol.93 , pp. 87-91
    • Moore, R.G.1    Chung, M.2    Granai, C.O.3
  • 132
    • 79551563284 scopus 로고    scopus 로고
    • International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma
    • Travis WD, Brambilla E, Noguchi M, et al. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma. J Thoracic Oncol 2011; 6: 244–285.
    • (2011) J Thoracic Oncol , vol.6 , pp. 244-285
    • Travis, W.D.1    Brambilla, E.2    Noguchi, M.3
  • 133
    • 1842582243 scopus 로고    scopus 로고
    • Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression
    • Rossi G, Murer B, Cavazza A, et al. Primary mucinous (so-called colloid) carcinomas of the lung: a clinicopathologic and immunohistochemical study with special reference to CDX-2 homeobox gene and MUC2 expression. Am J Surg Pathol 2004; 28: 442–452.
    • (2004) Am J Surg Pathol , vol.28 , pp. 442-452
    • Rossi, G.1    Murer, B.2    Cavazza, A.3
  • 134
    • 84859397680 scopus 로고    scopus 로고
    • Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis
    • Zhang Y, Sun Y, Pan Y, et al. Frequency of driver mutations in lung adenocarcinoma from female never-smokers varies with histologic subtypes and age at diagnosis. Clin Cancer Res 2012; 18: 1947–1953.
    • (2012) Clin Cancer Res , vol.18 , pp. 1947-1953
    • Zhang, Y.1    Sun, Y.2    Pan, Y.3
  • 135
    • 84871095066 scopus 로고    scopus 로고
    • Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose
    • Li H, Pan Y, Li Y, et al. Frequency of well-identified oncogenic driver mutations in lung adenocarcinoma of smokers varies with histological subtypes and graduated smoking dose. Lung Cancer 2013; 79: 8–13.
    • (2013) Lung Cancer , vol.79 , pp. 8-13
    • Li, H.1    Pan, Y.2    Li, Y.3
  • 136
    • 84866542321 scopus 로고    scopus 로고
    • [Relevance of molecular alterations in histopathologic subtyping of lung adenocarcinoma based on 2011 International Multidisciplinary Lung Adenocarcinoma Classification]
    • Liu B, Shi SS, Wang X, et al. [Relevance of molecular alterations in histopathologic subtyping of lung adenocarcinoma based on 2011 International Multidisciplinary Lung Adenocarcinoma Classification]. Chin J Pathol 2012; 41: 505–510.
    • (2012) Chin J Pathol , vol.41 , pp. 505-510
    • Liu, B.1    Shi, S.S.2    Wang, X.3
  • 137
    • 51649096934 scopus 로고    scopus 로고
    • A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma
    • Di Saverio S, Gutierrez J, Avisar E. A retrospective review with long term follow up of 11,400 cases of pure mucinous breast carcinoma. Breast Cancer Res Treat 2008; 111: 541–547.
    • (2008) Breast Cancer Res Treat , vol.111 , pp. 541-547
    • Di Saverio, S.1    Gutierrez, J.2    Avisar, E.3
  • 138
    • 85065032029 scopus 로고    scopus 로고
    • Clinicopathological characteristics and prognosis of mucinous breast carcinoma
    • Zhang M, Teng XD, Guo XX, et al. Clinicopathological characteristics and prognosis of mucinous breast carcinoma. J Cancer Res clinical oncology 2013.
    • (2013) J Cancer Res clinical oncology
    • Zhang, M.1    Teng, X.D.2    Guo, X.X.3
  • 139
    • 84878894721 scopus 로고    scopus 로고
    • Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women
    • Tseng HS, Lin C, Chan SE, et al. Pure mucinous carcinoma of the breast: clinicopathologic characteristics and long-term outcome among Taiwanese women. World J Surg Oncol 2013; 11: 139.
    • (2013) World J Surg Oncol , vol.11 , pp. 139
    • Tseng, H.S.1    Lin, C.2    Chan, S.E.3
  • 140
    • 84863067777 scopus 로고    scopus 로고
    • Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis
    • Bae SY, Choi MY, Cho DH, et al. Mucinous carcinoma of the breast in comparison with invasive ductal carcinoma: clinicopathologic characteristics and prognosis. J Breast Cancer 2011; 14: 308–313.
    • (2011) J Breast Cancer , vol.14 , pp. 308-313
    • Bae, S.Y.1    Choi, M.Y.2    Cho, D.H.3
  • 141
    • 0036890301 scopus 로고    scopus 로고
    • Mucinous cancers have fewer genomic alterations than more common classes of breast cancer
    • Fujii H, Anbazhagan R, Bornman DM, et al. Mucinous cancers have fewer genomic alterations than more common classes of breast cancer. Breast Cancer Res Treat 2002; 76: 255–260.
    • (2002) Breast Cancer Res Treat , vol.76 , pp. 255-260
    • Fujii, H.1    Anbazhagan, R.2    Bornman, D.M.3
  • 142
    • 70350683812 scopus 로고    scopus 로고
    • Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type
    • Weigelt B, Geyer FC, Horlings HM, et al. Mucinous and neuroendocrine breast carcinomas are transcriptionally distinct from invasive ductal carcinomas of no special type. Mod Pathol 2009; 22: 1401–1414.
    • (2009) Mod Pathol , vol.22 , pp. 1401-1414
    • Weigelt, B.1    Geyer, F.C.2    Horlings, H.M.3
  • 143
    • 84890428094 scopus 로고    scopus 로고
    • Genomic profiling of histological special types of breast cancer
    • Horlings HM, Weigelt B, Anderson EM, et al. Genomic profiling of histological special types of breast cancer. Breast Cancer Res Treat 2013; 142: 257–269.
    • (2013) Breast Cancer Res Treat , vol.142 , pp. 257-269
    • Horlings, H.M.1    Weigelt, B.2    Anderson, E.M.3
  • 144
    • 77958022477 scopus 로고    scopus 로고
    • Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type
    • Lacroix-Triki M, Suarez PH, MacKay A, et al. Mucinous carcinoma of the breast is genomically distinct from invasive ductal carcinomas of no special type. J Pathol 2010; 222: 282–298.
    • (2010) J Pathol , vol.222 , pp. 282-298
    • Lacroix-Triki, M.1    Suarez, P.H.2    MacKay, A.3
  • 145
    • 0037224889 scopus 로고    scopus 로고
    • Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma
    • Matsukita S, Nomoto M, Kitajima S, et al. Expression of mucins (MUC1, MUC2, MUC5AC and MUC6) in mucinous carcinoma of the breast: comparison with invasive ductal carcinoma. Histopathology 2003; 42: 26–36.
    • (2003) Histopathology , vol.42 , pp. 26-36
    • Matsukita, S.1    Nomoto, M.2    Kitajima, S.3
  • 146
    • 84867399030 scopus 로고    scopus 로고
    • Outcome of pure mucinous breast carcinoma compared to infiltrating ductal carcinoma: a population-based study from China
    • Cao AY, He M, Liu ZB, et al. Outcome of pure mucinous breast carcinoma compared to infiltrating ductal carcinoma: a population-based study from China. Ann Surg Oncol 2012; 19: 3019–3027.
    • (2012) Ann Surg Oncol , vol.19 , pp. 3019-3027
    • Cao, A.Y.1    He, M.2    Liu, Z.B.3
  • 147
    • 20444380691 scopus 로고    scopus 로고
    • Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast
    • Hsu YH, Shaw CK. Expression of p53, DCC, and HER-2/neu in mucinous carcinoma of the breast. Kaohsiung J Med Sci 2005; 21: 197–202.
    • (2005) Kaohsiung J Med Sci , vol.21 , pp. 197-202
    • Hsu, Y.H.1    Shaw, C.K.2
  • 148
    • 44849106397 scopus 로고    scopus 로고
    • Expression of androgen, estrogen and progesterone receptors in mucinous carcinoma of the breast
    • Cho LC, Hsu YH. Expression of androgen, estrogen and progesterone receptors in mucinous carcinoma of the breast. Kaohsiung J Med Sci 2008; 24: 227–232.
    • (2008) Kaohsiung J Med Sci , vol.24 , pp. 227-232
    • Cho, L.C.1    Hsu, Y.H.2
  • 149
    • 77952301633 scopus 로고    scopus 로고
    • Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified
    • Park S, Koo J, Kim JH, et al. Clinicopathological characteristics of mucinous carcinoma of the breast in Korea: comparison with invasive ductal carcinoma-not otherwise specified. J Korean Med Sci 2010; 25: 361–368.
    • (2010) J Korean Med Sci , vol.25 , pp. 361-368
    • Park, S.1    Koo, J.2    Kim, J.H.3
  • 150
    • 84877639944 scopus 로고    scopus 로고
    • MicroRNA and histopathological characterization of pure mucinous breast carcinoma
    • Zhou F, Li S, Meng HM, et al. MicroRNA and histopathological characterization of pure mucinous breast carcinoma. Cancer Biol Med 2013; 10: 22–27.
    • (2013) Cancer Biol Med , vol.10 , pp. 22-27
    • Zhou, F.1    Li, S.2    Meng, H.M.3
  • 151
    • 0032895974 scopus 로고    scopus 로고
    • Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas
    • Diab SG, Clark GM, Osborne CK, et al. Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas. J Clin Oncol 1999; 17: 1442–1448.
    • (1999) J Clin Oncol , vol.17 , pp. 1442-1448
    • Diab, S.G.1    Clark, G.M.2    Osborne, C.K.3
  • 152
    • 84869507148 scopus 로고    scopus 로고
    • Mucinous breast carcinomas lack PIK3CA and AKT1 mutations
    • Kehr EL, Jorns JM, Ang D, et al. Mucinous breast carcinomas lack PIK3CA and AKT1 mutations. Hum Pathol 2012; 43: 2207–2212.
    • (2012) Hum Pathol , vol.43 , pp. 2207-2212
    • Kehr, E.L.1    Jorns, J.M.2    Ang, D.3
  • 153
    • 52149086562 scopus 로고    scopus 로고
    • AKT1(E17K) in human solid tumours
    • Bleeker FE, Felicioni L, Buttitta F, et al. AKT1(E17K) in human solid tumours. Oncogene 2008; 27: 5648–5650.
    • (2008) Oncogene , vol.27 , pp. 5648-5650
    • Bleeker, F.E.1    Felicioni, L.2    Buttitta, F.3
  • 154
    • 32244445352 scopus 로고    scopus 로고
    • PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma
    • Buttitta F, Felicioni L, Barassi F, et al. PIK3CA mutation and histological type in breast carcinoma: high frequency of mutations in lobular carcinoma. J Pathol 2006; 208: 350–355.
    • (2006) J Pathol , vol.208 , pp. 350-355
    • Buttitta, F.1    Felicioni, L.2    Barassi, F.3
  • 155
    • 74749101634 scopus 로고    scopus 로고
    • PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast
    • Li H, Zhu R, Wang L, et al. PIK3CA mutations mostly begin to develop in ductal carcinoma of the breast. Exp Mol Pathol 2010; 88: 150–155.
    • (2010) Exp Mol Pathol , vol.88 , pp. 150-155
    • Li, H.1    Zhu, R.2    Wang, L.3
  • 156
    • 33846854921 scopus 로고    scopus 로고
    • Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women
    • Maruyama N, Miyoshi Y, Taguchi T, et al. Clinicopathologic analysis of breast cancers with PIK3CA mutations in Japanese women. Clin Cancer Res 2007; 13: 408–414.
    • (2007) Clin Cancer Res , vol.13 , pp. 408-414
    • Maruyama, N.1    Miyoshi, Y.2    Taguchi, T.3
  • 157
    • 74549137913 scopus 로고    scopus 로고
    • PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases
    • Michelucci A, Di Cristofano C, Lami A, et al. PIK3CA in breast carcinoma: a mutational analysis of sporadic and hereditary cases. Diagn Mol Pathol 2009; 18: 200–205.
    • (2009) Diagn Mol Pathol , vol.18 , pp. 200-205
    • Michelucci, A.1    Di Cristofano, C.2    Lami, A.3
  • 158
    • 84863983915 scopus 로고    scopus 로고
    • Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers
    • Santarpia L, Qi Y, Stemke-Hale K, et al. Mutation profiling identifies numerous rare drug targets and distinct mutation patterns in different clinical subtypes of breast cancers. Breast Cancer Res Treat 2012; 134: 333–343.
    • (2012) Breast Cancer Res Treat , vol.134 , pp. 333-343
    • Santarpia, L.1    Qi, Y.2    Stemke-Hale, K.3
  • 159
    • 84874042040 scopus 로고    scopus 로고
    • Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients
    • Tong L, Yang XX, Liu MF, et al. Mutational analysis of key EGFR pathway genes in Chinese breast cancer patients. Asian Pacific J Cancer Prev 2012; 13: 5599–5603.
    • (2012) Asian Pacific J Cancer Prev , vol.13 , pp. 5599-5603
    • Tong, L.1    Yang, X.X.2    Liu, M.F.3
  • 160
    • 0142021895 scopus 로고    scopus 로고
    • Microsatellite instability in hereditary and sporadic breast cancers
    • Adem C, Soderberg CL, Cunningham JM, et al. Microsatellite instability in hereditary and sporadic breast cancers. Int J Cancer 2003; 107: 580–582.
    • (2003) Int J Cancer , vol.107 , pp. 580-582
    • Adem, C.1    Soderberg, C.L.2    Cunningham, J.M.3
  • 161
    • 0032905311 scopus 로고    scopus 로고
    • Microsatellite instability is uncommon in breast cancer
    • Anbazhagan R, Fujii H, Gabrielson E. Microsatellite instability is uncommon in breast cancer. Clin Cancer Res 1999; 5: 839–844.
    • (1999) Clin Cancer Res , vol.5 , pp. 839-844
    • Anbazhagan, R.1    Fujii, H.2    Gabrielson, E.3
  • 162
    • 0242391894 scopus 로고    scopus 로고
    • MSI-low, a real phenomenon which varies in frequency among cancer types
    • Halford SE, Sawyer EJ, Lambros MB, et al. MSI-low, a real phenomenon which varies in frequency among cancer types. J Pathol 2003; 201: 389–394.
    • (2003) J Pathol , vol.201 , pp. 389-394
    • Halford, S.E.1    Sawyer, E.J.2    Lambros, M.B.3
  • 163
    • 79955085940 scopus 로고    scopus 로고
    • Absence of microsatellite instability in mucinous carcinomas of the breast
    • Lacroix-Triki M, Lambros MB, Geyer FC, et al. Absence of microsatellite instability in mucinous carcinomas of the breast. Int J Clin Exp Pathol 2010; 4: 22–31.
    • (2010) Int J Clin Exp Pathol , vol.4 , pp. 22-31
    • Lacroix-Triki, M.1    Lambros, M.B.2    Geyer, F.C.3
  • 164
    • 0027140481 scopus 로고
    • Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome
    • Peltomaki P, Lothe RA, Aaltonen LA, et al. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res 1993; 53: 5853–5855.
    • (1993) Cancer Res , vol.53 , pp. 5853-5855
    • Peltomaki, P.1    Lothe, R.A.2    Aaltonen, L.A.3
  • 165
    • 0029658742 scopus 로고    scopus 로고
    • Microsatellite instability in sporadic human breast cancers
    • Toyama T, Iwase H, Yamashita H, et al. Microsatellite instability in sporadic human breast cancers. Int J Cancer 1996; 68: 447–451.
    • (1996) Int J Cancer , vol.68 , pp. 447-451
    • Toyama, T.1    Iwase, H.2    Yamashita, H.3
  • 166
    • 0037199957 scopus 로고    scopus 로고
    • Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1
    • Perrais M, Pigny P, Copin MC, et al. Induction of MUC2 and MUC5AC mucins by factors of the epidermal growth factor (EGF) family is mediated by EGF receptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1. J Biol Chem 2002; 277: 32258–32267.
    • (2002) J Biol Chem , vol.277 , pp. 32258-32267
    • Perrais, M.1    Pigny, P.2    Copin, M.C.3
  • 167
    • 78149363075 scopus 로고    scopus 로고
    • Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway
    • Bai Z, Zhang Z, Ye Y, et al. Sodium butyrate induces differentiation of gastric cancer cells to intestinal cells via the PTEN/phosphoinositide 3-kinase pathway. Cell Biol Int 2010; 34: 1141–1145.
    • (2010) Cell Biol Int , vol.34 , pp. 1141-1145
    • Bai, Z.1    Zhang, Z.2    Ye, Y.3
  • 168
    • 84855176448 scopus 로고    scopus 로고
    • Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer
    • Catalano V, Loupakis F, Graziano F, et al. Prognosis of mucinous histology for patients with radically resected stage II and III colon cancer. Ann Oncol 2012; 23: 135–141.
    • (2012) Ann Oncol , vol.23 , pp. 135-141
    • Catalano, V.1    Loupakis, F.2    Graziano, F.3
  • 169
    • 0038002279 scopus 로고    scopus 로고
    • Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
    • Ribic CM, Sargent DJ, Moore MJ, et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003; 349: 247–257.
    • (2003) N Engl J Med , vol.349 , pp. 247-257
    • Ribic, C.M.1    Sargent, D.J.2    Moore, M.J.3
  • 170
    • 84855839649 scopus 로고    scopus 로고
    • Rectal cancer: mucinous carcinoma on magnetic resonance imaging indicates poor response to neoadjuvant chemoradiation
    • Oberholzer K, Menig M, Kreft A, et al. Rectal cancer: mucinous carcinoma on magnetic resonance imaging indicates poor response to neoadjuvant chemoradiation. Int J Rad Oncol Biol Phys 2012; 82: 842–848.
    • (2012) Int J Rad Oncol Biol Phys , vol.82 , pp. 842-848
    • Oberholzer, K.1    Menig, M.2    Kreft, A.3
  • 171
    • 80051549134 scopus 로고    scopus 로고
    • Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis
    • Shin US, Yu CS, Kim JH, et al. Mucinous rectal cancer: effectiveness of preoperative chemoradiotherapy and prognosis. Ann Surg Oncol 2011; 18: 2232–2239.
    • (2011) Ann Surg Oncol , vol.18 , pp. 2232-2239
    • Shin, U.S.1    Yu, C.S.2    Kim, J.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.